Cognitive Affective & Behavioral Neuroscience最新文献_第2页

Enhancing cognitive control of our decisions: Making the most of humor during the IGT in females and males. 加强对决策的认知控制：在女性和男性的 IGT 中充分利用幽默。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI: 10.3758/s13415-024-01210-y

Jorge Flores-Torres, Kateri McRae, German Campos-Arteaga, Lydia Gómez-Pérez

{"title":"Enhancing cognitive control of our decisions: Making the most of humor during the IGT in females and males.","authors":"Jorge Flores-Torres, Kateri McRae, German Campos-Arteaga, Lydia Gómez-Pérez","doi":"10.3758/s13415-024-01210-y","DOIUrl":"10.3758/s13415-024-01210-y","url":null,"abstract":"We studied the impact of humor on the Iowa Gambling Task (IGT) decision-making performance and the cognitive control exerted during this task, considering sex as a moderator, and examined whether cognitive control mediated the influence of humor on decision-making. Sixty participants (30 females) performed an extended version of the IGT (500 trials divided into 20 blocks). We randomly assigned them to either an experimental group (Humor Group; Hg; n = 30), where humorous videos were interspersed in the decision-making trials or a control group (Non-Humor Group; NHg; n = 30), where nonhumorous videos were interspersed in the decision-making trials. We recorded participant performance and feedback-related negativity (FRN) and P3b event-related potentials (ERP) during IGT feedback as task monitoring and attention allocation indicators, respectively. We expected that whereas humor would improve IGT decision-making under risk in females during the last blocks (17-20) as well as cognitive control (specifically attention allocation and task monitoring) across the entire IGT, it would impair them in males. Contrary to our expectations, humor improved IGT decision-making under risk for both sexes (specifically at blocks 19 and 20) and attention allocation for most IGT blocks (P3b amplitudes). However, humor impaired IGT decision-making under ambiguity in males during the block six and task monitoring (FRN amplitudes) for most IGT blocks. Attention allocation did not mediate the beneficial effect of humor on decision-making under risk in either sex. Task monitoring decrements fully mediated the humor's detrimental influence on men's decision-making under ambiguity during block six.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging. 白质高密度和大脑结构网络与健康老龄化的流体认知之间的分布式关联。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI: 10.3758/s13415-024-01219-3

Marc D Rudolph, Jessica R Cohen, David J Madden

{"title":"Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.","authors":"Marc D Rudolph, Jessica R Cohen, David J Madden","doi":"10.3758/s13415-024-01219-3","DOIUrl":"10.3758/s13415-024-01219-3","url":null,"abstract":"White matter hyperintensities (WMHs) are associated with age-related cognitive impairment and increased risk of Alzheimer's disease. However, the manner by which WMHs contribute to cognitive impairment is unclear. Using a combination of predictive modeling and network neuroscience, we investigated the relationship between structural white matter connectivity and age, fluid cognition, and WMHs in 68 healthy adults (18-78 years). Consistent with previous work, WMHs were increased in older adults and exhibited a strong negative association with fluid cognition. Extending previous work, using predictive modeling, we demonstrated that age, WMHs, and fluid cognition were jointly associated with widespread alterations in structural connectivity. Subcortical-cortical connections between the thalamus/basal ganglia and frontal and parietal regions of the default mode and frontoparietal networks were most prominent. At the network level, both age and WMHs were negatively associated with network density and communicability, and positively associated with modularity. Spatially, WMHs were most prominent in arterial zones served by the middle cerebral artery and associated lenticulostriate branches that supply subcortical regions. Finally, WMHs overlapped with all major white matter tracts, most prominently in tracts that facilitate subcortical-cortical communication and are implicated in fluid cognition, including the anterior thalamic-radiations and forceps minor. Finally, results of mediation analyses suggest that whole-brain WMH load influences age-related decline in fluid cognition. Thus, across multiple levels of analysis, we showed that WMHs were increased in older adults and associated with altered structural white matter connectivity and network topology involving subcortical-cortical pathways critical for fluid cognition.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural mechanisms of altruistic decision-making: EEG functional connectivity network analysis. 利他决策的神经机制：脑电图功能连接网络分析

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI: 10.3758/s13415-024-01214-8

Dina G Mitiureva, Evgenia O Terlichenko, Veronika M Zubko, Polina I Kabanova, Vasilisa D Abrosimova, Sofya M Skripkina, Elizaveta V Krivchenkova, Daria M Verkholaz, Anna S Borodkina, Alisa V Komarova, Andrey A Kiselnikov

{"title":"Neural mechanisms of altruistic decision-making: EEG functional connectivity network analysis.","authors":"Dina G Mitiureva, Evgenia O Terlichenko, Veronika M Zubko, Polina I Kabanova, Vasilisa D Abrosimova, Sofya M Skripkina, Elizaveta V Krivchenkova, Daria M Verkholaz, Anna S Borodkina, Alisa V Komarova, Andrey A Kiselnikov","doi":"10.3758/s13415-024-01214-8","DOIUrl":"10.3758/s13415-024-01214-8","url":null,"abstract":"Altruism is an enigmatic form of prosocial behavior, characterized by diverse motivations and significant interindividual differences. Studying neural mechanisms of altruism is crucial to identify objective markers of pro- and antisocial tendencies in behavior. This study was designed to delve into the mechanisms of altruism by analyzing EEG-based functional connectivity patterns within the framework of the network approach. To experimentally induce a situation of altruistic decision-making, we employed the Pain versus Gain (PvsG) task, which implies making choices concerning financial self-benefit and pain of the other. Our results reveal that the behavioral measure of altruism in the experiment correlated with emotional empathy, which is in line with the \"empathy-altruism\" hypothesis. Applying the network approach to EEG functional connectivity analysis, we discovered that the very process of decision-making in the PvsG is characterized by the synchronous activity of structures in the right hemisphere, which are involved in empathy for pain. The prosociality of decisions was reflected in functional connectivity between the rostral ACC and orbital IFG in the left hemisphere and the overall network centrality of the caudal ACC. This finding additionally points to the distinct functional roles of the ACC subregions in altruistic decision-making. The proposed neural mechanisms of altruism can further be used to identify neurophysiological markers of prosociality in behavior.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementations of sign- and goal-tracking behavior in humans: A scoping review. 人类标志和目标追踪行为的实施：范围综述。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-11-05 DOI: 10.3758/s13415-024-01230-8

Michelle Heck, Nancy Durieux, Patrick Anselme, Etienne Quertemont

{"title":"Implementations of sign- and goal-tracking behavior in humans: A scoping review.","authors":"Michelle Heck, Nancy Durieux, Patrick Anselme, Etienne Quertemont","doi":"10.3758/s13415-024-01230-8","DOIUrl":"https://doi.org/10.3758/s13415-024-01230-8","url":null,"abstract":"Animal research has identified two major phenotypes in the tendency to attribute incentive salience to a reward-associated cue. Individuals called \"sign-trackers\" (STs) preferentially approach the cue, assigning both predictive and incentive values to it. In contrast, individuals called \"goal-trackers\" (GTs) preferentially approach the location of the upcoming reward, assigning only a predictive value to the cue. The ST/GT model has been shown to be relevant to understanding addiction vulnerability and other pathological behaviors in animals. Therefore, recent studies tried to implement this animal model in the human population. This scoping review aimed to identify and map evidence of human sign- and goal-tracking. Studies that explicitly measured human sign- and goal-tracking or related phenomena (e.g., attentional bias induced by reward-related cues), using paradigms in line with the animal model, were eligible for this review. We searched for published, unpublished, and gray literature (PhD theses, posters, conference papers) through the following databases: MEDLINE, Scopus, PsycINFO, Embase, OSF, and Google Scholar. The JBI scoping review methodology was adopted. Screening and extraction were carried out by three reviewers, in pairs. A total of 48 studies were identified. These studies used various experimental paradigms and used the term \"sign-tracking\" inconsistently, sometimes implicitly or not at all. We conclude that the literature on human sign-tracking is very heterogeneous on many levels. Overall, evidence supports the existence of sign- and goal-tracking behaviors in humans, although further validated research is crucially needed.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour. 巴甫洛夫式不耐烦对即时奖励的预期会增加接近行为。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-10-28 DOI: 10.3758/s13415-024-01236-2

Floor Burghoorn, Anouk Scheres, John Monterosso, Mingqian Guo, Shan Luo, Karin Roelofs, Bernd Figner

{"title":"Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour.","authors":"Floor Burghoorn, Anouk Scheres, John Monterosso, Mingqian Guo, Shan Luo, Karin Roelofs, Bernd Figner","doi":"10.3758/s13415-024-01236-2","DOIUrl":"https://doi.org/10.3758/s13415-024-01236-2","url":null,"abstract":"People often exhibit intertemporal impatience by choosing immediate small over delayed larger rewards, which has been implicated across maladaptive behaviours and mental health symptoms. In this preregistered study, we tested the role of an intertemporal Pavlovian bias as possible psychological mechanism driving the temptation posed by immediate rewards. Concretely, we hypothesized that the anticipation of immediate rewards (compared with preference-matched delayed rewards) enhances goal-directed approach behaviour but interferes with goal-directed inhibition. Such a mechanism could contribute to the difficulty to inhibit ourselves in the face of immediate rewards (e.g., a drug), at the cost of long-term (e.g., health) goals. A sample of 184 participants completed a newly developed reinforcement learning go/no-go task with four trial types: Go to win immediate reward; Go to win delayed reward; No-go to win immediate reward; and No-go to win delayed reward trials. Go responding was increased in trials in which an immediate reward was available compared with trials in which a preference-matched delayed reward was available. Computational models showed that on average, this behavioural pattern was best captured by a cue-response bias reflecting a stronger elicitation of go responses upon presentation of an immediate (versus delayed) reward cue. The results of this study support the role of an intertemporal Pavlovian bias as a psychological mechanism contributing to impatient intertemporal choice.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tell me why: the missing w in episodic memory's what, where, and when. 告诉我为什么：外显记忆中的 "什么"、"哪里 "和 "何时 "缺少了 "W"。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-10-25 DOI: 10.3758/s13415-024-01234-4

Fernanda Morales-Calva, Stephanie L Leal

{"title":"Tell me why: the missing w in episodic memory's what, where, and when.","authors":"Fernanda Morales-Calva, Stephanie L Leal","doi":"10.3758/s13415-024-01234-4","DOIUrl":"https://doi.org/10.3758/s13415-024-01234-4","url":null,"abstract":"Endel Tulving defined episodic memory as consisting of a spatiotemporal context. It enables us to recollect personal experiences of people, things, places, and situations. In other words, it is made up of what, where, and when components. However, this definition does not include arguably the most important aspect of episodic memory: the why. Understanding why we remember has important implications to better understand how our memory system works and as a potential target of intervention for memory impairment. The intrinsic and extrinsic factors related to why some experiences are better remembered than others have been widely investigated but largely independently studied. How these factors interact with one another to drive an event to become a lasting memory is still unknown. This review summarizes research examining the why of episodic memory, where we aim to uncover the factors that drive core features of our memory. We discuss the concept of episodic memory examining the what, where, and when, and how the why is essential to each of these key components of episodic memory. Furthermore, we discuss the neural mechanisms known to support our rich episodic memories and how a why signal may provide critical modulatory impact on neural activity and communication. Finally, we discuss the individual differences that may further drive why we remember certain experiences over others. A better understanding of these elements, and how we experience memory in daily life, can elucidate why we remember what we remember, providing important insight into the overarching goal of our memory system.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometrics of drift-diffusion model parameters derived from the Eriksen flanker task: Reliability and validity in two independent samples. 从埃里克森侧翼任务中得出的漂移-扩散模型参数的心理测量学：两个独立样本的可靠性和有效性。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-10-23 DOI: 10.3758/s13415-024-01222-8

Brent Ian Rappaport, Stewart A Shankman, James E Glazer, Savannah N Buchanan, Anna Weinberg, Allison M Letkiewicz

{"title":"Psychometrics of drift-diffusion model parameters derived from the Eriksen flanker task: Reliability and validity in two independent samples.","authors":"Brent Ian Rappaport, Stewart A Shankman, James E Glazer, Savannah N Buchanan, Anna Weinberg, Allison M Letkiewicz","doi":"10.3758/s13415-024-01222-8","DOIUrl":"https://doi.org/10.3758/s13415-024-01222-8","url":null,"abstract":"The flanker task is a widely used measure of cognitive control abilities. Drift-diffusion modeling of flanker task behavior can yield separable parameters of cognitive control-related subprocesses, but the parameters' psychometrics are not well-established. We examined the reliability and validity of four behavioral measures: (1) raw accuracy, (2) reaction time (RT) interference, (3) NIH Toolbox flanker score, and (4) two drift-diffusion model (DDM) parameters-drift rate and boundary separation-capturing evidence accumulation efficiency and speed-accuracy trade-off, respectively. Participants from two independent studies - one cross-sectional (N = 381) and one with three timepoints (N = 83) - completed the flanker task while electroencephalography data were collected. Across both studies, drift rate and boundary separation demonstrated comparable split-half and test-retest reliability to accuracy, RT interference, and NIH Toolbox flanker score, but better incremental convergent validity with psychophysiological measures (i.e., the error-related negativity; ERN) and neuropsychological measures of cognitive control than the other behavioral indices. Greater drift rate (i.e., faster and more accurate responses) to congruent and incongruent stimuli, and smaller boundary separation to incongruent stimuli were related to 1) larger ERN amplitudes (in both studies) and 2) faster and more accurate inhibition and set-shifting over and above raw accuracy, reaction time, and NIH Toolbox flanker scores (in Study 1). Computational models, such as DDM, can parse behavioral performance into subprocesses that exhibit comparable reliability to other scoring approaches, but more meaningful relationships with other measures of cognitive control. The application of these computational models may be applied to existing data and enhance the identification of cognitive control deficits in psychiatric disorders.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-cultural comparison of intrinsic and extrinsic motivational drives for learning. 内在学习动力和外在学习动力的跨文化比较。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-10-18 DOI: 10.3758/s13415-024-01228-2

Zhaoqi Zhang, Lieke L F van Lieshout, Olympia Colizoli, Haoqian Li, Tongxi Yang, Chao Liu, Shaozheng Qin, Harold Bekkering

{"title":"A cross-cultural comparison of intrinsic and extrinsic motivational drives for learning.","authors":"Zhaoqi Zhang, Lieke L F van Lieshout, Olympia Colizoli, Haoqian Li, Tongxi Yang, Chao Liu, Shaozheng Qin, Harold Bekkering","doi":"10.3758/s13415-024-01228-2","DOIUrl":"https://doi.org/10.3758/s13415-024-01228-2","url":null,"abstract":"Intrinsic motivational drives, like the autonomous feeling of control, and extrinsic motivational drives, like monetary reward, can benefit learning. Extensive research has focused on neurobiological and psychological factors that affect these drives, but our understanding of the sociocultural factors is limited. Here, we compared the effects of autonomy and rewards on episodic recognition memory between students from Dutch and Chinese universities. In an exploratory learning task, participants viewed partially obscured objects that they needed to subsequently remember. We independently manipulated autonomy, as volitional control over an exploration trajectory, as well as the chance to receive monetary rewards. The learning task was followed by memory tests for objects and locations. For both cultural groups, we found that participants learned better in autonomous than non-autonomous conditions. However, the beneficial effect of reward on memory performance was stronger for Chinese than for Dutch participants. By incorporating the sociocultural brain perspective, we discuss how differences in norms and values between Eastern and Western cultures can be integrated with the neurocognitive framework about dorsal lateral and ventral medial prefrontal cortex and dopaminergic reward modulations on learning and memory. These findings have important implications for understanding the neurocognitive mechanisms in which both autonomy and extrinsic rewards are commonly used to motivate students in the realm of education and urge more attention to investigate cultural differences in learning.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiological signature of interoceptive attention: a spectral and source localization analysis. 感知间注意的电生理特征：频谱和源定位分析。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-10-17 DOI: 10.3758/s13415-024-01235-3

Davide Crivelli, Michela Balconi

{"title":"Electrophysiological signature of interoceptive attention: a spectral and source localization analysis.","authors":"Davide Crivelli, Michela Balconi","doi":"10.3758/s13415-024-01235-3","DOIUrl":"https://doi.org/10.3758/s13415-024-01235-3","url":null,"abstract":"The ability to attend to and consciously process interoceptive signals is deemed critical for the development of minimal self, adaptive self-regulation and affective experience, and optimal expression of both instrumental and executive cognitive functions. Yet, notwithstanding the richness of theoretical proposals concerning inferential accounts of interoception, empirical evidence is still scarce. Building on such premises, this study was designed to investigate the electrophysiological signature of cognitive processes leading to aware coding of interoceptive signals via EEG source localization. Thirty-six healthy participants completed an interoceptive accuracy task, i.e., the Heartbeat Counting Task (HCT), while we collected task-related and resting state electrophysiological activity. eLORETA modelling and statistical nonparametric mapping were used to estimate intracortical current density and link such estimates to participants' performance at the task. Source analysis highlighted higher current density estimates for alpha frequencies during HCT with respect to rest, with the primary cortical generator in the right parahippocampal gyrus. Also, a set of medial cortical structures-primarily represented by the cingulate gyrus-showed significant relation between task-related changes in current density estimates for beta oscillations and HCT scores. Findings suggest the informativity of EEG task-related measures of neural activation when used to assess interoceptive skills, as well as of the potential of metrics and analysis based on source localization in the quest to improve our understanding of interoceptive accuracy and neurofunctional correlates of related active inferences.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleus reuniens: Modulating emotional overgeneralization in peri-adolescents with anxiety. 重聚核：调节患有焦虑症的青少年的情绪过度泛化。

IF 2.5 3区医学

Cognitive Affective & Behavioral Neuroscience Pub Date : 2024-10-10 DOI: 10.3758/s13415-024-01226-4

M Vanessa Rivera Núñez, Dana L McMakin, Aaron T Mattfeld

{"title":"Nucleus reuniens: Modulating emotional overgeneralization in peri-adolescents with anxiety.","authors":"M Vanessa Rivera Núñez, Dana L McMakin, Aaron T Mattfeld","doi":"10.3758/s13415-024-01226-4","DOIUrl":"https://doi.org/10.3758/s13415-024-01226-4","url":null,"abstract":"Background: Anxiety affects 4.4-million children in the USA with an onset between childhood and adolescence, a period marked by neural changes that impact emotions and memory. Negative overgeneralization - or responding similarly to innocuous events that share features with past aversive experiences - is common in anxiety but remains mechanistically underspecified. The nucleus reuniens (RE) has been considered a crucial candidate in the modulation of memory specificity. Our study investigated its activation and functional connectivity with the medial prefrontal cortex (mPFC) and hippocampus (HPC) as neurobiological mechanisms of negative overgeneralization in anxious youth.Methods: As part of a secondary data analysis, we examined data from 34 participants between 9 and 14 years of age (mean age ± SD, 11.4 ± 2.0 years; 16 females) with varying degrees of anxiety severity. During the Study session participants rated images as negative, neutral, and positive. After 12 h, participants returned for a Test session, where they performed a memory recognition test with repeated (targets) and similar (lures) images. Labeling negative relative to neutral lures as \"old\" (false alarms) was our operational definition of negative overgeneralization.Results: Negative relative to neutral false alarmed stimuli displayed elevated RE activation (at Study and Test) and increased functional connectivity with the Cornu Ammonis (CA) 1 (at Test). Elevated anxiety severity was associated with reductions in the RE-mPFC functional coupling for neutral relative to negative stimuli. Exploratory analyses revealed similar patterns in activation and functional connectivity with positive stimuli.Conclusions: Our findings demonstrate the importance of the RE in negative overgeneralization and anxiety.","PeriodicalId":50672,"journal":{"name":"Cognitive Affective & Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0