Developmental Medicine and Child Neurology最新文献

{"title":"Considering context of use in the development, application, and interpretation of autism symptom measures.","authors":"Somer L Bishop, Shuting Zheng","doi":"10.1111/dmcn.16308","DOIUrl":"https://doi.org/10.1111/dmcn.16308","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of epilepsy in neonates with seizures.","authors":"Lakshmi Nagarajan","doi":"10.1111/dmcn.16305","DOIUrl":"https://doi.org/10.1111/dmcn.16305","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of respiratory and oral health for children and young adults with cerebral palsy.","authors":"Diane Sellers","doi":"10.1111/dmcn.16307","DOIUrl":"https://doi.org/10.1111/dmcn.16307","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromatin chaos: Unravelling acute neurodevelopmental regression in the context of infection.","authors":"Claire Thompson, Ming Lim","doi":"10.1111/dmcn.16309","DOIUrl":"https://doi.org/10.1111/dmcn.16309","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic variants in chromatin-related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders","authors":"","doi":"10.1111/dmcn.16299","DOIUrl":"10.1111/dmcn.16299","url":null,"abstract":"<p>Even though every cell in the body has the same DNA, different genes are turned on or off depending on the cell type. This allows cells to perform specialized jobs, like helping the brain process information, or the immune system fight infections. These changes in gene activity are controlled by a process called epigenetics, which acts like a switch to regulate gene function without altering the DNA itself. One key part of this process involves chromatin, a structure that helps organize DNA. Changes in genes related to chromatin can affect how cells function and may lead to complex health conditions that impact multiple organs.</p><p>We report on eight children who had genetic DNA changes in these chromatin-related genes. All of these children experienced a sudden worsening – a ‘regression’ of their neurodevelopmental condition after an infection or other immune triggers. Some lost social and language skills, while others developed new psychiatric symptoms like obsessive-compulsive disorder, tics, or severe anxiety. We also found that several children had a history of immune system problems, such as frequent infections or autoimmune conditions. One key finding was that these chromatin-related genes are active not only in brain cells but also in immune cells. This suggests that changes in these genes may make the immune system react differently to infections, which could then impact brain function.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 5","pages":"e99"},"PeriodicalIF":3.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Movements Assessment and Hammersmith Infant Neurological Examination for early diagnosis of cerebral palsy in infants born at term treated with therapeutic hypothermia","authors":"","doi":"10.1111/dmcn.16298","DOIUrl":"10.1111/dmcn.16298","url":null,"abstract":"<p>Cerebral palsy (CP) is the most common movement disability in children. A common cause of CP is neonatal encephalopathy which results from injury to the developing brain during pregnancy, birth, or shortly after birth. Research has shown that using therapeutic hypothermia (cooling infants) who show signs of neonatal encephalopathy can decrease brain injury. However, despite therapeutic hypothermia, infants are still at-risk for CP and it remains crucial to diagnose CP as early as possible to begin therapy. Our project explored if the use of two types of physical exams, the General Movements Assessment (GMA) and the Hammersmith Infant Neurological Examination (HINE), help predict CP in infants born at term with neonatal encephalopathy who underwent therapeutic hypothermia.</p><p>To achieve this goal, we conducted a study looking at 112 infants in our hospital who met specific qualifications for neonatal encephalopathy who underwent therapeutic hypothermia from 2018 to 2022. These infants were then followed-up in our Neonatal Follow-Up clinic at 3, 6, and 9 months of age. Trained physicians and therapists used observation of infant movements for the GMA at 3-month follow-up, and examined infant's posture, tone, reflexes, and movements characterized into a scoring system for the HINE at each follow-up. We used statistical analysis to determine if these exams could help predict CP.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 5","pages":"e98"},"PeriodicalIF":3.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial factors and participation in adults with developmental coordination disorder: A structural equation modelling analysis.","authors":"Shahar Zaguri-Vittenberg, Naomi Weintraub, Miri Tal-Saban","doi":"10.1111/dmcn.16302","DOIUrl":"https://doi.org/10.1111/dmcn.16302","url":null,"abstract":"<p><strong>Aim: </strong>To examine the effect of developmental coordination disorder (DCD) on biological (executive function deficit) and psychosocial (low self-esteem and social support) challenges, and the possible mediating effect of these biopsychosocial factors on the relationship between DCD and daily participation, including assistance in performance, performance level, pleasure in daily activities, and global occupational experience.</p><p><strong>Method: </strong>Fifty-five young adults with DCD (28 females; mean age [SD] = 27 years 7 months [3 years 7 months]) and 66 peers without DCD (34 females; mean age [SD] = 27 years 3 months [3 years 8 months]) were included in this structural equation modelling analysis study. Direct and indirect effects were tested using structural equation modelling.</p><p><strong>Results: </strong>DCD had a significantly negative direct effect on all biopsychosocial factors, the need of assistance in performance, and performance level. Self-esteem and social support mediated the effect of DCD on all participation dimensions, while executive function only mediated the effect on performance level and global occupational experience.</p><p><strong>Interpretation: </strong>Results suggest that participation adversities are not only the result of the motor deficits of individuals with DCD, but are also affected by their poor self-esteem, social support, and executive function. Hence, tailored interventions for this population, targeting daily participation, should consider the range of biopsychosocial risk factors affecting these individuals.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood disabilities, household poverty, and inequality: A population-based case-control study in rural Bangladesh.","authors":"Israt Jahan, Tasneem Karim, Risad Sultana, Genevieve Perrins, Mahmudul Hassan Al Imam, Mohammad Muhit, Nadia Badawi, Gulam Khandaker","doi":"10.1111/dmcn.16272","DOIUrl":"https://doi.org/10.1111/dmcn.16272","url":null,"abstract":"<p><strong>Aim: </strong>To explore the relationship between household poverty, inequality, and disability among children in rural Bangladesh.</p><p><strong>Method: </strong>This was a matched case-control study in Shahjadpur, northern Sirajganj, Bangladesh. Children aged younger than 18 years with disabilities (i.e.</p><p><strong>Cases: </strong>those with cerebral palsy, spina bifida, hydrocephalus, muscular dystrophy, spinal cord injury, amputation, club foot, cleft lip or palate, trauma or burn-related injury or impairment, congenital deformity, genetic condition, and visual, hearing, and speech impairments) and age-, sex-, and location-matched children without disabilities (i.e. controls) were recruited. Cases were identified using the key informant method. Household poverty likelihood and socioeconomic status (SES) were assessed using a validated poverty scorecard. Descriptive and inferential analyses were completed.</p><p><strong>Results: </strong>Between October 2017 and February 2018, 1274 cases and 1303 controls were recruited (median age at assessment 9 years 10 months [interquartile range 6 years 0 months-13 years 7 months] and 9 years 10 months [5 years 8 months-12 years 0 months] respectively). The household poverty likelihood was 7% higher among cases than controls (p < 0.001). Parental employment, family income, and school enrolment rate were significantly lower among cases than controls especially in the families with low SES. Both underweight and stunting were significantly higher among cases than controls (p < 0.001 for both). Receipt of rehabilitation services and health-care seeking from formal sectors were significantly lower among cases from families with low SES than high SES (60% vs. 71%, p = 0.03; 10% vs. 33%, p < 0.001 respectively).</p><p><strong>Interpretation: </strong>Our findings are crucial to develop interventions and reduce the inequalities between children with and without disabilities in low-resource settings such as Bangladesh as highlighted in the global agenda of the Sustainable Development Goals.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep developmental phenotyping in children with tuberous sclerosis complex, with and without autism.","authors":"Rebecca A Mitchell, Francesca Lami, Sarah M Barton, A Simon Harvey, Katrina Williams","doi":"10.1111/dmcn.16293","DOIUrl":"https://doi.org/10.1111/dmcn.16293","url":null,"abstract":"<p><strong>Aim: </strong>To characterize autism and co-occurring tuberous sclerosis-associated neuropsychiatric disorders (TAND) in children with tuberous sclerosis complex (TSC), addressing evidence gaps by using deep developmental phenotyping in a single cohort.</p><p><strong>Method: </strong>This cohort study assessed autism characteristics, intelligence, adaptive function, language, and co-occurring conditions, using multidisciplinary direct assessment, in 50 children with TSC, comparing those with and without autism.</p><p><strong>Results: </strong>Autistic children (28, 56%) had moderate mean scores for autistic characteristics (Autism Diagnostic Observation Schedule calibrated severity scores; social affect, 6.9 [standard deviation 2.5]; restricted and repetitive behaviour, 7.1 [standard deviation 2.3], but with considerable variation). Autistic children were more likely to be male (54% vs. 18%) and have intellectual disability (79% vs. 32%), language impairment (89% vs. 50%), executive dysfunction (70% vs. 29%), and externalizing behaviours (46% vs. 14%). Inattentive attention-deficit/hyperactivity disorder (ADHD) symptoms were frequent in autistic and not-autistic children (74% vs. 78%), and not influenced by intellectual ability. Language impairment occurred in 27% without autism or intellectual disability.</p><p><strong>Interpretation: </strong>TAND are complex and heterogenous in children with and without autism. Formal assessment of language function and ADHD symptoms should be considered in all children with TSC, regardless of autism categorization or intellectual ability. Language function needs greater consideration within TAND levels and clusters.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cognitive Orientation to daily Occupational Performance approach in childhood-onset disabilities.","authors":"Hortensia Gimeno, Helene Polatajko","doi":"10.1111/dmcn.16260","DOIUrl":"https://doi.org/10.1111/dmcn.16260","url":null,"abstract":"<p><p>The Cognitive Orientation to daily Occupational Performance (CO-OP) approach, a goal-oriented intervention focused on participation, is designed to improve performance by addressing personal goals important to children and their families. Introduced in 2001, CO-OP involves client-chosen functional goals, identifying performance issues through a process of dynamic performance analysis, and guiding the discovery of cognitive strategies to enhance skill acquisition, all within a problem-solving framework. The objectives of the approach are skill acquisition, strategy use, generalization, and transfer of learning. Developed within a research paradigm, a review of the literature indicates that CO-OP research has expanded, documenting its use across various paediatric populations, including children with neurodevelopmental disorders, cerebral palsy, and movement disorders, addressing a myriad of functional goals. In this review we illustrate the iterative development of CO-OP from single-case experimental designs to randomized controlled trials to evaluate the approach. The Canadian Occupational Performance Measure and the Performance Quality Rating Scale are the most common outcome measures. Methodological advancements, limitations, and an initial exploration of mechanisms of action are discussed, providing a foundation for further research and clinical application. Recommendations include the use of consistent measures, robust longitudinal studies, implementation research, and health economic analyses.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}