International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases最新文献

{"title":"Patients with infectious diseases undergoing mechanical ventilation in the intensive care unit have better prognosis after receiving metagenomic next-generation sequencing assay.","authors":"Yin Xi,&nbsp;Jing Zhou,&nbsp;Zhimin Lin,&nbsp;Weibo Liang,&nbsp;Chun Yang,&nbsp;Dongdong Liu,&nbsp;Yonghao Xu,&nbsp;Lingbo Nong,&nbsp;Sibei Chen,&nbsp;Yuheng Yu,&nbsp;Weiqun He,&nbsp;Jie Zhang,&nbsp;Rong Zhang,&nbsp;Xuesong Liu,&nbsp;Xiaoqing Liu,&nbsp;Ling Sang,&nbsp;Yuanda Xu,&nbsp;Yimin Li","doi":"10.1016/j.ijid.2022.07.062","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.062","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the relation between metagenomic next-generation sequencing (mNGS) and the prognosis of patients with infectious diseases undergoing mechanical ventilation in the intensive care unit (ICU).</p><p><strong>Methods: </strong>This is a single-center observational study, comparing nonrandomly assigned diagnostic approaches. We analyzed the medical records of 228 patients with suspected infectious diseases undergoing mechanical ventilation in the ICU from March 2018 to May 2020. The concordance of pathogen results was also assessed for the results of mNGS, culture, and polymerase chain reaction assays.</p><p><strong>Results: </strong>The 28-day mortality of the patients in the mNGS group was lower after the baseline difference correction (19.23% (20/104) vs 29.03% (36/124) , P = 0.039). Subgroup analysis showed that mNGS assay was associated with improved 28-day mortality of patients who are not immunosuppressed (14.06% vs 29.82%, P = 0.018). Not performing mNGS assay, higher acute physiology and chronic health evaluation II score, and hypertension are independent risk factors for 28-day mortality. The mNGS assay presented an advantage in pathogen positivity (69.8% double-positive and 25.0% mNGS-positive only), and the concordance between these two assays was 79.0%.</p><p><strong>Conclusion: </strong>mNGS survey may be associated with a better prognosis by reducing 28-day mortality of patients with infectious diseases on mechanical ventilation in the ICU. This technique presented an advantage in pathogen positivity over traditional methods.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"959-969"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40667261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial meningitis in patients with multiple myeloma: a prospective nationwide cohort study and review of the literature.","authors":"Fereshte Sheybani,&nbsp;Matthijs C Brouwer,&nbsp;Diederik van de Beek","doi":"10.1016/j.ijid.2022.06.038","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.06.038","url":null,"abstract":"<p><strong>Objectives: </strong>To study the clinical features of bacterial meningitis in patients with myeloma.</p><p><strong>Methods: </strong>We analyzed patients with myeloma who were included in a nationwide cohort of patients >16 years old with community-acquired bacterial meningitis in the Netherlands from 2006 to 2018. Subsequently, we reviewed the literature for articles reporting patients with myeloma with bacterial meningitis.</p><p><strong>Results: </strong>A total of 27 of 2306 episodes (1.6%) of bacterial meningitis occurred in patients with myeloma. Six of 27 patients (22%) underwent stem cell transplantation. Median cerebrospinal fluid (CSF) leukocyte count was 172/µl, and 12 of 26 patients (46%) had a CSF leukocyte count <100/µl. Streptococcus pneumoniae was the causative pathogen in 25 patients (93%). Fourteen patients (52%) had unfavorable outcomes, of whom 10 (37%) died. Ninety-one patients with myeloma with bacterial meningitis were described in the literature. The most common pathogen in these patients was S. pneumoniae (35 of 48; 73%) and four (20%) of 20 patients died.</p><p><strong>Conclusion: </strong>Bacterial meningitis in patients with multiple myeloma is a severe disease with high rates of unfavorable outcome. Patients often present with a lower CSF leukocyte count than patients with bacterial meningitis without multiple myeloma. Physicians should set a low threshold to perform lumbar puncture in patients with myeloma and start antibiotic treatment pending CSF chemistry and culture results.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"492-496"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40400439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annular rupioid secondary syphilis confined to the face.","authors":"Tianhang Yu,&nbsp;Jiaozi Che,&nbsp;Jikai Song,&nbsp;Xinsuo Duan,&nbsp;Jie Yang","doi":"10.1016/j.ijid.2022.07.028","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.028","url":null,"abstract":"<p><strong>Objectives: </strong>Syphilis is a sexually transmitted infection (STI) caused by treponema pallidum. Its rash usually affects the trunk and limbs extensively, including the palms and soles of the feet. Secondary syphilis confined to the face is extremely rare.</p><p><strong>Methods: </strong>We report a case of annular rupioid secondary syphilis, which was misdiagnosed as verruca vulgaris.</p><p><strong>Results: </strong>The patient's lesions were confined to the face and resembled oyster shells. Her serological tests results were positive for treponema pallidum particle agglutination assay (TPPA) and rapid plasma reagin (RPR) (1:64).</p><p><strong>Conclusion: </strong>According to epidemiological history, clinical presentation, non-treponemal tests, treponemal tests, and effective benzathine penicillin G treatment, confirmed secondary syphilis.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"644-646"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40527806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019.","authors":"Hedvig Glans,&nbsp;Leif Dotevall,&nbsp;Gert Van der Auwera,&nbsp;Aldert Bart,&nbsp;Johannes Blum,&nbsp;Pierre Buffet,&nbsp;Romain Guery,&nbsp;Jean-Pierre Gangneux,&nbsp;Saskia van Henten,&nbsp;Gundel Harms,&nbsp;Stefania Varani,&nbsp;Florence Robert-Gangneux,&nbsp;Robert Rongisch,&nbsp;Björn Andersson,&nbsp;Maria Bradley","doi":"10.1016/j.ijid.2022.06.025","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.06.025","url":null,"abstract":"<p><strong>Objectives: </strong>Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe.</p><p><strong>Methods: </strong>We conducted a retrospective study of parasitological confirmed CL cases caused by L. major and L. tropica during 2013-2019 in Europe. Data were collected from medical records and databases within the LeishMan network.</p><p><strong>Results: </strong>Of 206 included cases of CL, 75 were identified as L. major and 131 as L. tropica. Of patients with L. tropica infection, 80% were migrants, whereas 53% of patients with L. major infection had been visiting friends and relatives. Among patients with L. tropica, 48% were younger than 15 years. Pentavalent antimony cured 73% (L. major) and 78% (L. tropica) of patients. The cure rate for intralesional administration was 86% and 67% for systemic, on L. tropica. Liposomal amphotericin B had a cure rate of 44-63%.</p><p><strong>Conclusion: </strong>L. major infections were mostly found in individuals visiting friends and relatives, whereas L. tropica were mainly identified in migrants. No patients with L. major relapsed. Pentavalent antimony, liposomal amphotericin B, and cryotherapy had cure rates in accordance with previous studies.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"375-381"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40151448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of corticosteroid treatment in patients with severe fever with thrombocytopenia syndrome: A single-center retrospective cohort study.","authors":"Leiqun Xiong,&nbsp;Ling Xu,&nbsp;Xiaoying Lv,&nbsp;Xin Zheng","doi":"10.1016/j.ijid.2022.07.001","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.001","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect and safety of corticosteroid (CS) treatment in patients with severe fever with thrombocytopenia syndrome (SFTS).</p><p><strong>Methods: </strong>Patients with and without CS were retrospectively compared by Cox regression and 1:1 propensity score matching analysis to evaluate the effects of CS on mortality and secondary infections in patients with SFTS.</p><p><strong>Results: </strong>A total of 467 patients with SFTS were enrolled in the cohort study, there were 52 fatal cases and 415 nonfatal cases, the overall fatality rate was 11.1%. The mortality was observed in 36/144 (25%) and 16/323 (5%) patients in the CS-treated and non-CS-treated groups, respectively (P < 0.001). Multi variate Cox regression analysis showed that the difference was not statistically significant for CS treatment in fatality (P > 0.05, aHR 0.767, 95% CI 0.360-1.634). Difference in survival time between the CS-treated and non-CS-treated groups after propensity score matching had no statistical significance (Log-rank test P = 0.390), whereas there was a significant difference in secondary infections between the CS-treated and non-CS-treated groups (P = 0.007).</p><p><strong>Conclusion: </strong>Although the CS treatment had no impact on fatality in patients with SFTS, it increased the risk of secondary infections. Administration of CS in patients with SFTS should be carefully considered and evaluated the balance between therapeutic efficacy and adverse effects.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"1026-1033"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40571634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic next-generation sequencing for accurate diagnosis and management of lower respiratory tract infections.","authors":"Mengyuan Liang,&nbsp;Yamin Fan,&nbsp;Dongmei Zhang,&nbsp;Lian Yang,&nbsp;Xiaorong Wang,&nbsp;Sufei Wang,&nbsp;Juanjuan Xu,&nbsp;Jianchu Zhang","doi":"10.1016/j.ijid.2022.07.060","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.060","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the clinical value of metagenomic next-generation sequencing (mNGS) in patients with suspected lower respiratory tract infections.</p><p><strong>Methods: </strong>This retrospective study reviewed patients with suspected lower respiratory tract infections at the Wuhan Union Hospital. Data including demographic, laboratory, and radiological profiles; treatment; and outcomes were recorded and analyzed.</p><p><strong>Results: </strong>mNGS identified pathogenic microbes in 100/140 (71.4%) patients, although 135 (96.4%) had received empiric antibiotic treatment before the mNGS tests. Single bacterial infection (35/100, 35%) was the most common type of infection in patients with positive mNGS results, followed by single fungal infection (14/100, 14%), bacterial-viral coinfection (14/100, 14%), single viral infection (12/100, 12%), bacterial-fungal coinfection (9/100, 9%), fungal-viral coinfection (9/100, 9%), and bacterial-fungal-viral coinfection (7/100, 7%). Moreover, compared with culture test, mNGS showed higher sensitivity (63/85, 74.1% vs 22/85, 25.9% P = 0.001) and lower processing time (24 hours vs 48 hours). Antibiotic treatment was adjusted or confirmed based on the mNGS results in 123 (87.9%) patients, including five (3.6%), 33 (23.6%), and 85 (60.7%) patients, in whom treatment was downgraded, upgraded, and unchanged, respectively. Almost all patients, regardless of escalation, de-escalation, or no change in treatment, showed significant improvement in clinical symptoms and inflammatory indicators. In addition, 17 (12.1%) patients were referred to Wuhan Pulmonary Hospital for further treatment because of confirmed or suspected tuberculosis.</p><p><strong>Conclusion: </strong>mNGS could be a promising technique for microbiological diagnosis and antibiotic management, potentially improving outcomes for patients.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"921-929"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40584994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xpert MTB/RIF Ultra outperformed the Xpert assay in tuberculosis lymphadenitis diagnosis: a prospective head-to-head cohort study.","authors":"Xia Yu,&nbsp;Tingting Zhang,&nbsp;Yaoyao Kong,&nbsp;Fen Wang,&nbsp;Lingling Dong,&nbsp;Ming Han,&nbsp;Hairong Huang","doi":"10.1016/j.ijid.2022.07.039","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.039","url":null,"abstract":"<p><strong>Objectives: </strong>Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) Ultra (Xpert-Ultra) has shown better sensitivity in comparison with Xpert MTB/RIF (Xpert) in extrapulmonary tuberculosis (TB), whereas the head-to-head comparison of these methods in TB lymphadenitis had barely been performed.</p><p><strong>Methods: </strong>Patients with undiagnosed lymphadenopathy were recruited prospectively and consecutively, and fine-needle aspiration (FNA) biopsy or lymph node tissue was collected. The specimen was subjected to smear, culture, Xpert, and Xpert-Ultra assays. Culture and/or smear for acid-fast bacilli (AFB) or AFB observed on histopathology were performed as a reference.</p><p><strong>Results: </strong>A total of 106 participants were recruited, including 41 confirmed TB, 33 probable TB, and 32 non-TB lymphadenopathies. The head-to-head comparison for MTB detection showed that Xpert-Ultra produced the highest sensitivity when compared with smear, culture, and Xpert (75.7% vs 5.4 %, 13.5%, and 48.7%). When Xpert-Ultra outcomes were integrated for diagnosis, the percentage of confirmed TB lymphadenitis cases increased from 55.4% (41/74) to 85.1% (63/74). The sensitivities of Xpert-Ultra and Xpert on tissue were 73.6% (95% CI: 59.4-84.3) and 39.6% (95% CI: 26.8-54.0), respectively. The sensitivity of Xpert-Ultra on FNA samples (81.0%, 95% CI: 57.4-93.7) was higher than that of Xpert (71.4%, 95% CI: 47.7-87.8).</p><p><strong>Conclusion: </strong>Xpert-Ultra detected significantly more TB lymphadenitis cases than Xpert or culture. This superiority was particularly distinct using lymph node tissue than FNA detection.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"741-746"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40618421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"High population burden of Omicron variant (B.1.1.529) is associated with the emergence of severe hepatitis of unknown etiology in children\".","authors":"Hang Yi,&nbsp;Yiwen Lin,&nbsp;Bin Lu,&nbsp;Yousheng Mao","doi":"10.1016/j.ijid.2022.07.058","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.058","url":null,"abstract":"","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"1007-1008"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40584993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Post-Neurosurgical Infection due to KPC-Producing Klebsiella pneumoniae Treated with Meropenem-Vaborbactam: A Case Report.","authors":"Seohyun Choi,&nbsp;Marianna Fedorenko,&nbsp;Janet Lin-Torre,&nbsp;Nirav Mistry,&nbsp;Steven Smoke","doi":"10.1016/j.ijid.2022.07.073","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.073","url":null,"abstract":"<p><p>This case report describes a patient with post-neurosurgical infection and bacteremia caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae. There is limited evidence to guide antibiotic treatment decisions for such infections. The patient was treated with meropenem-vaborbactam (MEV). MEV monotherapy was associated with bacteremia clearance.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"1041-1043"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40697835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-NMDA receptor encephalitis presenting as fever with undetermined cause.","authors":"Chih-Wei Liang,&nbsp;Tun-Chieh Chen","doi":"10.1016/j.ijid.2022.06.019","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.06.019","url":null,"abstract":"<p><p>Autoimmune encephalitis is a rare disease, which should be differentiated from aseptic encephalitis. Possessing anti-N-methyl-D-aspartate (NMDA) receptor autoantibody is the leading cause of autoimmune encephalitis. However, it may pose a diagnostic challenge to clinicians, especially to nonpsychiatric or non-neurologic specialist, resulting in a delayed initiation of treatment. Hence, we share the case of a patient with anti-NMDA receptor encephalitis who was hospitalized in the infectious diseases ward, presenting with acute febrile illness that preceded characteristic neuropsychiatric symptoms.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"365-367"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39992818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}