Developmental Medicine and Child Neurology最新文献

Preverbal visual assessment for screening cerebral visual impairment: Diagnostic accuracy and clinical utility. 言语前视觉评估筛查脑视觉障碍：诊断准确性和临床应用。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-06 DOI: 10.1111/dmcn.70005

Karen L Harpster, Terry L Schwartz, Alaina Johnson, Reena Donofe, Li Lin, Melissa L Rice

{"title":"Preverbal visual assessment for screening cerebral visual impairment: Diagnostic accuracy and clinical utility.","authors":"Karen L Harpster, Terry L Schwartz, Alaina Johnson, Reena Donofe, Li Lin, Melissa L Rice","doi":"10.1111/dmcn.70005","DOIUrl":"https://doi.org/10.1111/dmcn.70005","url":null,"abstract":"Aim: To evaluate the relationship between Preverbal Visual Assessment (PreViAs) results and cerebral visual impairment (CVI) diagnosis.Method: This single-center retrospective chart review included children who completed a CVI interdisciplinary clinic or occupational therapy vision evaluation between May 2018 and May 2023 and had a completed PreViAs. Data were extracted from the electronic medical record. Data analysis included sensitivity, specificity, area under the curve, and Fisher's exact test.Results: Of the 205 charts screened, 98 met study criteria (81 with CVI, 17 without); ages ranged from 3 to 50 months. The mean age of children with CVI was 15.41 months (SD = 8.93) and without was 13.24 months (SD = 5.98). Among the PreViAs domains, visual processing showed the highest frequency of concern (CVI = 94%; non-CVI = 76%), while visual attention had the lowest (CVI = 72%; non-CVI = 41%). Visual processing demonstrated the highest sensitivity (93.8%), whereas visual attention showed the best balance of sensitivity (71.6%) and specificity (58.8%). Area under the curve ranged from 0.59 to 0.66. All domains demonstrated significant differences between children with and without CVI (Fisher's exact test, p < 0.05).Interpretation: Effective screening tools are critical for detection of CVI. The PreViAs is a sensitive screening tool in children at high risk for CVI. Children with concerns on the PreViAs should be referred for an interdisciplinary CVI evaluation.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An updated cerebral palsy description: Reflections on semantics, genetics, and the usefulness of a plain language version. 更新的脑瘫描述：对语义学、遗传学的反思，以及简单语言版本的有用性。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-04 DOI: 10.1111/dmcn.70024

Anina Ritterband-Rosenbaum, Line Zacho Greve, Pernille Ulrik Kaster, Patricia de Lipthay Behrend

引用次数: 0

Red-light flashing pens and seizures in children. 闪烁红灯的笔和儿童癫痫。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-03 DOI: 10.1111/dmcn.70001

Simone Gasparini, Alice Dainelli, Francesca Piras, Simona Balestrini, Renzo Guerrini

{"title":"Red-light flashing pens and seizures in children.","authors":"Simone Gasparini, Alice Dainelli, Francesca Piras, Simona Balestrini, Renzo Guerrini","doi":"10.1111/dmcn.70001","DOIUrl":"https://doi.org/10.1111/dmcn.70001","url":null,"abstract":"Photosensitive epilepsy is the most common form of stimulus-induced epilepsy. We describe two unrelated females aged 9 years and 10 years, with prolonged photic-induced absence seizures triggered by a commercially available red-light flashing pen popular among children. Both patients underwent clinical assessment and electroencephalography (EEG) with intermittent photic stimulation. Their EEGs showed a generalized photoparoxysmal response to intermittent photic stimulation. Exposure to the pen, performed in the 9-year-old, elicited a powerful photoparoxysmal discharge. Both patients were successfully treated with valproic acid, preventative measures, and avoidance of known triggers. These observations highlight the risk posed by poorly regulated flashing lights in consumer products. Despite past efforts to regulate visual stimuli in video games and media, current regulatory frameworks do not adequately address emerging light-emitting diode-based technologies, leaving vulnerable populations exposed to preventable risks. There is a pressing need for updated safety standards to prevent seizure-provoking stimuli, especially in products marketed to children.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling cerebral palsy in animals. 脑性麻痹动物模型。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-03 DOI: 10.1111/dmcn.70007

Katharina A Quinlan, Emily J Reedich, Elvia Mena Avila, Brendan C Moline, Landon T Genry, Megan R Detloff, Benjamin R Katholi, Deborah Gaebler-Spira, Bhooma R Aravamuthan

引用次数: 0

Three-year outcomes of repeated botulinum neurotoxin A injections to the lower extremities in young children with spastic cerebral palsy in GMFCS levels I to III. GMFCS等级为I至III级的痉挛性脑瘫幼儿下肢反复注射肉毒杆菌神经毒素A的3年结局

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-03 DOI: 10.1111/dmcn.70031

Darcy Fehlings, Emma Bohn, Lauren Switzer, Charles H Goldsmith, Unni Narayanan, Peter L Rosenbaum, F Virginia Wright, Gary Foster

{"title":"Three-year outcomes of repeated botulinum neurotoxin A injections to the lower extremities in young children with spastic cerebral palsy in GMFCS levels I to III.","authors":"Darcy Fehlings, Emma Bohn, Lauren Switzer, Charles H Goldsmith, Unni Narayanan, Peter L Rosenbaum, F Virginia Wright, Gary Foster","doi":"10.1111/dmcn.70031","DOIUrl":"https://doi.org/10.1111/dmcn.70031","url":null,"abstract":"Aim: To evaluate the effectiveness of repeated botulinum neurotoxin A (BoNT-A) injections on gross motor function over 3 years in ambulant children with spastic cerebral palsy (CP).Method: A prospective observational cohort study of 124 participants was conducted comparing outcomes in children (aged 2-6 years) with spastic CP functioning in Gross Motor Function Classification System (GMFCS) levels I to III who did and did not receive BoNT-A. The primary outcome was the 66-item Gross Motor Function Measure (GMFM-66), assessed at baseline and annually over 3 years. Secondary outcomes included passive ankle dorsiflexion with knee extended (PADKE) and several measures of activity and participation.Results: A total of 117 participants (94%), consisting of 61 cases and 56 comparisons, were assessed on the GMFM-66 at a follow-up of 1 year or longer, with 106 (85%) assessed at year 3. There were no significant differences in mean GMFM-66 scores adjusted for baseline differences between groups over time (β̂group = 0.92, standard error [SE] = 0.81, 95% confidence interval [CI] = -0.66 to 2.50; p = 0.256). A difference in PADKE favouring the comparison group was observed (β̂group = -4.17, SE = 1.58, 95% CI = -7.27 to -1.08; p = 0.009), approaching the 5° minimally important difference.Interpretation: Repeated BoNT-A injections over 3 years were not associated with improvements in gross motor function or passive ankle dorsiflexion range in young children with spastic CP functioning in GMFCS levels I to III compared to a comparison group not receiving BoNT-A.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The freedom to be a parent: Why expert therapy cannot be replaced at home. 做父母的自由：为什么专家治疗在家里无法被取代。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-03 DOI: 10.1111/dmcn.70032

Jani du Preez

引用次数: 0

A bio-ecological model for early screening of developmental coordination disorder. 发育协调障碍早期筛查的生物生态模型。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-10-03 DOI: 10.1111/dmcn.70000

Xiaotian Dai, Tai Ren, Gareth Williams, Gary Jones, Fei Li, Wenchong Du, Jing Hua

{"title":"A bio-ecological model for early screening of developmental coordination disorder.","authors":"Xiaotian Dai, Tai Ren, Gareth Williams, Gary Jones, Fei Li, Wenchong Du, Jing Hua","doi":"10.1111/dmcn.70000","DOIUrl":"https://doi.org/10.1111/dmcn.70000","url":null,"abstract":"Aim: To develop and externally validate a bio-ecological model for early screening of developmental coordination disorder (DCD) using maternal and environmental risk factors from electronic health records, aimed at improving early detection in children under 5 years.Method: This was a prospective study that examined data from 150 948 preschool children in China. Perinatal and sociodemographic predictors were integrated using logistic regression and random forest algorithms. The model was internally validated on split training and testing subsets and externally validated on an independent clinical sample of 1359 children aged 3 to 10 years, including confirmed diagnoses of DCD. Model performance was evaluated using the area under the curve (AUC), sensitivity, specificity, and accuracy.Results: In the group aged 3 to 5 years, the model achieved an AUC of 0.70, sensitivity of 71.43%, accuracy of 77.61%, and specificity of 78.00%. In the group aged 6 to 10 years, performance was moderate (AUC = 0.58; sensitivity = 54.88%; accuracy = 61.50%; specificity = 62.28%).Interpretation: This bio-ecological model offers a scalable, cost-effective tool to support the early identification of DCD using electronic health record data. It performs well in early childhood and maintains moderate accuracy in older children, supporting its utility for longer-term risk prediction. The model could enhance existing screening systems by enabling earlier triage and intervention. Further validation across diverse health care settings is warranted.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of progressive intellectual and neurological deterioration in UK children. 英国儿童进行性智力和神经退化的流行病学。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-09-29 DOI: 10.1111/dmcn.70008

Christopher M Verity, Polly J Maunder, Anne Marie Winstone, Suvankar Pal

{"title":"Epidemiology of progressive intellectual and neurological deterioration in UK children.","authors":"Christopher M Verity, Polly J Maunder, Anne Marie Winstone, Suvankar Pal","doi":"10.1111/dmcn.70008","DOIUrl":"https://doi.org/10.1111/dmcn.70008","url":null,"abstract":"Aim: To study the neurodegenerative diseases that cause progressive intellectual and neurological deterioration (PIND) in children in the UK.Method: This active prospective epidemiological study asked UK paediatricians to notify all childhood cases of PIND via the British Paediatric Surveillance Unit. Clinical data were obtained using a questionnaire or via a site visit. An independent PIND study Expert Group classified the cases.Results: Between May 1997 and April 2024 (27 years), 2373 children with PIND were identified who had an underlying diagnosis to explain their deterioration. There were six cases of variant Creutzfeldt-Jakob disease plus 2367 children (1265 males, 1102 females) with other diseases. The lifetime risk of having a diagnosed disease causing PIND was 0.1 in 1000 live births. Asian British children made up 28.6% of the 2183 cases with known ethnicity. Excluding variant Creutzfeldt-Jakob disease, diagnosed children had 259 diseases, identified before death in 99% of children (only 39 were known to have had postmortems). Increasingly, diagnosis was made using genetic studies. Sixty-one per cent (157 of 259) of the diseases were inborn errors of metabolism, affecting 78% of diagnosed children. There were 43 lysosomal diseases.Interpretation: This unique epidemiological study of many rare childhood neurodegenerative diseases provides valuable practical information about the presentation, clinical features, and inheritance of these complex disorders.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of the Gross Motor Function Measure in children with conditions other than cerebral palsy: A systematic review. 大运动功能测量在非脑瘫儿童中的应用：一项系统综述。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-09-26 DOI: 10.1111/dmcn.70020

引用次数: 0

Parents' experiences of having a child who had a stroke: A systematic review and meta-ethnography. 有一个中风孩子的父母的经历：一个系统的回顾和元人种志。

IF 4.3 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-09-26 DOI: 10.1111/dmcn.70004

Radhika Bhatia, Shereena Yoon, Ellie Simpson, Nancy McStravick, Vuokko Wallace

{"title":"Parents' experiences of having a child who had a stroke: A systematic review and meta-ethnography.","authors":"Radhika Bhatia, Shereena Yoon, Ellie Simpson, Nancy McStravick, Vuokko Wallace","doi":"10.1111/dmcn.70004","DOIUrl":"https://doi.org/10.1111/dmcn.70004","url":null,"abstract":"Aim: To explore and synthesize interview-based, qualitative research of parents' experiences of having a child who had a paediatric stroke.Method: A systematic search of literature identified seven studies that used qualitative, interview-based methods to investigate parents' experiences of having a child (younger than 25 years) who had a paediatric stroke. Data were extracted and appraised for quality. All seven studies were included in a meta-ethnography. An advisory group of two parents contributed to the analysis through two consultation meetings.Results: A conceptual model of parents' experiences was developed, highlighting the lack of childhood stroke awareness, insufficient support from healthcare professionals, and the role of societal norms. These factors significantly shaped both the emotional impact on parents and the trajectory of their experiences, from emergency response to adjustment.Interpretation: Greater awareness of childhood stroke, alongside sustained professional support for families, may substantially improve outcomes for parents and their children.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0