Developmental Medicine and Child Neurology最新文献_第8页

Orthopedic surgery after selective dorsal rhizotomy in children with cerebral palsy: A matched cohort study 脑瘫患儿选择性背神经根切断术后的骨科手术：一项匹配队列研究。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-10 DOI: 10.1111/dmcn.16468

{"title":"Orthopedic surgery after selective dorsal rhizotomy in children with cerebral palsy: A matched cohort study","authors":"","doi":"10.1111/dmcn.16468","DOIUrl":"10.1111/dmcn.16468","url":null,"abstract":"The effect of a selective dorsal rhizotomy (SDR) on the incidence of subsequent orthopedic surgery is unknown. Proponents of SDR often assert that the procedure lowers the need for orthopedic surgery, including surgery to address muscle contractures. There is no strong evidence to support this claim. Conversely, a recent, multi-center study evaluating the long-term effects of SDR suggested the procedure might increase the rate of subsequent orthopedic surgery. However, the study design could not account for differences in treatment philosophy between centers, which could have influenced the findings.In the current study, we estimated the effect of an SDR on the cumulative incidence of undergoing each of 10 common orthopedic surgeries. We used historical data from patients with and without a history of SDR (Yes-SDR, No-SDR) who received care at a center that offers SDR as part of a proactive spasticity management philosophy. We carefully matched limbs at baseline on indications for an SDR. We then used Kaplan–Meier analysis—a common statistical method that estimates the proportion of patients who have not yet experienced an event, like surgery, at different points in time—to compute the cumulative incidence of each of the surgeries as a function of age.Our results show that SDR does not consistently lower the incidence of orthopedic surgery. We found a higher cumulative incidence of orthopedic surgery in the Yes-SDR group for femoral derotation osteotomy and foot and ankle bone surgery. We found a lower cumulative incidence for rectus femoris transfer. We found no difference for any contracture relieving surgery (hamstrings, calf muscle, psoas, adductor), tibial derotation osteotomy, foot and ankle soft tissue surgery, or surgery to address crouch gait (distal femoral extension osteotomy or patellar tendon advancement).","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 10","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective 5-year natural history study of infantile PLA2G6-associated neurodegeneration. 婴儿pla2g6相关神经退行性变的5年前瞻性自然史研究。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-10 DOI: 10.1111/dmcn.16464

Allison Gregory, Kira M Anderson, Helena Loftus, Robin L Baudier, Jenny L Wilson, Penelope Hogarth, Susan J Hayflick

{"title":"Prospective 5-year natural history study of infantile PLA2G6-associated neurodegeneration.","authors":"Allison Gregory, Kira M Anderson, Helena Loftus, Robin L Baudier, Jenny L Wilson, Penelope Hogarth, Susan J Hayflick","doi":"10.1111/dmcn.16464","DOIUrl":"https://doi.org/10.1111/dmcn.16464","url":null,"abstract":"Aim: To prospectively characterize the age of developmental milestone attainment and loss, disease milestone acquisition, and associations between a quality of life measure and age in 40 children with infantile PLA2G6-associated neurodegeneration (PLAN).Method: We analysed developmental and disease milestones and health-related quality of life scores from the 97-item Infant Toddler Quality of Life Questionnaire (ITQOL-97) in a prospective, observational, longitudinal natural history study. Developmental and disease milestone attainments were visualized as histograms and Kaplan-Meier curves respectively. We used mixed-effects linear regression to assess the associations between ITQOL-97 domains and age and to compare marginal predictions to a US reference population.Results: The study group was comprised of 19 males and 21 females with a mean age at enrollment of 5 years 1 month (SD 3 years; range 1 year 7 months-16 years 8 months). Over the course of the disease, children continued to vocalize, smile, and laugh, while other milestones like walking were rarely met at any time. ITQOL-97 domains differed significantly from a US reference population in all areas except for 'general behavior'. The 'physical abilities' domain had the greatest change with age (-6.24 per year).Interpretation: In this first prospective natural history study of infantile PLAN, we characterize developmental and disease milestones, and longitudinal associations, with quality of life metrics. These data will provide valuable disease norms for use as clinical references and in the design of interventional trials.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individualized telehealth home program for children with cerebral palsy during the COVID-19 pandemic 2019冠状病毒病大流行期间脑瘫儿童个性化远程医疗家庭方案。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-09 DOI: 10.1111/dmcn.16467

引用次数: 0

Enforcing the rights of persons with childhood-onset disabilities: An international statement. 加强儿童残疾者的权利：一项国际声明。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-09 DOI: 10.1111/dmcn.16458

John Coughlan, Deirdre Fitzgerald

引用次数: 0

Longitudinal decline in upper-limb range of motion in adults with cerebral palsy. 成人脑瘫患者上肢活动范围的纵向下降。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-09 DOI: 10.1111/dmcn.16454

Erika Cloodt, Jenny Hedberg-Graff, Anna Lindgren, Marianne Arner, Evgenia Manousaki, Katina Pettersson, Elisabet Rodby-Bousquet

{"title":"Longitudinal decline in upper-limb range of motion in adults with cerebral palsy.","authors":"Erika Cloodt, Jenny Hedberg-Graff, Anna Lindgren, Marianne Arner, Evgenia Manousaki, Katina Pettersson, Elisabet Rodby-Bousquet","doi":"10.1111/dmcn.16454","DOIUrl":"https://doi.org/10.1111/dmcn.16454","url":null,"abstract":"To analyse longitudinal changes in passive range of motion (ROM) in the upper limb in adults with cerebral palsy (CP).Method: Passive ROM for shoulder abduction and flexion, supination, and elbow and wrist extension was analysed in a longitudinal cohort of adults aged 16 to 76 years from the Swedish CP registry. Individual ROM trajectories and mean ROM curves were calculated using the Manual Ability Classification System (MACS). A mixed-effects model was used to examine changes over 3 to 13 years 7 months.Results: In total, 1395 adults with CP were analysed (769 males, 626 females; median age 26 years). A continuous decline in shoulder ROM, supination, and wrist extension was observed across all MACS levels. Decline rates differed between MACS levels for shoulder flexion, elbow extension, and wrist extension, with steeper declines at higher MACS levels (levels IV and V). Adults classified in lower MACS levels (I and II) had greater initial ROM and slower declines compared to adults classified in higher MACS levels.Interpretation: Upper-limb ROM continuously declined in adults with CP, particularly at higher MACS levels. The varied decline rates highlight the need for tailored interventions and systematic follow-up to maintain ROM and functional ability, especially among individuals at higher risk.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision rehabilitation for cerebral palsy will require robust measures of motor control development. 脑瘫的精确康复将需要强有力的运动控制发展措施。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-07 DOI: 10.1111/dmcn.16460

Laura A Prosser

引用次数: 0

Deep brain stimulation for neurological and neurodevelopmental disorders in children: Current applications and future perspectives. 脑深部电刺激治疗儿童神经和神经发育障碍：当前应用和未来展望。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-06 DOI: 10.1111/dmcn.16452

Sydney A McQueen, Carolina Gorodetsky, George M Ibrahim

{"title":"Deep brain stimulation for neurological and neurodevelopmental disorders in children: Current applications and future perspectives.","authors":"Sydney A McQueen, Carolina Gorodetsky, George M Ibrahim","doi":"10.1111/dmcn.16452","DOIUrl":"https://doi.org/10.1111/dmcn.16452","url":null,"abstract":"Deep brain stimulation (DBS) has advanced the treatment of refractory neurological and neuropsychiatric conditions in adults, offering a reversible and adjustable therapy. While its application among children remains in its infancy, DBS holds potential for the treatment of conditions such as dystonia, epilepsy, and neurodevelopmental disorders including severe self-injurious behaviour. Paediatric DBS introduces unique opportunities for early intervention during critical periods of neuroplasticity, but also presents challenges related to developmental impacts, ethical considerations, and a limited evidence base. This review outlines the current state of DBS in children, highlighting key indications, clinical outcomes, and barriers to more widespread implementation. Advances in biomarkers and adaptive stimulation technologies are poised to refine patient selection and treatment paradigms, while multisite collaborations will be essential in building robust evidence and improving accessibility. As DBS evolves, it offers hope for improving the quality of life of children and their families facing a number of severe, treatment-resistant conditions.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dual risk of research funding and federal assistance program budgetary cuts in cerebral palsy care in the United States. 研究经费和联邦援助计划预算削减在美国脑瘫护理的双重风险。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-06 DOI: 10.1111/dmcn.16459

Devika A Shenoy, Anthony A Catanzano

引用次数: 0

Childhood white matter morphology and longitudinal change in symptoms of attention-deficit/hyperactivity disorder. 儿童白质形态和注意力缺陷/多动障碍症状的纵向变化。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-06 DOI: 10.1111/dmcn.16395

Keri S Rosch, Christian Hyde, Ian Fuelscher, Deana Crocetti, Mervyn Singh, Stewart H Mostofsky

{"title":"Childhood white matter morphology and longitudinal change in symptoms of attention-deficit/hyperactivity disorder.","authors":"Keri S Rosch, Christian Hyde, Ian Fuelscher, Deana Crocetti, Mervyn Singh, Stewart H Mostofsky","doi":"10.1111/dmcn.16395","DOIUrl":"10.1111/dmcn.16395","url":null,"abstract":"Aim: To identify features of childhood white matter morphology associated with longitudinal change in the symptoms of attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence and whether brain white matter microstructure in childhood predicts ADHD symptom progression into adolescence.Method: This was a single-site, prospective, longitudinal study of children with ADHD (n = 99, 31 females) and typically developing controls (n = 73, 24 females) assessed in childhood (aged 8-12 years) and adolescence (aged 12-17 years). Parent ratings of ADHD symptom severity were obtained in childhood and adolescence. Diffusion-weighted imaging data were collected in childhood; we derived measures of fiber bundle cross-section (morphology) using fixel-based analysis, a fiber-specific analytical framework. Linear regression was used to examine symptom change and nonparametric permutation testing was conducted for brain-behavior associations. Clinical trajectories and white matter microstructure were also compared between females and males to inform our understanding of the brain basis for sex differences in the clinical presentation of ADHD.Results: Females with ADHD showed greater improvement than males in inattention and similar reductions in hyperactivity and impulsivity from childhood to adolescence. Higher fiber cross-section in corticospinal and parieto-occipital pontine tracts in childhood was associated with greater improvement in the severity of ADHD hyperactivity and impulsivity symptoms into adolescence.Interpretation: ADHD symptom trajectories from childhood to adolescence differed between males and females and were related to individual variation in structural brain connectivity in childhood.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal reference centiles for the Gross Motor Function Measure-66 in children and adolescents with cerebral palsy. 脑瘫儿童和青少年大运动功能测量的纵向参考百分位数-66。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-05 DOI: 10.1111/dmcn.16455

Ibrahim Duran, Leonie Schafmeyer, Bruno Lentzen, Karoline Spiess, Titus Keller, Kyriakos Martakis, Eckhard Schoenau

{"title":"Longitudinal reference centiles for the Gross Motor Function Measure-66 in children and adolescents with cerebral palsy.","authors":"Ibrahim Duran, Leonie Schafmeyer, Bruno Lentzen, Karoline Spiess, Titus Keller, Kyriakos Martakis, Eckhard Schoenau","doi":"10.1111/dmcn.16455","DOIUrl":"https://doi.org/10.1111/dmcn.16455","url":null,"abstract":"Aim: To establish novel longitudinal reference values for the Gross Motor Function Measure-66 (GMFM-66) in children and adolescents with cerebral palsy aged 3 to 18 years, to enable more accurate assessments of changes in motor function.Method: This was a single-centre retrospective analysis of patients who participated in a rehabilitation programme between January 2006 and March 2022. The GMFM-66 was used to measure gross motor function. Paired GMFM-66 measurements from the follow-up phase of the rehabilitation programme were used to establish a reference centile for the change in GMFM-66 over a 6-month period using the lambda-mu-sigma method.Results: Reference centiles for GMFM-66 changes (over a 6-month period; ±1 month) were created using 1190 longitudinal data pairs of GMFM-66 measurements (mean age 8 years 4 months [standard deviation 7 years 11 months] at start of follow-up), Gross Motor Function Classification System levels I to V. The z-scores for GMFM-66 change of a validation dataset by the new tool and the previously described method to quantify a change in GMFM-66 by individual effect size were highly correlated (Pearson's rank correlation coefficient 0.981 [95% confidence interval 0.979-0.984], p < 0.001) INTERPRETATION: The new reference values showed a high correlation with the previously published reference values, which were limited to an age range of 3 to 12 years. The new reference values can be applied from an age of 3 to 18 years. This facilitates the evaluation of medical treatment after a 6-month period also for children with cerebral palsy who are older than 12 years.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0