发布求助
文献互助 智能选刊 最新文献

Current Opinion in Genetics & Development最新文献

筛选
英文 中文
Transcription-Export complex in neurodevelopmental disorders 神经发育障碍的转录-输出复合体
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-07-11 DOI: 10.1016/j.gde.2025.102380
Rudrarup Bhattacharjee , Shreya Agarwala , Danielle Mazurkiewicz , Jozef Gecz , Raman Kumar
{"title":"Transcription-Export complex in neurodevelopmental disorders","authors":"Rudrarup Bhattacharjee ,&nbsp;Shreya Agarwala ,&nbsp;Danielle Mazurkiewicz ,&nbsp;Jozef Gecz ,&nbsp;Raman Kumar","doi":"10.1016/j.gde.2025.102380","DOIUrl":"10.1016/j.gde.2025.102380","url":null,"abstract":"<div><div>The genomic information is insulated in the nucleus of all eukaryotic cells. Error-free transcription needs to be followed by an efficient export of the messenger RNAs (mRNA) to facilitate the regulated synthesis of proteins for carrying out cellular functions. The functionally conserved <u>Tr</u>anscription-<u>Ex</u>port (TREX) complex is a key player in mediating mRNA export from the nucleus to the cytoplasm, along with RNA processing steps including 3′-end processing, 5′ capping, transcriptional regulation, R-loop resolution, and splicing. TREX, a multifunctional complex, has important roles in stress response, mitotic progression, embryonic stem cell self-renewal and differentiation, and maintaining genome stability. Most of these processes are essential for the appropriate development and function of the brain. Consistent with this notion, partial loss of function variants in the TREX components THOC2, THOC6, and DDX39B were implicated in neurodevelopmental disorders. Furthermore, a growing body of evidence also highlighted the involvement of defective nucleocytoplasmic RNA transport in the development of neurodegenerative diseases. Overall, the TREX complex is emerging as a crucial player in neurological diseases, making it a critical target for both diagnosis and therapeutic intervention.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102380"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome instability in mammalian embryos implications for genome editing, development, and evolution 哺乳动物胚胎基因组不稳定性对基因组编辑、发育和进化的影响
IF 3.6 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-08-16 DOI: 10.1016/j.gde.2025.102395
Xiangyi Liu , Shuangyi Xu , Dieter Egli
{"title":"Genome instability in mammalian embryos implications for genome editing, development, and evolution","authors":"Xiangyi Liu ,&nbsp;Shuangyi Xu ,&nbsp;Dieter Egli","doi":"10.1016/j.gde.2025.102395","DOIUrl":"10.1016/j.gde.2025.102395","url":null,"abstract":"<div><div>Genomic instability is a significant challenge in early mammalian development and a cause for developmental failure and abnormalities, particularly in humans. Here, we review our knowledge and explore its significance of genome instability in early embryos across multiple mammalian species, including humans, rhesus macaques, mice, bovines, equines, and porcine. All these species but mice share one feature: frequent chromosomal aberrations, aneuploidy, and developmental failure. We discuss the impact of genome instability on embryonic development, the applicability of gene editing using Cas9, and potential evolutionary implications. We also explore the role of germ cell and early embryo mutations and the bottleneck effect in mammals in comparison to lower vertebrates. Understanding genome stability in mammalian embryos can contribute to our understanding of genetic variation in development and evolution.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102395"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity 编辑概述：3Rs更新：细胞身份和治疗可塑性的新时代
IF 3.6 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.gde.2025.102386
Peng Du , Jianlong Wang
{"title":"Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity","authors":"Peng Du ,&nbsp;Jianlong Wang","doi":"10.1016/j.gde.2025.102386","DOIUrl":"10.1016/j.gde.2025.102386","url":null,"abstract":"","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102386"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice 小鼠未分化精原细胞发育的动态三维表观基因组重组
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-07-22 DOI: 10.1016/j.gde.2025.102383
Masahiro Nagano , Mitinori Saitou
{"title":"Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice","authors":"Masahiro Nagano ,&nbsp;Mitinori Saitou","doi":"10.1016/j.gde.2025.102383","DOIUrl":"10.1016/j.gde.2025.102383","url":null,"abstract":"<div><div>Germ cells are unique in their ability to acquire totipotency. Toward this end, they reorganize their three-dimensional (3D) epigenome during their development, including epigenetic reprogramming in primordial germ cells that differentiate mitotic prospermatogonia and ensuing unique epigenetic programming for generating undifferentiated spermatogonia/spermatogonial stem cells (SSCs). Advances in low-input epigenomic and 3D genomic techniques, along with complementary in-depth characterization of scalable <em>in vitro</em> reconstitution systems for germ cell development, that is, <em>in vitro</em> gametogenesis, have elucidated a number of fundamental events during these processes, including insulation augmentation in highly open chromatin following epigenetic reprogramming in mitotic prospermatogonia and insulation erasure and further euchromatization accompanied by chromosomal radial repositioning in undifferentiated spermatogonia/SSCs. These 3D epigenomic organizations likely serve as a foundation for generating fully functional gametes. Elucidating the mechanisms underlying 3D epigenomic reorganization during germ cell development will be instrumental not only for understanding the basis for totipotency but also for further advancing <em>in vitro</em> gametogenesis.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102383"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the origin of the development: totipotent stem cells 探索发育的起源：全能干细胞
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-07-10 DOI: 10.1016/j.gde.2025.102377
Shiyu Li , Hui Shen , Bing Peng , Peng Du
{"title":"Exploring the origin of the development: totipotent stem cells","authors":"Shiyu Li ,&nbsp;Hui Shen ,&nbsp;Bing Peng ,&nbsp;Peng Du","doi":"10.1016/j.gde.2025.102377","DOIUrl":"10.1016/j.gde.2025.102377","url":null,"abstract":"<div><div>As the origin of the development, a fertilized egg owns the ability to generate a whole new organism, including both embryonic and extraembryonic tissues, representing the highest developmental potency, totipotency. For more than 40 years, pluripotent stem cells, with differentiation potential weaker than that of totipotent cells, have been easily derived from inner cell mass and maintained <em>in vitro</em>. Until now, capturing totipotent stem cells is still challenging. Recently, the stable culture of mouse and human totipotent blastomere–like cells was achieved for the first time using spliceosomal repression. Subsequently, other methods, particularly epigenetic manipulation, have also succeeded in culturing mouse totipotent stem cells. These advancements provide an excellent system for studying early embryonic development and offer new possibilities for regenerative medicine. However, the <em>in vitro</em> culture of totipotent stem cells has only been recently realized, and much further exploration is needed in this field. This review aims to compare different totipotent stem cells and discuss their potential applications in regenerative medicine and disease modeling.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102377"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking phenotype to genotype using comprehensive genomic comparisons 利用全面的基因组比较将表型与基因型联系起来
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI: 10.1016/j.gde.2025.102384
Leon Hilgers , Michael Hiller
{"title":"Linking phenotype to genotype using comprehensive genomic comparisons","authors":"Leon Hilgers ,&nbsp;Michael Hiller","doi":"10.1016/j.gde.2025.102384","DOIUrl":"10.1016/j.gde.2025.102384","url":null,"abstract":"<div><div>Comparative genomics is a powerful approach to illuminate the genetic basis of phenotypic diversity across macro-evolutionary timescales. Recent advances in sequencing, genome assembly, annotation, and comparative methods promoted large-scale analyses that unveiled genomic determinants contributing to differences in cognition, metabolism, and body plans as well as phenotypes with biomedical relevance, such as cancer resistance, longevity, and viral tolerance. These studies highlight joint contributions of multiple molecular mechanisms and indicate an underappreciated role for gene and enhancer losses driving phenotypic change. However, challenges remain, including comprehensive phenotype databases and genome annotations, improved approaches for identifying lineage-specific adaptations, and functional tests. Here, we review recent progress, highlight major discoveries, and discuss future directions for linking phenotype to genotype using comparative genomics.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102384"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks 比较转录组学的进化：生物尺度、系统发育跨度和建模框架
IF 3.6 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.gde.2025.102387
Matteo Zambon , Federica Mantica , Mafalda Dias , Jonathan Frazer , Manuel Irimia
{"title":"Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks","authors":"Matteo Zambon ,&nbsp;Federica Mantica ,&nbsp;Mafalda Dias ,&nbsp;Jonathan Frazer ,&nbsp;Manuel Irimia","doi":"10.1016/j.gde.2025.102387","DOIUrl":"10.1016/j.gde.2025.102387","url":null,"abstract":"<div><div>Comparative transcriptomic studies are key to understanding how molecular evolution drives phenotypic divergence across the tree of life. Here, we discuss three major directions in which the field of comparative transcriptomics is evolving. The first one is enabled by advances in sequencing technologies. Bulk RNA sequencing emerged two decades ago as a key tool to characterize transcriptomic states, enabling evolutionary comparisons at the tissue and organ levels. However, single-cell and spatial transcriptomics are now driving a shift toward a paradigm centered around cell types. Second, while comparative transcriptomic studies have historically focused on a few key model organisms and on species closely related to humans, recent trends have shifted toward both broader phylogenetic coverage and deeper sampling within clades. In parallel, the growing amount of transcriptomic data, together with the advent of machine learning approaches, are leading to the development of new modeling frameworks. These frameworks range from reconstruction of cell type phylogenies to prediction of RNA coverage from genomic sequence alone and have propelled significant progress in evolutionary biology and its biomedical applications.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"94 ","pages":"Article 102387"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological roles of nonsense-mediated RNA decay: insights from the nervous system 无义介导的RNA衰变的生物学作用：来自神经系统的见解
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-08-01 Epub Date: 2025-05-22 DOI: 10.1016/j.gde.2025.102356
Kun Tan , Miles F Wilkinson
{"title":"Biological roles of nonsense-mediated RNA decay: insights from the nervous system","authors":"Kun Tan ,&nbsp;Miles F Wilkinson","doi":"10.1016/j.gde.2025.102356","DOIUrl":"10.1016/j.gde.2025.102356","url":null,"abstract":"<div><div>Nonsense-mediated RNA decay (NMD) is a highly selective and conserved RNA turnover pathway. The discovery that NMD is not only a quality control pathway that degrades aberrant mRNAs but also degrades subsets of normal mRNAs has led to the hypothesis that NMD influences and controls normal biological events. In this review, we lay out the support for this hypothesis, with a focus on NMD’s roles in the nervous system. Studies have demonstrated roles for NMD in several aspects of nervous system development, including neural cell generation and differentiation. Studies in mice have provided evidence that NMD inhibits neural inflammation and promotes mature neuron functions, including dendritic spine maturation and synaptic plasticity, providing a potential explanation for why NMD deficiency leads to cognitive and behavioral dysfunction in mice and humans.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102356"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
mRNA translational control of regeneration 再生的mRNA翻译控制
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-08-01 Epub Date: 2025-06-07 DOI: 10.1016/j.gde.2025.102367
Mehdi Amiri , Nahum Sonenberg , Soroush Tahmasebi
{"title":"mRNA translational control of regeneration","authors":"Mehdi Amiri ,&nbsp;Nahum Sonenberg ,&nbsp;Soroush Tahmasebi","doi":"10.1016/j.gde.2025.102367","DOIUrl":"10.1016/j.gde.2025.102367","url":null,"abstract":"<div><div>mRNA translation is rapidly upregulated after injury to supply proteins required for tissue regeneration. Augmented protein synthesis during regeneration has long been associated with increases in ribosome biogenesis and mTORC1 activity. Emerging evidence highlights the roles of multiple signaling pathways, RNA-binding proteins, and RNA modifications in tissue repair. Here, we review recent research on the molecular mechanisms underlying translational control in response to tissue damage. The findings underscore the importance of mRNA translation in regeneration and its potential therapeutic applications in tissue repair.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102367"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing missing context in regulatory variation across primate evolution 解决灵长类动物进化中调控变异缺失的背景
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-08-01 Epub Date: 2025-06-26 DOI: 10.1016/j.gde.2025.102374
Genevieve Housman , Audrey Arner , Amy Longtin , Christian Gagnon , Arun Durvasula , Amanda Lea
{"title":"Addressing missing context in regulatory variation across primate evolution","authors":"Genevieve Housman ,&nbsp;Audrey Arner ,&nbsp;Amy Longtin ,&nbsp;Christian Gagnon ,&nbsp;Arun Durvasula ,&nbsp;Amanda Lea","doi":"10.1016/j.gde.2025.102374","DOIUrl":"10.1016/j.gde.2025.102374","url":null,"abstract":"<div><div>In primates, loci associated with adaptive trait variation often fall in noncoding regions. Understanding the mechanisms linking these regulatory variants to fitness-relevant phenotypes remains challenging but can be addressed using functional genomic data. However, such data are rarely generated at scale in nonhuman primates. When they are, only select tissues, cell types, developmental stages, and cellular environments are typically considered, despite growing appreciation that adaptive variants often exhibit context-dependent effects. In this review, we (1) discuss why context-dependent regulatory loci might be especially relevant for understanding adaptive evolution in primates, (2) explore challenges and emerging solutions for mapping such context-dependent variation, and (3) discuss the scientific questions these data could address. Filling these gaps will provide critical insights into evolutionary processes, human disease, and regulatory adaptation.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102374"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书