Developmental Medicine and Child Neurology最新文献_第7页

Assessing gross motor function in cerebral palsy: What standardized scores do not tell us. 评估脑瘫的大运动功能：标准化分数不能告诉我们什么。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-19 DOI: 10.1111/dmcn.16480

Peter Rosenbaum

引用次数: 0

Clinical features and outcomes of paediatric probable antibody-negative autoimmune encephalitis 小儿可能的抗体阴性自身免疫性脑炎的临床特点和结局。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-19 DOI: 10.1111/dmcn.16491

{"title":"Clinical features and outcomes of paediatric probable antibody-negative autoimmune encephalitis","authors":"","doi":"10.1111/dmcn.16491","DOIUrl":"10.1111/dmcn.16491","url":null,"abstract":"Autoimmune encephalitis is a serious brain inflammation in which the immune system attacks the brain, leading to seizures, confusion, cognitive decline, and psychiatric symptoms. Although many autoimmune encephalitis-related antibodies have been discovered, some children with typical signs of autoimmune encephalitis test negative for known antibodies. These cases are referred to as antibody-negative autoimmune encephalitis (Ab-negative AE).In this study, we reviewed the clinical features, treatments, and outcomes of 66 children diagnosed with probable Ab-negative AE at a major children's hospital in the Republic of Korea.We found that: (1) Most children presented with altered mental status (92%) and seizures (85%). Nearly 90% received immunotherapy with high-dose steroids and/or intravenous immunoglobulin, and about one-third received additional treatments such as rituximab or tocilizumab. (2) Over 90% showed good functional recovery 1 year after treatment. (3) However, 44% continued to experience seizures, and around one-third had ongoing cognitive or behavioral problems after 1 year. (4) Children who had status epilepticus—a prolonged and severe seizure—at disease onset were more likely to have persistent seizures 1 year later.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 10","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and safety of abobotulinumtoxinA in pediatric lower limb spasticity: A phase IV, prospective, observational, multicenter study 肉毒杆菌毒素A治疗小儿下肢痉挛的有效性和安全性：一项前瞻性、观察性、多中心的IV期研究。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-19 DOI: 10.1111/dmcn.16487

引用次数: 0

Age at onset and gene variants predict lifespan and disease duration in childhood neuronal ceroid lipofuscinoses 发病年龄和基因变异预测儿童神经性脑蜡样脂褐变的寿命和病程。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-19 DOI: 10.1111/dmcn.16489

{"title":"Age at onset and gene variants predict lifespan and disease duration in childhood neuronal ceroid lipofuscinoses","authors":"","doi":"10.1111/dmcn.16489","DOIUrl":"10.1111/dmcn.16489","url":null,"abstract":"Dementia is a worldwide public health priority associated with prolonged life expectancy and aging. It is possibly due to interacting genetic and environmental factors. There is growing evidence that the number of young adults and children affected with dementia is increasing. Neuronal ceroid lipofuscinoses (NCLs) are the most frequent diseases leading to dementia in childhood and adolescence. They are genetic disorders (gene mutations are inherited by both parents). Several symptoms are associated with the cognitive decline: vision impairment, seizures, motor dysfunction, impaired speech and deglutition, sleep disturbances, etc. A targeted treatment is available for one form (CLN2 disease), resulting in slowing down the rate of disease progression. Knowledge of the natural history of NCLs has become crucial for families and caregivers to manage the patients' disease courses and sustain their quality of life.We investigated the relationship between age at onset and disease duration in a cohort of patients with NCL (mutated in eight NCL genes) subdivided in three groups according to the age of disease onset. Clinical data were then matched with the involved genes and the pathogenicity (the ability of an organism to cause disease) of mutations. The outcome (in terms of lifespan) was primarily related to the age at disease onset: the earliest onset meaningfully correlates with the shortest disease duration and survival. Neither the age at onset nor the survival were influenced by the kind of mutations. Most severely affected phenotypes were associated with selected genes and the impaired functions of their product (lysosomal enzymes).","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 10","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Control Assessment of the Lower Extremity for Infants and Toddlers (Mini-SCALE): Development and validation of a clinical assessment 婴幼儿下肢选择性控制评估（迷你量表）：临床评估的发展和验证。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-19 DOI: 10.1111/dmcn.16493

{"title":"Selective Control Assessment of the Lower Extremity for Infants and Toddlers (Mini-SCALE): Development and validation of a clinical assessment","authors":"","doi":"10.1111/dmcn.16493","DOIUrl":"10.1111/dmcn.16493","url":null,"abstract":"For many parents of children with spastic cerebral palsy (CP), one of the biggest concerns is how their child will learn to move, stand, and eventually walk. A major reason functional motor skills are difficult for children with CP is a problem called poor selective motor control, the ability to move one joint of the leg without moving others. Selective motor control is essential for coordinated movement, but is often impaired in children with CP.Until now, there has not been a validated clinical measure of selective motor control for infants and toddlers. That is why this new study is so important. Researchers developed a tool called Mini-SCALE (Selective Control Assessment of the Lower Extremity for Infants and Toddlers) to help clinicians better understand how young children (ages 3 months to under 4 years) are developing selective motor control. To ensure that Mini-SCALE was clear, valid, and useful, a team of 16 experts, including a parent of a child with CP, reviewed it. Mini-SCALE was then administered to 50 children, both with and without CP, along with an established test of motor development while parents participated in the process.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 10","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep brain stimulation for neurological and neurodevelopmental disorders in children: Current applications and future perspectives 脑深部电刺激治疗儿童神经和神经发育障碍：当前应用和未来展望。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-19 DOI: 10.1111/dmcn.16486

引用次数: 0

Longitudinal assessment of the upper limb in adults with cerebral palsy. 成人脑瘫患者上肢的纵向评估。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-17 DOI: 10.1111/dmcn.16450

Prue Morgan

引用次数: 0

Application of the Gross Motor Function Measure in children with conditions other than cerebral palsy: A systematic review. 大运动功能测量在非脑瘫儿童中的应用：一项系统综述。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-14 DOI: 10.1111/dmcn.16465

Hirokazu Abe, Shuhei Higashi, Nobuaki Himuro

{"title":"Application of the Gross Motor Function Measure in children with conditions other than cerebral palsy: A systematic review.","authors":"Hirokazu Abe, Shuhei Higashi, Nobuaki Himuro","doi":"10.1111/dmcn.16465","DOIUrl":"https://doi.org/10.1111/dmcn.16465","url":null,"abstract":"Aim: To investigate the application and evaluate the measurement properties of the Gross Motor Function Measure (GMFM) in children with conditions other than cerebral palsy (CP).Method: A systematic review was conducted using five electronic databases to identify studies that used the GMFM in children with conditions other than CP. Methodological quality and measurement properties were evaluated using established standards for assessing outcome measures.Results: We identified 210 studies across various paediatric conditions. Measurement property studies examined eight conditions: acquired brain injury, spinal muscular atrophy, Fukuyama congenital muscular dystrophy, Down syndrome, osteogenesis imperfecta, acute lymphoblastic leukaemia (ALL), leukodystrophy, and Pompe disease. Evidence quality was generally low to very low owing to small sample sizes and methodological limitations. Reliability showed sufficient ratings across most conditions. Content validity was examined only for ALL and demonstrated sufficient ratings. Responsiveness and construct validity showed variable results across conditions. Clinical application analysis revealed inadequate methodological reporting and widespread use without appropriate validation.Interpretation: GMFM validation for conditions other than CP remains insufficient despite widespread use. Content validity verification and enhanced methodological rigor are critically needed. Clinicians should interpret results cautiously until robust validation is established.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal hypoglycaemic brain injury, a common cause of early-childhood epilepsy in India: A prospective longitudinal study on aetiologies and outcomes. 新生儿低血糖性脑损伤是印度儿童早期癫痫的常见原因：一项关于病因和结果的前瞻性纵向研究。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-14 DOI: 10.1111/dmcn.16469

Chitra Gupta, Bhuvandeep Narang, S G Thenral, Rakhi Sharma, Sagnik Chatterjee, V Ramprasad, Sakthivel Murugan, Pradeep Goyal, Rajiv Kumar Bansal, Vivek Jain

{"title":"Neonatal hypoglycaemic brain injury, a common cause of early-childhood epilepsy in India: A prospective longitudinal study on aetiologies and outcomes.","authors":"Chitra Gupta, Bhuvandeep Narang, S G Thenral, Rakhi Sharma, Sagnik Chatterjee, V Ramprasad, Sakthivel Murugan, Pradeep Goyal, Rajiv Kumar Bansal, Vivek Jain","doi":"10.1111/dmcn.16469","DOIUrl":"https://doi.org/10.1111/dmcn.16469","url":null,"abstract":"Aim: To evaluate the aetiologies and long-term seizure outcomes in early childhood epilepsy in a low- to middle-income country (India).Method: This prospective descriptive study enrolled 231 children with epilepsy onset before age 5 years, over a 12-month period. A comprehensive neuroradiological and genetic evaluation was performed. Differences in epilepsy and neurodevelopmental profiles of the two most common acquired causes - neonatal hypoglycaemic brain injury (NHBI) and neonatal asphyxial brain injury (NABI) - were analysed. Seizure control at 24-month follow-up could be confirmed for 209 patients.Results: In 172 (74%) patients, an aetiology could be identified. The structural group was the most common (126, 55%), followed by unknown (48, 21%), genetic (41, 18%), and metabolic (5, 2%). At 24-month follow-up, 57 (27%) patients had poor seizure control. NHBI was the most common single cause (50, 22%) of epilepsy. NHBI was associated with focal seizures (p < 0.001), autistic features (p = 0.05), and hypotonia (p = 0.03), while NABI more often led to epileptic spasms (p = 0.05) and hypertonia (p < 0.001).Interpretation: NHBI was the leading cause of epilepsy in our cohort. These findings highlight the need to revise newborn feeding practices to reduce the long-term burden of epilepsy among Indian children.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaze responses in children with cerebral palsy, cerebral visual impairment, and severe intellectual and developmental disabilities 脑瘫、脑视力障碍和严重智力和发育障碍儿童的凝视反应

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-08-10 DOI: 10.1111/dmcn.16466

{"title":"Gaze responses in children with cerebral palsy, cerebral visual impairment, and severe intellectual and developmental disabilities","authors":"","doi":"10.1111/dmcn.16466","DOIUrl":"10.1111/dmcn.16466","url":null,"abstract":"Children with severe cerebral palsy, cerebral visual impairment (CVI), and significant developmental disabilities have significantly impaired visual function and their caretakers are challenged in understanding how best to engage the residual vision they have. Our study looked for ways to assess and better understand their visual functioning by using a variety of sensory inputs.The study included 40 children with severe cerebral palsy, and intellectual and developmental disabilities; 20 of whom also had CVI. In a darkened room, they were presented with simple sensory inputs (a light, a sound, or a touch) individually or in pairs (light and sound; light with touch). Computerized video analysis enabled precise measurement of how often, for how long, and how quickly they looked at the stimuli.Children with CVI often took longer to respond to visual stimuli and overall held their gaze for a shorter time compared to children without CVI.Most importantly, children with CVI looked more often and for a longer time to multisensory stimuli (sound with light) compared to auditory alone. This ‘sensory enhancement’ suggests that using more than one sense at a time can help capture their visual attention. Both groups looked longest toward the sound of a human voice and to an object held in their own hand, compared to the other sound and touch stimuli.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 10","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0