Developmental Medicine and Child Neurology最新文献

{"title":"Neurodevelopmental and neurological features in children with hypochondroplasia.","authors":"","doi":"10.1111/dmcn.70521","DOIUrl":"10.1111/dmcn.70521","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":"e203"},"PeriodicalIF":3.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of telehealth-delivered Alberta Infant Motor Scale for Australian parents: A mixed-methods analysis.","authors":"Kate L Rawnsley, Alicia J Spittle, Jeanie L Y Cheong, Louisa Remedios","doi":"10.1111/dmcn.70290","DOIUrl":"10.1111/dmcn.70290","url":null,"abstract":"<p><strong>Aim: </strong>To describe the factors shaping Australian parents' acceptability of synchronous telehealth delivery of the Alberta Infant Motor Scale (AIMS), an infant gross motor assessment.</p><p><strong>Method: </strong>A mixed-methods approach was used to describe the experiences of parents whose infants received telehealth and face-to-face AIMS assessments. A quantitative component used questionnaire responses (n = 102) and a qualitative component involved semi-structured interviews (n = 13). Descriptive statistics, deductive content analysis (questionnaire data), and inductive content analysis (interview data) were used for analysis.</p><p><strong>Results: </strong>Most parents (89%) reported telehealth was an acceptable way to complete the AIMS assessment. Most (97%) would accept a telehealth appointment if a face-to-face assessment was not available. Four categories were identified from interview data that influenced parents' perceptions of telehealth: (1) visibility of the child; (2) accuracy of representation; (3) trust in the unfamiliar; and (4) the parental experience.</p><p><strong>Interpretation: </strong>Telehealth delivery of the AIMS is acceptable to Australian parents. However, around half of participants preferred face-to-face assessment. Findings suggest families be provided with choice, with clinicians supporting parents to understand the benefits and challenges of each modality, considering families' circumstances, preferences, capabilities, and access to technology.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":"1610-1620"},"PeriodicalIF":3.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attrition in a telehealth caregiver-mediated behavioral intervention for children with tuberous sclerosis complex: A mixed-methods study.","authors":"Carly Hyde Tillis, Connie Kasari, Nicole McDonald, Monique Vobecky, Maria Pizzano, Jonathan Panganiban, Brandon Gharapetian, Elise Y Tran, Charles A Nelson, Elizabeth A Thiele, Shafali Jeste","doi":"10.1111/dmcn.70384","DOIUrl":"10.1111/dmcn.70384","url":null,"abstract":"<p><strong>Aim: </strong>To examine factors contributing to attrition in a telehealth, caregiver-mediated behavioral intervention for young children with tuberous sclerosis complex (TSC).</p><p><strong>Method: </strong>This randomized waitlist-control trial (n = 59) included children (12-39 months) with TSC and their caregivers. A convergent parallel mixed-methods design investigated factors influencing attrition. Quantitative analyses used negative binomial regression to explore predictors of session completion; qualitative data were thematically analyzed and integrated with quantitative patterns to complement and expand findings.</p><p><strong>Results: </strong>Negative binomial regression did not yield a significant overall model and explained limited variance. Two candidate predictors showed exploratory associations with fewer completed sessions: higher seizure severity (incidence rate ratio [IRR] = 0.95, p = 0.046) and COVID-era enrollment (IRR = 0.77, p = 0.046). Distance to site and socioeconomic risk were not associated with attrition. Qualitative data reinforced medical crises as primary reasons for attrition and expanded on perceived benefit and other factors contributing to overall caregiver burden.</p><p><strong>Interpretation: </strong>In this clinical trial, socioeconomic, ethnic, and geographic factors were not associated with attrition, although the study was underpowered to detect small or moderate effects. Families of children facing complex developmental disability may nonetheless require additional adaptation and support to sustain engagement in telehealth caregiver-mediated interventions. Mixed-methods integration highlighted the multifaceted nature of attrition and the need for more precise measures to understand it.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":"1621-1629"},"PeriodicalIF":3.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal complications, mode of delivery, and neurological morbidity in children with COL4A1/A2 variants.","authors":"","doi":"10.1111/dmcn.70529","DOIUrl":"10.1111/dmcn.70529","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":"e213-e214"},"PeriodicalIF":3.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism spectrum disorder assessment in cerebral palsy and other early-onset motor conditions: A scoping review.","authors":"","doi":"10.1111/dmcn.70522","DOIUrl":"10.1111/dmcn.70522","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":"e204-e205"},"PeriodicalIF":3.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Aumenta la exposición prenatal al paracetamol el riesgo de trastorno del espectro autista y trastorno por déficit de atención con hiperactividad? Una revisión paraguas y un meta-meta-análisis.","authors":"Hoda Tayebi-Hillali, María Blanco-Suárez, Berta Rivas-Mundiña, Jacobo Limeres-Posse, Márcio Diniz-Freitas, Pedro Diz-Dios","doi":"10.1111/dmcn.70536","DOIUrl":"https://doi.org/10.1111/dmcn.70536","url":null,"abstract":"<p><p>Este meta-metaanálisis sintetiza la evidencia disponible sobre la exposición prenatal al paracetamol y los desenlaces del neurodesarrollo. Los análisis crudos sugieren pequeñas asociaciones con el trastorno del espectro autista (TEA) y el trastorno por déficit de atención e hiperactividad (TDAH); sin embargo, estas asociaciones se atenúan de forma considerable cuando los análisis se restringen a metaanálisis de alta calidad y a estudios primarios con bajo riesgo de sesgo. En conjunto, los hallazgos indican que no existe evidencia epidemiológica sólida que respalde una asociación causal entre la exposición prenatal al paracetamol y el desarrollo de TEA o TDAH.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149247321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hammersmith Infant Neurological Examination: Prediction of neurodevelopmental delay in children born between 29 and 36 weeks of gestation.","authors":"Léanne Brabant, Mathieu Dehaes, Mi-Suk Kang Dufour, Marie-Michèle Gagnon, Véronique Belval, Catherine Bernard, Mélanie Gagnon, Gabriel Côté-Corriveau, Thuy Mai Luu, Marie-Noëlle Simard","doi":"10.1111/dmcn.70574","DOIUrl":"https://doi.org/10.1111/dmcn.70574","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the ability of the Hammersmith Infant Neurological Examination (HINE) at 3 months 2 weeks corrected age to identify developmental difficulties at 2 years corrected age in infants born preterm between 29 and 36 weeks of gestation.</p><p><strong>Method: </strong>In this prospective cohort study, the HINE was administered at 3 months 2 weeks corrected age. Development was assessed at 2 years corrected age using the Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley-4) and MacArthur-Bates Communicative Development Inventories. Developmental delay was defined using Bayley-4 scores less than 1 SD below the mean; expressive language delay was defined as a score less than the 10th centile for the number of spoken words expected for age. The cohort was largely free of brain lesions typically associated with cerebral palsy (5% intraventricular hemorrhage, with no other major brain lesions reported). Associations were examined using linear regression, screening performance using receiver operating characteristic curves, and incremental predictive value by comparing adjusted R² across models, including perinatal and socioenvironmental factors with and without the HINE.</p><p><strong>Results: </strong>A total of 174 infants were included in the analyses. The HINE total score was not associated with motor, cognitive, or language outcomes. Discriminative performance was poor (area under the curve = 0.48-0.57); adding the HINE total score to models including perinatal and socioenvironmental factors did not improve predictive performance.</p><p><strong>Interpretation: </strong>A single HINE at 3 months 2 weeks corrected age has limited utility for identifying mild-to-moderate developmental difficulties in this population and should not be used alone to determine developmental surveillance needs. Longitudinal surveillance incorporating complementary sources of developmental, clinical, and socioenvironmental information may be more effective.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor difficulties, motor-related health care, and associating factors in children born extremely preterm.","authors":"Daniela Nosko, Nelly Padilla, Katarina Svensson, Ulrika Ådén, Maria Örtqvist","doi":"10.1111/dmcn.70578","DOIUrl":"https://doi.org/10.1111/dmcn.70578","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the prevalence of non-cerebral-palsy (CP) motor difficulties in children born extremely preterm (EPT) in Sweden, and the proportion of children receiving motor-related health care (MRHC) and related factors.</p><p><strong>Method: </strong>An observational, retrospective, cross-sectional registry study was performed on 856 children (435 males) born EPT at 5 years 6 months available from the Swedish Neonatal Quality Register (SNQ). Children with CP or severe neurodevelopmental disorders were excluded (n = 137). In total, 856 children had complete data. Motor function was assessed using the Movement Assessment Battery for Children, Second Edition (≤ 5th centile defined as clinically significant difficulty). The SNQ provided data on health care visits, behavioural issues, and neonatal risk factors. MRHC was defined as one or more physiotherapy visits in the past year.</p><p><strong>Results: </strong>Clinically significant motor difficulties were present in 218 of 856 (25.5%, 95% confidence interval [CI] = 22.5-28.4) children born EPT; only 30 of 177 (16.9%, 95% CI = 11.4-22.5) of them received MRHC. Receiving MRHC was associated with hyperactivity/inattention difficulties (odds ratio [OR] = 4.43; 95% CI = 1.52-12.88), bronchopulmonary dysplasia (OR = 4.38; 95% CI = 1.49-12.93), and access to additional health care services (OR = 16.07; 95% CI = 2.09-123.40).</p><p><strong>Interpretation: </strong>Clinically significant motor difficulties in children born EPT are underestimated and insufficiently managed. Factors associated with receiving MRHC suggest that care is reactive and driven more by comorbidities than motor needs. These findings reveal a critical care gap and underscore the need for standardized international guidelines for extended follow-up and management of non-CP motor difficulties.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ηip dysplasia in children with spina bifida after prenatal surgical closure.","authors":"Domenic Grisch, Aurelia Hof, Charlotte Vlachopoulos, Britta K Krautwurst, Christos Tsagkaris, Thomas Dreher","doi":"10.1111/dmcn.70546","DOIUrl":"https://doi.org/10.1111/dmcn.70546","url":null,"abstract":"<p><strong>Aim: </strong>To determine the prevalence of neonatal hip dysplasia in children with spina bifida after prenatal surgical closure and examine its association with functional level and preterm birth.</p><p><strong>Method: </strong>We conducted a retrospective analysis of prospectively collected standardized registry data from a tertiary specialized centre providing comprehensive spina bifida diagnosis, treatment, and follow-up. Standardized hip ultrasound according to the Graf method was performed as part of a protocolized clinical pathway after prenatal surgery, within the first week of life corrected for preterm birth. The primary outcome was the prevalence of hip dysplasia at the initial ultrasound. Associations between hip status, functional level, and gestational age were assessed using Spearman's rank correlation.</p><p><strong>Results: </strong>A total of 212 children (101 males, 111 females) underwent prenatal surgical closure between 1st January 2011 and 30th August 2022; 168 children (336 hips) had available neonatal ultrasound data and were included in the analysis. Preterm birth was present in 138 (82%) of 168 children, including 99 (59%) born late preterm, 35 (21%) born very preterm, and four (2%) born extremely preterm. At the initial ultrasound, 286 (85%) of 336 hips were mature, 33 (9.8%) were immature, and 17 (5.1%) were dysplastic. Worse hip status was weakly associated with a higher functional level (r = -0.243; p < 0.001), whereas no significant association was found between hip dysplasia and preterm birth (p = 0.080).</p><p><strong>Interpretation: </strong>The prevalence of neonatal hip dysplasia in children with spina bifida after prenatal surgical closure was within the range reported for the general population.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervenções de fisioterapia para crianças e adolescentes com mielomeningocele: Uma revisão sistemática.","authors":"Lorena Costa Ferreira, Isabella Saraiva Christovão, Robert J Palisano, Ana Cristina Resende Camargos","doi":"10.1111/dmcn.70583","DOIUrl":"https://doi.org/10.1111/dmcn.70583","url":null,"abstract":"<p><p>Principais achados da revisão sistemática sobre intervenções de fisioterapia para crianças e adolescentes com mielomeningocele.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}