Developmental Medicine and Child Neurology最新文献

{"title":"Morbidities and comorbidities associated with optic nerve hypoplasia and septo-optic-pituitary dysplasia","authors":"","doi":"10.1111/dmcn.16247","DOIUrl":"10.1111/dmcn.16247","url":null,"abstract":"<p>Optic nerve hypoplasia (ONH) and septo-optic-pituitary dysplasia (SOD) are disorders in which the eye nerves are small. In SOD, other brain abnormalities are also present. These disorders are the leading causes of poor vision in children in high-income countries. There is no cure for the impaired vision. There are no studies quantifying the frequency of the medical conditions associated with ONH and SOD cases compared to people without ONH or SOD, despite their importance for planning healthcare and services delivery. Our study bridges that gap by comparing the frequency of the various medical conditions in 124 cases with ONH and SOD to the frequency of the same medical conditions in 620 unrelated cases and 76 siblings of the cases with ONH and SOD.</p><p>We used population-based health databases to obtain the relevant medical information. These databases are housed at the Manitoba Centre for Health Policy at the University of Manitoba, Canada. We found that visual impairment and visual impairment associated with deficiency in some of the hormones produced in the brain (hypopituitarism) were the main medical conditions in patients with ONH and SOD, respectively. In addition, developmental delay or intellectual disability, autism spectrum disorder, epilepsy, cerebral palsy, and mood or anxiety disorders were important conditions that were more common in cases with ONH and SOD compared to people without ONH and SOD. We also found that cases with ONH and hypopituitarism were at the highest risk of being affected by the aforementioned medical conditions and that these medical conditions may accrue with age.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 3","pages":"e77"},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive functioning in children and young adults with monogenic neurodevelopmental disorders.","authors":"Emma K Baker, Miya St John, Ruth Braden, Lottie D Morison, Elana J Forbes, Fatma Lelik, Stephen J C Hearps, David J Amor, Angela T Morgan","doi":"10.1111/dmcn.16227","DOIUrl":"https://doi.org/10.1111/dmcn.16227","url":null,"abstract":"<p><strong>Aim: </strong>To examine the adaptive behaviour profiles of children with monogenic neurodevelopmental disorders (NDDs) to determine whether syndrome-specific or transdiagnostic approaches provide a better understanding of the adaptive behavioural phenotypes of these NDDs.</p><p><strong>Method: </strong>This cross-sectional study included parents and caregivers of 243 (48% female) individuals (age range = 1-25 years; mean = 8 years 10 months, SD = 5 years 8 months) with genetically confirmed monogenic NDDs (CDK13, DYRK1A, FOXP2, KAT6A, KANSL1, SETBP1, BRPF1, and DDX3X). Parents and caregivers completed the Vineland Adaptive Behavior Scales, Third Edition to assess communication, daily living, socialization, and motor skills.</p><p><strong>Results: </strong>Linear regression models comparing mean adaptive behaviours between monogenic NDDs, adjusting for the presence of intellectual disability, revealed few group differences. Children with variants in BRPF1 or KANSL1 had better adaptive behaviour skills compared to children with variants in CDK13, DDX3X, DYRK1A, and KAT6A, although group differences varied across domains. A latent profile analysis showed compelling evidence for a five-profile model. These profiles were homogeneous, with similar delays across the subdomain scores in each profile. Additionally, each monogenic NDD was represented in each profile, with a few exceptions.</p><p><strong>Interpretation: </strong>Transdiagnostic approaches to understand adaptive behaviour in monogenic NDDs provide a better understanding of individual strengths and challenges, enabling more targeted support.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral palsy pain instruments: Recommended tools for clinical research studies by the National Institute of Neurological Disorders and Stroke Cerebral Palsy Common Data Elements project","authors":"","doi":"10.1111/dmcn.16246","DOIUrl":"10.1111/dmcn.16246","url":null,"abstract":"<p>This study describes the process of updating the cerebral palsy (CP) common data elements (CDEs), specifically identifying tools that capture the impact of chronic pain on children's everyday functioning.</p><p>A CDE is a precisely defined question paired with a set of structured responses, used systematically across different sites, studies, or clinical trials to ensure consistent data collection. The CDEs consist of specific terminology with identification of common definitions, standardized case-report forms, and standardized tools/instruments. The overarching aim of developing condition-specific CDEs is to accelerate research, enable prompt uptake of evidence into clinical practice, and to deliver the best quality of care to individuals who require it.</p><p>Following an adapted CP chronic pain tools' rating system, and a review of psychometric properties, clinical utility, and compliance with inclusion/exclusion criteria, a set of recommended pain tools was posted online for external public comment in May 2022.</p><p>Fifteen chronic pain tools met inclusion criteria, representing constructs across all components of the International Classification of Functioning, Disability and Health.</p><p>This paper describes the first condition-specific pain CDEs for a pediatric population. The novel CP CDE pain tools harmonize the assessment of chronic pain, addressing not only intensity of chronic pain, but also the functional impact of experiencing pain in everyday activities.</p><p>Beyond research applications, this comprehensive set of CP CDE pain tools also serves as a clinical resource for teaching, standardizing the selection of pain measures and pain assessments, adopting a biopsychosocial approach to pain evaluation, harmonizing data collection and reporting, and guiding quality-improvement projects to further develop the care of children and young people with CP and chronic pain.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 3","pages":"e76"},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral problems in migrant children born preterm: Is it about language or is it about the system?","authors":"Frank Müller,&nbsp;Christine Happle,&nbsp;Eva Noack","doi":"10.1111/dmcn.16242","DOIUrl":"10.1111/dmcn.16242","url":null,"abstract":"&lt;p&gt;Preterm birth affects millions of children globally, and providing equitable care poses particular challenges in increasingly diverse societies. The study by Jaekel et al. convincingly demonstrates a correlation between children's first language linguistic distance to German and behavioral and emotional problems in children born preterm. [Correction added on 18 February 2025 after first online publication: The author's name Jaeckel was changed to Jaekel in the preceding sentence.] This interrelation is especially relevant in Germany where, as the authors point out, about 42% of children have at least one immigrant parent and preterm birth affects approximately 1% to 2% of all infants.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;A central question arises. Do these findings primarily reflect language differences and communication problems that emerge from them, or do they indicate broader systemic challenges in early childhood education, childcare systems, and pediatric care? The actual German language proficiency of children or their parents was not assessed in the study. However, the authors assume that greater linguistic distance of the primary learned language results in lower German language proficiency, making it more difficult for both children and parents to navigate society. When children struggle with communication, this may cascade into frustration or feelings of isolation, increasing their risk for behavioral and emotional problems. Similarly, parents may face barriers to accessing and effectively utilizing available support services.&lt;/p&gt;&lt;p&gt;However, the presumed language barriers might also serve as a proxy for a range of intersectional factors and deeper structural inequities faced by immigrant families, particularly those from Turkish or Arabic-speaking backgrounds.&lt;/p&gt;&lt;p&gt;According to a recent federal report, individuals with Turkish migration backgrounds face a significantly higher poverty risk compared to both native Germans and other migrant groups (https://www.bpb.de/kurz-knapp/zahlen-und-fakten/sozialbericht-2024/553284/erwerbs-haushaltseinkommen-und-armutsrisikoquote/). While medical care for many children born preterm in Germany is coordinated in specialized pediatric care clinics providing regular follow-up visits, their access to early childhood education through kindergarten and pre-K institutions is less stringently supported. In Germany, children from migrant families are less likely to attend preschool institutions.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; These institutions are widely available and facilitate the development of children's socio-emotional, cognitive, physical, and communication skills. It is recognized that early childhood education promotes educational equity as it can compensate for unfavorable developmental conditions such as household poverty, low literacy, or post-immigration stress through specific socio-pedagogical support.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;However, this requires sufficient investment in social infrastructure.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 5","pages":"557-558"},"PeriodicalIF":3.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental variability in paediatric SGCE-related myoclonus dystonia syndrome.","authors":"Clément Tarrano, Yulia Worbe","doi":"10.1111/dmcn.16241","DOIUrl":"https://doi.org/10.1111/dmcn.16241","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early developmental trajectories of the impaired hand in infants with unilateral cerebral palsy.","authors":"Leanne Sakzewski, Susan Greaves, Ann-Christin Eliasson, Margaret Wallen, Iona Novak, Robert S Ware, Jill Heathcock, Nathalie Maitre, Roslyn N Boyd","doi":"10.1111/dmcn.16240","DOIUrl":"https://doi.org/10.1111/dmcn.16240","url":null,"abstract":"<p><strong>Aim: </strong>To identify developmental trajectories of impaired hand function in infants aged 3 to 15 months with unilateral cerebral palsy (CP).</p><p><strong>Method: </strong>Sixty-three infants (37 male; median gestational age 37 weeks [interquartile range 30-39.1 weeks]) recruited as part of a randomized trial with a confirmed diagnosis of unilateral CP were included. All infants received early upper limb therapy. The Hand Assessment for Infants (HAI) was completed at baseline and until 12 to 15 months corrected age. Group-based trajectory modelling identified groups with similar trajectories of development of impaired hand function. Multinomial logistic regression determined associations between demographic variables and trajectory membership.</p><p><strong>Results: </strong>The three-group trajectory model comprised 'low' 29%, 'moderate' 35%, and 'high' 36% functioning groups. The relative risk ratio of being in the low or moderate relative to high group increased by 16% (95% confidence interval [CI] 1.02-1.32) and 14% (95% CI 1.01-1.29) respectively for each 1 week increase in gestational age. Males were more likely to be in the low relative to high group (relative risk ratio 7.22; 95% CI 1.6-32.5).</p><p><strong>Interpretation: </strong>Three distinct trajectories of development of the impaired hand were identified. Males and infants born closer to term age were at higher risk of being in a low group with little improvement over time, despite receiving early intervention.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and risk factors for osteoporosis and fragility fracture in adults with cerebral palsy: A systematic review","authors":"Anne Trinh,&nbsp;Ellen Fremion,&nbsp;Shayan Bhathena,&nbsp;Craig F. Munns,&nbsp;Prue Morgan,&nbsp;Daniel G. Whitney,&nbsp;Bernadette Gillick,&nbsp;Margaret Zacharin,&nbsp;Darcy Fehlings,&nbsp;Amanda J. Vincent,&nbsp;Frances Milat","doi":"10.1111/dmcn.16234","DOIUrl":"10.1111/dmcn.16234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To systematically review the prevalence and incidence of osteoporosis, osteopenia, low bone mass, and fragility fracture in adults with cerebral palsy (CP), and identify the risk factors for osteoporosis and fracture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A systematic literature search was performed in the MEDLINE, PubMed, CINAHL, AMED, Cochrane Reviews, EMBASE, and EBM database reviews from inception until May 2024. Search terms covered a combination of keywords for CP, fracture, osteoporosis, incidence and prevalence, and risk factors. Participants were adults with CP aged 18 years and older. JBI critical appraisal instruments were used to assess quality and risk of bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen of 303 studies met the eligibility criteria to assess the prevalence and incidence of osteoporosis and fracture, and 16 of 663 studies to assess risk factors. Osteoporosis prevalence was 5% in a general adult population with CP, increasing to 43% in those attending outpatient clinics. Osteoporosis incidence reported in one study was 2.85 per 1000 person years. Prevalence of fragility fracture was 5.5% overall but up to 38% in outpatient settings. Risk factors for osteoporosis and fracture included mobility status, nutritional status, and anticonvulsant use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>Low bone density and fracture is common in adults with CP with reduced mobility. The main risk factors for poor bone health are related to reduced mobility, nutrition, and anticonvulsant use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 5","pages":"563-571"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-system resilience for disabled children and their families during crisis and emergency","authors":"Tali-Noy Hindi","doi":"10.1111/dmcn.16158","DOIUrl":"10.1111/dmcn.16158","url":null,"abstract":"&lt;p&gt;Emergency management is complex, requiring different layers of actions taken by diverse actors. Emergency activities such as evacuations, assistance, and casualty management issues are undertaken by government agencies, civil society organizations, and private-sector companies that can be used to finance, build, operate projects, and provide emergency services. Merrick et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; have established agreement on specific policies and practices for services supporting disabled children during emergencies. The authors revised these solutions into draft recommendations focused on localized decision-making in three key areas: (1) prioritizing care for high-risk health issues; (2) organizing and delivering care; and (3) communicating changes in care provision during future emergencies. This article is fundamental since it underscores the fact that acute crises no longer have a geographically localized impact; their influence expands to far-reaching locations due to globalization. Hence, it is vital to prepare for acute crises that will almost certainly occur in the future.&lt;/p&gt;&lt;p&gt;Moreover, different governmental ministries, regional and local authorities, and service providers are responsible for preparing services, to operate in routine and emergency situations, and enhancing their resilience. The recommendations in the Merrick et al. study include cross-service and sector provision such as the ‘Every Contact Counts’ approach. However, research shows that devolution of power to local governments in crisis is only partially effective. During an ongoing acute crisis, budget cuts and reallocation should be expected, thus forcing local authorities to reduce services provided routinely to residents. This reduction would inevitably be even higher in weaker local authorities.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Most recommendations emphasize the prevalent approach in rehabilitation psychology studies that describes the effects of crisis and distress on the individual. However, a disabled child's low level of functioning has far-reaching consequences for family members, just as a low level of family functioning affects the health and well-being of the disabled child. Therefore, current policy studies refer to family resilience as the reactivity of the family to complex challenges such as the effects of climate change, epidemics, or war.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;The impact of crises on families with disabled children is multidimensional. Families face many challenges that are exacerbated by the complex circumstances of caring for disabled children. Intersecting factors that endanger or promote family resilience describe how marginalized groups face multiple layers of risk that interact with low-resource intensity.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;The concept of coping with multiple stressors arising from disruptions and threats across various systems is referred to as multisystemic resilience, where the resilience of one system can influenc","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 5","pages":"561-562"},"PeriodicalIF":3.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidities and comorbidities associated with optic nerve hypoplasia and septo-optic-pituitary dysplasia.","authors":"Michael S Salman, Chelsea A Ruth, Marina S Yogendran, Lisa M Lix","doi":"10.1111/dmcn.16235","DOIUrl":"https://doi.org/10.1111/dmcn.16235","url":null,"abstract":"<p><strong>Aim: </strong>To quantify optic nerve hypoplasia (ONH) and septo-optic-pituitary dysplasia (SOD) morbidities and comorbidities.</p><p><strong>Method: </strong>A retrospective population-based study with a case-control design was undertaken using administrative health data from Manitoba, Canada. Cases were 124 patients with ONH or SOD (70 males, 54 females; age range 6 months-36 years 8 months [mean 13 years, SD 7 years 2 months]) diagnosed from 1990 to 2019, matched to 620 unrelated population-based controls (350 males, 270 females; age range 0-36 years 8 months [mean 12 years 5 months, SD 7 years 2 months]) on birth year, sex, and area of residence. Additionally, 76 cases with ONH or SOD (46 males, 30 females; age range 2 years 5 months-36 years 8 months [mean 13 years 11 months, SD 7 years 3 months]) were matched one-to-one with sibling controls (40 males, 36 females; age range 7 months-33 years 1 month [mean 11 years 8 months, SD 7 years 3 months]). We used χ² or Fisher's exact tests to test for differences in prevalence in morbidities and comorbidities between cases and controls; odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Cox proportional hazards models were used to test for differences in subgroups of cases; hazard ratios and 95% CIs were estimated.</p><p><strong>Results: </strong>Visual impairment and visual impairment with hypopituitarism were core morbidities associated with ONH and SOD cases respectively compared to unrelated controls (OR = 58.6, 95% CI = 22.5-152.5; OR = 243.4, 95% CI = 32.9-1799.0 respectively). Developmental delay or intellectual disability (OR = 6.9, 95% CI = 3.3-14.4), autism spectrum disorder (OR = 4.0, 95% CI = 2.0-8.3), epilepsy (OR = 14.9, 95% CI = 6.1-36.5), cerebral palsy (OR = 40.9, 95% CI = 14.0-119.6), and mood or anxiety disorders (OR = 1.7, 95% CI = 1.0-2.8) were the comorbidities more common among cases with ONH and SOD. Cases matched to siblings showed similar results except for mood and anxiety disorders.</p><p><strong>Interpretation: </strong>Visual impairment and visual impairment with hypopituitarism are the main morbidities in patients with ONH and SOD respectively, while developmental delay or intellectual disability, autism spectrum disorder, epilepsy, cerebral palsy, and mood or anxiety disorders are important comorbidities.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of cerebral palsy and cognitive delay among high-risk children in a developing nation: A successful early detection programme","authors":"","doi":"10.1111/dmcn.16236","DOIUrl":"10.1111/dmcn.16236","url":null,"abstract":"<p>Therapy for children with cerebral palsy (CP) and other developmental disabilities is most effective if started early in life. Targeting therapy early requires detection programs that are appropriate for the resources that are available. In high-income, predominantly western countries, it is recommended that brain MRI and serial examinations be used to predict CP. However, in low- and middle-income countries (LMICs), there is often limited access to MRI, and repeating developmental assessments over time is difficult. With the majority of children with CP and other developmental disabilities living in LMICs, it is important to perform early detection research in LMICs to provide practical recommendations, useful in various clinical settings.</p><p>We integrated the General Movements Assessment (GMA) and Hammersmith Infant Neurological Examination (HINE) in the routine follow-up of 201 Sri Lankan infants at risk for CP. In a busy neurology clinic, the GMA was done twice, at approximately term to assess for writhing movements and at 3 to 4 months to assess fidgety movements. The HINE was done at approximately 5 to 6 months. At 2 years of age, a neurological examination was done to determine whether the child had CP. In addition, the Bayley Scales of Infant and Toddler Development was also done at 2 to 3½ years of age to detect non-CP developmental disorders.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 3","pages":"e75"},"PeriodicalIF":3.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}