Transcranial direct current stimulation and motor function in children with cerebral palsy: A systematic review and meta-analysis.

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Developmental Medicine and Child Neurology Pub Date : 2025-05-13 DOI:10.1111/dmcn.16365

Hyunjoon Kim, Marie M Kelly, Xiwen Su, Claudio L Ferre

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引用次数: 0

Abstract

Aim: To provide meta-analytical evidence regarding the effects of transcranial direct current stimulation (tDCS) on motor function in children with cerebral palsy (CP) across different stimulation protocols.

Method: Using JBI methodology, we applied a random effects model to quantify motor function changes after tDCS. Moderator analyses examined the impact of electrode polarity and stimulation site. Subgroup analyses evaluated the impact of therapy inclusion and the number of sessions.

Results: tDCS improved motor function in children with CP (Hedges' g = 0.53; 95% confidence interval [CI] = 0.24-0.81). Moderator analyses revealed statistically significant efficacy of anodal tDCS (Hedges' g = 0.73; 95% CI = 0.45-1.02), especially applied to the primary motor cortex (M1) (Hedges' g = 0.81; 95% CI = 0.52-1.11). Subgroup analyses showed tDCS efficacy with (Hedges' g = 0.86; 95% CI = 0.52-1.20) and without therapy (Hedges' g = 0.70; 95% CI = 0.21-1.19), and in single (Hedges' g = 0.85; 95% CI = 0.39-1.31) and multiple sessions (Hedges' g = 0.78; 95% CI = 0.42-1.14). Limb-specific analysis showed positive effects for lower-limb function (Hedges' g = 0.88; 95% CI = 0.50-1.25). When anodal tDCS was applied to the M1, both lower (Hedges' g = 1.02; 95% CI = 0.70-1.35) and upper (Hedges' g = 0.50; 95% CI = 0.16-0.83) limbs showed improvements.

Interpretation: Anodal tDCS, particularly when applied to the M1, may effectively improve motor function in children with CP.

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经颅直流电刺激对脑瘫儿童运动功能的影响：一项系统综述和荟萃分析。

目的：为不同刺激方案下经颅直流电刺激（tDCS）对脑瘫儿童运动功能的影响提供meta分析证据。方法：采用JBI方法，采用随机效应模型量化tDCS后运动功能的变化。慢化剂分析检查了电极极性和刺激部位的影响。亚组分析评估了纳入治疗的影响和疗程的数量。结果：tDCS可改善CP患儿的运动功能(Hedges’g = 0.53；95%置信区间[CI] = 0.24-0.81)。调节分析显示，阳极tDCS的疗效具有统计学意义(Hedges' g = 0.73；95% CI = 0.45-1.02)，尤其适用于初级运动皮层（M1） (Hedges' g = 0.81；95% ci = 0.52-1.11)。亚组分析显示tDCS疗效显著(Hedges’g = 0.86；95% CI = 0.52-1.20)和未治疗(Hedges’g = 0.70；95% CI = 0.21-1.19)和单一(Hedges的g = 0.85；95% CI = 0.39-1.31)和多个疗程(Hedges的g = 0.78；95% ci = 0.42-1.14)。肢体特异性分析显示对下肢功能有积极作用(Hedges' g = 0.88；95% ci = 0.50-1.25)。当负极tDCS应用于M1时，两者均降低(Hedges' g = 1.02；95% CI = 0.70-1.35)和更高(Hedges' g = 0.50；95% CI = 0.16-0.83)。解释：阳极tDCS，特别是应用于M1时，可以有效改善CP患儿的运动功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Medicine and Child Neurology 医学-临床神经学

CiteScore

7.80

自引率

13.20%

发文量

338

审稿时长

3-6 weeks

期刊介绍： Wiley-Blackwell is pleased to publish Developmental Medicine & Child Neurology (DMCN), a Mac Keith Press publication and official journal of the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and the British Paediatric Neurology Association (BPNA). For over 50 years, DMCN has defined the field of paediatric neurology and neurodisability and is one of the world’s leading journals in the whole field of paediatrics. DMCN disseminates a range of information worldwide to improve the lives of disabled children and their families. The high quality of published articles is maintained by expert review, including independent statistical assessment, before acceptance.