Developmental Medicine and Child Neurology最新文献_第6页

Psychosocial experiences of clinicians providing care for children with severe neurological impairment 为严重神经损伤儿童提供护理的临床医生的社会心理体验。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-07 DOI: 10.1111/dmcn.16061

{"title":"Psychosocial experiences of clinicians providing care for children with severe neurological impairment","authors":"","doi":"10.1111/dmcn.16061","DOIUrl":"10.1111/dmcn.16061","url":null,"abstract":"The clinical care for children with severe neurological impairment (SNI) has undergone major advances, and services have adapted with the promise of many potential new treatments on the horizon. Children with SNI are living longer and patients with complex needs have outpaced the number of clinicians trained to adequately provide care.This growing gap and the limited supports places added pressure on clinicians. They struggle with uncertainty and feel ill-equipped to provide appropriate management and counselling for children with rare and complex SNI.This research study asked clinicians about their experiences caring for children with SNI. We also asked clinicians what could be developed to better support them in their role.We conducted 24 interviews with clinicians. We asked clinicians to tell us about their experiences caring for children with SNI and how their experiences impacted their mental, physical, and social–emotional wellbeing over time.Clinicians described a combination of physical, emotional, and mental health impacts. Stressors were related to inadequate training and support for patients with SNI. This often caused clinicians to experience isolation, anxiety, and self-doubt and a sense of powerlessness. Many clinicians were able to make use of strategies to help them cope with complex challenges including creating meaningful connections with families and their clinical teams. Learning to approach scenarios with greater acceptance of the limitations of their medical knowledge and capacity to change the situation was associated with increased clinician wellbeing.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does botulinum neurotoxin A make walking easier in children with cerebral palsy? A randomized clinical trial A 型肉毒杆菌神经毒素能让脑瘫儿童更容易行走吗？随机临床试验。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-07 DOI: 10.1111/dmcn.16064

{"title":"Does botulinum neurotoxin A make walking easier in children with cerebral palsy? A randomized clinical trial","authors":"","doi":"10.1111/dmcn.16064","DOIUrl":"10.1111/dmcn.16064","url":null,"abstract":"Injections with botulinum neurotoxin A (BoNT-A) are frequently used as treatment of spasticity (increased muscle tone) in children with cerebral palsy (CP). However, the evidence of a functional effect, like improved walking, is insufficient.The aim of this study was to investigate whether BoNT-A makes walking easier in children with CP. Energy cost during comfortable walking was used to assess ease of walking before and after treatment. We also wanted to investigate if walking capacity improved, habitual physical activity increased, and if leg pain was reduced. The children also reported self-perceived effect.The study was a randomized controlled trial where the children were randomly allocated to receive either BoNT-A or saline water (placebo).The results showed that one treatment with BoNT-A did not make walking easier compared to placebo within a time span of 12 weeks. However, a decrease in energy cost, twice as large as in the placebo group, was observed at 6 months follow-up. This suggests a possible delayed effect. On the other hand, we did not find any improvement in walking capacity or in habitual physical activity. However, there was some evidence that leg pain was reduced in children treated with BoNT-A.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of severe brain injury on trends of gestational age-related neurodevelopmental outcomes in very preterm infants: A population cohort study 严重脑损伤对早产儿胎龄相关神经发育结果趋势的影响：一项人群队列研究。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-07 DOI: 10.1111/dmcn.16062

引用次数: 0

Muscle satellite cells and fibro-adipogenic progenitors from muscle contractures of children with cerebral palsy have impaired regenerative capacity 来自脑瘫儿童肌肉挛缩处的肌肉卫星细胞和纤维脂肪生成祖细胞的再生能力受损。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-07 DOI: 10.1111/dmcn.16063

{"title":"Muscle satellite cells and fibro-adipogenic progenitors from muscle contractures of children with cerebral palsy have impaired regenerative capacity","authors":"","doi":"10.1111/dmcn.16063","DOIUrl":"10.1111/dmcn.16063","url":null,"abstract":"In cerebral palsy (CP), muscles often develop contractures, where the muscle is shorter and stiffer than healthy muscle. This impairs muscle function, limiting the ability of children with CP to have full range of motion and function of their muscles.Muscles are made up of millions of cells and several different cell types. One of these key cell types form new muscle when the muscle is injured or growing. Another cell type produces a network of proteins that provide support and structure to the muscle. The goal of this study was to understand how these two cell types change with contracture. This will allow us to identify changes in cell behavior in CP and therefore identify targets to improve muscle function.To do so, we compared cells taken from muscle biopsies of six children with CP and six typically developing (TD) children. We found that cells from children with CP did not form muscle as much as TD cells. These cells also had worse muscle formation on stiffnesses that represent contractures compared to healthy-like stiffnesses. This indicates that when the muscle is injured in CP, it cannot recover as easily. We found that treatment with a drug called verteporfin slightly improved muscle formation. We also found that the cells that produce the proteins and structure in muscle change into a more diseased state in CP compared to TD.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research priorities in child neurology: Balancing pragmatism and progress worldwide. 儿童神经学的研究重点：平衡实用主义与世界范围内的进步。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-06 DOI: 10.1111/dmcn.16050

Pratibha Singhi

引用次数: 0

Efficacy and threshold dose of intensive training targeting mobility for children with cerebral palsy: A systematic review and meta-analysis. 针对脑瘫儿童行动能力强化训练的疗效和阈值剂量：系统回顾与荟萃分析。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-06 DOI: 10.1111/dmcn.16040

Isabella Pessóta Sudati, Leanne Sakzewski, Carolina Fioroni Ribeiro da Silva, Michelle Jackman, Matthew Haddon, Dayna Pool, Maharshi Patel, Roslyn N Boyd, Ana Carolina de Campos

{"title":"Efficacy and threshold dose of intensive training targeting mobility for children with cerebral palsy: A systematic review and meta-analysis.","authors":"Isabella Pessóta Sudati, Leanne Sakzewski, Carolina Fioroni Ribeiro da Silva, Michelle Jackman, Matthew Haddon, Dayna Pool, Maharshi Patel, Roslyn N Boyd, Ana Carolina de Campos","doi":"10.1111/dmcn.16040","DOIUrl":"https://doi.org/10.1111/dmcn.16040","url":null,"abstract":"Aim: To systematically review the evidence for intensive mobility training in cerebral palsy (CP) and to determine the minimum effective dose to improve mobility.Method: Randomized controlled trials (RCTs) or quasi-RCTs that included participants with CP, and which used intensive task-oriented training (TOT) mobility interventions and reported mobility outcomes, were included. Five databases were searched; two independent reviewers selected studies and extracted data. The Grading of Recommendations Assessment, Development, and Evaluation system and the Cochrane Risk of Bias 2 tool were used to rate the certainty of evidence at the outcomes level and to determine the risk of bias respectively. Meta-analyses were conducted with clinically homogeneous studies. Threshold dose was analysed through meta-regression.Results: Forty-six RCTs with 1449 participants (mean age range 1 year 2 months to 16 years 4 months) were included. TOT had statistically and clinically significant effects on walking speed (p = 0.001), cadence (p = 0.02), gross motor function (p = 0.03), and functional mobility (p = 0.009) compared with control interventions. The threshold dose was undeterminable owing to the high heterogeneity of studies.Interpretation: TOT may improve walking speed, walking endurance, and balance. Studies with homogeneous samples and outcomes are needed to support clinical recommendations for intensive mobility interventions.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of teleassessment in family-centered approaches for cerebral palsy. 远程评估在以家庭为中心的脑瘫治疗方法中的作用。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-05 DOI: 10.1111/dmcn.16053

Sefa Ünes

引用次数: 0

A parent-administered sensorimotor intervention for oral feeding in infants born preterm: A randomized clinical study. 早产儿口腔喂养的家长感知运动干预：随机临床研究。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-05 DOI: 10.1111/dmcn.16046

Sandra Fucile, Laurie Snider, Karel O'Brien, Lorraine Smith, Kimberly Dow

{"title":"A parent-administered sensorimotor intervention for oral feeding in infants born preterm: A randomized clinical study.","authors":"Sandra Fucile, Laurie Snider, Karel O'Brien, Lorraine Smith, Kimberly Dow","doi":"10.1111/dmcn.16046","DOIUrl":"https://doi.org/10.1111/dmcn.16046","url":null,"abstract":"Aim: To evaluate the effect of a parent-administered sensorimotor intervention (PASI) program on developmental outcomes of infants born preterm during their stay in the neonatal intensive care unit (NICU).Method: A randomized clinical study was conducted with 94 infants (mean gestational age 31 weeks [SD 2.2 weeks]; 1658 g [SD 478 g]; 49 males, 45 females) initially enrolled and randomly assigned to an experimental or a control group. Infants in the experimental group received a PASI, consisting of tactile input to oral structures, trunk/limbs, and non-nutritive sucking for 15 minutes, once a day, for 10 days. Infants in the control group received standard care. Outcomes included attainment of complete oral feeds, occurrence of direct breastfeeding at hospital discharge, and motor function assessed using the Test of Infant Motor Performance (TIMP).Results: A total of 80 infants completed the study. Infants in the experimental group achieved complete oral feeds sooner (11.9 [SD 4.3] vs 15.3 [SD 6.5] days, p = 0.013), and a greater number of them received direct breastfeeds (22 vs 12, p = 0.010) than controls. Infants in both groups had equivalent motor functions scores on the TIMP (46.9 [SD 4.8], 46.8 [SD 8.4], p = 0.961).Interpretation: A PASI program may enhance an infant's oral feeding skills. These findings provide evidence to advocate for the institution of PASI in NICUs.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transitioning health care for adults with cerebral palsy. 为患有大脑性麻痹的成年人提供过渡性医疗保健服务。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-04 DOI: 10.1111/dmcn.16055

Edward Hurvitz, Duncan Wyeth, Mark Peterson

引用次数: 0

Typical and atypical MRI patterns of rare brain disorders: The challenge of low numbers. 罕见脑部疾病的典型和非典型磁共振成像模式：数量少的挑战。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2024-08-02 DOI: 10.1111/dmcn.16049

Nicole I Wolf, Marc Engelen, Marjo S van der Knaap

引用次数: 0