Rift Valley fever seropositivity in humans and domestic ruminants and associated risk factors in Sengerema, Ilala, and Rufiji districts, Tanzania.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Pub Date : 2022-09-01 Epub Date: 2022-07-08 DOI:10.1016/j.ijid.2022.07.012

Calvin Sindato, Esron D Karimuribo, Francesco Vairo, Gerald Misinzo, Mark M Rweyemamu, Muzamil Mahdi Abdel Hamid, Najmul Haider, Patrick K Tungu, Richard Kock, Susan F Rumisha, Togolai Mbilu, Francine Ntoumi, Alimuddin Zumla, Leonard E G Mboera

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引用次数: 4

Abstract

Objectives: Data on Rift Valley fever virus (RVFV) prevalence in urban settings and pastoral areas of Tanzania are scarce. We performed a cross-sectional study of RVFV seroprevalence and determinants in humans and animals from Ilala, Rufiji, and Sengerema districts of Tanzania.

Methods: Blood samples from the study participants were tested for anti-RVFV immunoglobulin G (IgG) antibodies using an enzyme-linked immunosorbent assay. Logistic regression was used to determine association between exposure risk practices and RVFV seropositivity.

Results: The study involved 664 humans, 361 cattle, 394 goats, and 242 sheep. The overall anti-RVFV IgG seroprevalence in humans and animals was 2.1% (95% confidence interval [CI] 0.01-0.04) and 9.5% (n = 95, 95% CI 0.08-0.12), respectively. Seroprevalence in humans in Rufiji, Ilala, and Sengerema was 3.0% (n = 225, 95% CI 0.01-0.06), 1.8% (n = 230, 95% CI-0.005- 0.04), and 1.4% (n = 209, 95% CI 0.01-0.04), respectively (P >0.05). Seroprevalence in animals in Sengerema, Rufiji, and Ilala was 12.1% (n = 40, 95% CI 0.09-0.16), 11.1% (n = 37, 95% CI 0.08-0.15), and 5.4% (n = 18, 95% CI 0.03-0.08), respectively (P = 0.006). Handling of carcasses increased the odds of RVFV seropositivity 12-fold (odds ratio 11.84, 95% CI 1.97-71.16).

Conclusion: The study confirms previous occurrence of RVFV in multiple species in the study districts. Animal handling practices appear to be essential determinants of seropositivity.

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坦桑尼亚Sengerema、Ilala和Rufiji地区人类和家养反刍动物裂谷热血清阳性及相关危险因素。

目标:关于坦桑尼亚城市环境和牧区裂谷热病毒(RVFV)流行的数据很少。我们对来自坦桑尼亚Ilala、Rufiji和Sengerema地区的人类和动物的裂谷热病毒血清患病率和决定因素进行了横断面研究。方法:采用酶联免疫吸附法对研究参与者的血液样本进行抗裂谷热病毒免疫球蛋白G (IgG)抗体检测。使用逻辑回归来确定暴露风险实践与裂谷热病毒血清阳性之间的关系。结果:该研究涉及664人、361头牛、394只山羊和242只绵羊。人类和动物抗裂谷病毒IgG血清总阳性率分别为2.1%(95%可信区间[CI] 0.01-0.04)和9.5% (n = 95, 95% CI 0.08-0.12)。Rufiji、Ilala和Sengerema人群血清阳性率分别为3.0% (n = 225, 95% CI 0.01 ~ 0.06)、1.8% (n = 230, 95% CI-0.005 ~ 0.04)和1.4% (n = 209, 95% CI 0.01 ~ 0.04) (P >0.05)。Sengerema、Rufiji和Ilala的动物血清患病率分别为12.1% (n = 40, 95% CI 0.09-0.16)、11.1% (n = 37, 95% CI 0.08-0.15)和5.4% (n = 18, 95% CI 0.03-0.08) (P = 0.006)。处理尸体使RVFV血清阳性的几率增加了12倍(优势比11.84,95% CI 1.97-71.16)。结论:本研究证实了研究区存在多种裂谷热病毒。动物处理方法似乎是血清阳性的重要决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

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