Developmental Medicine and Child Neurology最新文献

{"title":"Participation in activities of daily living after the Akwenda Intervention Program for children and young people with cerebral palsy in Uganda: A cluster-randomized trial.","authors":"Elizabeth Asige, Gillian Saloojee, Godfrey Wanjala, Carin Andrews, Lukia H Namaganda, Angelina Kakooza-Mwesige, Diane L Damiano, Hans Forssberg","doi":"10.1111/dmcn.16258","DOIUrl":"https://doi.org/10.1111/dmcn.16258","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy of the Akwenda Intervention Program on participation attendance and involvement of children and young people with cerebral palsy (CP) in rural Uganda.</p><p><strong>Method: </strong>This was a cluster-randomized, controlled, single-blind, interventional study of 100 participants with CP (aged 2-23 years; 48 females; allocated to the intervention or waiting list control group). Picture My Participation interviews assessed participation attendance and involvement in 20 home and community activities. Group differences were analysed using a Mann-Whitney U test and effect sizes were calculated. Change in attendance was related to age and functional level, and to improvements in child functioning, which was published in a previous report from the same study.</p><p><strong>Results: </strong>Attendance increased more in the intervention compared to the control group (p < 0.001; r = 0.48; z = -4.62) and across both Gross Motor Function Classification System (GMFCS) subgroups and two age subgroups (2-5 years and 13-23 years). Positive correlations were found between increases in attendance and higher GMFCS levels (ρ = 0.25, p = 0.03) and with all three caregiver assistance scales and the social function child scale of the Ugandan version of the Pediatric Evaluation of Disability Inventory. The intervention group had larger increases in involvement than the controls (p < 0.001; r = 0.41; z = -3.95), although positive changes were seen in both groups.</p><p><strong>Interpretation: </strong>The Akwenda Intervention Program, which intervened at the level of the child, family, and community, was successful in enhancing participation for children with CP.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gross Motor Function Measure-66 Item Sets for use with infants and toddlers at high risk for cerebral palsy: Construct validity and responsiveness.","authors":"Natalie A Koziol, Christiana D Butera, Lin-Ya Hsu, Silvana Alves Pereira, Stacey C Dusing","doi":"10.1111/dmcn.16259","DOIUrl":"https://doi.org/10.1111/dmcn.16259","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the construct validity and responsiveness of the Gross Motor Function Measure-66 Item Set (GMFM-66-IS), a standardized criterion-referenced observational measure, for use with children younger than 24 months with or at high risk for cerebral palsy (CP).</p><p><strong>Method: </strong>Non-experimental integrative data analysis was performed on secondary data from three clinical trials involving children with or at high risk for CP (n = 79, 42 males, mean corrected age = 11.3 months [SD = 4.9]), and one observational study of typically developing children (n = 32, 14 males, mean age = 5.7 months [SD = 0.8]). The GMFM-66-IS and comparator instrument (gross motor subtest from the Bayley Scales of Infant and Toddler Development, Third Edition [Bayley-III] or Bayley Scales of Infant and Toddler Development, Fourth Edition [Bayley-4], depending on the study) were administered at baseline and 3 months later. Comparator groups were based on neurological impairment, clinical rating of gross motor change, and CP status. Correlations (r) and regression-adjusted standardized mean differences (Hedges' g) were computed.</p><p><strong>Results: </strong>GMFM-66-IS and Bayley scores were correlated at baseline (r = 0.83), 3 months later (r = 0.88), and across time (r = 0.83). Children with mild impairment had higher mean GMFM-66-IS scores at baseline (g = 0.87) and 3 months later (g = 0.95). Children rated as demonstrating greater than expected gross motor change had larger mean GMFM-66-IS change scores than children demonstrating less than expected change (g = 0.62). Typically developing children had larger mean GMFM-66-IS change scores (g = 1.00).</p><p><strong>Interpretation: </strong>GMFM-66-IS scores were supported by evidence of strong construct validity and moderate responsiveness.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the GMFM-66 Item Set optimal to measure progress in young infants at high risk of cerebral palsy?","authors":"Virginia Knox","doi":"10.1111/dmcn.16261","DOIUrl":"https://doi.org/10.1111/dmcn.16261","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain in adults with cerebral palsy: A systematic review.","authors":"Jennifer M Ryan, Jessica Burke, Rachel Byrne, Emily Capellari, Adrienne Harvey, Neil E O'Connell, Donna Omichinski, Elisabet Rodby-Bousquet, Mark Peterson","doi":"10.1111/dmcn.16254","DOIUrl":"https://doi.org/10.1111/dmcn.16254","url":null,"abstract":"<p><strong>Aim: </strong>To describe the prevalence and incidence of pain, identify prognostic factors for pain, determine psychometric properties of tools to assess pain, and evaluate effectiveness of interventions for reducing pain among adults with cerebral palsy (CP).</p><p><strong>Method: </strong>Six databases were searched to identify studies published since 1990 in any language that met eligibility criteria defined for each objective. Titles, abstracts, and full texts were screened by two independent reviewers.</p><p><strong>Results: </strong>Sixty-three studies were identified; 47 reporting prevalence, 28 reporting prognostic factors, four reporting psychometric properties, five evaluating intervention effectiveness. Pain prevalence ranged from 24% to 89%. Prevalence was higher among adults with CP than in adults without it. Communication function, sex, and age were prognostic factors for pain prevalence. Numerical, verbal, and pictorial rating scales were valid for assessing pain intensity in adults with CP. Pharmacological and surgical interventions had no effect on pain. An active lifestyle and sports intervention reduced pain in adults with CP compared with usual care.</p><p><strong>Interpretation: </strong>Many adults with CP experience pain, although prevalence estimates vary considerably. The quality of evidence for prognostic factors and interventions is very low to low. There is a lack of evidence about effective pain management among adults with CP.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of the Motor Optimality Score-Revised in infants with an increased risk of adverse neurodevelopmental outcomes.","authors":"Carly Luke, Arend F Bos, Michelle Jackman, Robert S Ware, Anya Gordon, Christine Finn, Dyvonne H Baptist, Katherine A Benfer, Margot Bosanquet, Roslyn N Boyd","doi":"10.1111/dmcn.16256","DOIUrl":"https://doi.org/10.1111/dmcn.16256","url":null,"abstract":"<p><strong>Aim: </strong>To determine reproducibility of the Motor Optimality Score-Revised (MOS-R) to assess infants at high risk of adverse neurodevelopmental outcomes, including cerebral palsy (CP), autism, and developmental delays.</p><p><strong>Method: </strong>Thirty infants (18 males, 12 females, gestational age mean [range] = 32.5 [23-41] weeks) were randomly selected, according to 2-year outcome (typically developing; CP; or adverse neurodevelopmental outcome [ad-NDO]) from a prospective cohort. Participants had two General Movements videos between 12 weeks and 15 + 6 weeks corrected age. Six assessors, masked to history and outcomes, independently scored the MOS-R from videos. Assessors scored either one (Group 1; n = 3) or two videos for each infant (Group 2; n = 3). Intraclass correlation coefficient (ICC), Gwet's agreement coefficient, and limits of agreement were calculated.</p><p><strong>Results: </strong>Combined interassessor reliability (IRR) over six assessors for total MOS-R was 'fair' (ICC = 0.56, 95% confidence interval [CI] 0.41-0.72), and 'excellent' with consensus agreement (ICC = 0.99, 95% CI 0.98-0.99). Analyses demonstrated a mean interrater difference of 0.316 (95% limits of agreement -11.51, 12.14) over 450 comparisons (15 pairs). IRR was 'moderate' to 'almost perfect' across subcategories, with the highest reliability 'movement patterns' (Gwet's agreement coefficient = 0.73-1.00) and the lowest 'postural patterns' (0.45-0.73). Assessors who scored two videos (Group 2) demonstrated higher reproducibility. IRR for total MOS-R was 'excellent' when infants were typically developing (ICC = 0.90), and 'good' for CP (0.74) and ad-NDO (0.68).</p><p><strong>Interpretation: </strong>The MOS-R is a highly reproducible tool for assessing infants at high risk of ad-NDOs and is feasible for implementation in clinical settings. Reproducibility is best when the tool is used by experienced assessors to gain consensus agreement.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consciousness trajectories and functional independence after acute brain injury in children with prolonged disorder of consciousness","authors":"","doi":"10.1111/dmcn.16265","DOIUrl":"10.1111/dmcn.16265","url":null,"abstract":"<p>Prolonged disorders of consciousness (PDoC) refer to a state of unconsciousness that persists for a minimum of 4 weeks following an acute brain injury. While there is an increasing amount of evidence regarding the management and prognosis for adults, research on the assessment of consciousness trajectories (i.e. how consciousness has changed over time) and related factors in children has been limited. In this retrospective cohort study, the consciousness trajectories and functional independence in children with PDoC after acute brain injury were investigated.</p><p>This study included 152 cases from 1st January 2014 to 31st June 31 2021. The most common cause of brain injury was intracranial infection (caused by bacteria, viruses, or fungi), followed by trauma and hereditary/metabolism, hypoxic–ischemic encephalopathy (a type of brain damage caused by a lack of oxygen to the brain before or shortly after birth), and inflammation. The rates of consciousness recovery at 3 months, 6 months, and 12 months post-injury were 21.6%, 36.6%, and 48.5% respectively, and most children regained consciousness around 4 months after injury.</p><p>Factors included onset age of 3 years or older, the cause of brain trauma, electroencephalogram (EEG) grade IV or below, and the absence of bilateral impairments in the posterior cingulate (controlling state of arousal) and basal ganglia (responsible primarily for motor control) were identified as predictors of consciousness recovery. Additionally, EEG grade IV or below, the absence of bilateral impairments in the frontal lobes (high cognitive function), and occipital lobes (responsible for visual perception) were associated with favorable functional outcome.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e82"},"PeriodicalIF":3.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early developmental trajectories of the impaired hand in infants with unilateral cerebral palsy","authors":"","doi":"10.1111/dmcn.16266","DOIUrl":"10.1111/dmcn.16266","url":null,"abstract":"<p>We looked at the developmental trajectories (which describes the progression of a given behaviour as individuals age) of impaired hand function in 63 infants with unilateral cerebral palsy. We assessed hand function using the Hand Assessment for Infants either two or three times between 3- and 15-months corrected age. The Hand Assessment for Infants measures the degree and quality of goal-directed actions performed with each hand separately and both hands together.</p><p>We used group-based trajectory modelling which has been developed to determine subgroups within a given population. We found there were three distinctly different trajectories for low, moderate, and high functioning infants.</p><p>There were 23 infants (35%) in the moderate group and 22 (36%) in the high functioning group. Eighteen infants (29%) were in the low functioning group and showed no appreciable change in hand function between 3- and 15-months corrected age, despite all receiving early targeted upper limb training, either modified constraint-induced movement therapy or bimanual therapy. Infants born closer to term equivalent age were at a higher risk of being in the low compared to high functioning group.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e83"},"PeriodicalIF":3.8,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymicrogyria in infants with symptomatic congenital cytomegalovirus at birth is associated with epilepsy: A retrospective, descriptive cohort study","authors":"","doi":"10.1111/dmcn.16263","DOIUrl":"10.1111/dmcn.16263","url":null,"abstract":"<p>Cytomegalovirus (CMV) is the most common virus that is passed from mother to infant during pregnancy. Some infants with congenital CMV (cCMV) show symptoms at birth, like hearing problems, small head size, or growth problems. These infants are at higher risk of long-term problems like epilepsy, resulting in seizures (fits). This study aimed to find out if magnetic resonance imaging (MRI) features at birth could predict which children are more likely to develop epilepsy.</p><p>The study looked at 90 children with cCMV. Seventy-two children had symptoms at birth, and 18 did not have symptoms. Seven children developed epilepsy, which was 7.8% of all children with cCMV and 9.7% of those who had symptoms at birth. None of the children without symptoms at birth developed epilepsy. The study found that specific brain changes on MRI, particularly a condition called polymicrogyria (atypical brain development with too many small folds in the brain), were closely linked to epilepsy. Infants with polymicrogyria were 35 times more likely to develop epilepsy. Other features, like smaller head size at birth, and white matter damage on MRI, were also more common in children who developed epilepsy.</p><p>All seven children with epilepsy required medications to reduce their seizures, and only three achieved seizure control. Four children needed more than two medications and still had frequent seizures.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e80"},"PeriodicalIF":3.8,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral palsy and perinatal mortality in children born in Norway to immigrant mothers","authors":"","doi":"10.1111/dmcn.16271","DOIUrl":"10.1111/dmcn.16271","url":null,"abstract":"<p>This study aimed to compare the birth prevalence and clinical characteristics of cerebral palsy (CP) between children born to non-immigrant mothers and those born to immigrant mothers from high-income countries (HICs) and low- and middle-income countries (LMICs), as well as perinatal mortality rates. Data were collected from the Medical Birth Registry of Norway and the Norwegian Quality and Surveillance Registry for Cerebral Palsy, covering live births and perinatal deaths from 2000 to 2016.</p><p>Results showed that the prevalence of CP was higher among children of non-immigrant mothers, with a decreasing trend over time. Children of immigrant mothers from HICs had lower odds of CP, while those from LMICs also had lower odds despite higher rates of consanguinity and lower folate use during pregnancy. Perinatal mortality was higher among mothers from LMICs. Clinical characteristics of CP were similar across groups, but children from LMICs had a higher incidence of intellectual disabilities and brain grey matter injuries.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e89"},"PeriodicalIF":3.8,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive functioning in children and young adults with monogenic neurodevelopmental disorders","authors":"","doi":"10.1111/dmcn.16264","DOIUrl":"10.1111/dmcn.16264","url":null,"abstract":"<p>This study looked at the adaptive behaviour profiles of children and young adults with different neurodevelopmental disorders (e.g. autism, intellectual disability), with known genetic causes. Adaptive behaviours are the practical skills that an individual needs to function independently in everyday life (e.g. interacting with other people, shopping, personal grooming, etc.). Understanding these behaviours within individual neurodevelopmental disorders, as well as comparing these behaviours across different disorders can help us to identify and develop suitable interventions for these conditions.</p><p>The study included 243 children and young adults aged 1 to 25 years with one of eight genetic neurodevelopmental disorders (<i>CDK13</i>, <i>DYRK1A</i>, <i>FOXP2</i>, <i>KAT6A</i>, <i>KANSL1</i>, <i>SETBP1</i>, <i>BRPF1</i>, and <i>DDX3X</i>). Parents completed the standardized interview of the Vineland Adaptive Behavior Scales, Third Edition, a common measure of adaptive behaviour that assesses communication, daily living, socialization, and motor skills.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e81"},"PeriodicalIF":3.8,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}