Giovanni Grandi, Vincenzo Bettoli, Vincenzina Bruni, Alessandro Gambera, Rossella E Nappi, Angelo Cagnacci
{"title":"The prolonged-release oral formulations: a new era in hormonal contraception technology?","authors":"Giovanni Grandi, Vincenzo Bettoli, Vincenzina Bruni, Alessandro Gambera, Rossella E Nappi, Angelo Cagnacci","doi":"10.1080/13625187.2024.2444241","DOIUrl":"10.1080/13625187.2024.2444241","url":null,"abstract":"","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bruna Marmett, Julia Mathias Reis, Amanda Ferreira de Carvalho, Daniela Dal Forno Kinalski, Carmem Lisiane Escouto de Souza, Natália Jaeger Basso Werle, Mayara Ribeiro Masseli, Ana Paula Beck da Silva Etges, Carisi Anne Polanczyk, Tiago Chagas Dalcin, Sérgio Luis Amantea
{"title":"The cost burden of adolescent and young adult pregnancy: real-world evidence from the Brazilian public health care system.","authors":"Bruna Marmett, Julia Mathias Reis, Amanda Ferreira de Carvalho, Daniela Dal Forno Kinalski, Carmem Lisiane Escouto de Souza, Natália Jaeger Basso Werle, Mayara Ribeiro Masseli, Ana Paula Beck da Silva Etges, Carisi Anne Polanczyk, Tiago Chagas Dalcin, Sérgio Luis Amantea","doi":"10.1080/13625187.2024.2416587","DOIUrl":"10.1080/13625187.2024.2416587","url":null,"abstract":"<p><strong>Background: </strong>In low- and middle-income countries, pregnancy in adolescence represents an important public health issue. Rates of early pregnancy have significant social and economic consequences that extend beyond the individual sphere, impacting public/governmental budgets.</p><p><strong>Aim: </strong>To estimate the cost implications of early pregnancies from the perspective of the Brazilian Unified Public Health System.</p><p><strong>Methods: </strong>This retrospective secondary data analysis focuses on assessing direct hospital costs. The study cohort comprises adolescents and young adults who underwent prenatal care at a reference maternity hospital between January and December 2021. Individual procedure costs were extracted from hospital records and converted into monetary values using the Brazilian Federal Fee. The sample size for each group was determined based on preliminary data collected during a pilot study. Descriptive analyses presented costs stratified by age groups. To estimate budgetary impacts and sensitivity we used national live birth incidence rates.</p><p><strong>Results: </strong>The mean cost per case of adolescent pregnancy was US$ 704.92 (SD: 1,707.74) and for adult pregnancy was US$ 592.40 (SD: 941.43). The cost of hospital admission accounted for 61% of the total cost of adolescent pregnancies. The annual budget impact of pregnancies among women under 30 years was estimated at US$ 1 billion, with 239 million coming from women under 20 years old.</p><p><strong>Conclusion: </strong>Pregnancy in adolescence may lead to a significant annual budget impact, representing 24% of costs attributed to pregnancies among women under 30 years. Costs related to hospital admissions and complications represent a substantial share of the total costs of adolescent pregnancy.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"13-19"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine Stewart, Rose Stevens, Fiona Kennedy, Paulina Cecula, Elena Rueda Carrasco, Jennifer Hall
{"title":"Experiences and impacts of side effects among contraceptive users in the UK: exploring individual narratives of contraceptive side effects.","authors":"Catherine Stewart, Rose Stevens, Fiona Kennedy, Paulina Cecula, Elena Rueda Carrasco, Jennifer Hall","doi":"10.1080/13625187.2024.2410841","DOIUrl":"10.1080/13625187.2024.2410841","url":null,"abstract":"<p><strong>Purpose: </strong>While many women worldwide use contraception, there is a paucity of research on individual experiences of side effects. To address this gap, we investigated individual's contraception experiences.</p><p><strong>Methods: </strong>Women aged 18 to 35, living in the UK were invited to participate in an online survey on contraception. Free text responses were collected. Through a directed content analysis approach, we developed a coding framework (based on existing literature and initial response review) including six themes; method(s) of contraception, side effect(s) experienced, impact of side effect(s), timing of side effect(s), interactions with healthcare practitioners, and trial-and-error.</p><p><strong>Results: </strong>Overall, 337 participants provided free-text responses. Side effect experiences and impacts varied greatly between individuals and contraceptives. Most participants described negative effects, including mental health issues and bleeding problems. However, some shared positive experiences mainly related to bleeding management or the absence of side effects. Participants described how side effects often varied or appeared over time. Some participants felt unheard by healthcare practitioners.</p><p><strong>Conclusions: </strong>This study highlights how specific contraceptive experience is to the individual. We advocate for a patient-centred approach to contraceptive counselling. Practitioners should play an active role in improving contraception prescription, acknowledging the diverse experiences and preferences of patients.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"27-32"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The pre-<i>Roe</i> legal framework: a dissecting study of the evolution of abortion laws and their socio-legal implications.","authors":"Johnny Sakr","doi":"10.1080/13625187.2024.2448973","DOIUrl":"https://doi.org/10.1080/13625187.2024.2448973","url":null,"abstract":"<p><strong>Introduction: </strong>The historical evolution of abortion laws in the United States reflects significant shifts in societal attitudes and legal frameworks, particularly concerning reproductive rights and maternal consent. Prior to <i>Roe v. Wade</i>, abortion was largely criminalised, but gradual changes in public opinion and legislation paved the way for liberalised abortion laws.</p><p><strong>Objective: </strong>This study aims to examine the legal and societal developments shaping abortion laws in the United States from the early 19th century to the pre-<i>Roe</i> era, focusing on the interplay between public opinion and legislative milestones.</p><p><strong>Methods: </strong>A historical-legal methodology was employed, analysing primary sources such as court rulings and statutes, alongside secondary literature. The research explores the evolving legal definitions of foetal personhood and maternal autonomy, contextualised within broader societal changes.</p><p><strong>Results: </strong>The findings reveal a transformation in perceptions of abortion, from being viewed as a criminal act to a recognised right influenced by medical, social, and political factors. Legal frameworks increasingly reflected public support for women's autonomy, culminating in the <i>Roe v. Wade</i> decision.</p><p><strong>Conclusions: </strong>This study provides historical context for contemporary abortion debates, highlighting how pre-<i>Roe</i> legal and societal changes continue to inform discussions on women's health, autonomy, and reproductive rights.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abraham Fessehaye Sium, Sarah Prager, Matthew Reeves
{"title":"Patient acceptability of intra-amniotic digoxin versus intracardiac lidocaine for inducing foetal demise prior to second trimester medical abortion: a prospective cohort.","authors":"Abraham Fessehaye Sium, Sarah Prager, Matthew Reeves","doi":"10.1080/13625187.2024.2444237","DOIUrl":"https://doi.org/10.1080/13625187.2024.2444237","url":null,"abstract":"<p><strong>Objective: </strong>To compare patient acceptability of inducing foetal demise procedures between intracardiac lidocaine and intra-amniotic digoxin administration prior to second trimester medical abortion.</p><p><strong>Methods: </strong>We enrolled a prospective cohort of women who received either intra-cardiac lidocaine or intra-amniotic digoxin during second trimester medical abortion at later gestation (20-28 weeks) at our centre between April 2023 and March 2024. Data were collected prospectively using a structured questionnaire. For data analysis, Chi-squared test and Fisher's exact test were performed as appropriate. P-value less than 0.05 was used to present results significance.</p><p><strong>Results: </strong>A total of 151 women (101 who had intra-amniotic digoxin injection and 50 women who had foetal intracardiac lidocaine injection) were analysed. The groups had similar mean gestational age (22.42 weeks vs 22.65 weeks, in the digoxin vs lidocaine groups respectively, p-value = 0.50). More women from the digoxin group described the pain associated with foeticide administration as 'as expected' than in the intra-cardiac lidocaine group (48% vs 30%, p-value = 0.005). Similarly, more women in the digoxin group described their overall experience of foeticide administration as 'not bad' compared to those who received intra-cardiac lidocaine (59.4% vs 32%, p-value = 0.006). Likewise, more women in the digoxin group stated they would recommend the same procedure for friends or family members should they face the same problem than in the lidocaine group (43% vs 14%, p-value = 0.001).</p><p><strong>Conclusions: </strong>Our study shows that intra-amniotic digoxin has superior patient acceptability than intracardiac lidocaine by women undergoing safe second trimester medical abortion at later gestion.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriele S Merki-Feld, Riley Bove, Lisa B Haddad, Kerstin Hellwig, Jan Hillert, Maria Houtchens, Melinda Magyari, Scott Montgomery, Manuela Simoni, Egon Stenager, Heidi Thompson, Zeliha Tulek, Kurt Marhardt, Rossella E Nappi
{"title":"Family planning and contraception in people with multiple sclerosis: perspectives for obstetricians, gynaecologists, and other health care professionals involved in reproductive planning.","authors":"Gabriele S Merki-Feld, Riley Bove, Lisa B Haddad, Kerstin Hellwig, Jan Hillert, Maria Houtchens, Melinda Magyari, Scott Montgomery, Manuela Simoni, Egon Stenager, Heidi Thompson, Zeliha Tulek, Kurt Marhardt, Rossella E Nappi","doi":"10.1080/13625187.2024.2434843","DOIUrl":"https://doi.org/10.1080/13625187.2024.2434843","url":null,"abstract":"<p><strong>Purpose: </strong>Multiple sclerosis (MS) is often diagnosed in people of reproductive age. However, family planning counselling is not always integrated within MS care. Decisions on family planning can be further complicated by potential side effects associated with several disease-modifying therapies. While neurologists may lack training in contraceptive use and family planning counselling, obstetricians and gynaecologists (OB-GYNs) and other health care professionals involved in reproductive life planning (RHCPs) may lack detailed knowledge and experience around the use of contemporary MS treatments.</p><p><strong>Material and methods: </strong>Through a modified Delphi consensus programme, a multidisciplinary steering committee of 13 international experts developed practical clinical recommendations on contraceptive use and family planning for people with MS (PwMS). This article offers insights to help OB-GYNs and RHCPs implement these recommendations, focusing on contraceptive decision-making and MS medications.</p><p><strong>Results: </strong>The perspectives discussed emphasise providing education on MS to OB-GYNs and other RHCPs, enabling informed counselling for PwMS and their partners regarding contraception and family planning. Close collaboration among the multidisciplinary team, including neurologists, is crucial in providing reproductive care for PwMS.</p><p><strong>Conclusions: </strong>The detailed perspectives provided aim to enable OB-GYNs and other RHCPs to provide informed counselling for PwMS and their partners regarding contraception and family planning.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mandatory spousal authorisation for abortion: characteristics of countries in which it exists and the potential for modernisation of the law.","authors":"Sam Rowlands","doi":"10.1080/13625187.2024.2434844","DOIUrl":"https://doi.org/10.1080/13625187.2024.2434844","url":null,"abstract":"<p><strong>Purpose: </strong>Spousal authorisation for abortion (SA) is in direct conflict with the right to bodily autonomy. The World Health Organisation guideline on abortion specifically recommends that abortion should be available on request without third-party authorisation. The objectives of this study were to: a) determine which countries insist by law on SA, b) describe shared characteristics of these countries, c) assess the impact of such legislation on access to abortion and d) evaluate the chances of repeal of such laws.</p><p><strong>Methods: </strong>Interrogation of known databases on global abortion laws. Grouping of countries with SA laws according to their characteristics. A literature review of material on how mandatory SA relates to reproductive rights.</p><p><strong>Results: </strong>Fifteen countries were found to require SA. Nine of these countries have low freedom and democracy scores. Three South Eastern Asian countries, Japan, South Korea and Taiwan, have high freedom and democracy scores and no dominant religion. Broader studies on third-party authorisation for abortion show delayed access to abortion and emphasise the general principle that it is the healthcare seeker alone whose consent should be required for a health intervention. A qualitative study from Türkiye showed specifically how SA requirements could impair access to abortion.</p><p><strong>Conclusions: </strong>Twelve of the countries do not appear to have the necessary government or societal conditions necessary for abortion law modernisation in the near future. In contrast, Japan, South Korea and Taiwan are prime candidates for immediate liberalisation of their abortion laws.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Grandi, Lia Feliciello, Alice Sgandurra, Valeria Pedrini, Gloria Guariglia, Valentina Ferrari, Nicoletta Del Duca, Antonio La Marca
{"title":"Tips and tricks for the management of contraceptive etonogestrel implant in clinical practice: an Expert Opinion.","authors":"Giovanni Grandi, Lia Feliciello, Alice Sgandurra, Valeria Pedrini, Gloria Guariglia, Valentina Ferrari, Nicoletta Del Duca, Antonio La Marca","doi":"10.1080/13625187.2024.2434846","DOIUrl":"https://doi.org/10.1080/13625187.2024.2434846","url":null,"abstract":"<p><p>The use of long-acting reversible contraceptives (LARCs) is increasing globally due to their higher ability to effectively prevent unintended pregnancies in comparison to short-acting reversible contraceptives (SARCs), especially in adolescence. LARCs include intrauterine devices (copper- or levonorgestrel-releasing) and subcutaneous implants. For LARCs application a dedicated training is needed. Particularly, this Expert Opinion is aiming to open to expert debates on the subcutaneous implant, in particular etonogestrel (ENG)-releasing one, as a cutting-edge form of hormonal contraception. It provides up-to-date guidance about practical advice and technical tips for the ENG implant insertion/removal derived from many years of clinical experience, along with recommendations for the management of unscheduled bleeding during contraception with this method.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Viscola, Ana C Marcelino, Paula da C Pereira, Ilza Monteiro, Ximena Espejo-Arce, Luis Bahamondes
{"title":"Improvement of laboratory markers of anaemia in the treatment of heavy menstrual bleeding with a 19.5-mg intrauterine device: a pilot study.","authors":"Marco Viscola, Ana C Marcelino, Paula da C Pereira, Ilza Monteiro, Ximena Espejo-Arce, Luis Bahamondes","doi":"10.1080/13625187.2024.2406496","DOIUrl":"10.1080/13625187.2024.2406496","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate improvements in laboratory markers of anaemia (haemoglobin, haematocrit, serum iron, and ferritin) in women with subjective heavy menstrual bleeding (HMB) treated with the levonorgestrel 19.5-mg intrauterine device.</p><p><strong>Materials and methods: </strong>We conducted a pilot study at the Department of Obstetrics and Gynaecology, University of Campinas, Faculty of Medical Sciences, Campinas, SP, Brazil. We compared anaemia markers in 73 women aged 18-48 years suffering from HMB, one year after placement of the IUD.</p><p><strong>Results: </strong>The mean age of participants was 30.0 years (range 24-38); more than half were white, and the mean body mass index (kg/m<sup>2</sup>) was 27.0. Twenty (27.4%) participants exited the study due to loss to follow-up (<i>n</i> = 12; 16.4%), expulsion (<i>n</i> = 7; 9.6%) and uterine perforation (<i>n</i> = 1; 1.4%). One-year post-IUD placement, amenorrhoea was reported by 10 (13.7%) women. According to intention-to-treat and per protocol analyses, the proportion of women with normal haemoglobin levels significantly improved (<i>p</i> = 0.014 in both analyses), as did haematocrit (<i>p</i> < 0.001 in both analyses) and serum iron (<i>p</i> = 0.003 in both analyses) compared to baseline evaluations. The proportion of women with normal ferritin levels also improved (<i>p</i> < 0.001) in both analyses using a cut-off of 15 ng/ml, though no significant difference was observed using a 30 ng/ml cut-off (<i>p</i> = 0.083 in both analyses).</p><p><strong>Conclusion: </strong>The levonorgestrel 19.5-mg IUD effectively improved laboratory markers of anaemia one year after placement in women with HMB.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"282-286"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yajing Wu, Qing Zhang, Jie Zeng, Youling Zeng, Yuliang Zou
{"title":"Associations of the implementation of the three-child policy with changes in contraceptive methods among women who underwent induced abortion: a cross-sectional study of Wuhan, a megacity in central China.","authors":"Yajing Wu, Qing Zhang, Jie Zeng, Youling Zeng, Yuliang Zou","doi":"10.1080/13625187.2024.2400967","DOIUrl":"10.1080/13625187.2024.2400967","url":null,"abstract":"<p><strong>Background: </strong>Induced abortion, as a legal medical practice in China, has an enormous negative impact on women's sexual and reproductive health. After the implementation of the three-child policy, guiding women to choose appropriate contraceptive measures to protect their fertility is the focus of China's family planning. But little is known about the impact of the family planning policy on women's contraceptive behaviour.</p><p><strong>Methods: </strong>We collected 7022 cases who underwent abortion between July 2020 and June 2022 in Wuhan. Based on the time of implementation of the policy, the study population was divided into two groups, namely, the pre-policy group (before July 2021, Group 1) and the post-policy group (after July 2021, Group 2). Logistic regression was used to analyse the effect of the policy on women's choice of different contraceptive methods for abortion.</p><p><strong>Results: </strong>There were a total of 3487 cases in Group 1, accounting for 49.65%, and 3535 cases in Group 2, accounting for 50.34%. The proportion of women choosing efficient contraceptive methods after the Three-Child Policy decreased compared with before. A correlation was observed between the implementation of the Three-Child Policy and whether to choose efficient contraceptive methods after abortion (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The study has found that after the Three-Child Policy, women opting for induced abortion tend to prefer less effective contraceptive methods, particularly condoms. There is a marked shift towards more effective contraception methods both before and after the implementation of the Three-Child Policy.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"269-275"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}