Clinica Terapeutica最新文献

{"title":"Association Between Thyroid Function and Metabolic Dysfunction-Associated Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Case-Control Study.","authors":"Ihab Anwar Orabi, Ahmed A Elhadidy, Ola Abd Elfattah Ali Amro, Asmaa A Attia, Amr A Abdelkader, Elham Shabaan Mohamed, Mohammad Mossaad Abd Allah Alsayyad, Ahmed Fakeih Sakr Elfors, Marian Wagieh Mansour Abdelmalak, Sherif Mohamed Elsayed Amin Hegab, Tamer Hassan Rashwan, Hatem Attia Mostafa Ismail, Hanan A Hegazy, S A Mashaal","doi":"10.7417/CT.2026.2108","DOIUrl":"10.7417/CT.2026.2108","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent among patients with type 2 diabetes mellitus (T2DM) and is closely linked to metabolic disturbances such as insulin resistance and dyslipidemia. Thyroid hormones play a critical role in regulating hepatic lipid metabolism and energy homeostasis; however, their relationship with MAFLD in diabetic populations remains incompletely defined.</p><p><strong>Methods: </strong>In this case-control study, 150 patients with T2DM were enrolled, including 75 patients with MAFLD and 75 without MAFLD. Hepatic steatosis was confirmed using transient elastography with controlled attenuation parameter (CAP). Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were measured using chemiluminescent immunoassays. Clinical, anthropometric, and biochemical parameters were assessed. Multivariate logistic regression analysis was performed to identify independent predictors of MAFLD.</p><p><strong>Results: </strong>Patients with MAFLD had significantly lower FT3 levels and higher TSH levels compared with diabetic controls without MAFLD (p = 0.016 and p < 0.001, respectively), while FT4 levels were comparable between groups. MAFLD was also associated with an adverse metabolic profile, including elevated triglycerides, total cholesterol, and low-density lipoprotein cholesterol, along with reduced high-density lipoprotein cholesterol (all p < 0.001). Liver enzymes were significantly higher in the MAFLD group. In multivariate analysis, elevated TSH (OR = 3.62, 95% CI: 1.21-10.84, p = 0.021) and triglycerides (OR = 1.43, 95% CI: 1.14-1.80, p = 0.002) were independently associated with MAFLD, whereas FT3 was not independently associated after adjustment.</p><p><strong>Conclusions: </strong>Elevated TSH levels are independently associated with MAFLD in patients with T2DM, suggesting a link between thyroid function and hepatic steatosis beyond traditional metabolic risk factors. These findings highlight the potential role of thyroid function, particularly TSH, in the metabolic risk stratification of patients with diabetes and warrant further investigation into thyroid-liver interactions.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 5","pages":"1079-1085"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Pediatric Living Donor Liver Transplantation for Cholestatic Liver Disease in Different Body Weight Groups. A Retrospective Cohort Study.","authors":"Marolla Maher Iskander, Amr Ahmed Abdelaal, Mostafa Abdo Mohamed, Mohamed Eladawy, Mahmmoud Talaat Ryan","doi":"10.7417/CT.2026.2119","DOIUrl":"10.7417/CT.2026.2119","url":null,"abstract":"<p><strong>Background: </strong>Cholestatic liver diseases are the leading indication for pediatric liver transplantation, and low recipient body weight remains a major concern in pediatric living donor liver transplantation (LDLT) because of perceived higher technical complexity and poorer outcomes creating controversy over optimal timing for transplantation.</p><p><strong>Objective: </strong>To evaluate the effect of recipient body weight on postoperative complications and survival after LDLT for cholestatic liver diseases in children.</p><p><strong>Methods: </strong>This retrospective cohort study included 102 pediatric recipients younger than 18 years who underwent LDLT for cholestatic liver diseases between August 2015 and June 2024 at two Cairo transplant centers. Recipients were stratified into three body weight groups: less than 10 kg (n=28), 10-15 kg (n=26), and more than 15 kg (n=48). Demographic, operative, postoperative, and survival outcomes were compared across groups using appropriate statistical tests, and survival was assessed by Kaplan-Meier analysis with log-rank testing.</p><p><strong>Results: </strong>Median age was 6 years and median body weight was 15 kg; 59.8% of recipients were male. Biliary atresia (38.3%) and progressive familial intrahepatic cholestasis (34.3%) were the leading indications for transplantation. Left lateral segment grafts were used in 60.8% of cases, and the median graft-to-recipient weight ratio was 2.11. Recipients weighing less than 10 kg had significantly higher postoperative pneumonia rates (51.7%) and portal vein thrombosis rates (14.3%). Biliary complications occurred across all groups, with bile leak in 9.8 % and biliary stricture in 12.7% bile leak followed by stricture in 5.8 %, without significant between-group differences. Early mortality rates were 25.0%, 19.2%, and 14.6% in the less than 10 kg, 10-15 kg, and more than 15 kg groups, respectively, without significant difference. One-year survival was 71.4%, 76.9%, and 87.5%, and three-year survival was 71.4%, 76.9%, and 81.3%, respectively, also without significant differences.</p><p><strong>Conclusions: </strong>Children weighing less than 10 kg at the time of LDLT have higher postoperative morbidity, particularly pneumonia and portal vein thrombosis, but achieve survival comparable to that of heavier recipients. Low body weight alone should not be considered a contraindication to pediatric LDLT in experienced centers.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 5","pages":"1166-1175"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonoelastographic Evaluation of the Triangular Fibrocartilage Complex Injuries Compared to Coronal T2 &Gradient-echo MRI Images: A cross sectional study.","authors":"Rahma Farghaly Aly, Marwa Ibrahim Fahmy, Muhammad Gamal Abd El Atty, Samar Ramzy Ragheb","doi":"10.7417/CT.2026.2109","DOIUrl":"10.7417/CT.2026.2109","url":null,"abstract":"<p><strong>Background: </strong>The triangular fibrocartilage complex (TFCC) is a key fibrocartilaginous and ligamentous structure located on the ulnar side of the wrist. It plays a crucial role in separating the ulnocarpal joint from the distal radioulnar joint (DRUJ) and is essential for stabilizing the DRUJ. In addition to maintaining joint stability, the TFCC also functions as a shock absorber, distributing axial loads transmitted through the ulnar aspect of the wrist.</p><p><strong>Objective: </strong>To evaluate the diagnostic utility of high resolution ultrasound and strain elastography in detecting TFCC injuries, focusing primarily on the articular disc, in comparison to MRI using sensitive sequences.</p><p><strong>Patients and methods: </strong>This study is cross sectional study conducted at the US Radiology Unit; Radiology Department, Ain Shams University Hospitals (ASUH), and the magnetic resonance imaging (MRI) Radiology Unit; Radiology Department, ASUH on 26 patients included in this study. Patients who came to the orthopaedic hand clinic presented with ulnar side wrist pain.</p><p><strong>Results: </strong>The results of the study demonstrated a strong correlation between strain elastography (SE) and MRI in the detection of TFCC injuries. Quantitative Sonoelastography (SEL) measurements showed consistent patterns of altered tissue stiffness in patients with confirmed TFCC pathology on MRI, suggesting that SEL can reliably reflect the biomechanical changes associated with TFCC damage. Statistical analysis revealed a significant positive correlation between SEL findings and MRI-detected abnormalities, supporting the potential of SEL as a complementary diagnostic modality.</p><p><strong>Conclusion: </strong>These findings indicate that SEL may represent a promising adjunctive imaging modality for the early assessment of TFCC injuries, particularly in settings where MRI availability is limited. So incorporating SEL in the diagnostic workflow could help stratify patients, identifying those who may benefit from more advanced imaging modalities such as magnetic resonance arthrography (MRA) or diagnostic arthroscopy for further evaluation and confirmation. This approach may enhance diagnostic accuracy while minimizing unnecessary invasive procedures.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 5","pages":"1086-1095"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Biologic and Targeted DMARDs in Patients with Rheumatic Diseases Undergoing Orthopedic Surgery: A Systematic Review and Meta-Analysis.","authors":"Zenat Khired, Mohamed Abdelrazek, Maamon Aljonaid, Hala Ahmed Ramadan, Amr M Soliman, Neeveen Abdel Latif Fahmy Elshewy, Mohamed Hashem Youssef Abdou, Hail Turki Alharthi, Yasser A Elmotaleb Gazar, Mohamed Ali, Ibrahim Ezz, Moataz Eldeeb, Mona El Sayed Youssef, Nazik Abdallah Ahmed Saad, Elham Shabaan Mohamed","doi":"10.7417/CT.2026.2127","DOIUrl":"10.7417/CT.2026.2127","url":null,"abstract":"<p><strong>Background: </strong>Biologic (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) have revolutionized the management of inflammatory rheumatic diseases. However, their perioperative use in orthopedic surgery presents a clinical dilemma between increased infection risk and disease flare upon discontinuation.</p><p><strong>Objectives: </strong>To evaluate the impact of perioperative continuation versus withholding of bDMARDs/tsDMARDs on postoperative complications, inflammatory biomarkers, drug-related toxicities, and disease flare.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines. PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane CENTRAL were searched up to January 2025. Randomized controlled trials and observational studies were included. Risk of bias was assessed using RoB 2.0 and the Newcastle-Ottawa Scale. Pooled odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Certainty of evidence was evaluated using GRADE.</p><p><strong>Results: </strong>Sixty-seven studies were analyzed (42 contributing quantitative data; 51,394 unique patients). The primary SSI outcome (k=16) encompasses the complete patient pool (N=51,394). Perioperative continuation of bDMARDs/tsDMARDs was associated with increased SSI risk (corrected OR 1.27; 95% CI 1.12-1.44) and a non-significant trend toward higher PJI risk after data correction (corrected OR 1.24; 95% CI 0.88-1.75). Continuation significantly reduced disease flare risk (OR 0.41; 95% CI 0.29-0.58). Continuation was also associated with lower perioperative CRP and IL-6 levels.</p><p><strong>Conclusions: </strong>Perioperative continuation of bDMARDs and tsDMARDs increases infection risk but reduces disease flare. Management should be individualized, considering drug-specific risks, including biomarker suppression and thromboembolism.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 5","pages":"1242-1256"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisystem Burden of Paediatric Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Neuropsychiatric, Renal, Ocular, and Immunological Outcomes.","authors":"Mona Atef Alatar, Hesham M Hefny, Ibrahim Fawzy Ezz, Yasmin Mahmoud, Noura Abdel Alim Hassanin Ahmed, Mustafa Adel Elmenawy, Amal H Ali, Mohamed Ahmed Noureldin, Mohamed Khairy Qura, Rasha Muhammad Ibrahim Rashed, Muhammad H Abu Elaish, Mohamed Al-Adl Ali Ali, Hanan F Ibrahim, Husam M Faramawi, M A Ayoub","doi":"10.7417/CT.2026.2128","DOIUrl":"10.7417/CT.2026.2128","url":null,"abstract":"<p><strong>Background: </strong>Paediatric systemic lupus erythematosus (pSLE) is associated with more aggressive disease and higher rates of organ involvement than adult-onset disease. However, the relationship between disease activity and multisystem manifestations has not been comprehensively quantified.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. Five databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) were searched for observational studies published between 2015 and 2024. Studies including paediatric SLE patients with quantified disease activity were eligible. Random-effects meta-analysis was performed to estimate pooled odds ratios (ORs) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Twenty studies involving 4,934 patients were included. Lupus nephritis was the most frequent manifestation (44-76%), followed by neuropsychiatric involvement (16-40%) and ocular findings (5-32%). High disease activity was significantly associated with lupus nephritis (OR 3.7, 95% CI 2.8-4.9), neuropsychiatric involvement (OR 2.9, 95% CI 2.2-3.9), and immunological abnormalities (OR 3.4, 95% CI 2.5-4.6). Subgroup analyses demonstrated higher disease burden in Asian and Middle Eastern cohorts. Heterogeneity ranged from moderate to substantial across outcomes.</p><p><strong>Conclusions: </strong>High disease activity in pSLE is strongly associated with major organ involvement across multiple systems. These findings support the use of disease activity indices for risk stratification and highlight the need for multidisciplinary monitoring and region-specific management strategies.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 5","pages":"1257-1272"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular myocardial strain analysis by feature tracking cardiac magnetic resonance in patients with autoimmune rheumatic diseases: A case-control study.","authors":"Eman Khaled Ahmed ElMahdy, Ahmed Samir Ibrahim, Susan Adil Ali AbdulRahim, Sara W Tantway","doi":"10.7417/CT.2026.2118","DOIUrl":"10.7417/CT.2026.2118","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular involvement is a major contributor to morbidity and mortality in autoimmune rheumatic diseases (ARDs). Subclinical myocardial dysfunction may occur despite preserved conventional cardiac function. Cardiac magnetic resonance feature tracking (CMR-FT) enables sensitive assessment of myocardial deformation and may aid in early detection of cardiac involvement.</p><p><strong>Objective: </strong>To evaluate left ventricular myocardial strain using CMR-FT in patients with ARDs for detection of subclinical myocardial dysfunction.</p><p><strong>Methods: </strong>This case-control study included 30 patients with ARDs and 10 age- and sex-matched healthy controls at Department of Radiology, Ain Shams University Hospitals. All participants underwent cardiac magnetic resonance imaging using standard cine balanced steady-state free precession sequences. Feature-tracking analysis was performed to assess global longitudinal strain (GLS), global circumferential strain (GCS), and strain rate parameters. Strain values were compared between patients and controls, and correlations with disease duration and activity markers were analyzed.</p><p><strong>Results: </strong>Left ventricular ejection fraction was preserved in both groups, although slightly lower in ARDs patients compared with controls (58.73% ± 5.01 vs. 61.8% ± 2.3). Patients with ARDs demonstrated significantly impaired myocardial deformation, with lower GLS (-17.51% vs. -21.07%, p = 0.001) and GCS (-18.72% vs. -23.27%, p = 0.001) compared with controls. Significant reductions were also observed in circumferential and longitudinal strain rate parameters. No late gadolinium enhancement was detected in the studied patients. Both GLS and GCS showed significant associations with disease duration and inflammatory activity indices. Similar findings were observed in systemic lupus erythematosus and rheumatoid arthritis subgroups.</p><p><strong>Conclusion: </strong>Patients with autoimmune rheumatic diseases exhibit subclinical left ventricular dysfunction despite preserved ejection fraction and absence of myocardial fibrosis on late gadolinium enhancement imaging. CMR feature tracking represents a sensitive and noninvasive imaging technique for early identification of myocardial involvement in ARDs.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 5","pages":"1159-1165"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Focal Muscle Vibration in Post-Anterior Cruciate Ligament Reconstruction Rehabilitation: A Case Report.","authors":"Filippo Camerota, Massimiliana Isola, Giacomo Muscatello, Federico Zangrando, Gianluca Cinotti, Marco Paoloni, Gianfranco Morico, Manuela Minozzi, Massimiliano Mangone, Claudia Celletti","doi":"10.7417/CT.2026.2092","DOIUrl":"10.7417/CT.2026.2092","url":null,"abstract":"<p><strong>Background: </strong>Anterior cruciate ligament (ACL) reconstruction is frequently followed by proprioceptive deficits and residual instability. Focal muscle vibration (FMV) is a rehabilitative technique that may enhance neuromotor recovery through proprioceptive stimulation.</p><p><strong>Case presentation: </strong>We report the case of an 18-year-old patient who underwent left ACL reconstruction using semitendinosus and gracilis tendons. The patient completed an FMV protocol (100 Hz, 0.1-0.5 mm, six consecutive sessions, 80 min/session) applied to selected muscles (vastus medialis, biceps femoris, gastrocnemius, gluteus maximus). Gait kinematics and kinetics, stabilometric parameters, and knee range of motion (ROM) were assessed.</p><p><strong>Results: </strong>Following treatment, improvements were observed in knee flexion ROM, gait speed and cadence, pelvic retroversion reduction, and normalization of knee extensor moment during mid-stance. Stabilometric analysis revealed a marked reduction in sway area and sway path length.</p><p><strong>Conclusions: </strong>FMV appears to exert beneficial effects on postural control, gait function, and joint mobility in the early phase following ACL reconstruction. Larger randomized controlled trials are warranted to confirm these preliminary findings.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 4","pages":"974-978"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes, clinical manifestations, and treatment efficacy of recurrent pulmonary tuberculosis.","authors":"Daniyar Dilmagambetov, Galiya Tanzharykova, Amangeldy Zhangireyev, Altyn Almagambetova, Kalzhan Yermekbayeva","doi":"10.7417/CT.2026.2059","DOIUrl":"10.7417/CT.2026.2059","url":null,"abstract":"<p><strong>Objective: </strong>Within the contemporary medical and scientific community, research aimed at identifying the causes, analysing the clinical manifestations, and evaluating the effectiveness of treatment for recurrent pulmonary tuberculosis has become particularly relevant considering an increasing number of cases of Mycobacterium tuberculosis (MTB) resistance to anti-tuberculosis drugs (ATDs).</p><p><strong>Methods: </strong>The study encompasses an analysis of the primary factors contributing to recurrences, including socio-economic conditions, alcohol abuse, comorbidities, incarceration, human immunodeficiency virus (HIV), and others. The morbidity structure is examined, key clinical manifestations and complications of recurrent tuberculosis are identified, and the efficacy of chemotherapy is assessed depending on the drug resistance of MTB. Statistical analysis demonstrated the percentage of successful cessation of bacterial excretion and cavity closure, as well as treatment outcomes.</p><p><strong>Results: </strong>Thus, the study represents a comprehensive analysis aimed at improving the understanding of the dynamics and factors of recurrent pulmonary tuberculosis, which is crucial for the development of more effective treatment.</p><p><strong>Conclusions: </strong>The study holds practical value for healthcare professionals, as it provides data and observations that can be utilised to enhance strategies for the diagnosis, treatment, and prevention of the disease, thereby contributing to improved healthcare quality, the effectiveness of therapeutic interventions, and ultimately the health and well-being of patients.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 4","pages":"684-696"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Workplace First Responders' Competence in Out-of-Hospital Cardiac Arrest Management: A Cross-Sectional Study.","authors":"Salvatore Ammirati, Giuliana Federico, Shizuka Kibi, Fabiola Del Parco, Giuseppe La Torre","doi":"10.7417/CT.2026.2073","DOIUrl":"10.7417/CT.2026.2073","url":null,"abstract":"<p><strong>Background: </strong>Out-of-Hospital Cardiac arrest (OHCA) represents a major health threat worldwide. Survival of the victims depends on a strong chain of survival, a coordinated set of actions drawn from first-aid responders in the community. Basic Life Support (BLS) training programs are of great importance in preparing first responders to emergency situations. Given that adults spend most of their time at work, the presence of trained employees is key to ensure immediate lifesaving procedures.</p><p><strong>Objective: </strong>This cross-sectional study investigates the preparedness of a large University first-aid responders in mitigating medical emergencies and especially sudden cardiac arrest. It also discusses the importance of BLS training programs in equipping employees with the necessary skills to respond effectively to medical emergencies.</p><p><strong>Methods: </strong>A survey questionnaire, consisting of 20 questions, was administered to 520 workplace first-aid responder workers. Questions assessed basic life support (BLS) competencies and gathered socio-demographic data. Univariate and multiple logistic regression analyses were conducted on a dataset of 355 responses.</p><p><strong>Results: </strong>Among the participants (70% response rate), the average test score was 9.59 out of 11. No significant impact was found among the tested variables, including gender, age, self-confidence, and time since the last training. However, differences were observed across academic departments, with Architecture scoring higher and History, Philosophy, and Literature scoring lower.</p><p><strong>Conclusions: </strong>Findings from this study support the effectiveness of the Italian legislation in promoting preparedness among first aid respondents in the work environment. While the overall competence levels are high, the variations across departments indicate areas for targeted improvement.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 4","pages":"801-808"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically oriented morphology of pronator quadratus muscle of the forearm: A descriptive cross-sectional study.","authors":"B V Murlimanju, Shubhangi Yadav, S R Vikram, Ashwin R Rai, Rajanigandha Vadgaonkar, Melisha Michael D Souza, Rahul V Shetty, Subbashree Sabapathi, Vandana Blossom","doi":"10.7417/CT.2026.2071","DOIUrl":"10.7417/CT.2026.2071","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to detail the morphology of the pronator quadratus muscle (PQM) and to study its morphometry. The objectives were to perform side-based, sex-based analyses.</p><p><strong>Methods: </strong>A total of 70 upper extremities (35 right and 35 left) from adult embalmed cadavers were included in this study. The quadrilateral-shaped pronator quadratus was pointed at its medio-superior angle, medio-inferior angle, latero-superior angle and latero-inferior angle. These points were used to measure the lateral length, medial length, proximal width and distal width via a digital Vernier caliper (Mitutoyo, Japan). The midpoints of the elbow and wrist joints were considered for measuring the distance of the muscle from these joints.</p><p><strong>Results: </strong>The outline of the muscle in this study was square shaped in 33 (47.1%), rectangular in 9 (12.8%), rhomboid in 8 (11.4%), trapezoidal in 16 (22.8%) and truncated in 4 (5.7%) specimens. PQM had aponeurotic fibers at the ulnar attachment in 47 patients (67.1%), at the radial attachment in 11 patients (15.8%) and from both bones of the forearm in 12 patients (17.1%). The mean lateral and medial lengths of the PQM were 4.64 ± 0.94 cm and 5.66 ± 1 cm, respectively. The mean proximal and distal widths were 4.09 ± 1 cm and 3.74 ± 0.67 cm, respectively. The muscle was located 19.53±24.29 cm away from the elbow and 2.61±7.27 cm from the wrist joint. The mean distance of the AIN from its origin to entry into the PQM was 12.69 ± 1.52 cm. The lateral length of the PQM in males was considerably greater than that in females (p <0.05). The dimensions compared between the right and left sides were not statistically significant (p > 0.05).</p><p><strong>Conclusion: </strong>This study of our sample population provides in‑depth morphometric data on PQM, which can be used to assist in orthopedic and reconstructive surgical procedures such as tendon transfers, flap surgeries and nerve repairs.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"177 4","pages":"783-793"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}