Cognitive Affective & Behavioral Neuroscience最新文献

{"title":"Large nesting in deer mice co-occurs with jumping but not running stereotypies: Insights into compulsive-like behavioural heterogeneity.","authors":"Anmarie van Staden, Timothy R Sampson, Christine Lochner, De Wet Wolmarans","doi":"10.3758/s13415-026-01510-5","DOIUrl":"https://doi.org/10.3758/s13415-026-01510-5","url":null,"abstract":"<p><p>Subpopulations of deer mice present with distinct compulsive-like behavioural phenotypes, i.e., large nesting (large nest-building [LNB]) and high motor stereotypy (HS). Large nest-building and HS associate with unique dopaminergic and adenosinergic mechanisms. Large nest-building is also characterized by increased risk-taking behaviour, which has not yet been shown in HS mice. We hypothesised that LNB and HS represent distinct compulsive-like outcomes that would not manifest in the same subjects. We also hypothesised that LNB and HS would each respond uniquely to dopamine D₁ receptor modulation, confirming distinct neurobiological profiles that could guide future studies aimed at enhancing treatment outcomes. Briefly, 267 mice were screened for nesting behaviour, of which 36 mice were selected for normal nesting (normal nest-building [NNB]) and 44 for LNB. Mice were subsequently exposed to either control injections or to the highly selective D₁ agonist (SKF-38393), D₁ antagonist (ecopipam), or the A₁ agonist (capadenoson) for 32 days. Mice were then retested for nesting and stereotypy expression and risk-prone open field behaviour. We show that LNB is associated with lower overall motor stereotypical expression compared with NNB. We also show that vertical jumping co-occurs with both NNB and LNB behaviour, whereas pattern running is only shown by NNB mice and that neither LNB nor HS was impacted by selective D₁ receptor modulation. Collectively, these results strengthen earlier observations in deer mice with respect to compulsive-like behavioural heterogeneity and provide a solid foundation for research into the aetiology of equally persistent and repetitive but unique compulsive-like behavioural phenotypes.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of effort and expectancy on reward-related event-related potentials: Evidence from a novel effort and expectancy paradigm (EEP).","authors":"Nicholas J Santopetro, Jessica R Simon, C J Brush, Elizabeth M Mulligan, Jonathan Ryan, Greg Hajcak","doi":"10.3758/s13415-026-01507-0","DOIUrl":"https://doi.org/10.3758/s13415-026-01507-0","url":null,"abstract":"<p><p>Effort justification theories posit that reward is more salient after exerting effort, while effort discounting theories suggest that effort is costly and makes outcomes less salient. Reward expectation can also impact salience and influence effort and reward dynamics. To investigate the influence of both effort and expectancy of reward timing on reward-locked neural indices (i.e., RewP and P300), we created a novel monetary reward task (i.e., Effort & Expectancy Paradigm [EEP]) that modulates high and low amounts of physical effort (or passive waiting) and reward expectancy (i.e., countdown compared with no countdown trials). Eighty-two undergraduate students (61.7% female) completed surveys and the EEP during a continuous EEG recording. Principal component analysis (PCA) was used to better understand the temporal and spatial subcomponents of reward-related ERPs, resulting in RewP and P300 factors. High effort trials resulted in larger RewP and P300 compared with waiting, and both the RewP and P300 were larger when reward was less expected (i.e., no countdown) compared with when reward was more expected (i.e., countdown). P300 main effects were further qualified by unique interactions between effort (press or wait), amount of effort (high or low), and expectancy (countdown or no countdown). Finally, only RewP emerged as a neural correlate of self-reported hedonic capacity. Present results suggest that salient stimuli (e.g., effortful and unexpected reward timing) enhance neural measures of reward consumption and increase allocation of cognitive resources. Reduced RewP elicited from this novel task might reflect disrupted reward processing in individuals experiencing elevated anhedonia.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It is what it is: A comparative fMRI study on the regulation of negative emotions via distraction, reappraisal, and acceptance.","authors":"Alexander H J Sahm, Stephanie N L Schmidt, Alexander Wolber, Matthias Burghart, Daniela Mier","doi":"10.3758/s13415-026-01501-6","DOIUrl":"https://doi.org/10.3758/s13415-026-01501-6","url":null,"abstract":"<p><p>While the neural correlates of emotion regulation (ER) have frequently been investigated, only a few studies have compared the neural correlates of several ER strategies against one another. We present the fMRI data from 42 female participants who, in a within-subject design, viewed negative images depicting human suffering as well as neutral landscapes. For the negative images only, participants applied the ER strategies of distraction, reappraisal, and acceptance. Emotion regulation compared with viewing negative stimuli showed activation in frontal and temporoparietal regions. Direct comparisons between strategies revealed increased engagement of prefrontal and cingulate networks during acceptance and reappraisal compared with distraction, while distraction showed stronger recruitment of occipital and parietal regions. Acceptance differed from reappraisal with greater activation in the dorsomedial prefrontal cortex and fusiform and lingual gyri. Our results indicate that distraction mostly relies on regions involved in visual perception and attention. Acceptance and reappraisal resemble one another in the recruitment of areas related to cognitive control. However, acceptance also shows activation in areas related to visual processing that is absent in reappraisal, possibly reflective of deeper engagement with the stimulus. These findings highlight both commonalities and differences among major ER strategies.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared control-network recruitment and task-dependent brain-behavior associations in bilingual language and rule switching.","authors":"Tingting Guo, Yan Jing Wu, Jingyu Chen, Xuedi Liu, Si Chen, Peng Peng, Yanzhuo Li, Xinyi Xie, Ruoqi Wen, Taomei Guo","doi":"10.3758/s13415-026-01511-4","DOIUrl":"https://doi.org/10.3758/s13415-026-01511-4","url":null,"abstract":"<p><p>Bilingual language control is thought to draw on domain-general cognitive control, yet it remains unclear whether cross-task overlap in neural recruitment is accompanied by similar brain-behavior relationships. Previous connectivity studies have typically estimated functional connectivity (FC) across entire tasks or blocks, obscuring network changes specific to switch trials. We combined hierarchical drift-diffusion modeling, regional activation, and beta-series FC in 126 Chinese-English bilinguals (123 with usable fMRI data) who completed language- and rule-switching tasks. Both tasks reduced drift rates and prolonged nondecision times on switch trials. They also recruited a common 28-region switch-sensitive control core and showed increased switch-related FC within this core and between the core and default mode, subcortical, and cerebellar systems. At the individual-difference level, generalized estimating equations revealed task-dependent brain-behavior relationships: core-within and core-subcortical FC were more positively associated with drift-rate switch cost during language switching than during rule switching. Together, the results identify partial overlap in regional recruitment, similarly directed system-level FC changes, and distinct FC-evidence-accumulation relationships across tasks.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149276618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbitofrontal-ventral striatal coupling: A model of the neurobehavioral architecture of craving in substance use disorders.","authors":"Reza Maleeh","doi":"10.3758/s13415-026-01506-1","DOIUrl":"https://doi.org/10.3758/s13415-026-01506-1","url":null,"abstract":"<p><p>Neuroimaging has identified cue-elicited activity in ventral striatum and orbitofrontal cortex (OFC) as a reliable signature of craving, yet activation magnitude in either region is an inconsistent predictor of clinical outcome. This theoretical review develops a model on which the clinically consequential variable is not activation but effective coupling: the cue-evoked gain-the factor by which an input is amplified-with which OFC valuation signals modulate ventral striatal action-selection activity. I formalize this gain as valuation-policy coupling (λ), which governs the probability that a drug-related appraisal recruits approach and consumption policies; it is a latent construct indexed by effective OFC-accumbens connectivity, approach bias under load, and pharmacological challenge. Two moderators-meta-awareness and elaborative versus nonelaborative engagement-determine whether the urge is re-entered or exited, and jointly specify a neurocognitive space in which craving occupies a high-λ, high-meta-awareness, elaborative vertex. The framework predicts an awareness-amplification effect-noticing an urge intensifies it under high λ and weakens it under low λ-specifies when mindfulness-based relapse prevention should attenuate craving and when it should not, and yields a discriminative prediction: λ-reducing interventions should reduce cue-modulated OFC-ventral-striatum coupling while leaving regional activation comparatively preserved. λ is a parameter of craving rather than of relapse-which also requires cognitive-control parameters-and a candidate transdiagnostic mechanism. Claims are labeled by evidential status; the λ-meta-awareness interaction is the model's principal hypothesis, and failure conditions are stated explicitly.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision dynamics of negative bias in subclinical depression during ambiguous facial emotion perception.","authors":"Chia-Chu Yang, Yi-Chun Tsai, Shi-Syuan Chiu, Tzu-Ling Liu, Chi-Hung Juan","doi":"10.3758/s13415-026-01505-2","DOIUrl":"https://doi.org/10.3758/s13415-026-01505-2","url":null,"abstract":"<p><p>Individuals with depressive tendencies may categorize ambiguous facial expressions toward negative rather than happy endpoints, but the associated decision-process components remained unclear. The study examined whether the categorization shift was associated with differences in perceptual criterion, discrimination sensitivity, response dynamics, or diffusion-model parameters. Fifty-nine participants, comprising a depressive tendency group and a comparison group, categorized morphed Sad-Happy and Angry-Happy expressions presented in a 750-ms face/mask sequence or a 1500-ms face/no-mask sequence. Psychometric functions, area-under-the-curve (AUC) analyses, quadratic mixed-effects models of response time, and a hierarchical drift-diffusion model were applied. Across conditions, the depressive tendency group showed lower points of subjective equality than the comparison group, indicating a relative shift in the categorization boundary toward the negative versus happy endpoint, without a corresponding group difference in discrimination sensitivity. AUC analyses similarly indicated higher negative-response probabilities in the depressive tendency group, particularly within the low-negativity portion of the continuum. Condition-specific patterns were observed, but direct tests did not support a larger Sad-Happy group difference in the 1500-ms than in the 750-ms presentation sequence. In the focal Sad-Happy 1500-ms face/no-mask sequence, the selected drift-diffusion model indicated a group-related drift-criterion shift toward the Sad boundary and modestly longer non-decision time in the depressive tendency group, whereas starting-point bias and boundary separation did not differ between groups. These findings are consistent with a relative categorization shift toward negative versus Happy facial-expression endpoints among participants with depressive tendencies. The diffusion-model results provided a model-dependent account of the focal choice-response-time pattern under the present presentation-sequence structure.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attentional emotional bias in Huntington's disease: The \"Hyper-Positive\" effect.","authors":"Stefania Righi, Viola Benedetti, Agnese Zonino, Gioele Gavazzi, Elena Giachi, Elena Capacci, Maria Pia Viggiano, Francesco Rotella, Lapo Pierguidi, Camilla Ferrari","doi":"10.3758/s13415-026-01503-4","DOIUrl":"https://doi.org/10.3758/s13415-026-01503-4","url":null,"abstract":"<p><p>In addition to motor symptoms, Huntington's disease (HD) is associated with cognitive deficits, including the ability to recognize emotions (fear, disgust, and anger) from faces and voices, while happiness and neutral expressions are relatively preserved. Yet the underlying mechanisms remain unclear. We investigated both explicit emotion recognition and implicit attentional biases in manifest HD patients to assess whether altered attentional orienting may explain the selective deficit in negative emotions. To our knowledge, this represents the first study of its kind in HD. Twenty patients with manifest HD and 25 controls completed an explicit facial emotion recognition task (neutral, disgust, fear, and happiness) and two dot-probe tasks (100 ms and 500 ms SOAs) to dissociate automatic and controlled attentional processes. Attentional Facilitation Index (AFI) and Disengagement Index (DI) were calculated. Huntington's disease patients showed reduced accuracy and slower reaction times in recognizing negative emotions (fear and disgust). At the 100-ms SOA in the dot-probe task, they exhibited reduced attentional facilitation for fearful faces and greater facilitation for happy faces compared with controls, with a similar pattern observed for attentional disengagement. No significant differences emerged at 500 ms SOA. These findings reveal a \"hyperpositivity effect\" in HD: an early automatic prioritization of positive stimuli alongside reduced attentional capture by negative ones. This pattern, which parallels the positivity bias in normal aging, may contribute to the selective impairment in negative emotion recognition. A plausible underlying mechanism involves striatal dopaminergic dysregulation. Longitudinal studies in premanifest gene carriers are needed to clarify this bias's development.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frustrative nonreward engages midfrontal theta power and modulates effort expenditure.","authors":"Nellia Bellaert, Federico Cassioli, Wan-Ling Tseng, Mandy Rossignol","doi":"10.3758/s13415-026-01499-x","DOIUrl":"https://doi.org/10.3758/s13415-026-01499-x","url":null,"abstract":"<p><p>Irritability is characterized by a propensity to experience frustration and has been associated with reduced self-reported willingness to expend effort for rewards. Frustration may be relevant to effortful reward pursuit, but its effects on effort expenditure have rarely been experimentally tested in humans. To address this gap, this study introduced a frustration induction in the Effort-Doors task to elicit frustrative nonreward (FNR), a negative emotional state triggered by unexpected reward loss, and examined its effects on physical effort expenditure and feedback-related electroencephalographic (EEG) activity. We also tested whether these effects vary as a function of state and trait measures of motivation and affect. Linear mixed-effects models tested the effects of FNR induction on self-reported, behavioral, and EEG measures in young adults (N = 83) completing the Frustrative Effort-Doors task. Models tested manipulation effects, trial-level post-feedback adjustment, and moderation by state and trait measures. Midfrontal theta power (MFθ) extracted using multivariate spatial filtering was examined as a function of feedback (win vs. FNR), effort (low vs. high), and subsequent behavioral adjustments. The frustration condition was associated with decreased self-reported state motivation and increased frustration, arousal, and response speed. Midfrontal theta power was larger following FNR feedback and increased with state frustration during high-effort trials. Higher state frustration was associated with reduced response vigor during effort execution following FNR feedback. MFθ did not predict trial-to-trial behavioral adjustments. These findings indicate that FNR recruits MFθ, a neural marker of cognitive control, while state frustration modulates physical effort execution following unexpected reward loss.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Age and culture modulate object processing and object-scene binding in the ventral visual area.","authors":"Joshua O Goh, Michael W Chee, Jiat Chow Tan, Vinod Venkatraman, Andrew Hebrank, Eric D Leshikar, Lucas Jenkins, Bradley P Sutton, Angela H Gutchess, Denise C Park","doi":"10.3758/s13415-026-01500-7","DOIUrl":"https://doi.org/10.3758/s13415-026-01500-7","url":null,"abstract":"","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrugator activity reflects integrated simulation and multifaceted evaluation when processing affective language: Frowning responses to reading about emotions of morally good and bad characters.","authors":"Li Kloostra, Marijke Beulen, Jos J A van Berkum, Marijn E Struiksma","doi":"10.3758/s13415-026-01464-8","DOIUrl":"10.3758/s13415-026-01464-8","url":null,"abstract":"<p><p>Corrugator supercilii (\"frowning muscle\") activity tracks affective valence of linguistic stimuli. According to embodied cognition accounts, this reflects simulation of the emotion at lexical and/or situational levels. Additionally, it may indicate evaluation, i.e., how we feel about an affective event within a context. This study used facial electromyography (fEMG) to examine corrugator responses as participants read short stories. Each story included segments, describing some character's morally good or bad behavior, a behavior rating, and sentence-initial phrases describing the character's positive or negative affective states (e.g., \"Mark is frustrated\"), followed by the reason for this. Our prior studies showed substantially more frowning when good characters were \"frustrated\" compared with \"happy\" but minimal differences for bad characters, suggesting a multiple-drivers account where both simulation and evaluation influence responses. Crucially, they can counteract in the context of bad characters, e.g., \"happy\" has positive valence but is unfair in context and the opposite applies to \"frustrated.\" To emphasize characters' moral status and amplify fairness-based evaluations, an embedded morality judgment rating task was introduced. We hypothesized stronger frowning for \"happy\" than \"frustrated\" bad characters due to fairness considerations now outweighing simulation. However, results revealed increased frowning for \"frustrated\" bad characters. The rating task might have unexpectedly reduced, rather than boosted, evaluative processing through cognitive interference. Nevertheless, previously observed frowning patterns for moral characters were replicated. These findings support a multiple-drivers model but suggest that evaluative processes are more complex and multifaceted than current models capture, calling for revisions to incorporate these complexities into affective processing theories.</p>","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":" ","pages":"2118-2138"},"PeriodicalIF":3.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}