Developmental Medicine and Child Neurology最新文献_第6页

Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review 使用功能性近红外光谱评估脑性瘫痪的皮质活动、功能连通性和神经可塑性：范围综述。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16286

{"title":"Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review","authors":"","doi":"10.1111/dmcn.16286","DOIUrl":"10.1111/dmcn.16286","url":null,"abstract":"Cerebral palsy (CP) is caused by an early brain injury and can lead to lifelong movement challenges. Understanding brain function in CP is important for designing effective treatments, but traditional brain imaging methods are costly, require children to stay still, and cannot measure brain activity during real-world tasks.This review examined how functional near-infrared spectroscopy (fNIRS), an innovative tool that uses light to measure brain activity, contributes to understanding brain function in individuals with CP. Unlike conventional imaging, fNIRS is child-friendly, portable, and affordable, making it ideal for studying brain activity in everyday settings. Sixteen studies that used fNIRS in children and adults with CP aged 3 to 43 years were analyzed.Key findings included: (1) Brain activity in individuals with CP is different from typically developing peers, even during simple movements. (2) Higher activity in motor regions of the brain often reflect more severe movement difficulties. (3) Therapy-induced changes in brain activity are frequently linked to functional improvements.Despite its benefits, fNIRS has limitations. It cannot assess brain structure or activity of the deeper regions of the brain, and data collection can be challenging for individuals with darker skin tones or thick hair. Other challenges include small study sizes, inconsistent research methods, uncertain reliability, and underrepresentation of individuals with severe CP, making comparisons with other studies difficult.The authors recommend larger, standardized studies that involve families in study planning and design, and include individuals with severe CP. They also suggest using fNIRS to study brain activity during real-world tasks (such as playing or walking in everyday settings at home or in therapy clinics) to address practical challenges and reflect the needs of people living with CP.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 5","pages":"e96"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16286","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The risk of epilepsy following neonatal seizures 新生儿癫痫发作后癫痫的风险。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16288

引用次数: 0

Gross Motor Function Measure-66 Item Sets for use with infants and toddlers at high risk for cerebral palsy: Construct validity and responsiveness 大运动功能测量-用于脑瘫高危婴幼儿的项目集：结构效度和反应性。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16289

{"title":"Gross Motor Function Measure-66 Item Sets for use with infants and toddlers at high risk for cerebral palsy: Construct validity and responsiveness","authors":"","doi":"10.1111/dmcn.16289","DOIUrl":"10.1111/dmcn.16289","url":null,"abstract":"There is a critical need to develop, evaluate, deliver, and monitor response to quality interventions designed for young children with cerebral palsy (CP). To do so requires measures of children's gross motor skills (movement involving the whole body such as walking, running, jumping, and hopping) that are accurate, reliable, and practically feasible. One such promising tool is the Gross Motor Function Measure-66 Item Sets (GMFM-66-IS), but this tool has not been sufficiently evaluated for use with very young children with CP. The GMFM measures how much of a task the child can do versus how well the child performs the task.The purpose of this non-experimental study was to examine the accuracy of the GMFM-66-IS in evaluating the gross motor skills of children less than 24 months of age who have or are at high risk for CP. Non-experimental studies take place in real-life settings, where the researchers cannot control all possible variables. Analyses were based on existing data from three clinical trials of children with or at high risk for CP (79 infants and toddlers) and one observational study of typically developing children (32 infants). Children's gross motor skills were measured at two timepoints, 3 months apart.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e94"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating uncertainty following paediatric disorders of consciousness. 儿童意识障碍后的不确定性导航。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16280

Lorna Wales

引用次数: 0

Gross Motor Family Report: Refinement and evaluation of psychometric properties 粗大运动家庭报告：心理测量特性的完善与评估。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16270

{"title":"Gross Motor Family Report: Refinement and evaluation of psychometric properties","authors":"","doi":"10.1111/dmcn.16270","DOIUrl":"10.1111/dmcn.16270","url":null,"abstract":"The Gross Motor Family Report (GM-FR) is a new way for families in their own homes and communities to tell us about what their children with cerebral palsy (CP) can do to move around in their everyday life. Doctors and therapists have usually looked at what they thought was important about the motor skills of young people with CP. This new study set out to ask different questions. We wanted to hear the opinion of families about what is important for doctors and therapists to know about what their children can do.Once the new measure was created, we needed to test its usefulness with parents of children and adolescents with CP. Twelve families shared their opinions with the researchers. Their ideas and advice helped us make changes in the GM-FR. We added a new scoring system, pictures of children doing the activities, and descriptions of what we were interested in. The result was the creation of the GM-FR, with 28 items. After that, 146 families scored the GM-FR v.2.0, and we calculated how accurate the measure was. Then, 46 parents scored the measure twice within 7 to 30 days. Through this, we learned that the two measures showed similar results.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e87-e88"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

General Movements Assessment and Hammersmith Infant Neurological Examination for early diagnosis of cerebral palsy in infants born at term treated with therapeutic hypothermia. 一般运动评估和Hammersmith婴儿神经学检查对治疗性低温治疗的足月婴儿脑瘫的早期诊断。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16277

Sara N Moss, Jennifer C Keene, Sarah L Winter, Mariana Baserga, Lauren Ayala, Wendy G Evans, Betsy E Ostrander

{"title":"General Movements Assessment and Hammersmith Infant Neurological Examination for early diagnosis of cerebral palsy in infants born at term treated with therapeutic hypothermia.","authors":"Sara N Moss, Jennifer C Keene, Sarah L Winter, Mariana Baserga, Lauren Ayala, Wendy G Evans, Betsy E Ostrander","doi":"10.1111/dmcn.16277","DOIUrl":"https://doi.org/10.1111/dmcn.16277","url":null,"abstract":"Aim: To establish if the General Movements Assessment (GMA) and Hammersmith Infant Neurological Examination (HINE) support the early diagnosis of cerebral palsy (CP) in a cohort of infants who have undergone therapeutic hypothermia.Method: This was a retrospective cohort study from a large single center between 2018 and 2022. Sample size included surviving 112 infants with follow-up (68 males, 44 females) with a mean gestational age of 39 weeks (interquartile range 38-40), diagnosed with moderate or severe neonatal encephalopathy who underwent therapeutic hypothermia. Groups were compared using Fisher's exact and Mann-Whitney U tests.Results: The absence of normal fidgety movements at the 3-month GMA was highly associated with CP (p < 0.001, sensitivity 89%, specificity 89%). HINE scores were associated with CP at 3 months, 6 months, and 9 months (p < 0.001; sensitivity 82%-90%, specificity 95%-100%). The HINE scores, which optimally differentiated those with and without CP, were less than 47 at 3 months, less than 51 at 6 months, and less than 64 at the 9-month follow-up.Interpretation: The GMA and HINE were predictive of CP in infants born at term with neonatal encephalopathy who had undergone therapeutic hypothermia. Atypical (absent or abnormal) fidgety movements on the GMA at 3 months and the HINE score at 3 months, 6 months, and 9 months were all highly associated with CP diagnosis with more than 80% sensitivity and more than 90% specificity. The optimal HINE cutoff score for predicting CP may differ from infants born preterm and will benefit from further analysis.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Training intensity of robot-assisted gait training in children with cerebral palsy 脑瘫儿童机器人辅助步态训练的训练强度。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16283

{"title":"Training intensity of robot-assisted gait training in children with cerebral palsy","authors":"","doi":"10.1111/dmcn.16283","DOIUrl":"10.1111/dmcn.16283","url":null,"abstract":"To enhance active participation and independence in daily living, a key therapeutic goal for patients with cerebral palsy (CP) is to improve walking ability. Recent advances in technology suggested that robot-assisted gait training (RAGT) may be an alternative method of treatment. The authors compared three different intensities of RAGT for achieving favourable outcomes in children with CP. This study was conducted using a randomized controlled, single-blind design, which is set up so that the treatment each participant receives is not known by the participants but is known by the researchers.Thirty children with CP classified in Gross Motor Function Classification System levels II and III were assigned to three different RAGT intensity groups: (1) high-intensity (fastest walking speed and lowest body weight support [BWS]); (2) low-intensity (slowest speed and highest BWS); and (3) comfortable intensity (intermediate speed and intermediate BWS).The RAGT intervention was performed three times a week for 6 weeks with each group using the Walkbot-K system. The Walkbot-K is a trajectory-controlled, treadmill-tethered, robot-assisted locomotor training device with a built-in ankle actuator to assist ankle motion.The Gross Motor Function Measure (GMFM) is an observational clinical tool designed to evaluate change in gross motor function in children with CP. The 88-item GMFM was significantly improved after training in the high-intensity and comfortable intensity groups, whereas gait speed was improved in the comfortable intensity group, without statistically significant group differences. Only the low-intensity group showed improvement on the stability index. Everyday functional performance significantly improved in all three groups, with the comfortable intensity group showing the greatest improvement.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 4","pages":"e90"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eating and drinking abilities and respiratory and oral health in children and young adults with cerebral palsy. 脑瘫儿童和青年的饮食能力与呼吸和口腔健康。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-20 DOI: 10.1111/dmcn.16262

Alexandra Sorhage, A Marie Blackmore, Catherine A Byrnes, Caitlin Agnew, Emily F M Webster, Anna Mackey, Jimmy Chong, Timothy M Hill, Dug Yeo Han, Ngaire Susan Stott

{"title":"Eating and drinking abilities and respiratory and oral health in children and young adults with cerebral palsy.","authors":"Alexandra Sorhage, A Marie Blackmore, Catherine A Byrnes, Caitlin Agnew, Emily F M Webster, Anna Mackey, Jimmy Chong, Timothy M Hill, Dug Yeo Han, Ngaire Susan Stott","doi":"10.1111/dmcn.16262","DOIUrl":"https://doi.org/10.1111/dmcn.16262","url":null,"abstract":"Aim: To investigate the potential risk factors of respiratory illness (ethnicity, oral health, and eating and drinking ability) in children and young adults with cerebral palsy (CP).Method: This was an observational study using a validated CP Respiratory and Oral Health questionnaire with 90 participants (median age 12 years [range: 1-26 years]; 51 males; and 26 New Zealand Māori).Results: Multivariate analysis, accounting for ethnicity and Gross Motor Function Classification System (GMFCS) levels, showed that those participants who were classified in Eating and Drinking Ability Classification System (EDACS) levels III to V reported more previous respiratory disease episodes (odds ratio [OR] = 4.13, 95% confidence interval [CI] = 1.12-15.2, p = 0.033), increased daily/weekly respiratory symptoms (OR = 9.14, 95% CI = 2.03-41.2, p = 0.004), and increased mealtime respiratory symptoms (OR = 13.8, 95% CI = 2.48-76.8, p = 0.002). Both EDACS levels III to V and GMFCS levels IV and V were independently associated with increased propensity to reflux or seizures (OR = 8.16, 95% CI = 1.77-37.5, p = 0.007; OR = 3.37, 95% CI = 1.09-10.4, p < 0.034). Mealtime symptoms of vomiting or regurgitation (relative risk = 1.58, 95% CI = 1.17-2.13, p = 0.032) and daily coughing (relative risk = 1.55, 95% CI = 1.14-2.11, p = 0.023) were associated with a higher risk of reporting one or more oral health symptoms. Toothache was more common in participants classified in EDACS levels III to V (χ2, p = 0.021).Interpretation: Children with CP classified in EDACS levels III to V are at a higher risk of respiratory disease and toothache and should be screened appropriately. Regurgitation or vomiting of food and daily coughing are linked with poorer oral health.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The risk of epilepsy after neonatal seizures. 新生儿癫痫发作后的癫痫风险。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-19 DOI: 10.1111/dmcn.16255

Jeanette Tinggaard, Signe V Pedersen, Mads L Larsen, Andreas K Jensen, Gorm Greisen, Bo M Hansen, Christina E Hoei-Hansen

{"title":"The risk of epilepsy after neonatal seizures.","authors":"Jeanette Tinggaard, Signe V Pedersen, Mads L Larsen, Andreas K Jensen, Gorm Greisen, Bo M Hansen, Christina E Hoei-Hansen","doi":"10.1111/dmcn.16255","DOIUrl":"https://doi.org/10.1111/dmcn.16255","url":null,"abstract":"Aim: To estimate the cumulative risk of epilepsy after neonatal seizures and identify subpopulations at increased risk.Method: This was a nationwide register-based cohort study including all children born in Denmark between 1997 and 2018. The cumulative risk of epilepsy in children with and without neonatal seizures was compared. Furthermore, neonatal seizures were stratified according to aetiology.Results: We followed 1 294 377 children and identified 1998 neonatal survivors with neonatal seizures. The cumulative risk of epilepsy was 20.4% (95% confidence interval [CI] = 18.5-22.3) among children with neonatal seizures, compared to 1.15% (95% CI = 1.12-1.18) among children without. Epilepsy was diagnosed before 1 year of age in 11.4% of children with neonatal seizures, in an additional 4.5% between 1 year and 5 years, 3.1% between 5 years and 10 years, and 1.4% between 10 years and 22 years. The aetiologies of neonatal cerebral infarction, haemorrhage, or malformations (adjusted hazard ratio = 2.49, 95% CI = 1.98-3.14) and low Apgar score (1.49, 95% CI = 1.12-1.98) were associated with the highest risk of epilepsy, compared to children with seizures of unknown aetiology.Interpretation: Epilepsy after neonatal seizures is common and remains a substantial risk throughout childhood. Aetiological risk factors are identifiable and relevant when planning appropriate information for parents and follow-up.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review. 使用功能性近红外光谱评估脑性瘫痪的皮质活动、功能连通性和神经可塑性：范围综述。

IF 3.8 2区医学

Developmental Medicine and Child Neurology Pub Date : 2025-02-18 DOI: 10.1111/dmcn.16238

Owais A Khan, Simin Rahman, Kanishka Baduni, Christopher M Modlesky

{"title":"Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review.","authors":"Owais A Khan, Simin Rahman, Kanishka Baduni, Christopher M Modlesky","doi":"10.1111/dmcn.16238","DOIUrl":"https://doi.org/10.1111/dmcn.16238","url":null,"abstract":"Aim: To map and critically appraise the literature on the feasibility and current use of functional near-infrared spectroscopy (fNIRS) to assess cortical activity, functional connectivity, and neuroplasticity in individuals with cerebral palsy (CP).Method: A scoping review methodology was prospectively registered and reported following Preferred Reporting Items for Systematic review and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR) guidelines. A systematic search was conducted in four databases. Empirical studies using fNIRS to assess neural activity, functional connectivity, or neuroplasticity in individuals with CP aged 3 years or older were included.Results: Sixteen studies met the inclusion criteria. Individuals with CP (age range = 3-43 years; 70% unilateral CP) underwent fNIRS-based assessment for task-evoked activity (studies [n] = 15) and/or resting-state functional connectivity (n = 3). Preliminary observations suggest greater magnitude, extent, and ipsilateral hemispheric lateralization of sensorimotor cortex activity in CP, while magnitude and patterns of prefrontal cortex activity in CP appear dependent on task demands. Normalization of fNIRS-based activity metrics observed postintervention (n = 3) paralleled improvements in functional outcomes, highlighting their potential as promising biomarkers for functional gains in CP.Interpretation: This review details the use of fNIRS in CP, highlights research gaps and technical limitations, and offers recommendations to support fNIRS implementation for ecologically valid functional neuroimaging in individuals with CP.","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0