Developmental Medicine and Child Neurology最新文献

{"title":"Vertigo and dizziness syndromes in children and adolescents: Clinical presentation and diagnostic pathway.","authors":"","doi":"10.1111/dmcn.70591","DOIUrl":"https://doi.org/10.1111/dmcn.70591","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCC1 neuropathy mimics childhood axonal Guillain-Barré syndrome with variable clinical severity and survival.","authors":"","doi":"10.1111/dmcn.70585","DOIUrl":"https://doi.org/10.1111/dmcn.70585","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency in early pregnancy and the risk of developing cerebral palsy: A case-control study.","authors":"Ebba Bergman, Lars Rylander, Christian Lindh, Jesse D Thacher","doi":"10.1111/dmcn.70573","DOIUrl":"https://doi.org/10.1111/dmcn.70573","url":null,"abstract":"<p><strong>Aim: </strong>To investigate whether maternal deficiency of vitamin D in early pregnancy increases the risk of cerebral palsy (CP) in offspring.</p><p><strong>Method: </strong>This registry and biobank-based case-control study consisted of mother-child pairs from Scania, Sweden. Cases (n = 322) were identified from a nationwide CP-register born between 1995 and 2014. Random population controls (n = 343) and preterm controls (n = 258) were identified from a birth registry. Serum samples taken during pregnancy were obtained from a biobank and 25(OH)D₃ concentrations were categorized into three groups: sufficient (≥ 75 nmol/L), insufficient (50-74.9 nmol/L), and deficient (< 50 nmol/L). Logistic regression was used to investigate associations between 25(OH)D₃ concentrations and CP. Separate analyses were completed among children born preterm and at term, as well as for subtypes of CP.</p><p><strong>Results: </strong>Deficiency of 25(OH)D₃ was not associated with a significantly higher risk of CP compared with sufficient values in the studied groups of all children (odds ratio [OR]: 1.34; 95% confidence interval [CI]: 0.86-2.10), children born at term (OR: 1.48; 95% CI: 0.89-2.44), and children born preterm (OR: 0.74; 95% CI: 0.37-1.46).</p><p><strong>Interpretation: </strong>No apparent association between 25(OH)D₃ and CP was observed; however, the relatively small sample size and reliance on a single vitamin D measurement may have limited the detection of modest effects.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle tone and pain in children with spastic cerebral palsy.","authors":"","doi":"10.1111/dmcn.70586","DOIUrl":"https://doi.org/10.1111/dmcn.70586","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of the term 'Rett-like' in relation to Rett syndrome: A systematic review.","authors":"","doi":"10.1111/dmcn.70592","DOIUrl":"https://doi.org/10.1111/dmcn.70592","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the Hammersmith Infant Neurological Examination proforma to facilitate the recording of neurological findings.","authors":"Eugenio Mercuri, Leena Haataja, Daniela Ricci, Domenico M Romeo, Marianna Moro, Frances M Cowan","doi":"10.1111/dmcn.70577","DOIUrl":"https://doi.org/10.1111/dmcn.70577","url":null,"abstract":"<p><strong>Aim: </strong>To report on changes to the Hammersmith Infant Neurological Examination (HINE) proforma that facilitate the recording of neurological findings.</p><p><strong>Method: </strong>We first identified items that would benefit from more detail in the way they were presented on the proforma to aid correct administration and scoring. We then introduced additional details without changing the scoring system. These changes were piloted in infants with and without neurological concerns to find out whether examiners found the changes confusing or if the changes made might affect the original scoring system.</p><p><strong>Results: </strong>Eight of the 26 items in the main section of the HINE were identified for possible change: three items in the tone section, two in the reflexes and reactions section, and three in the posture section. For these items, more detail was added to the recording options within each column, without altering the main structure of the proforma or the scoring system. Users did not find the additions an extra burden; they felt that the more detailed options facilitated accuracy in recording observations and that the scoring of the proforma was not affected.</p><p><strong>Interpretation: </strong>Small changes made to the HINE proforma facilitate more accuracy in recording detail in the examination, particularly with regard to tone and posture, without changing the established scoring system. This should facilitate the recording of more subtle changes that reflect typical development or may occur in response to possible intervention.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Athletes, extremophiles, and muscle in spastic cerebral palsy: Distinguishing impairment from adaptation.","authors":"Bernard Dan","doi":"10.1111/dmcn.70580","DOIUrl":"https://doi.org/10.1111/dmcn.70580","url":null,"abstract":"","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor-based interventions for brain structure and function in children with developmental coordination disorder: A systematic review.","authors":"Maja Van Grinderbeek, Alessandro Crippa, Linde Cauwelier, Katrijn Klingels, Evi Verbecque","doi":"10.1111/dmcn.70514","DOIUrl":"https://doi.org/10.1111/dmcn.70514","url":null,"abstract":"<p><strong>Aim: </strong>To synthesize evidence on the effects of a motor-based intervention on the brain in children with developmental coordination disorder (DCD), and to determine the impact of the different motor-based interventions on the stages of motor learning.</p><p><strong>Method: </strong>For this systematic review, three databases were searched by two independent reviewers. Studies were included if they involved (1) children with (probable) DCD (3-18 years), (2) long-term motor-based interventions, and (3) at least one brain imaging outcome. Two independent reviewers assessed risk of bias (RoB2 and ROBINS-I V2) and evaluated the quality of evidence (GRADE).</p><p><strong>Results: </strong>Seven articles met the selection criteria. Risk of bias ranged from some to moderate (n = 4), to high (n = 3). Various imaging techniques (e.g. functional near-infrared spectroscopy), outcome measures (e.g. oxyhaemoglobin), and regions of interest (e.g. fronto-parietal network) were investigated in the included studies. Despite the neuroplastic changes exhibited by children with DCD post-intervention, the direction and pattern differed from typically developing peers. Increased functional connectivity after intervention was observed in attentional regions, suggesting compensatory mechanisms. The interventions focused on the cognitive (n = 4) and associative (n = 3) stages of motor learning. None of the interventions addressed the autonomous stage.</p><p><strong>Interpretation: </strong>Current evidence tentatively indicates that children with DCD can exhibit intervention-induced neuroplasticity, facilitating motor skill learning. These changes differ from typically developing profiles and therefore seem to reflect compensatory mechanisms. Further research is critical to better understand these differential patterns, essential for interpreting neuroplastic changes to tailor future motor-based therapies.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral upper-limb palsy of the newborn infant: Taxonomy, differential diagnosis, and clinical pathways.","authors":"Yegee Han, Yangmyung Ma, Kanwal Yousaf, Evangeline Wassmer, Andrea Jester","doi":"10.1111/dmcn.70575","DOIUrl":"https://doi.org/10.1111/dmcn.70575","url":null,"abstract":"<p><p>Bilateral reduction or absence of upper-limb movement in a newborn infant is a rare but critical presentation that cannot be anchored on the unilateral paradigm of brachial plexus birth injury (BPBI). Bilaterality substantially widens the differential to include cervical spinal cord injury, neuromuscular disorders, and non-neurological movement limitation; thus, default attribution to bilateral BPBI risks missing a serious central pathology. No standardized terminology or investigation framework currently addresses this phenotype. This review introduces bilateral upper-limb palsy of the newborn infant (BULPN) and proposes a three-category taxonomy separating 'true BULPN' (bilateral plexus-level palsy at birth) from mimics and acquired (postnatal-onset) palsy. True BULPN is most consistently reported in breech delivery and it is frequently asymmetric; published cohorts describe a high burden of concurrent phrenic nerve palsy. A localization-first diagnostic algorithm and time-anchored, severity-stratified management pathways are presented to support safer and more targeted clinical assessment and management, and reduce the risk of misdiagnosis.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health difficulties in cerebral palsy: A qualitative study of young people's and parents' perspectives","authors":"Manjula Manikandan,&nbsp;Jennifer Fortune,&nbsp;Jessica Burke,&nbsp;Aisling Walsh,&nbsp;Aoife Twohig,&nbsp;Ian McClelland,&nbsp;Amanda Breen,&nbsp;Meriel Norris,&nbsp;Jennifer M. Ryan,&nbsp;RELATE-CP study team","doi":"10.1111/dmcn.70229","DOIUrl":"10.1111/dmcn.70229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore the experiences of mental health difficulties and access to mental health support among young people with cerebral palsy (CP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We used a qualitative descriptive design. Participants were young people with CP aged 13 to 25 years and parents of children with CP (6–25 years). Nineteen semi-structured interviews were conducted. A narrative thematic analysis was conducted to identify themes related to their mental health experiences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four themes were identified from the data: (1) understanding manifestations of mental health, triggers, and the importance of early intervention; (2) structural and human challenges in accessing mental health services; (3) the interplay between mental health and personal, social, educational, and familial challenges; (4) navigating future aspirations and holistic mental health support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>People with CP face complex, interconnected challenges to their mental health, influenced by personal, family, social, and systemic factors. Mental health difficulties often go unrecognized or are inadequately addressed, highlighting the need for early identification, integrated service provision, and holistic, person-centred interventions that support young people and their families.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"68 11","pages":"1538-1550"},"PeriodicalIF":3.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.70229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}