Developmental Medicine and Child Neurology最新文献

{"title":"Surgical and health outcomes of non-ambulatory children with cerebral palsy and severe scoliosis: A population-based, longitudinal study.","authors":"","doi":"10.1111/dmcn.70010","DOIUrl":"https://doi.org/10.1111/dmcn.70010","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal hypoglycaemic brain injury, a common cause of early-childhood epilepsy in India: A prospective longitudinal study on aetiologies and outcomes.","authors":"","doi":"10.1111/dmcn.70017","DOIUrl":"https://doi.org/10.1111/dmcn.70017","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listening, learning, and (co-)leading: Addressing the experiences of falls among people with cerebral palsy across the lifespan.","authors":"Linda Nguyen","doi":"10.1111/dmcn.70023","DOIUrl":"https://doi.org/10.1111/dmcn.70023","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting neurodevelopmental outcomes in Australian First Nations infants: The transdiagnostic utility of early screening tools.","authors":"Carly Luke, Katherine A Benfer, Leeann Mick-Ramsamy, Robert S Ware, Margot Bosanquet, Natasha Reid, Arend F Bos, Roslyn N Boyd","doi":"10.1111/dmcn.70003","DOIUrl":"https://doi.org/10.1111/dmcn.70003","url":null,"abstract":"<p><strong>Aim: </strong>To determine the predictive relationship between evidence-based screening tools and neurodevelopmental outcomes in Australian First Nations infants.</p><p><strong>Method: </strong>This prospective cohort study invited First Nations families to participate in a culturally adapted early developmental screening programme. A total of 156 infants (55.1% male, mean gestational age = 33.6 weeks, SD = 4.6) were screened using the Prechtl's General Movements Assessment, with optimality scoring using the Motor Optimality Score-Revised (MOS-R) at 3 to 5 months and the Hammersmith Infant Neurological Examination (HINE) at 4 to 9 months. Participants completed 'baby movement (BM) checks' at two time points (BM1, 3-5 months corrected age; BM2, 4-9 months corrected age), with final movement and learning checks at 12 months corrected age. At 12 months corrected age, standardized motor, cognitive, and communication assessments, neurodisability-specific symptomology, or a diagnosis made by a paediatrician classified infants as developing typically ('on track') or (1) with a high chance of or confirmed cerebral palsy (CP) or (2) non-CP neurodevelopmental delay (NDD), including autism and fetal alcohol spectrum disorder (FASD). Predictive relationships were investigated using logistic regression and diagnostic statistics.</p><p><strong>Results: </strong>At 12 months, 127 of 147 (86%) eligible infants (n = 9 withdrawn or deceased) were classified as 'on track' (n = 55, 43%), NDD (n = 59, 47%), or CP (n = 13, 10%). MOS-R (≥ 14 weeks). The HINE distinguished infants as 'on track', CP, or NDD. Each 1-point decrease on both tools increased the odds of NDD (OR_MOS-R = 1.40, 95% confidence interval [CI] = 1.00-1.96; OR_HINE = 1.12, 95% CI = 1.05-1.21) and CP (OR_MOS-R = 1.47, 95% CI = 1.08-2.01; OR_HINE = 1.41, 95% CI = 1.21-1.65,). The MOS-R (cut-off of less than 23) and HINE (moderate to severely reduced) were best for identifying any NDD and CP (MOS-R: sensitivity = 84%, specificity = 38%; HINE: sensitivity = 64%, specificity = 63%). Combined trajectories across both tools were the strongest predictors of CP (sensitivity = 73%, specificity = 96%), autism (sensitivity = 59%, specificity = 95%), and FASD (sensitivity = 89%, specificity = 93%).</p><p><strong>Interpretation: </strong>Evidence-based screening tools demonstrate promising transdiagnostic prediction of 'on-track' development and not only high chance of CP but also autism, FASD, and other NDDs.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of trofinetide in Rett syndrome: Lessons from an approved drug for a severe neurodevelopmental disorder.","authors":"Walter E Kaufmann","doi":"10.1111/dmcn.70025","DOIUrl":"https://doi.org/10.1111/dmcn.70025","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric challenges and opportunities in optimizing the Infantile Neuroaxonal Dystrophy Rating Scale.","authors":"Ali Reza Tavasoli","doi":"10.1111/dmcn.70002","DOIUrl":"https://doi.org/10.1111/dmcn.70002","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Infantile Neuroaxonal Dystrophy Rating Scale.","authors":"Alessandra Girardi, Linda Abetz-Webb, Katja Rudell, Paldeep S Atwal, Alexander Fay","doi":"10.1111/dmcn.16506","DOIUrl":"https://doi.org/10.1111/dmcn.16506","url":null,"abstract":"<p><strong>Aim: </strong>To assess the psychometric characteristics of the Infantile Neuroaxonal Dystrophy Rating Scale (INAD-RS).</p><p><strong>Method: </strong>We retrospectively analysed interim data from the INAD Natural History Study using clinicians' ratings (n = 39) of patients with infantile neuroaxonal dystrophy (INAD). Data were analysed to explore the internal consistency, test-retest reliability, known group validity, and longitudinal changes of the INAD-RS.</p><p><strong>Results: </strong>The analysis identified good internal consistency, convergent validity, and test-retest reliability across scale domains assessing gross motor, fine motor, bulbar, ocular, and temporo-frontal functions, whereas the domain of autonomic nervous system function contributed weakly to the overall INAD-RS score. Furthermore, preliminary evidence suggested that INAD-RS total scores discriminated among clinical phenotypes and was sensitive to change over time.</p><p><strong>Interpretation: </strong>The psychometric properties of the INAD-RS showed construct validity and reliability for five out of six domains (autonomic nervous system excluded). The scale is a promising instrument for evaluating children with INAD in clinical research and clinical practice. Although promising, further evidence is needed to refine the scale and support its suitability for assessing disease progression in clinical trials and clinical practice.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of selective dorsal rhizotomy in ambulatory children and young people with cerebral palsy: A scoping review.","authors":"Deepti Chugh, Eleanor Main, Gillian Waite, Lucy Alderson, Kristian Aquilina, Cherry Kilbride, Tim Theologis, Hortensia Gimeno","doi":"10.1111/dmcn.16496","DOIUrl":"https://doi.org/10.1111/dmcn.16496","url":null,"abstract":"<p><strong>Aim: </strong>To identify outcomes reported after selective dorsal rhizotomy (SDR) in ambulant children and young people with cerebral palsy in different domains of the International Classification of Functioning, Disability and Health (ICF).</p><p><strong>Method: </strong>A scoping review using the JBI Scoping Review methodology was conducted. Six databases were searched for literature published between 1993 and 2024.</p><p><strong>Results: </strong>A total of 214 published papers met the inclusion criteria. Outcomes under the body function and structure domain were most frequently investigated (n = 199, 93%), followed by activity (n = 123, 58%) and participation (n = 33, 15%) across all studies. Quality of life was reported in 16 (8%) studies, and four (2%) studies mentioned individualized goals for SDR surgery. A combination of validated measures and subjective outcomes was used, with 119 (56%) studies reporting outcomes in two or more domains.</p><p><strong>Interpretation: </strong>Impairment-based outcomes remain the primary focus in SDR research. A small shift in emphasis towards participant-reported outcome measures has been seen in recent years. Few studies reported on the impact of personal and environmental factors. Future SDR studies need to incorporate all domains of the ICF to enhance understanding and capture holistic, meaningful changes in the lives of children and young people with cerebral palsy and their families.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timed walk tests in spina bifida: A new functional vital sign?","authors":"Shubhra Mukherjee","doi":"10.1111/dmcn.16508","DOIUrl":"https://doi.org/10.1111/dmcn.16508","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neuropsychological perspective on the proposed updated description of cerebral palsy.","authors":"Kristine Stadskleiv, Olga Laporta-Hoyos, Júlia Ballester-Plané, Els Ortibus, Ingrid Honan, Petra Karlsson, Samudragupta Bora, Jacqueline N Kaufman, Seth Warschausky, Roser Pueyo","doi":"10.1111/dmcn.16462","DOIUrl":"https://doi.org/10.1111/dmcn.16462","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}