International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases最新文献

Mitochondrial DNA content as a diagnostic marker for antituberculosis drug-induced liver injury. 线粒体DNA含量作为抗结核药物性肝损伤的诊断指标。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-08-02 DOI: 10.1016/j.ijid.2022.07.071

Wanvisa Udomsinprasert, Jiraphun Jittikoon, Usa Chaikledkaew, Wacharapol Saengsiwaritt, Noppadol Chanhom, Supharat Suvichapanich, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Wasun Chantratita

{"title":"Mitochondrial DNA content as a diagnostic marker for antituberculosis drug-induced liver injury.","authors":"Wanvisa Udomsinprasert, Jiraphun Jittikoon, Usa Chaikledkaew, Wacharapol Saengsiwaritt, Noppadol Chanhom, Supharat Suvichapanich, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Wasun Chantratita","doi":"10.1016/j.ijid.2022.07.071","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.071","url":null,"abstract":"Objectives: This study aimed to investigate whether mitochondrial DNA (mtDNA) content, an index of mitochondrial dysfunction, was associated with clinical parameters indicating anti-tuberculosis (TB) drug-induced liver injury (ATDILI) in TB patients and could emerge as an ATDILI biomarker.Methods: Leukocyte mtDNA content in 102 TB patients (49 ATDILI cases and 53 non-ATDILI cases) and 100 age-matched healthy controls was measured using real-time polymerase chain reaction.Results: Compared with healthy controls, both TB patients with and without ATDILI had significantly decreased mtDNA content. Compared with the patients without ATDILI, mtDNA content was significantly increased in those with ATDILI. Higher mtDNA content was observed to be independently associated with increased susceptibility to ATDILI. Increased mtDNA content measured within 1-7 days of treatment was independently associated with elevated levels of serum aminotransferases assessed within 8-60 days of treatment. After initiating treatment within 1-7 days, mtDNA content was detected to be more sensitive and selective for differentiating TB patients with ATDILI from those without ATDILI than serum aminotransferases. Kaplan-Meier analysis revealed a significant correlation between elevated mtDNA content and increased rate of ATDILI occurrence in TB patients, attested by Cox regression analysis, adjusting for confounders.Conclusion: Changes in leukocyte mtDNA content would reflect ATDILI progression and could be used as a potential stratification tool for identifying TB patients at risk of ATDILI.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"1034-1040"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Accuracy of Xpert MTB/RIF Ultra for the diagnosis of tuberculosis in adult patients: a retrospective cohort study. Xpert MTB/RIF Ultra诊断成人结核病的准确性:一项回顾性队列研究。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-08 DOI: 10.1016/j.ijid.2022.07.016

Chintan Kaswala, Yvonne Schmiedel, Debasree Kundu, Mithun Mohan George, Divya Dayanand, Emily Devasagayam, Abi Manesh S, Selwyn Selva Kumar, Joy S Michael, Marilyn M Ninan, Geeta Chacko, Anand Zachariah, Sowmya Sathyendra, Samuel George Hansdak, Ramya Iyadurai, Devasahayam Jesudas Christopher, Richa Gupta, Rajiv Karthik, Ooriapadickal Cherian Abraham, George M Varghese

{"title":"Accuracy of Xpert MTB/RIF Ultra for the diagnosis of tuberculosis in adult patients: a retrospective cohort study.","authors":"Chintan Kaswala, Yvonne Schmiedel, Debasree Kundu, Mithun Mohan George, Divya Dayanand, Emily Devasagayam, Abi Manesh S, Selwyn Selva Kumar, Joy S Michael, Marilyn M Ninan, Geeta Chacko, Anand Zachariah, Sowmya Sathyendra, Samuel George Hansdak, Ramya Iyadurai, Devasahayam Jesudas Christopher, Richa Gupta, Rajiv Karthik, Ooriapadickal Cherian Abraham, George M Varghese","doi":"10.1016/j.ijid.2022.07.016","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.016","url":null,"abstract":"Objectives: The value of the \"trace\" result in Xpert Ultra for diagnosing active tuberculosis (TB) remains unclear. Our study evaluated the diagnostic accuracy of Xpert MTB/RIF Ultra (Xpert Ultra) (Cepheid, Sunnyvale, USA) over Xpert MTB/RIF (Xpert) (Cepheid, Sunnyvale, USA) and mycobacterial culture when compared with a composite reference standard (CRS).Methods: A retrospective single-center observational study was conducted in a tertiary care hospital in South India. Over three months, patients (aged ≥15 years) data on Xpert Ultra tests and mycobacterial culture of pulmonary and extrapulmonary samples were extracted from their electronic medical records. Patients were defined as TB cases based on the CRS criteria. Sensitivity, specificity, positive and negative predictive values of diagnostic tests were calculated by comparing them to the CRS.Results: Xpert Ultra was more sensitive (87.8%) than Xpert (72.1%) and culture (44.1%). The specificity of Xpert Ultra was lower (98.1%) than those of Xpert (100%) and culture (100%). The sensitivity (92%) and specificity (100%) of Xpert Ultra were highest when performed on pus samples.Conclusions: Xpert Ultra with the trace category is superior to the conventional Xpert, and mycobacterial culture in identifying TB.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"566-568"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Development and clinical application of a rapid and visual loop-mediated isothermal amplification test for tetM gene in Clostridioides difficile strains cultured from feces. 粪便培养艰难梭菌tetM基因快速、视觉环介导等温扩增试验的建立及临床应用

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-16 DOI: 10.1016/j.ijid.2022.07.032

Minyi Lin, Zitong Li, Qianyun Lin, Pu Wang, Wei Liu, Jing Yuan, Zhongsi Hong, Ye Chen

{"title":"Development and clinical application of a rapid and visual loop-mediated isothermal amplification test for tetM gene in Clostridioides difficile strains cultured from feces.","authors":"Minyi Lin, Zitong Li, Qianyun Lin, Pu Wang, Wei Liu, Jing Yuan, Zhongsi Hong, Ye Chen","doi":"10.1016/j.ijid.2022.07.032","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.032","url":null,"abstract":"Objectives: In this study, we aimed to develop a rapid and visual loop-mediated isothermal amplification (LAMP) assay targeting the tetM gene in Clostridioides difficile strains cultured from feces.Methods: Primers were designed to recognize the tetM gene in C. difficile by LAMP, using turbidity and visual detection. The sensitivity and specificity of LAMP primers were determined. In addition, we conducted both LAMP and polymerase chain reaction (PCR) for the tcdA, tcdB, cdtA, cdtB, ermB, and tetM genes in 300 toxigenic C. difficile strains cultured from feces.Results: The target DNA was amplified and visualized within 60 minutes at a temperature of 62°C. A total of 26 bacterial strains were found negative for tetM, which manifested high specificity of the primers. The detection limit of LAMP was 36.1 pg/µl, which was 100-fold more sensitive than PCR. The positive rate of tetM in toxigenic C. difficile strains cultured from feces was 93.3% by both LAMP and PCR. The proportion of toxin types in those C. difficile strains was 95.7% for A+B+CDT-, 4% for A-B+CDT-, and 0.3% for A+B+CDT+, respectively.Conclusion: This is the first study examining the tetM gene by LAMP in C. difficile strains cultured from feces. Its high specificity, sensitivity, and visual detection make the new assay a powerful diagnostic tool for rapid testing.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"676-684"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40511122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmacokinetics and Safety of WHO-Recommended Dosage and Higher Dosage of Levofloxacin for Tuberculosis Treatment in Children: a Pilot Study. 世卫组织推荐剂量和更高剂量左氧氟沙星治疗儿童结核病的药代动力学和安全性:一项初步研究。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-13 DOI: 10.1016/j.ijid.2022.07.029

Watsamon Jantarabenjakul, Piyarat Suntarattiwong, Noppadol Wacharachaisurapol, Praon Supradish Na Ayudhya, Weeraya Phaisal, Monta Tawan, Juthamanee Moonwong, Tavitiya Sudjaritruk, Pajaree Chariyavilaskul, Thanyawee Puthanakit

{"title":"Pharmacokinetics and Safety of WHO-Recommended Dosage and Higher Dosage of Levofloxacin for Tuberculosis Treatment in Children: a Pilot Study.","authors":"Watsamon Jantarabenjakul, Piyarat Suntarattiwong, Noppadol Wacharachaisurapol, Praon Supradish Na Ayudhya, Weeraya Phaisal, Monta Tawan, Juthamanee Moonwong, Tavitiya Sudjaritruk, Pajaree Chariyavilaskul, Thanyawee Puthanakit","doi":"10.1016/j.ijid.2022.07.029","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.029","url":null,"abstract":"Objectives: To evaluate the pharmacokinetic parameters of the 2020 World Health Organization (WHO)-recommended pediatric dosage of levofloxacin and the higher-than-WHO dosage.Methods: Children aged 1-15 years with tuberculosis who received levofloxacin-based treatment for at least 7 days were enrolled. First, five children were enrolled to receive the WHO-recommended dosage (15-20 mg/kg/day), then an additional five children received a dosage higher than the WHO-recommended dosage (20-30 mg/kg/day). Blood samples were collected at predose and postdose 1, 2, 4, 6, 8, and 12 hours. A target of the ratio of the free area under the concentration-time curve to minimum inhibitory concentration (fAUC/MIC) was 100.Results: The median (interquartile range) age was 9.6 (4.9-10.5) and 12.0 (10.1-12.3) years in the WHO dosage and higher-than-WHO dosage groups, respectively. The median (interquartile range) duration of antituberculosis treatment was 24 (8-24) weeks. The geometric mean (95% confidence interval) of fAUC/MIC was 60.4 (43.5-84.0) and 103.2 (70.1-151.8) in the WHO and higher-than-WHO dosage groups, respectively. There was no adverse event of QT prolongation or any other grade 3 or 4 adverse events.Conclusion: Levofloxacin at a higher dose of 20-30 mg/kg/day could achieve the fAUC/MIC target in children.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"603-608"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40527804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Global variation in early epidemic growth rates and reproduction number of seasonal influenza. 季节性流感早期流行增长率和繁殖数量的全球变化。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-06-17 DOI: 10.1016/j.ijid.2022.06.022

Rory Thompson, James Gareth Wood, Stefano Tempia, David John Muscatello

{"title":"Global variation in early epidemic growth rates and reproduction number of seasonal influenza.","authors":"Rory Thompson, James Gareth Wood, Stefano Tempia, David John Muscatello","doi":"10.1016/j.ijid.2022.06.022","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.06.022","url":null,"abstract":"Background: Little is known about global variation in early epidemic growth rates and effective reproduction numbers (Re) of seasonal influenza. We aimed to estimate global variation in Re of influenza type A and B during a single period.Methods: Country influenza detection time series from September 2017 through January 2019 were obtained from an international database. Type A and B epidemics by country were selected on the basis of Re estimates for a five-week moving window, advanced by week. Associations of Re with absolute latitude, human development index, percent of the population aged <15 years, and percent of those living in rural areas in each country were assessed.Results: Time series were included for 119 of 169 available countries. There were 100 countries with influenza A and 79 with B epidemics. Median Re for both influenza A and B epidemics was 1.23 (ranges: A 1.10, 1.60; B 1.06, 1.58). Re of influenza B but not A was independently associated with absolute latitude, increasing by 0.022 (95% confidence interval 0.002, 0.043) per 10 degrees.Conclusion: The Re of influenza A and B were similar. Only the Re of influenza B was associated with country characteristics, which was increasing with distance from the equator. The approach may be suitable for continuous Re surveillance.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"382-388"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39992821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Failure to account for population size introduces spurious correlation for almost all diseases at a country level. 如果不考虑人口规模，就会导致国家层面上几乎所有疾病的虚假相关性。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-09 DOI: 10.1016/j.ijid.2022.07.020

K A Sheldrick

引用次数: 0

Rift Valley fever seropositivity in humans and domestic ruminants and associated risk factors in Sengerema, Ilala, and Rufiji districts, Tanzania. 坦桑尼亚Sengerema、Ilala和Rufiji地区人类和家养反刍动物裂谷热血清阳性及相关危险因素。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-08 DOI: 10.1016/j.ijid.2022.07.012

Calvin Sindato, Esron D Karimuribo, Francesco Vairo, Gerald Misinzo, Mark M Rweyemamu, Muzamil Mahdi Abdel Hamid, Najmul Haider, Patrick K Tungu, Richard Kock, Susan F Rumisha, Togolai Mbilu, Francine Ntoumi, Alimuddin Zumla, Leonard E G Mboera

{"title":"Rift Valley fever seropositivity in humans and domestic ruminants and associated risk factors in Sengerema, Ilala, and Rufiji districts, Tanzania.","authors":"Calvin Sindato, Esron D Karimuribo, Francesco Vairo, Gerald Misinzo, Mark M Rweyemamu, Muzamil Mahdi Abdel Hamid, Najmul Haider, Patrick K Tungu, Richard Kock, Susan F Rumisha, Togolai Mbilu, Francine Ntoumi, Alimuddin Zumla, Leonard E G Mboera","doi":"10.1016/j.ijid.2022.07.012","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.012","url":null,"abstract":"Objectives: Data on Rift Valley fever virus (RVFV) prevalence in urban settings and pastoral areas of Tanzania are scarce. We performed a cross-sectional study of RVFV seroprevalence and determinants in humans and animals from Ilala, Rufiji, and Sengerema districts of Tanzania.Methods: Blood samples from the study participants were tested for anti-RVFV immunoglobulin G (IgG) antibodies using an enzyme-linked immunosorbent assay. Logistic regression was used to determine association between exposure risk practices and RVFV seropositivity.Results: The study involved 664 humans, 361 cattle, 394 goats, and 242 sheep. The overall anti-RVFV IgG seroprevalence in humans and animals was 2.1% (95% confidence interval [CI] 0.01-0.04) and 9.5% (n = 95, 95% CI 0.08-0.12), respectively. Seroprevalence in humans in Rufiji, Ilala, and Sengerema was 3.0% (n = 225, 95% CI 0.01-0.06), 1.8% (n = 230, 95% CI-0.005- 0.04), and 1.4% (n = 209, 95% CI 0.01-0.04), respectively (P >0.05). Seroprevalence in animals in Sengerema, Rufiji, and Ilala was 12.1% (n = 40, 95% CI 0.09-0.16), 11.1% (n = 37, 95% CI 0.08-0.15), and 5.4% (n = 18, 95% CI 0.03-0.08), respectively (P = 0.006). Handling of carcasses increased the odds of RVFV seropositivity 12-fold (odds ratio 11.84, 95% CI 1.97-71.16).Conclusion: The study confirms previous occurrence of RVFV in multiple species in the study districts. Animal handling practices appear to be essential determinants of seropositivity.","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"559-565"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

First evidence of human infection by Xiphinema brevicollum (Nematoda: Longidoridae). 人类感染短短剑螺旋体的首个证据(线虫:长线虫科)。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-08 DOI: 10.1016/j.ijid.2022.07.007

Djamel Haouchine, Stéphane Mantelet, Anthony Marteau, Sophie Brun, Philippe Dabi, Meryem Abbas, Arezki Izri, Mohammad Akhoundi

引用次数: 0

A case of immune complex type hemolytic anemia induced by initial micafungin administration. 初服米卡芬致免疫复合物型溶血性贫血1例。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-15 DOI: 10.1016/j.ijid.2022.07.023

Hiroto Ishii, Tomohiko Sato, Miyuki Ishibashi, Hiroki Yokoyama, Takeshi Saito, Tetsunori Tasaki, Shingo Yano

引用次数: 1

Peritoneal tuberculosis mimicking peritoneal carcinomatosis in a patient with gallbladder carcinoma. 胆囊癌患者的腹膜结核样腹膜癌。

IF 8.4

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-30 DOI: 10.1016/j.ijid.2022.07.065

Imen Ben Ismail, Marwen Sghaier, Saber Rebii, Ayoub Zoghlami

引用次数: 1