International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases最新文献_第10页

Population pharmacokinetic model of isoniazid in patients with tuberculosis in Tunisia. 突尼斯肺结核患者异烟肼人群药代动力学模型。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-01-19 DOI: 10.1016/j.ijid.2021.01.033

N Ben Fredj, H Ben Romdhane, J B Woillard, M Chickaid, N Ben Fadhel, Z Chadly, A Chaabane, N Boughattas, K Aouam

{"title":"Population pharmacokinetic model of isoniazid in patients with tuberculosis in Tunisia.","authors":"N Ben Fredj, H Ben Romdhane, J B Woillard, M Chickaid, N Ben Fadhel, Z Chadly, A Chaabane, N Boughattas, K Aouam","doi":"10.1016/j.ijid.2021.01.033","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.01.033","url":null,"abstract":"Aims: To develop a pharmacokinetic model of isoniazid (INH) concentration taking into account demographic factors and genetic variables [N-acetyltransferase 2 (NAT2) genotype], and to propose an initial INH dosage that could maximize the probability of achieving the desired INH concentration.Methods: A retrospective analysis was undertaken of INH concentration data collected from patients with tuberculosis in Tunisia.Results: In total, 118 patients were included in this study. The one-compartment model [volume of distribution (V), elimination rate (Ke)] was found to have good predictive performance. Multi-variate analysis showed that NAT2 affected both V and Ke significantly, but age, gender and weight did not. Internal validation of the final model showed correlation of 0.95 between individual predicted INH concentration 3 h after drug intake (C3) and observed C3. External validation showed that percentage mean absolute prediction error and percentage root mean squared error were 9.11% (range 0.62-35.8%) and 11.6%, respectively. Monte-Carlo simulation showed that doses of at least 225 mg/24 h and at least 450 mg/24 h attained a therapeutic concentration in >80% of patients in the NAT2 slow acetylator group and the NAT2 rapid/intermediate acetylator group, respectively.Conclusion: The pharmacokinetic model allowed optimization of individual dosing regimens of INH in patients with tuberculosis in Tunisia. This tool may facilitate improved efficacy of INH and prevent its toxicity in this population.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"562-567"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.01.033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38844228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnostic value of the modified Duke criteria in suspected infective endocarditis -The PRO-ENDOCARDITIS study. 改良的Duke标准在疑似感染性心内膜炎中的诊断价值——PRO-ENDOCARDITIS研究。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-01-27 DOI: 10.1016/j.ijid.2021.01.046

Amir A Mahabadi, Ihab Mahmoud, Iryna Dykun, Matthias Totzeck, Peter-Michael Rath, Arjang Ruhparwar, Jan Buer, Tienush Rassaf

{"title":"Diagnostic value of the modified Duke criteria in suspected infective endocarditis -The PRO-ENDOCARDITIS study.","authors":"Amir A Mahabadi, Ihab Mahmoud, Iryna Dykun, Matthias Totzeck, Peter-Michael Rath, Arjang Ruhparwar, Jan Buer, Tienush Rassaf","doi":"10.1016/j.ijid.2021.01.046","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.01.046","url":null,"abstract":"Objectives: To determine whether relevant comorbidities stratify patients with and without IE and whether these may improve the diagnostic accuracy, in addition to the modified Duke criteria.Methods and results: 261 consecutive patients (aged 60.1 ± 16.1 years, 62.8% male) with suspected IE were prospectively included in this single-center observational trial. Modified Duke criteria and relevant comorbidities as well as clinical characteristics, were assessed. Forty-seven patients had IE, as confirmed by a clinical event committee. Patients with IE had a higher frequency of positive blood cultures (70.2% vs. 36.9%, p < 0.0001), embolic diseases (36.2% vs. 10.8%, p < 0.0001), heart murmurs (27.7% vs. 11.7%, p = 0.01), and intensive care therapy (74.5% vs. 58.4%, p = 0.04). In receiver operating characteristics, the combination of modified Duke criteria without transesophageal echocardiography led to an area under the curve of 0.783 (0.715-0.851). The predictive value was only marginally improved by the addition of heart murmur and intensive care therapy (0.794 [0.724-0.863]). In contrast, transesophageal echocardiography alone achieved an area under the curve of 0.956 (0.937-0.977) and was further improved when adding modified Duke criteria, heart murmur, and intensive care therapy (0.999 [0.998-1.000]).Conclusion: Modified Duke criteria provide excellent diagnostic value for evaluating suspected IE, mainly driven by transesophageal echocardiography.Trial registration: NCT03365193.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"556-561"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.01.046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38870373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Rapidly fatal tropical pyomyositis in an elderly diabetic woman. 1例老年糖尿病妇女迅速致死性热带肌炎。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-02-01 DOI: 10.1016/j.ijid.2021.01.060

Cindy Tiemi Matsumoto, Stefânia Bazanelli Prebianchi, Nancy Cristina Junqueira Bellei, Gilberto Turcato, Marcelo Nascimento Burattini

{"title":"Rapidly fatal tropical pyomyositis in an elderly diabetic woman.","authors":"Cindy Tiemi Matsumoto, Stefânia Bazanelli Prebianchi, Nancy Cristina Junqueira Bellei, Gilberto Turcato, Marcelo Nascimento Burattini","doi":"10.1016/j.ijid.2021.01.060","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.01.060","url":null,"abstract":"Necrotizing soft tissue infection, with or without myositis, is classified among the most dangerous infectious emergencies in clinical practice. The authors report a case of an older diabetic woman who presented to the orthopedic service with right elbow pain after a small trauma with skin abrasion and released with an analgesic prescription. After 48h, she presented to the emergency room with a history of developing bullous and necrotic lesions in the upper right limb, hypotension, and numbness, with rapid and fatal evolution despite adequate clinical and surgical therapeutic support. Muscle biopsy showed necrotizing myositis. Blood culture was positive for Panton-Valentine leukocidin producing (PVL-positive) methicillin-resistant S. aureus. Although PVL has a strong epidemiologic association with Community-Acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, it can also be found in CA-MSSA in the context of necrotizing pneumonia and skin and soft tissue infections. Although infrequent, CA-MRSA or CA-MSSA PVL+ infections should always be suspected in high-risk patients because they can rapidly evolve with severe, sometimes fatal complications.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"677-679"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.01.060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25332772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterium tuberculosis sterilizing activity of faropenem, pyrazinamide and linezolid combination and failure to shorten the therapy duration. 法罗培南、吡嗪酰胺和利奈唑胺联合对结核分枝杆菌的杀菌活性及缩短治疗时间的失败。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-02-05 DOI: 10.1016/j.ijid.2021.01.062

Tawanda Gumbo, Carleton M Sherman, Devyani Deshpande, Jan-Willem Alffenaar, Shashikant Srivastava

{"title":"Mycobacterium tuberculosis sterilizing activity of faropenem, pyrazinamide and linezolid combination and failure to shorten the therapy duration.","authors":"Tawanda Gumbo, Carleton M Sherman, Devyani Deshpande, Jan-Willem Alffenaar, Shashikant Srivastava","doi":"10.1016/j.ijid.2021.01.062","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.01.062","url":null,"abstract":"Background: Faropenem (F), an orally bioavailable β-lactam, kills Mycobacterium tuberculosis (Mtb) without the help of a β-lactamase inhibitor. This study explored the sterilizing effect of adding F once or twice daily to a linezolid (L) plus pyrazinamide (Z) backbone regimen.Methods: In vitro studies were performed using the hollow fiber model of tuberculosis (HFS-TB) to compare the kill rates of: 1) ZL two-drug combination; 2) F administered once daily plus ZL (F1ZL); 3) F administered twice-daily plus once daily ZL (F2ZL); 4) F2ZL with high-dose Z (F2ZhiL); 5) standard therapy of isoniazid, rifampin and Z; and 6) non-treated controls. The study was performed over 56 days with three HFS-TB replicates for each regimen.Results: Mtb in the non-treated HFS-TB grew at a rate of 0.018 ± 0.007 log10 CFU/mL/day. The exponential kill rates for standard therapy were 6.6-13.2-fold higher than ZL dual therapy. The F1ZL and F2ZL regimens ranked third. The pre-existing isoniazid-resistant sub-population in the inoculum (1.34 ± 0.57 log10 CFU/mL) grew to 4.21 ± 0.58 log10 CFU/mL in 56 days in non-treated HFS-TB. However, no isoniazid-resistant sub-population was recorded in any of the FZL combination regimens.Conclusion: Due to the slow kill rate compared to standard therapy, FZL regimens are unlikely to shorten therapy duration. Efficacy of these regimens against drug-resistant tuberculosis needs to be determined.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"680-684"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.01.062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25347646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Severe iron-deficiency anaemia due to hookworm infection diagnosed by capsule endoscopy. 胶囊内窥镜诊断钩虫感染所致严重缺铁性贫血。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-01-11 DOI: 10.1016/j.ijid.2021.01.014

Hasna Chergui, Mohammad Akhoundi, Anthony Marteau, Bakhtiar Bejou, Celine Lekhal, David Deutsch, Stephane Mantelet, Robert Benamouzig, Arezki Izri

引用次数: 2

The moving epidemic method applied to influenza surveillance in Guangdong, China. 移动流行法在广东省流感监测中的应用。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-01-27 DOI: 10.1016/j.ijid.2021.01.058

Min Kang, Xiaohua Tan, Meiyun Ye, Yu Liao, Tie Song, Shixing Tang

{"title":"The moving epidemic method applied to influenza surveillance in Guangdong, China.","authors":"Min Kang, Xiaohua Tan, Meiyun Ye, Yu Liao, Tie Song, Shixing Tang","doi":"10.1016/j.ijid.2021.01.058","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.01.058","url":null,"abstract":"Objectives: The moving epidemic method (MEM) has been well used for assessing seasonal influenza epidemics in temperate regions. This study used the MEM to establish epidemic threshold for influenza in Guangdong, a subtropical province in China.Methods: Influenza virology surveillance data from 2011/2012 to 2017/2018 seasons in Guangdong were used with the MEM to calculate the epidemic thresholds and timeously detect the 2018/2019 influenza season epidemic. The weekly positive proportion of influenza A(H1N1)pdm09, A(H3N2), B/Victoria-lineage and B/Yamagata-lineage were separately adapted to calculate the subtype-specific epidemic thresholds. The performance of MEM was evaluated using a cross-validation procedure.Results: For the 2018/2019 influenza season, the epidemic threshold of a weekly positive proportion was 15.08%. Epidemic detection for the 2018/2019 season was 1 week in advance. Influenza A(H1N1)pdm09, B/Yamagata-lineage and B/Victoria-lineage prevailed during winter and spring and their epidemic thresholds were 5.12%, 4.53% and 4.38%, respectively. Influenza A(H3N2) was active in the summer, with an epidemic threshold of 11.99%.Conclusions: Using influenza virology surveillance data stratified by types of influenza virus, the MEM was effectively used in Guangdong, China. This study provided a practical way for subtropical regions to establish local influenza epidemic thresholds.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"594-600"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.01.058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25311654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Candida parapsilosis neutropenic enterocolitis. 假丝酵母菌傍空空性嗜中性粒细胞减少性小肠结肠炎。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-01-09 DOI: 10.1016/j.ijid.2020.12.084

Shuku Sato, Yotaro Tamai

引用次数: 0

Pulmonary vasculitis due to infection with Mycobacterium goodii: A case report. 好地分枝杆菌感染致肺血管炎1例。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2020-12-29 DOI: 10.1016/j.ijid.2020.12.074

Elena Pfeuffer-Jovic, Jan Heyckendorf, Udo Reischl, Rainer M Bohle, Thorsten Bley, Andreas Buck, Heinrike Wilkens, Hans-Joachim Schäfers, Heinz-Jakob Langen, Matthias Held

引用次数: 0

Extending contact screening within a 50-m radius of an index tuberculosis patient using Xpert MTB/RIF in urban Pakistan: Did it impact treatment outcomes? 在巴基斯坦城市使用Xpert MTB/RIF在指数结核病患者半径50米范围内扩大接触筛查:是否影响治疗结果?

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2021-01-27 DOI: 10.1016/j.ijid.2021.01.054

Mahboob Ul Haq, Sven G Hinderaker, Razia Fatima, Hemant Deepak Shewade, Einar Heldal, Abdullah Latif, Ajay M V Kumar

{"title":"Extending contact screening within a 50-m radius of an index tuberculosis patient using Xpert MTB/RIF in urban Pakistan: Did it impact treatment outcomes?","authors":"Mahboob Ul Haq, Sven G Hinderaker, Razia Fatima, Hemant Deepak Shewade, Einar Heldal, Abdullah Latif, Ajay M V Kumar","doi":"10.1016/j.ijid.2021.01.054","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.01.054","url":null,"abstract":"Background: Pakistan implemented initiatives to detect tuberculosis (TB) patients through extended contact screening (ECS); it improved case detection but treatment outcomes need assessment.Objectives: To compare treatment outcomes of pulmonary TB (PTB) patients detected by ECS with those detected by routine passive case finding (PCF).Methods: A cohort study using secondary program data conducted in Lahore, Faisalabad and Rawalpindi districts and Islamabad in 2013-15. We used log binomial regression models to assess if ECS was associated with unfavorable treatment outcomes (death, loss-to-follow-up, failure, not evaluated) after adjusting for potential confounders.Results: We included 79,431 people with PTB; 4604 (5.8%) were detected by ECS with 4052 (88%) bacteriologically confirmed. In all PTB patients the proportion with unfavorable outcomes was not significantly different in ECS group (9.6%) compared to PCF (9.9%), however, among bacteriologically confirmed patients unfavorable outcomes were significantly lower in ECS (9.9%) than PCF group (11.6%, P = 0.001). ECS was associated with a lower risk of unfavorable outcomes (adjusted relative risk (aRR) 0.90; 95% CI 0.82-0.99) among 'all PTB' patients and bacteriologically confirmed PTB patients (aRR 0.91; 95% CI 0.82-1.00).Conclusion: In PTB patients detected by ECS the treatment outcomes were not inferior to those detected by PCF.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"634-640"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.01.054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25311713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cowpox: How dangerous could it be for humans? Case report. 牛痘:对人类有多危险?病例报告。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2021-03-01 Epub Date: 2020-12-24 DOI: 10.1016/j.ijid.2020.12.061

Dagny C Krankowska, Piotr A Woźniak, Aneta Cybula, Justyna Izdebska, Magdalena Suchacz, Katarzyna Samelska, Alicja Wiercińska-Drapało, Jacek P Szaflik

{"title":"Cowpox: How dangerous could it be for humans? Case report.","authors":"Dagny C Krankowska, Piotr A Woźniak, Aneta Cybula, Justyna Izdebska, Magdalena Suchacz, Katarzyna Samelska, Alicja Wiercińska-Drapało, Jacek P Szaflik","doi":"10.1016/j.ijid.2020.12.061","DOIUrl":"https://doi.org/10.1016/j.ijid.2020.12.061","url":null,"abstract":"Cowpox is a rare zoonosis transmitted to humans mainly from cats. The disease usually causes skin lesions; however, the ocular form may lead to other serious complications. We describe a case of cowpox in a rare location of the upper eyelid of an immunocompetent male, which lead to necrosis of the upper eyelid, keratitis and leucomatous opacity, and the neovascularization of the cornea. The patient underwent several surgeries, including reconstruction surgery of the eyelids, correction of the medial canthus, and corneal neurotization with supraorbicular nerve transplantation. Suspicion of cowpox should be made in patients where there are poorly healing skin lesions accompanied by a painful black eschar with erythema and local lymphadenopathy. Ocular cowpox may lead to serious complications and possibly mimic anthrax. Diagnosis of cowpox can be confirmed by detection of cowpox virus DNA by polymerase chain reaction. Patients should be advised to protect themselves while handling sick animals.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"239-241"},"PeriodicalIF":8.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38748676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6