International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases最新文献_第7页

Factors and virological significance of hepatitis B virus pregenomic RNA status after 5 years of antiviral therapy. 抗病毒治疗5年后乙型肝炎病毒基因组前RNA状态的影响因素及病毒学意义

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-03-03 DOI: 10.1016/j.ijid.2021.02.116

Jiali Pan, Jinghang Xu, Hao Luo, Ning Tan, Qian Kang, Hongyu Chen, Ran Cheng, Yifan Han, Yuqing Yang, Xiaoyuan Xu

{"title":"Factors and virological significance of hepatitis B virus pregenomic RNA status after 5 years of antiviral therapy.","authors":"Jiali Pan, Jinghang Xu, Hao Luo, Ning Tan, Qian Kang, Hongyu Chen, Ran Cheng, Yifan Han, Yuqing Yang, Xiaoyuan Xu","doi":"10.1016/j.ijid.2021.02.116","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.116","url":null,"abstract":"Objectives: To investigate the factors and virological significance of serum hepatitis B virus (HBV) pregenomic RNA (pgRNA) status after long-term antiviral therapy with nucleos(t)ide analogues (NAs) in patients with chronic hepatitis B (CHB).Methods: In total, 51 treatment-naïve patients with CHB were included in the study. Clinical data were collected at baseline, during 5 years and at year 10 of NA treatment. Serum HBV pgRNA status of 51 patients was determined at year 5.Results: At year 5, 45% of the patients remained positive for HBV pgRNA. There were significant differences in baseline hepatitis B e antigen (HBeAg) status, HBV DNA load and hepatitis B surface antigen (HBsAg) levels between patients testing positive and negative for HBV pgRNA at year 5. Serum HBV pgRNA status and serum HBV DNA load were correlated after 5 years of NA treatment (r = 0.347, P = 0.013). Being HBV pgRNA positive at year 5 was an independent risk factor for sustainedly undetectable HBV DNA after 10 years of NA treatment (odds ratio 13.638, 95% confidence interval 1.32-140.81; P = 0.028). Furthermore, HBV pgRNA status at year 5 was associated with HBV DNA re-appearance at year 10 (P = 0.009).Conclusions: HBV pgRNA status at year 5 can reveal HBV covalently closed circular DNA (cccDNA) activity, and HBV pgRNA positivity after long-term antiviral therapy may indicate higher transcriptional activity of HBV cccDNA. Long-term dynamic monitoring of HBV pgRNA should be considered.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"418-423"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25442822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Multiple colon ulcers in a patient with HIV: Do not forget amoebiasis. 艾滋病患者多发结肠溃疡:不要忘记阿米巴病。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-03-15 DOI: 10.1016/j.ijid.2021.03.028

Satoshi Hayano, Ryo Yoshimaru, Michiko Nagamine

引用次数: 0

Prevalence and genotype distribution of hepatitis C virus in Mongolia: Systematic review and meta-analysis. 蒙古丙型肝炎病毒的流行和基因型分布:系统回顾和荟萃分析

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-02-15 DOI: 10.1016/j.ijid.2021.02.040

Karima Chaabna, Delgermaa Dashzeveg, Tserendulam Shagdarsuren, Rami H Al-Rifai

{"title":"Prevalence and genotype distribution of hepatitis C virus in Mongolia: Systematic review and meta-analysis.","authors":"Karima Chaabna, Delgermaa Dashzeveg, Tserendulam Shagdarsuren, Rami H Al-Rifai","doi":"10.1016/j.ijid.2021.02.040","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.040","url":null,"abstract":"Objective: To characterize hepatitis C virus (HCV) infection epidemiology in Mongolia.Method: Publications on HCV antibody (Ab) and RNA prevalence, and/or genotypes/subtypes were systematically reviewed and reported following PRISMA guidelines. Random-effects meta-analyses and age adjustments were conducted to estimate the prevalence of Mongolians exposed to HCV (pooled HCV-Ab prevalence) by time period, sex, and at-risk populations; and to estimate the prevalence of chronically-infected HCV individuals.Results: The national pooled HCV-Ab prevalence was 12.3% in 2000-2009 and 11.2% in 2013. Sex-specific pooled prevalence appeared higher among females than males (14.0% versus 6.8%). Age-specific pooled prevalence significantly increased from 3.7% among children (aged 0-10 years) to 34.1% among people aged ≥50 years (p < 0.001). Among the adult general population (low-risk population), the national age-adjusted prevalence was 8.1%. Age-adjusted chronic infection prevalence in adults was 6.0%. Among healthcare workers, pooled prevalence was 18.0%. Among patients with liver diseases, pooled prevalence was 53.7%. Among individuals engaging in risky sexual behaviors, pooled prevalence was 11.1%. The identified circulating genotypes/subtypes were 1b (58.0%), 2a (21.7%), and 1a (20.2%).Conclusion: The national HCV prevalence in Mongolia appeared to be among the highest worldwide. Higher prevalence in the clinical setting indicated potential ongoing HCV iatrogenic and occupational transmission. Additionally, HCV transmission in community settings should be investigated.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"377-388"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25380674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Prevalence and associated factors of diabetes mellitus among tuberculosis patients in Brunei Darussalam: A 6-year retrospective cohort study. 文莱达鲁萨兰国肺结核患者糖尿病患病率及相关因素:一项为期6年的回顾性队列研究

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-02-18 DOI: 10.1016/j.ijid.2021.02.064

Nurfakhrina Omar, Justin Wong, Kyaw Thu, Md Fathi Alikhan, Liling Chaw

{"title":"Prevalence and associated factors of diabetes mellitus among tuberculosis patients in Brunei Darussalam: A 6-year retrospective cohort study.","authors":"Nurfakhrina Omar, Justin Wong, Kyaw Thu, Md Fathi Alikhan, Liling Chaw","doi":"10.1016/j.ijid.2021.02.064","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.064","url":null,"abstract":"Objectives: To determine the prevalence and associated factors of diabetes mellitus (DM) among tuberculosis (TB) cases in Brunei Darussalam.Methods: We conducted a retrospective cohort study among all TB patients registered between 2013 and 2018. Collected data include sociodemographics, comorbidities, and information related to their TB diagnosis and treatment outcomes. Associated factors of having DM among TB patients were investigated using logistic regression analyses.Results: We identified a total of 1362 TB patients, among which 462 (33.9% [95%CI: 31.4%,36.5%]) also have DM. 70.6% (n = 326) were diagnosed with DM at least six months prior to their TB diagnosis. The incidence of newly diagnosed DM among TB patients was 74.2 per 1000 population. Significant factors of having TB and DM comorbidity were age (adjusted OR (adj. OR) = 1.04 [95%CI: 10.3,1.05]), classified as smear-positive pulmonary TB (adj. OR = 5.77 [95%CI: 3.71,9.22]), having the following underlying conditions: hypertension/heart disease (adj. OR = 24.05 [95%CI: 5.80,100.05]), renal disease (adj. OR = 7.34 [95%CI: 2.88,20.22]) and chronic obstructive pulmonary disease/asthma (adj. OR = 0.38 [95%CI: 0.22,0.64]).Conclusion: About one-third of TB cases in Brunei were also diagnosed with DM. Bi-directional screening could be a good strategy to facilitate early detection and treatment of both diseases.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"267-273"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25387604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Clonal lineages and antimicrobial resistance of nonencapsulated Streptococcus pneumoniae in the post-pneumococcal conjugate vaccine era in Japan. 日本后肺炎球菌结合疫苗时代非包封肺炎链球菌的克隆谱系和耐药性

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-03-03 DOI: 10.1016/j.ijid.2021.02.109

Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Ayako Sumi, Nobumichi Kobayashi

{"title":"Clonal lineages and antimicrobial resistance of nonencapsulated Streptococcus pneumoniae in the post-pneumococcal conjugate vaccine era in Japan.","authors":"Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Ayako Sumi, Nobumichi Kobayashi","doi":"10.1016/j.ijid.2021.02.109","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.109","url":null,"abstract":"Objectives: The emergence and spread of nonencapsulated Streptococcus pneumoniae (NESp) is a public health concern in the post-pneumococcal conjugate vaccine era. We analyzed the prevalence, molecular characteristics, and antimicrobial resistance of NESp responsible for noninvasive infections in northern Japan.Methods: NESp isolates were identified using molecular and phenotypical methods among 4463 S. pneumoniae isolates from noninvasive infection cases during 4 study periods between January 2011 and January 2019. NESp isolates were analyzed for antimicrobial susceptibility, genotype, and virulence-associated genes.Results: Seventy-one NESp isolates were identified (1.6% of total clinical isolates) and assigned to the null capsule clade (NCC)1 (pspK+) (94.4%) or NCC2 (aliC+/aliD+) (5.6%). The dominant sequence types (STs) were ST7502 (23.9%), ST4845 (19.7%), ST16214 (11.3%), ST11379 (9.9%), and ST7786 (7.0%). These 5 dominant STs and all 7 novel STs were related to the sporadic NESp lineage ST1106 or PMEN clone Denmark14-ST230. High non-susceptibility rates of NESp were observed for trimethoprim-sulfamethoxazole, erythromycin, and tetracycline (>92.9%), and multidrug resistance was observed in 88.7% of the NESp isolates, including all ST7502, ST4845, and ST11379 isolates.Conclusions: The study revealed that the dominant clonal groups of NESp were associated with a high prevalence of non-susceptibility to antimicrobials in northern Japan.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"695-701"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25442824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Epidemiological and clinical profile between influenza A and B virus in Costa Rican children. 哥斯达黎加儿童甲型和乙型流感病毒的流行病学和临床特征。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-03-09 DOI: 10.1016/j.ijid.2021.03.006

Silvia Ávila-Morales, Sebastián Ospina-Henao, Rolando Ulloa-Gutierrez, María L Ávila-Agüero

{"title":"Epidemiological and clinical profile between influenza A and B virus in Costa Rican children.","authors":"Silvia Ávila-Morales, Sebastián Ospina-Henao, Rolando Ulloa-Gutierrez, María L Ávila-Agüero","doi":"10.1016/j.ijid.2021.03.006","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.03.006","url":null,"abstract":"Objective: We aimed to evaluate the clinical and epidemiological behavior of influenza type A versus type B and analyze if there was any correlation or differences between the characteristics of both groups.Methods: An observational, retrospective, descriptive, and population-based study based of children who were hospitalized at the only national pediatric hospital of Costa Rica from January 1, 2010 to December 31, 2018 and had a confirmed influenza virus infection.Results: 336 patients were analyzed. Mean age was 35,6 ± 36,7 months (3,0 ± 3,1 years). The only significant variables at 25% in relation to influenza type A or B virus were: sex, month of diagnosis, fever, vomiting, cough, use of antibiotics and admission to the PICU. The hospitalization rate at our hospital increased between the months of October to December, with a higher percentage of cases in November and December, which reveals that the \"real peak\" in our population begins between 3 to 4 months after the end of the vaccination campaign. Patients with influenza A virus had a 2.5 times greater risk of being admitted to the PICU. Mortality rate was 0.6% and 0% among influenza A and B children, respectively.Conclusions: Variables in which a causality was found with type A or B virus were: admission to the PICU, month of diagnosis, and cough. However, influenza B clinical behavior continues to be unpredictable.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"763-768"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.03.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25469785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15. 2014- 2015年丹麦性活跃的男男性行为hiv感染者中脑膜炎奈瑟菌的口腔和肛门携带情况

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-02-18 DOI: 10.1016/j.ijid.2021.02.062

Michaela Tinggaard, Hans-Christian Slotved, Kurt Fuursted, Maiken Worsøe Rosenstierne, Gitte Kronborg, Anne-Mette Lebech, Kristina Thorsteinsson, Terese L Katzenstein, Merete Storgaard, Inge Kristine Holden, Isik Somuncu Johansen, Thomas Benfield

{"title":"Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15.","authors":"Michaela Tinggaard, Hans-Christian Slotved, Kurt Fuursted, Maiken Worsøe Rosenstierne, Gitte Kronborg, Anne-Mette Lebech, Kristina Thorsteinsson, Terese L Katzenstein, Merete Storgaard, Inge Kristine Holden, Isik Somuncu Johansen, Thomas Benfield","doi":"10.1016/j.ijid.2021.02.062","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.062","url":null,"abstract":"Introduction: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV.Methods: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis.Results: Among 82 MSM, the Nm carriage rate was 31.7% (95% CI 21.9-42.9) at baseline. The oral carriage rate was 24.4% (95% CI 15.6-35.1) and the anal rate was 11.0% (95% CI 5.1-19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up.Conclusion: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"337-344"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25387602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Recrudescence of a high parasitaemia, severe Plasmodium falciparum malaria episode, treated by artesunate monotherapy. 高寄生虫血症复发，严重恶性疟原虫疟疾发作，用青蒿琥酯单药治疗。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-02-23 DOI: 10.1016/j.ijid.2021.02.080

Sophie Landre, Anne-Lise Bienvenu, Patrick Miailhes, Paul Abraham, Marie Simon, Agathe Becker, Anne Conrad, Guillaume Bonnot, Yobouet Ines Kouakou, Christian Chidiac, Gilles Leboucher, Thomas Rimmelé, Laurent Argaud, Stephane Picot

引用次数: 3

Global COVID-19 vaccine equity should precede requiring travelers proof of vaccination. 在要求旅行者提供疫苗接种证明之前，应确保全球COVID-19疫苗公平。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-02-26 DOI: 10.1016/j.ijid.2021.02.061

Carlos Franco-Paredes, Jose Antonio Suarez, Andrés F Henao-Martínez

引用次数: 6

In response to: Multiple assays in a real-time RT-PCR severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) panel can mitigate the risk of loss of sensitivity by new genomic variants during the COVID-19 outbreak. 针对以下问题:在COVID-19疫情期间，严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)实时RT-PCR检测组中的多项检测可降低新基因组变异导致敏感性丧失的风险。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-04-01 Epub Date: 2021-01-27 DOI: 10.1016/j.ijid.2021.01.049

Luis Peñarrubia, Maria Ruiz, Roberto Porco, Sonia N Rao, Stephen A Vella, Martí Juanola-Falgarona, Davide Manissero, Marta López-Fontanals, Josep Pareja

引用次数: 4