Chromosome Research最新文献

Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule. 耐热酵母K. marxianus中的着丝粒介导对单个微管的附着。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-07-03 DOI: 10.1007/s10577-025-09772-4

Daniel J Barrero, Sabrine Hedouin, Yizi Mao, Charles L Asbury, Andrew B Stergachis, Eileen O'Toole, Sue Biggins

{"title":"Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule.","authors":"Daniel J Barrero, Sabrine Hedouin, Yizi Mao, Charles L Asbury, Andrew B Stergachis, Eileen O'Toole, Sue Biggins","doi":"10.1007/s10577-025-09772-4","DOIUrl":"10.1007/s10577-025-09772-4","url":null,"abstract":"Eukaryotic chromosome segregation requires spindle microtubules to attach to chromosomes through kinetochores. The chromosomal locus that mediates kinetochore assembly is the centromere and is epigenetically specified in most organisms by a centromeric histone H3 variant called CENP-A. An exception to this is budding yeast, which have short, sequenced-defined point centromeres. In S. cerevisiae, a single CENP-A nucleosome is formed at the centromere and is sufficient for kinetochore assembly. The thermophilic budding yeast Kluyveromyces marxianus also has a point centromere, but its length is nearly double the S. cerevisiae centromere and the number of centromeric nucleosomes and kinetochore attachment sites is unknown. Purification of native kinetochores from K. marxianus yielded a mixed population, with one subpopulation that appeared to consist of doublets, making it unclear whether K. marxianus shares the same attachment architecture as S. cerevisiae. Here, we demonstrate that though the doublet kinetochores have a functional impact on kinetochore strength, kinetochore localization throughout the cell cycle appears conserved between these two yeasts. In addition, whole spindle electron tomography demonstrates that a single microtubule binds to each chromosome. Single-molecule nucleosome mapping analysis suggests the presence of a single centromeric nucleosome. Taken together, we propose that the K. marxianus point centromere assembles a single centromeric nucleosome that mediates attachment to one microtubule.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"14"},"PeriodicalIF":2.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CENP-A and centromere evolution in equids. 马科动物的CENP-A与着丝粒进化。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-06-30 DOI: 10.1007/s10577-025-09773-3

Eleonora Cappelletti, Francesca M Piras, Marialaura Biundo, Rebecca R Bellone, Carrie J Finno, Ted S Kalbfleisch, Jessica L Petersen, Solomon G Nergadze, Elena Giulotto

{"title":"CENP-A and centromere evolution in equids.","authors":"Eleonora Cappelletti, Francesca M Piras, Marialaura Biundo, Rebecca R Bellone, Carrie J Finno, Ted S Kalbfleisch, Jessica L Petersen, Solomon G Nergadze, Elena Giulotto","doi":"10.1007/s10577-025-09773-3","DOIUrl":"10.1007/s10577-025-09773-3","url":null,"abstract":"While the centromeric function is conserved and epigenetically specified by CENP-A, centromeric DNA, typically composed of satellite repeats, is highly divergent and rapidly evolving. In the species of the genus Equus (horses, asses and zebras), also known as equids, the numerous centromeres devoid of satellite repeats enabled us to carry out molecular analysis of centromeric chromatin establishing a unique model system for mammalian centromere biology. In this review, after a brief description of the rapid evolution of equids, we outline one of our most relevant initial discoveries: the position of CENP-A binding domains is variable among individuals giving rise to epialleles which are inherited as Mendelian traits. This positional variability was recently confirmed in human centromeres whose repetitive DNA organization could be analyzed thanks to telomere-to-telomere (T2T) genome assemblies. Another unexpected observation was that, in equids, CENP-B does not bind the centromeric core and is uncoupled from CENP-A and CENP-C. CENP-B is absent from the majority of chromosomes while the CENP-B binding DNA sequence (CENP-B box) is comprised within a satellite that is localized at pericentromeric or terminal positions. Finally, comparative molecular and cytogenetic analyses of satellite-free centromeres revealed that the birth of neocentromeres during the evolution of this genus occurred through two alternative mechanisms: centromere repositioning and Robertsonian fusion. These events played a key role in karyotype reshuffling and speciation. Investigating centromere organization in equids provided new insights into the complexity of centromere organization across the vast biodiversity of the mammalian world, where the majority of species remain understudied.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"13"},"PeriodicalIF":2.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-coverage whole-genome sequencing for differentiating cervical cancer from cervical intraepithelial neoplasia and benign diseases. 低覆盖率全基因组测序鉴别宫颈癌与宫颈上皮内瘤变及良性疾病。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-06-20 DOI: 10.1007/s10577-025-09770-6

Tingting Zhang, Fang Gu, Jia Yi He, Weihua Li, Ruxue Han, Xinyu Liu, Chan Dai, Zhendong Qin, Di Zhang, Jun Lu, Hua Li

{"title":"Low-coverage whole-genome sequencing for differentiating cervical cancer from cervical intraepithelial neoplasia and benign diseases.","authors":"Tingting Zhang, Fang Gu, Jia Yi He, Weihua Li, Ruxue Han, Xinyu Liu, Chan Dai, Zhendong Qin, Di Zhang, Jun Lu, Hua Li","doi":"10.1007/s10577-025-09770-6","DOIUrl":"10.1007/s10577-025-09770-6","url":null,"abstract":"Objectives: This study aimed to analyze chromosomal arm-level copy number variations (CNVs) in benign diseases, cervical intraepithelial neoplasia (CIN), and cervical cancer (CC) using low-coverage whole genome sequencing (LC-WGS) and evaluate the efficacy of the ultrasensitive chromosomal aneuploidy detector (UCAD) model in distinguishing CC from CIN and benign diseases.Methods: Cervical exfoliated cell specimens from 50 patients were collected for high-risk human papillomavirus(hr-HPV) testing, ThinPrep Cytologic Test (TCT), and CNV detection via LC-WGS. UCAD was employed to analyze chromosomal changes, with validation using WGS data from the National Center for Biotechnology Information(NCBI) database.Results: Among 50 patients, 8 had benign disease, 3 CIN1, 15 CIN2, 6 CIN2-3, 13 CIN3, and 5 CC. Chromosomal instability was detected in 9 patients (18%): all 5 CC cases, 3 CIN3 cases, and 1 CIN1 case. Gains in 3q were observed in all CC and CIN3 cases with CNVs. UCAD achieved 100% sensitivity and 91.11% specificity in differentiating CC from CIN and benign diseases, outperforming hr-HPV and TCT. The UCAD model was also applied to 5 CC and 1 high-grade squamous intraepithelial lesion (HSIL) cases obtained from the NCBI database, and the findings validated its ability to detect chromosomal aberrations in all cases.Conclusions: CNV analysis of cervical exfoliated cells shows promise for CC detection, with UCAD demonstrating high accuracy. Further validation in larger cohorts is needed to confirm its clinical utility.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"12"},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure. 常规核小体和CENP-A核小体之间的溶液构象差异在高压下由可逆变形加剧。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-06-12 DOI: 10.1007/s10577-025-09769-z

Kushol Gupta, Nikolina Sekulić, Praveen Kumar Allu, Nicklas Sapp, Qingqiu Huang, Kathryn Sarachan, Mikkel Christensen, Reidar Lund, Susan Krueger, Joseph E Curtis, Richard E Gillilan, Gregory D Van Duyne, Ben E Black

{"title":"Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure.","authors":"Kushol Gupta, Nikolina Sekulić, Praveen Kumar Allu, Nicklas Sapp, Qingqiu Huang, Kathryn Sarachan, Mikkel Christensen, Reidar Lund, Susan Krueger, Joseph E Curtis, Richard E Gillilan, Gregory D Van Duyne, Ben E Black","doi":"10.1007/s10577-025-09769-z","DOIUrl":"10.1007/s10577-025-09769-z","url":null,"abstract":"Solution-based interrogation of the physical nature of nucleosomes has its roots in X-ray and neutron scattering experiments, including those that provided the initial observation that DNA wraps around core histones. In this study, we performed a comprehensive small-angle scattering study to compare canonical nucleosomes with variant centromeric nucleosomes harboring the histone variant, CENP-A. We used nucleosome core particles (NCPs) assembled on an artificial positioning sequence (Widom 601) and compared these to those assembled on a natural α-satellite DNA from human centromeres. We establish the native solution properties of octameric H3 and CENP-A NCPs using analytical ultracentrifugation (AUC), small-angle X-ray scattering (SAXS), and contrast variation small-angle neutron scattering (CV-SANS). Using high-pressure SAXS (HP-SAXS), we discovered that both histone and DNA sequence have an impact on the stability of octameric nucleosomes in solution under high pressure (300 MPa), with evidence of reversible unwrapping in these experimental conditions. Both canonical nucleosomes harboring conventional histone H3 and their centromeric counterparts harboring CENP-A have a substantial increase in their radius of gyration, but this increase is much less prominent for centromeric nucleosomes. More broadly for chromosome-related research, we note that as HP-SAXS methodologies expand in their utility, we anticipate this will provide a powerful solution-based approach to study nucleosomes and higher-order chromatin complexes.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"11"},"PeriodicalIF":2.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appearance of transient heteromorphic large chromosome in glyphosate-resistant Amaranthus tuberculatus. 抗草甘膦苋瞬时异型大染色体的出现。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-05-14 DOI: 10.1007/s10577-025-09768-0

Rajendran Sathishraj, Yoonha Ju, Bikram S Gill, Dal-Hoe Koo

{"title":"Appearance of transient heteromorphic large chromosome in glyphosate-resistant Amaranthus tuberculatus.","authors":"Rajendran Sathishraj, Yoonha Ju, Bikram S Gill, Dal-Hoe Koo","doi":"10.1007/s10577-025-09768-0","DOIUrl":"10.1007/s10577-025-09768-0","url":null,"abstract":"Glyphosate resistance in crop weeds is commonly attributed to rapid evolution through the amplification of the target gene, EPSPS (5-enolpyruvylshikimate-3-phosphate synthase). This amplification typically occurs through mechanisms such as unequal recombination, segmental duplications within the target chromosome, or the formation of ring chromosomes and extrachromosomal circular (ecc) DNA elements containing EPSPS. However, structural abnormalities in chromosomes not directly associated with EPSPS amplification have not been documented in the glyphosate-resistant weed population. Here, we describe the presence of a large chromosome found exclusively in the glyphosate-resistant Amaranthus tuberculatus (waterhemp) population but absent in susceptible counterparts. This large chromosome (~ 6 μm) is approximately twice the size of normal chromosomes (~ 2-3 μm) and is present in both male and female euploid plants (2n = 32) in a heteromorphic state. It aroses through pericentromeric heterochromatin expansion and duplications of the 5S rDNA locus but notably lacks the EPSPS gene. The large chromosome pairs with its normal homolog but was not transmitted to progeny in controlled greenhouse matings, suggesting a fitness cost in the absence of glyphosate selection pressure. This large chromosome offers a potential resource for the investigation of chromosome evolution of adaptive traits for glyphosate resistance in A. tuberculatus.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"9"},"PeriodicalIF":2.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marking dad's centromeres: maintaining CENP-A in sperm. 标记父亲的着丝粒：维持精子中的CENP-A。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-04-26 DOI: 10.1007/s10577-025-09766-2

Miriama Štiavnická, Rachel S Keegan, Elaine M Dunleavy

引用次数: 0

CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education. CRISPR-CISH：用于研究和生命科学教育的原位显色DNA重复检测系统。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-04-22 DOI: 10.1007/s10577-025-09767-1

Bhanu Prakash Potlapalli, Fabian Dassau, Jörg Fuchs, Deboprio Roy Sushmoy, Andreas Houben

{"title":"CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education.","authors":"Bhanu Prakash Potlapalli, Fabian Dassau, Jörg Fuchs, Deboprio Roy Sushmoy, Andreas Houben","doi":"10.1007/s10577-025-09767-1","DOIUrl":"10.1007/s10577-025-09767-1","url":null,"abstract":"In situ hybridization is a technique to visualize specific DNA sequences within nuclei and chromosomes. Various DNA in situ fluorescent labeling methods have been developed, which typically involve global DNA denaturation prior to the probe hybridization and often require fluorescence microscopes for visualization. Here, we report the development of a CRISPR/dCas9-mediated chromogenic in situ DNA detection (CRISPR-CISH) method that combines chromogenic signal detection with CRISPR imaging. This non-fluorescent approach uses 3' biotin-labeled tracrRNA and target-specific crRNA to form mature gRNA, which activates dCas9 to bind to target sequences. The subsequent application of streptavidin alkaline phosphatase or horseradish peroxidase generates chromogenic, target-specific signals that can be analyzed using conventional bright-field microscopes. Additionally, chromatin counterstains were identified to aid in the interpretation of CRISPR-CISH-generated target signals. This advancement makes in situ DNA detection techniques more accessible to researchers, diagnostic applications, and educational institutions in resource-limited settings.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"7"},"PeriodicalIF":2.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The landscape of transposable element distribution in the genome of Neotropical fish Apareiodon sp. (Characiformes: Parodontidae). 新热带鱼parareiodon sp.基因组转座因子分布景观（特征：parareiodon科）。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-04-05 DOI: 10.1007/s10577-025-09765-3

Fernanda Souza de Oliveira, Toby Brann, Ivan Rodrigo Wolf, Viviane Nogaroto, Cesar Martins, Anna Victoria Protasio, Marcelo Ricardo Vicari

{"title":"The landscape of transposable element distribution in the genome of Neotropical fish Apareiodon sp. (Characiformes: Parodontidae).","authors":"Fernanda Souza de Oliveira, Toby Brann, Ivan Rodrigo Wolf, Viviane Nogaroto, Cesar Martins, Anna Victoria Protasio, Marcelo Ricardo Vicari","doi":"10.1007/s10577-025-09765-3","DOIUrl":"10.1007/s10577-025-09765-3","url":null,"abstract":"Transposable elements (TEs) are widely present in eukaryotic genomes, where they can contribute to genome size and functional modifications. As new genomes are sequenced and annotated, more studies can be conducted regarding TE content, distribution, and genome evolution. TEs are extensively diversified in fish genomes resulting in an important role in genome and chromosome evolution. However, curated TE libraries are still scarce in non-model organisms, making it difficult to evaluate TE's impact on genomic modifications thoroughly. Here, we aimed to obtain a curated TE library from the neotropical fish Apareiodon sp. genome. The prospection and curation of the TE library resulted in 244 families from 18 superfamilies of DNA transposons and retrotransposons, which comprise about 10% of the genome, with most insertions fitting in one or a few families. A greater diversity of retrotransposon families is present, especially for Ty3 superfamily. Despite the greater number of retrotransposon families, DNA transposons are the most abundant in the genome, with 37% of all TE insertions belonging to the Tc1-Mariner superfamily. Complete TE copies were observed for almost all superfamilies, with most of the sequences on the Tc1-Mariner group. DNA transposons and SINEs presented older insertions in the genome, followed by LINEs and LTR retrotransposons. TE genome density is highest in the cs25 scaffold, and enriched for Helitron elements. With these data, allied to previous studies on chromosome evolution, we suggest that cs25 bears the W chromosome specific region of the Apareiodon sp. genome, with the presence of significant amount of Helitron insertions.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"6"},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells. TOP2B是SH-SY5Y细胞经维甲酸处理后发生区室强度变化的必要条件。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-04-04 DOI: 10.1007/s10577-025-09764-4

Erica M Hildebrand, Ian G Cowell, Mushtaq M Khazeem, Snehal Sambare, Ozgun Uyan, Job Dekker, Caroline A Austin

{"title":"TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells.","authors":"Erica M Hildebrand, Ian G Cowell, Mushtaq M Khazeem, Snehal Sambare, Ozgun Uyan, Job Dekker, Caroline A Austin","doi":"10.1007/s10577-025-09764-4","DOIUrl":"10.1007/s10577-025-09764-4","url":null,"abstract":"DNA topoisomerase II beta (TOP2B) is required for correct execution of certain developmental transcriptional programs and for signal-induced transcriptional activation, including transcriptional activation by nuclear hormone ligands such as retinoic acid. In addition, TOP2B is enriched at genomic locations occupied by CCCTC-Binding factor (CTCF) and cohesin (RAD21). suggesting a role in chromosome looping and/or establishing or maintaining aspects of chromosome 3D structure. This led us to investigate the effect of TOP2B inactivation on patterns of intra- and inter- chromosomal interaction that reflect the 3D architecture of the genome. Using the retinoic acid responsive SH-SY5Y neuroblastoma cell line model, we had previously demonstrated many gene expression changes upon retinoic acid treatment and upon deletion of TOP2B. We report here that these expression changes in TOP2B null versus WT cells are accompanied by surprisingly subtle changes in local chromosome organization. However, we do observe quantitative changes in chromosome organization on a megabase scale. First, lack of TOP2B did affect compartment strength changes that occur upon ATRA treatment. Second, we observe an excess of very long-range interactions, reminiscent of interactions seen in mitotic cells, suggesting the possibility that in the absence of TOP2B some mitotic interactions are retained. Third, we see quantitative changes in centromere-telomere interactions, again indicating global changes at the megabase and chromosome level. These data support the surprising conclusion that TOP2B has only a minor role in chromosome dynamics and organization.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"33 1","pages":"5"},"PeriodicalIF":2.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First prenatal case of jumping-like translocations: unraveling complex chromosomal rearrangements. 第一个跳跃样易位的产前病例：解开复杂的染色体重排。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2025-03-12 DOI: 10.1007/s10577-025-09763-5

Kevin Cassinari, Anne Claire Brehin, Ferdi Kundul, Mathieu Castelain, Sophie Patrier-Sallebert, Alain Diguet, Eric Verspyck, Claude Houdayer, Géraldine Joly-Hélas, Pascal Chambon

引用次数: 0