Improvement of laboratory markers of anaemia in the treatment of heavy menstrual bleeding with a 19.5-mg intrauterine device: a pilot study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1080/13625187.2024.2406496

Marco Viscola, Ana C Marcelino, Paula da C Pereira, Ilza Monteiro, Ximena Espejo-Arce, Luis Bahamondes

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Abstract

Objectives: To evaluate improvements in laboratory markers of anaemia (haemoglobin, haematocrit, serum iron, and ferritin) in women with subjective heavy menstrual bleeding (HMB) treated with the levonorgestrel 19.5-mg intrauterine device.

Materials and methods: We conducted a pilot study at the Department of Obstetrics and Gynaecology, University of Campinas, Faculty of Medical Sciences, Campinas, SP, Brazil. We compared anaemia markers in 73 women aged 18-48 years suffering from HMB, one year after placement of the IUD.

Results: The mean age of participants was 30.0 years (range 24-38); more than half were white, and the mean body mass index (kg/m²) was 27.0. Twenty (27.4%) participants exited the study due to loss to follow-up (n = 12; 16.4%), expulsion (n = 7; 9.6%) and uterine perforation (n = 1; 1.4%). One-year post-IUD placement, amenorrhoea was reported by 10 (13.7%) women. According to intention-to-treat and per protocol analyses, the proportion of women with normal haemoglobin levels significantly improved (p = 0.014 in both analyses), as did haematocrit (p < 0.001 in both analyses) and serum iron (p = 0.003 in both analyses) compared to baseline evaluations. The proportion of women with normal ferritin levels also improved (p < 0.001) in both analyses using a cut-off of 15 ng/ml, though no significant difference was observed using a 30 ng/ml cut-off (p = 0.083 in both analyses).

Conclusion: The levonorgestrel 19.5-mg IUD effectively improved laboratory markers of anaemia one year after placement in women with HMB.

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在使用 19.5 毫克宫内节育器治疗大量月经出血时改善贫血的实验室指标：一项试点研究。

研究目的评估接受左炔诺孕酮 19.5 毫克宫内节育器治疗的主观大量月经出血（HMB）妇女贫血实验室指标（血红蛋白、血细胞比容、血清铁和铁蛋白）的改善情况：我们在巴西 SP 坎皮纳斯市坎皮纳斯大学医学系妇产科进行了一项试点研究。我们比较了 73 名年龄在 18-48 岁之间、患有子宫内膜异位症的妇女在放置宫内节育器一年后的贫血指标：参与者的平均年龄为 30.0 岁（24-38 岁不等）；半数以上为白人，平均体重指数（kg/m2）为 27.0。20 名参与者（27.4%）退出了研究，退出原因包括失去随访（12 人；16.4%）、宫内节育器脱出（7 人；9.6%）和子宫穿孔（1 人；1.4%）。放置宫内节育器一年后，有 10 名妇女（13.7%）报告闭经。根据意向治疗分析和按方案分析，与基线评估结果相比，血红蛋白水平正常的妇女比例显著提高（两项分析的P = 0.014），血细胞比容也显著提高（两项分析的P = 0.003）。铁蛋白水平正常的妇女比例也有所提高（两项分析中的 p p = 0.083）：结论：左炔诺孕酮 19.5 毫克宫内节育器能有效改善 HMB 妇女放置一年后的贫血实验室指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.