International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases最新文献

{"title":"In vitro synergistic antifungal activities of caspofungin in combination with fluconazole or voriconazole against Candida species determined by the Etest method.","authors":"Qianting Yang,&nbsp;Zhiyong Liu,&nbsp;Yan Wang,&nbsp;Jiao Xie,&nbsp;Kanghuai Zhang,&nbsp;Yalin Dong,&nbsp;Yun F Wang","doi":"10.1016/j.ijid.2022.07.056","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.056","url":null,"abstract":"<p><strong>Objectives: </strong>Increased resistance of Candida species, especially Candida. glabrata is problematic. Combination antifungal therapies were studied to solve the problem.</p><p><strong>Methods: </strong>In this study, combinations of caspofungin with fluconazole and voriconazole were evaluated in 28 Candida species (including 15 C. glabrata and 12 with FKS mutation) at 24 and 48 hours using two Etest methods (direct cover method and MIC/MIC method).</p><p><strong>Results: </strong>For Candida isolates, direct cover method showed synergy of caspofungin-fluconazole and caspofungin-voriconazole against 12/28 (43%) isolates at 24 hours, and against 16/28 (57%) isolates at 48 hours. The MIC/MIC method showed synergy of caspofungin-fluconazole and caspofungin-voriconazole against 11/28 (39%) and 12/28 (43%) isolates at 24 hours, and against 16/28 (57%) and 17/28 (61%) isolates at 48 hours, respectively. For C. glabrata, direct cover method showed synergy of caspofungin-fluconazole and caspofungin-voriconazole against 11/15 (73%) and 10/15 (67%) isolates at 24 hours, and 11/15 (73%) and 13/15 (87%) isolates at 48 hours, respectively. The MIC/MIC method showed synergy of caspofungin-fluconazole and caspofungin-voriconazole against both 11/15 (73%) isolates at 24 hours, and 10/15 (67%) and 14/15 (93%) isolates at 48 hours, respectively.</p><p><strong>Conclusion: </strong>A combination of caspofungin and fluconazole or voriconazole might be effective against infections caused by Candida species, especially C. glabrata with FKS mutation.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"982-990"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40652452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case-fatality and sequelae following acute bacterial meningitis in South Africa, 2016 through 2020.","authors":"Susan Meiring,&nbsp;Cheryl Cohen,&nbsp;Linda de Gouveia,&nbsp;Mignon du Plessis,&nbsp;Vanessa Quan,&nbsp;Jackie Kleynhans,&nbsp;Colin Menezes,&nbsp;Gary Reubenson,&nbsp;Halima Dawood,&nbsp;Maphoshane Nchabeleng,&nbsp;Mohamed Said,&nbsp;Nomonde Mvelase,&nbsp;Prasha Mahabeer,&nbsp;Rispah Chomba,&nbsp;Ruth Lekalakala,&nbsp;Trusha Nana,&nbsp;Vindana Chibabhai,&nbsp;Marianne Black,&nbsp;Anne von Gottberg","doi":"10.1016/j.ijid.2022.07.068","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.068","url":null,"abstract":"<p><strong>Objectives: </strong>Providing country-specific estimates of case fatality and sequelae from bacterial meningitis (BM) is important to evaluate and monitor progress toward the World Health Organization's roadmap to \"defeating meningitis by 2030\".</p><p><strong>Methods: </strong>From 2016-2020, GERMS-SA conducted enhanced surveillance at 26 hospitals across South Africa. Episodes of laboratory-confirmed BM due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis were included. Risk factors for in-hospital death and sequelae at hospital discharge among survivors were analyzed.</p><p><strong>Results: </strong>Of 12,717 invasive bacterial infections reported nationally, 39% (4980) were from enhanced surveillance sites, including 4159 pneumococcal, 640 H. influenzae, and 181 meningococcal infections. BM accounted for 32% (1319/4159) of pneumococcal, 21% (136/640) of H. influenzae, and 83% (151/181) of meningococcal invasive diseases. Clinical data were available for 91% (1455/1606) of BM: 26% (376/1455) were aged <5 years, 50% (726/1455) were female, and 62% (723/1171) with known HIV results, were HIV-infected. In-hospital case fatality was 37% (534/1455), and 24% (222/921) of survivors had adverse sequelae. Risk factors for death included altered mental status, HIV infection, and comorbidities. Risk factors for adverse sequelae included altered mental status and antimicrobial nonsusceptibility.</p><p><strong>Conclusion: </strong>BM in South Africa has a high case fatality, and adverse sequelae frequently occur among survivors. Those with comorbidities (including HIV) are at the highest risk.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"1056-1066"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40674728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the transmission dynamics of a large-scale measles outbreak in Southern Vietnam.","authors":"Thi Huyen Trang Nguyen,&nbsp;Thuong Vu Nguyen,&nbsp;Quang Chan Luong,&nbsp;Thang Vinh Ho,&nbsp;Christel Faes,&nbsp;Niel Hens","doi":"10.1016/j.ijid.2022.07.055","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.055","url":null,"abstract":"<p><strong>Objectives: </strong>Southern Vietnam experienced a large measles outbreak of over 26,000 cases during 2018-2020. We aimed to understand and quantify the measles spread in space-time dependence and the transmissibility during the outbreak.</p><p><strong>Methods: </strong>Measles surveillance reported cases between January 2018 and June 2020, vaccination coverage, and population data at provinicial level were used. To illustrate the spatio-temporal pattern of disease spread, we employed the endemic-epidemic multivariate time series model decomposing measles risk additively into autoregressive, spatio-temporal, and endemic components. Likelihood-based estimation procedures were performed to determine the time-varying reproductive number R_e of measles.</p><p><strong>Results: </strong>Our analysis showed that the incidence of measles was associated with vaccination coverage heterogeneity and spatial interaction between provincial units. The risk of infections was dominated by between-province transmission (36.1% to 78.8%), followed by local endogenous transmission (4.1% to 61.5%). In contrast, the endemic behavior had a relatively small contribution (2.4% to 33.4%) across provinces. In the exponential phase of the epidemic, R_e was above the threshold with a maximum value of 2.34 (95% CI: 2.20-2.46).</p><p><strong>Conclusion: </strong>Local vaccination coverage and human mobility are important factors contributing to the measles dynamics in Southern Vietnam, and the high risk of inter-provincial transmission is of most concern. Strengthening the disease surveillance is recommended, and further research is essential to understand the relative contribution of population immunity and control measures in measles epidemics.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"1009-1017"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40652454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Corrigendum Helicobacter pylori, clinical, laboratory and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: a case-control study'.","authors":"Yalda Lucero,&nbsp;Anne J Lagomarcino,&nbsp;Juan P Torres,&nbsp;Patricia Roessler,&nbsp;Nora Mamani,&nbsp;Sergio George,&nbsp;Nicole Huerta,&nbsp;Monica Gonzalez,&nbsp;Miguel O'Ryan G","doi":"10.1016/j.ijid.2022.05.063","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.05.063","url":null,"abstract":"","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"442"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40571133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of compliance with mandatory clinical trial registration.","authors":"Ronan M Docherty,&nbsp;Helen F Galley","doi":"10.1016/j.ijid.2022.07.066","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.066","url":null,"abstract":"","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"957-958"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Vaginal Myiasis: Successful Management With Ivermectin.","authors":"César Payán-Gómez,&nbsp;Ana María Cabal-Herrera,&nbsp;Jurany Andrea Caicedo-Rosales,&nbsp;Wilmar Saldarriaga-Gil","doi":"10.1016/j.ijid.2022.06.021","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.06.021","url":null,"abstract":"<p><p>Myiasis refers to infestation of living animals or humans by maggots or fly larvae. Urogenital myiasis is a rare condition that is linked to poor sanitary conditions and limited access to healthcare and with few published case reports. Here, we describe the case of a 67-year-old homeless woman with multiple comorbidities, who presented with extensive vaginal myiasis requiring inpatient management with ivermectin, ceftriaxone, and metronidazole and daily larvae extraction and debridement. The relevance of this case is providing a report of a successful management with ivermectin of a case of severe vaginal myiasis. Severe cases of vaginal myiasis can require repeated debridement of necrotic tissue and systemic antibiotics in addition to antiparasitic medication. People living under poor sanitary conditions and with poor hygienic practices are at increased risk for severe vaginal myiasis.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"398-400"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39992404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhinofacial entomophthoramycosis: an uncommon infection of the subcutaneous tissue.","authors":"Kawisara Krasaewes,&nbsp;Saisawat Chaiyasate,&nbsp;Romanee Chaiwarith","doi":"10.1016/j.ijid.2022.06.056","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.06.056","url":null,"abstract":"<p><p>Entomophthoramycosis can be found in subtropical and tropical regions. This case illustrates common clinical features of conidiobolomycosis. Although this disease is not common, physicians working in these regions should be familiar with the clinical manifestations to enable early diagnosis and treatment.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"710-711"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40573600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive positive pressure ventilation to prevent respiratory complications of severe tetanus- sedation and methodological insights.","authors":"Abhijit S Nair,&nbsp;Antonio M Esquinas","doi":"10.1016/j.ijid.2022.07.008","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.008","url":null,"abstract":"","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"721"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40581805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Susceptibility to endemic Aedes-borne viruses among pregnant women in Risaralda, Colombia.","authors":"Jaime A Cardona-Ospina,&nbsp;Adriana M Trujillo,&nbsp;Erika V Jiménez-Posada,&nbsp;Juan C Sepúlveda-Arias,&nbsp;Fredy A Tabares-Villa,&nbsp;Joanne S Altieri-Rivera,&nbsp;Alejandro Monsalve,&nbsp;Juliana Restrepo-Chica,&nbsp;Daniela Osorio,&nbsp;Daniel Espinoza,&nbsp;Yerun Zhu,&nbsp;Juan D Castrillón-Spitia,&nbsp;Valentina Henao-SanMartin,&nbsp;David R Murillo-Garcia,&nbsp;Natalia Millán,&nbsp;Sandra X Olaya,&nbsp;Ana M Valencia-Montoya,&nbsp;Hugo A Bedoya-Arias,&nbsp;Rhuvi Villamizar-Peña,&nbsp;Estefanía Gutierrez-Ocampo,&nbsp;Yeimer Holguin-Rivera,&nbsp;Isabella Cortés-Bonilla,&nbsp;Maria C Cardona-Trujillo,&nbsp;Alejandra García-Barco,&nbsp;D Katterine Bonilla-Aldana,&nbsp;Guillermo J Lagos-Grisales,&nbsp;Alfonso J Rodríguez-Morales,&nbsp;Matthew H Collins","doi":"10.1016/j.ijid.2022.07.017","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.017","url":null,"abstract":"<p><strong>Objectives: </strong>Aedes-borne viruses (ABV) affect humans on every inhabited continent and frequently cause epidemics. Recent epidemics of chikungunya and Zika viruses (ZIKV) highlight that preparedness for future epidemics requires assessment of susceptibility, particularly among high-risk groups. We sought to determine immunity against the three major circulating ABV among pregnant women in an ABV-endemic area of Colombia.</p><p><strong>Methods: </strong>A cross-sectional seroprevalence study was performed, enrolling women presenting to Labor and Delivery. Cord blood and maternal peripheral blood samples were obtained. IgG seroprevalence to flaviviruses and chikungunya was determined by ELISA. An abbreviated neutralization test was used to estimate the frequency and magnitude of immunity to Zika and four dengue serotypes. Cluster analyses explored epidemiologic factors associated with seroprevalence.</p><p><strong>Results: </strong>Most women exhibited high levels of neutralizing antibodies to one or more ABV; however, nearly 20% were seronegative for flaviviruses. Our research took place after the epidemic peak of the ZIKV outbreak in Colombia in 2016. However, only 20% of pregnant women had high levels of Zika-neutralizing antibodies consistent with likely protective immunity to ZIKV.</p><p><strong>Conclusion: </strong>Hence, a high proportion of pregnant women in Risaralda remain susceptible to one or more ABV including the teratogenic ZIKV, indicating a risk for future epidemics in this region.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"832-840"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of metagenomic next-generation sequencing in the pathogen detection of invasive osteoarticular infection.","authors":"Xinyu Fang,&nbsp;Yuanqing Cai,&nbsp;Xiaoqing Chen,&nbsp;Changyu Huang,&nbsp;Yiming Lin,&nbsp;Zida Huang,&nbsp;Chaofan Zhang,&nbsp;Ying Huang,&nbsp;Wenbo Li,&nbsp;Wenming Zhang","doi":"10.1016/j.ijid.2022.07.061","DOIUrl":"https://doi.org/10.1016/j.ijid.2022.07.061","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to analyze the pathogenic bacteria spectrum in invasive and primary osteoarticular infection (IOI and POI) and compare the pathogen detection rate of metagenomic next-generation sequencing (mNGS) and microbial culture in IOI and POI.</p><p><strong>Methods: </strong>The suspected POI and IOI cases from 2014-2021 were included. The diagnosis of POI or IOI was made by at least two orthopedic surgeons, two infectious diseases specialists, and one senior microbiologist. Demographic characteristics, microbial culture results, and so on were recorded. The pathogenic bacteria spectrum in IOI and POI were analyzed, and the ability of mNGS and microbial culture in pathogen detection in IOI and POI were compared.</p><p><strong>Results: </strong>There were 52 POI cases and 92 IOI cases; the common pathogen in POI and IOI were both Staphylococcus aureus. There are more cases with negative microbial culture results and multiple infections in IOI, and many cases were caused by rare and fastidious bacteria. The introduction of the mNGS could significantly increase the pathogen detection rate to 92.39% in IOI, which was 8.69% higher than that of microbial culture (P = 0.007), whereas the improvement in POI was limited to about 2%.</p><p><strong>Conclusion: </strong>mNGS is an promising tool for IOI pathogen detection.</p>","PeriodicalId":505767,"journal":{"name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","volume":" ","pages":"996-1001"},"PeriodicalIF":8.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40584992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}