特定非整倍体的建模：从核型操作到生物学见解。

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chromosome Research Pub Date : 2023-08-29 DOI:10.1007/s10577-023-09735-7

My Anh Truong, Paula Cané-Gasull, Susanne M A Lens

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引用次数: 0

摘要

染色体数目异常或非整倍体是发育障碍的基础，也是癌症的常见特征，不同的癌症类型表现出不同的染色体增失模式。为了了解特定的非整倍体是如何在某些组织中出现的，以及它们是如何促进疾病发展的，已经开发了各种方法来改变哺乳动物细胞和小鼠的核型。在这篇综述中，我们概述了在人类和小鼠细胞系统中诱导或选择特定染色体得失的经典和新策略。我们强调了这些定制的非整倍体模型如何帮助我们扩展特定非整倍性对（癌症）细胞生理学的影响的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modeling specific aneuploidies: from karyotype manipulations to biological insights.

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Modeling specific aneuploidies: from karyotype manipulations to biological insights.

An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how specific aneuploidies emerge in certain tissues and how they contribute to disease development, various methods have been developed to alter the karyotype of mammalian cells and mice. In this review, we provide an overview of both classic and novel strategies for inducing or selecting specific chromosomal gains and losses in human and murine cell systems. We highlight how these customized aneuploidy models helped expanding our knowledge of the consequences of specific aneuploidies to (cancer) cell physiology.

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来源期刊

Chromosome Research 生物-生化与分子生物学

CiteScore

4.70

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Chromosome Research publishes manuscripts from work based on all organisms and encourages submissions in the following areas including, but not limited, to: · Chromosomes and their linkage to diseases; · Chromosome organization within the nucleus; · Chromatin biology (transcription, non-coding RNA, etc); · Chromosome structure, function and mechanics; · Chromosome and DNA repair; · Epigenetic chromosomal functions (centromeres, telomeres, replication, imprinting, dosage compensation, sex determination, chromosome remodeling); · Architectural/epigenomic organization of the genome; · Functional annotation of the genome; · Functional and comparative genomics in plants and animals; · Karyology studies that help resolve difficult taxonomic problems or that provide clues to fundamental mechanisms of genome and karyotype evolution in plants and animals; · Mitosis and Meiosis; · Cancer cytogenomics.