International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases最新文献

{"title":"Rotavirus genotype trends from 2013 to 2018 and vaccine effectiveness in southern Vietnam.","authors":"Dung Thi Thuy Truong,&nbsp;Ji-Man Kang,&nbsp;Ngoc Thi Hong Tran,&nbsp;Lan Trong Phan,&nbsp;Hung Thanh Nguyen,&nbsp;Thang Vinh Ho,&nbsp;Thao Thi Thanh Nguyen,&nbsp;Phuc Le Hoang,&nbsp;Trang Mai Thuy Pham,&nbsp;Thuy Dieu Nguyen,&nbsp;Thang Anh Hoang,&nbsp;Quang Chan Luong,&nbsp;Quang Duy Pham,&nbsp;Jong Gyun Ahn,&nbsp;Sangchul Yoon,&nbsp;Thuong Vu Nguyen,&nbsp;Joon-Sup Yeom","doi":"10.1016/j.ijid.2021.02.047","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.047","url":null,"abstract":"<p><strong>Objectives: </strong>Rotavirus (RV) genotypes vary geographically, and this can affect vaccine effectiveness (VE). This study investigated the genotype distribution of RV and explored VE before introducing the RV vaccine to the national immunization programme in Vietnam.</p><p><strong>Methods: </strong>This hospital-based surveillance study was conducted at Children's Hospital 1, Ho Chi Minh City in 2013-2018. Stool samples and relevant data, including vaccination history, were collected from children aged <5 years who were hospitalized with gastroenteritis. RV was detected using enzyme immunoassays and then genotyped. Children aged ≥6 months were included in the VE analysis.</p><p><strong>Results: </strong>Overall, 5176 children were included in this study. RV was detected in 2421 children (46.8%). RV positivity decreased over the study period and was associated with age, seasonality, location and previous vaccination. Among 1105 RV-positive samples, G3P[8] was the most prevalent genotype (43.1%), followed by G8P[8] (19.7%), G1P[8] (12.9%) and G2P[4] (12.9%). Overall VE was 69.7% [95% confidence interval (CI) 53.3-80.6%] in fully vaccinated children and 58.6% (95% CI 44.1-69.4%) in children who had received at least one dose of RV vaccine. VE was highest for G3P[8] (95% CI 75.1-84.5%) and lowest for G2P[4] (95% CI 32.4-57.2%).</p><p><strong>Conclusions: </strong>RV remains a major cause of acute gastroenteritis requiring hospitalization in southern Vietnam. The RV vaccine is effective, but its effectiveness varies with RV genotype.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"277-285"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25376453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An immunocompetent female with Mycobacterium abscessus cervical lymphadenitis mimicking malignancy.","authors":"Jessica Yan Qi Tan,&nbsp;Humaira Shafi","doi":"10.1016/j.ijid.2021.02.044","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.044","url":null,"abstract":"","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"239-240"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25380678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral cotton wool spots after ambulatory COVID-19.","authors":"Alison X Chan,&nbsp;Michele Ritter,&nbsp;Mathieu F Bakhoum","doi":"10.1016/j.ijid.2021.02.119","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.119","url":null,"abstract":"","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"414-415"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25448800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of long-term safety and efficacy of nucleos(t)ide analogue therapy for chronic hepatitis B throughout pregnancy.","authors":"Jin Shang,&nbsp;Huan Liu,&nbsp;Qin Wen,&nbsp;Rili M Ise,&nbsp;You Tu,&nbsp;Lang Bai,&nbsp;Hong Tang","doi":"10.1016/j.ijid.2021.03.023","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.03.023","url":null,"abstract":"<p><strong>Background: </strong>Limited data exist regarding the efficacy and long-term safety of nucleos(t)ide analogue therapy throughout pregnancy for women with chronic hepatitis B and their children.</p><p><strong>Methods: </strong>This retrospective cohort study included 165 women in total: 91 women received telbivudine (LDT) and 74 women received tenofovir (TDF) throughout pregnancy. The virological response and safety in women were recorded, and the physical development and bone mineral density in children were evaluated up to 5 years of age.</p><p><strong>Results: </strong>The rate of virological breakthrough in women was 4.24% overall (7.70% in LDT group and 0% in TDF group; P < 0.05). No cases of renal injury or other obstetric adverse events occurred in either group of women. Among the children, only one child had a significantly low Z score for weight for age (<-2), and no children had a significantly low Z score for height for age or bone mineral density. No significant difference was found between the children in the two groups.</p><p><strong>Conclusions: </strong>Nucleos(t)ide analogue therapy with TDF or LDT throughout pregnancy had no effect on the long-term physical development and bone development of children. In addition, the use of TDF throughout pregnancy had better long-term antiviral efficacy than LDT in women, with no evidence of renal toxicity.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"626-631"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.03.023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25481120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis.","authors":"Richard Court, Chad M Centner, Maxwell Chirehwa, Lubbe Wiesner, Paolo Denti, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Helen McIlleron","doi":"10.1016/j.ijid.2021.03.001","DOIUrl":"10.1016/j.ijid.2021.03.001","url":null,"abstract":"<p><strong>Background: </strong>Cycloserine, or its structural analogue terizidone, has been associated with neuropsychiatric toxicity (psychosis, depression, and neuropathy). Prospective clinical data on the incidence of and risk factors for neuropsychiatric toxicity in TB patients treated with cycloserine are limited.</p><p><strong>Methods: </strong>A prospective evaluation of neuropsychiatric toxicity was performed using validated screening tools in patients with multidrug-resistant tuberculosis treated with terizidone. Cox proportional hazard modelling was performed to explore the effects of clinical variables and measures of cycloserine pharmacokinetics in plasma.</p><p><strong>Results: </strong>A total 144 participants were recruited: 86 were male and 58 were female; their median age was 35.7 years and 91 (63%) were HIV-infected. Fifty-five (38%) participants developed at least one neuropsychiatric event (30 cases per 100 person-months): 50 (35%) neuropathy, 14 (10%) depression, and 11 (8%) psychosis. Neuropathy was independently associated with cycloserine clearance ((adjusted hazard ratio 0.34 (aHR), P = 0.03)) and high-dose pyridoxine (200 mg vs 150 mg daily, aHR: 2.79, P = 0.01).</p><p><strong>Conclusions: </strong>A high incidence of early neuropsychiatric toxicity was observed in this cohort of patients treated with terizidone. Cycloserine clearance and higher doses of pyridoxine are associated with incident or worsening peripheral neuropathy.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"688-694"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/11/nihms-1697305.PMC8126338.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25462560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive pulmonary aspergillosis is a frequent complication in patients with severe fever with thrombocytopenia syndrome: A retrospective study.","authors":"Ying Xu,&nbsp;Mingran Shao,&nbsp;Ning Liu,&nbsp;Jian Tang,&nbsp;Qin Gu,&nbsp;Danjiang Dong","doi":"10.1016/j.ijid.2021.02.088","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.088","url":null,"abstract":"<p><strong>Objectives: </strong>Invasive pulmonary aspergillosis (IPA) usually occurs in immunocompromised hosts. It has recently been reported that patients with severe fever with thrombocytopenia syndrome (SFTS) can also develop IPA. The aim of this study was to determine the incidence of IPA in SFTS patients and to investigate the relevant clinical, imaging, and laboratory characteristics.</p><p><strong>Methods: </strong>A retrospective review was conducted of all patients with SFTS admitted to Nanjing Drum Tower Hospital, a tertiary hospital in Nanjing City, China, between January 2016 and December 2019. The patients were divided into two groups according to whether they had IPA: the IPA group and the non-IPA group. Data on clinical manifestations, laboratory findings, imaging characteristics, treatments, and outcomes were collected and analysed.</p><p><strong>Results: </strong>A total of 91 SFTS patients were included, of whom 29 (31.9%) developed IPA. In-hospital mortality (22.0%) was higher in the IPA group than in the non-IPA group. Univariate logistic regression showed that diabetes, cough, wheezing, amylase level, vasopressor use, encephalopathy, and intensive care unit transfer were risk factors for the development of IPA. Multivariate logistic regression analysis identified wheezing as an independent predictor of IPA in SFTS patients.</p><p><strong>Conclusions: </strong>SFTS combined with IPA is associated with high morbidity and mortality. It is necessary to strengthen screening for fungal infections after admission in SFTS patients. However, whether early antifungal prophylaxis should be administered needs further investigation.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"646-652"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25419320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First probable case of congenital Zika syndrome in Lao People's Democratic Republic.","authors":"Elodie Calvez,&nbsp;Phommady Vetsaphong,&nbsp;Somphavanh Somlor,&nbsp;Thonglakhone Xaybounsou,&nbsp;Souksakhone Viengphouthong,&nbsp;Myrielle Dupont-Rouzeyrol,&nbsp;Virginie Pommelet,&nbsp;Paul T Brey","doi":"10.1016/j.ijid.2021.03.019","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.03.019","url":null,"abstract":"<p><p>Zika virus (ZIKV) is a Flavivirus transmitted by Aedes mosquitoes, and was responsible for a worldwide outbreak between 2013 and 2016. However, no ZIKV outbreak has been described in Southeast Asia since 2017. In this study, we report the first microcephaly case with probable ZIKV infection during pregnancy in Lao People's Democratic Republic.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"595-597"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.03.019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25471697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual case of oral condyloma lata.","authors":"T Dai,&nbsp;N J Song","doi":"10.1016/j.ijid.2021.02.051","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.051","url":null,"abstract":"<p><p>Cutaneous secondary syphilis presents with various manifestations, including condyloma lata (confluented moist papules). This article reports an unusual case of oral condyloma lata. A 56-year-old man presented with a 2-month history of foreign body sensation and sore throat. Physical examination revealed a hypertrophic, reddish-brown, flat-topped, moist plaque in the right amygdaloid fossa. This raised clinical suspicion of lymphoma. However, further enquiry revealed that the patient had extramarital sexual history with a female sex worker. Rapid plasma regain and Treponema pallidum particle agglutination tests were both positive. The patient's wife was diagnosed with early latent syphilis. Both the patient and his wife were treated with penicillin G benzathine, and the lesion in the male patient disappeared in 2 weeks. To the authors' knowledge, a single condyloma lata in the amygdaloid fossa mimicking lymphoma has not been reported previously. Awareness of the usual manifestations of syphilis can avoid unnecessary biopsy, and early diagnosis and treatment may prevent irreversible complications. Partner notification is very important to reduce the risk of transmission, and persistent or recurrent infection.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"349-350"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25385026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa.","authors":"Yuri Ushijima,&nbsp;Haruka Abe,&nbsp;Takehiro Ozeki,&nbsp;Georgelin N Ondo,&nbsp;Marien J V M Mbadinga,&nbsp;Rodrigue Bikangui,&nbsp;Chimène Nze-Nkogue,&nbsp;Etienne F Akomo-Okoue,&nbsp;Ghislain W E Ella,&nbsp;Lilian B M Koumba,&nbsp;Branly C B B Nso,&nbsp;Rodrigue Mintsa-Nguema,&nbsp;Patrice Makouloutou-Nzassi,&nbsp;Boris K Makanga,&nbsp;Fred L M Nguelet,&nbsp;Vahid R Zadeh,&nbsp;Shuzo Urata,&nbsp;Armel V N Mbouna,&nbsp;Marguerite Massinga-Loembe,&nbsp;Selidji T Agnandji,&nbsp;Bertrand Lell,&nbsp;Jiro Yasuda","doi":"10.1016/j.ijid.2021.02.105","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.105","url":null,"abstract":"<p><strong>Objectives: </strong>Lymphocytic choriomeningitis virus (LCMV), a human pathogenic arenavirus, is distributed worldwide. However, no human cases have been reported in Africa. This study aimed to investigate the current situation and potential risks of LCMV infection in Gabon, Central Africa.</p><p><strong>Methods: </strong>A total of 492 human samples were screened to detect LCMV genome RNA and anti-LCMV IgG antibodies using reverse transcription-quantitative PCR and enzyme-linked immunosorbent assay (ELISA), respectively. ELISA-positive samples were further examined using a neutralization assay. Viral RNAs and antibodies were also analyzed in 326 animal samples, including rodents, shrews, and bushmeat.</p><p><strong>Results: </strong>While no LCMV RNA was detected in human samples, the overall seroprevalence was 21.5% and was significantly higher in male and adult populations. The neutralization assay identified seven samples with neutralizing activity. LCMV RNA was detected in one species of rodent (Lophuromys sikapusi) and a porcupine, and anti-LCMV IgG antibodies were detected in four rodents and three shrews.</p><p><strong>Conclusions: </strong>This study determined for the first time the seroprevalence of LCMV in Gabon, and revealed that local rodents, shrews, and porcupines in areas surrounding semi-urban cities posed an infection risk. Hence, LCMV infection should be considered a significant public health concern in Africa.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"452-459"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25434347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and socio-environmental determinants of multidrug-resistant vibrio cholerae 01 in older children and adults in Bangladesh.","authors":"Stephanie C Garbern,&nbsp;Tzu-Chun Chu,&nbsp;Phillip Yang,&nbsp;Monique Gainey,&nbsp;Sabiha Nasrin,&nbsp;Samika Kanekar,&nbsp;Kexin Qu,&nbsp;Eric J Nelson,&nbsp;Daniel T Leung,&nbsp;Dilruba Ahmed,&nbsp;Christopher H Schmid,&nbsp;Nur H Alam,&nbsp;Adam C Levine","doi":"10.1016/j.ijid.2021.02.102","DOIUrl":"https://doi.org/10.1016/j.ijid.2021.02.102","url":null,"abstract":"<p><strong>Objectives: </strong>Few studies have evaluated determinants of multidrug-resistant (MDR) Vibrio cholerae O1 in older children and adults. This study aimed to characterize the prevalence of MDR V. cholerae O1 and associated risk factors among patients over five years of age in Bangladesh.</p><p><strong>Methods: </strong>Stool culture and antimicrobial susceptibility testing were performed as a part of a larger study at Dhaka Hospital in Bangladesh from March 2019-March 2020. Univariate statistics and multiple logistic regression were used to assess the association between a range of variables and MDR V. cholerae O1.</p><p><strong>Results: </strong>MDR was found in 175 of 623 (28.1%) V. cholerae O1 isolates. High levels of resistance were found to erythromycin (99.2%), trimethoprim-sulfamethoxazole (99.7%), and ampicillin (88.9%), while susceptibility was high to tetracyclines (99.7%), azithromycin (99.2%), ciprofloxacin (99.8%), and cephalosporins (98.6%). MDR was associated with prior antibiotic use, longer transport time to hospital, higher income, non-flush toilet use, greater stool frequency, lower blood pressure, lower mid-upper arm circumference, and lower percent dehydration.</p><p><strong>Conclusions: </strong>MDR V. cholerae O1 was common among patients over five in an urban hospital in Bangladesh. Significant factors associated with MDR may be actionable in identifying patients with a high likelihood of MDR.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"436-441"},"PeriodicalIF":8.4,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijid.2021.02.102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25418052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}