Abraham Fessehaye Sium, Sarah Prager, Matthew Reeves
{"title":"Patient acceptability of intra-amniotic digoxin versus intracardiac lidocaine for inducing foetal demise prior to second trimester medical abortion: a prospective cohort.","authors":"Abraham Fessehaye Sium, Sarah Prager, Matthew Reeves","doi":"10.1080/13625187.2024.2444237","DOIUrl":"10.1080/13625187.2024.2444237","url":null,"abstract":"<p><strong>Objective: </strong>To compare patient acceptability of inducing foetal demise procedures between intracardiac lidocaine and intra-amniotic digoxin administration prior to second trimester medical abortion.</p><p><strong>Methods: </strong>We enrolled a prospective cohort of women who received either intra-cardiac lidocaine or intra-amniotic digoxin during second trimester medical abortion at later gestation (20-28 weeks) at our centre between April 2023 and March 2024. Data were collected prospectively using a structured questionnaire. For data analysis, Chi-squared test and Fisher's exact test were performed as appropriate. P-value less than 0.05 was used to present results significance.</p><p><strong>Results: </strong>A total of 151 women (101 who had intra-amniotic digoxin injection and 50 women who had foetal intracardiac lidocaine injection) were analysed. The groups had similar mean gestational age (22.42 weeks vs 22.65 weeks, in the digoxin vs lidocaine groups respectively, p-value = 0.50). More women from the digoxin group described the pain associated with foeticide administration as 'as expected' than in the intra-cardiac lidocaine group (48% vs 30%, p-value = 0.005). Similarly, more women in the digoxin group described their overall experience of foeticide administration as 'not bad' compared to those who received intra-cardiac lidocaine (59.4% vs 32%, p-value = 0.006). Likewise, more women in the digoxin group stated they would recommend the same procedure for friends or family members should they face the same problem than in the lidocaine group (43% vs 14%, p-value = 0.001).</p><p><strong>Conclusions: </strong>Our study shows that intra-amniotic digoxin has superior patient acceptability than intracardiac lidocaine by women undergoing safe second trimester medical abortion at later gestion.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"119-122"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The pre-<i>Roe</i> legal framework: a dissecting study of the evolution of abortion laws and their socio-legal implications.","authors":"Johnny Sakr","doi":"10.1080/13625187.2024.2448973","DOIUrl":"10.1080/13625187.2024.2448973","url":null,"abstract":"<p><strong>Introduction: </strong>The historical evolution of abortion laws in the United States reflects significant shifts in societal attitudes and legal frameworks, particularly concerning reproductive rights and maternal consent. Prior to <i>Roe v. Wade</i>, abortion was largely criminalised, but gradual changes in public opinion and legislation paved the way for liberalised abortion laws.</p><p><strong>Objective: </strong>This study aims to examine the legal and societal developments shaping abortion laws in the United States from the early 19th century to the pre-<i>Roe</i> era, focusing on the interplay between public opinion and legislative milestones.</p><p><strong>Methods: </strong>A historical-legal methodology was employed, analysing primary sources such as court rulings and statutes, alongside secondary literature. The research explores the evolving legal definitions of foetal personhood and maternal autonomy, contextualised within broader societal changes.</p><p><strong>Results: </strong>The findings reveal a transformation in perceptions of abortion, from being viewed as a criminal act to a recognised right influenced by medical, social, and political factors. Legal frameworks increasingly reflected public support for women's autonomy, culminating in the <i>Roe v. Wade</i> decision.</p><p><strong>Conclusions: </strong>This study provides historical context for contemporary abortion debates, highlighting how pre-<i>Roe</i> legal and societal changes continue to inform discussions on women's health, autonomy, and reproductive rights.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"97-103"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A pilot randomised study to compare sub-lingual and vaginal routes of low-dose misoprostol following two sequential doses of mifepristone for second-trimester medical abortion.","authors":"Pavithra Justa, Rashmi Bagga, Anil E, Subhas Chandra Saha, Jaswinder Kalra, Vanita Jain, Aashima Arora","doi":"10.1080/13625187.2025.2452178","DOIUrl":"10.1080/13625187.2025.2452178","url":null,"abstract":"<p><strong>Primary objective: </strong>A randomized study to compare the induction abortion interval (IAI) using two different routes of Low-dose misoprostol administration Sublingual (S/L) and vaginal, after priming with two sequential doses of mifepristone for second-trimester medical abortion.</p><p><strong>Study design: </strong>After randomization in two groups, participants received two doses of mifepristone (200 mg) 24 h apart. On day 3, 200mcg of misoprostol was given by S/L route to group 1 and by vaginal route to group 2, (400mcg among women with gestation ≤16 weeks) and every 6 hours for a maximum of 3 doses.</p><p><strong>Results: </strong>The mean IAI (13.71±8.55 h and 13.22±8.22 h; <i>p</i>=0.768), mean number of misoprostol doses (2.08±1.08 and 2.54±1.12, <i>p</i>=0.05) and mean misoprostol dose (453.9±224.93 and 492.31±208.23 mcg, <i>p</i>=0.409) was similar. The complete abortion rate after 24 h (77.5% vs 87.5%, <i>p</i>=0.23), after 48 h (95% vs 97.5%, <i>p</i>=1.00) and minimal untoward effects seen were all similar in the two groups.</p><p><strong>Conclusions: </strong>Both SL and vaginal routes of misoprostol, after two doses of mifepristone were equally effective. The mean cumulative doses of misoprostol were similar, and a complete abortion rate of > 95% at 48 h was achieved with either route.<math><mo>></mo><mn>95</mn></math>.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"113-118"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grace Riley, Elizabeth Wang, Camille Flynn, Ashley Lopez, Aparna Sridhar
{"title":"Evaluating the fidelity of AI-generated information on long-acting reversible contraceptive methods.","authors":"Grace Riley, Elizabeth Wang, Camille Flynn, Ashley Lopez, Aparna Sridhar","doi":"10.1080/13625187.2025.2450011","DOIUrl":"10.1080/13625187.2025.2450011","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI) has many applications in health care. Popular AI chatbots, such as ChatGPT, have the potential to make complex health topics more accessible to the general public. The study aims to assess the accuracy of current long-acting reversible contraception information provided by ChatGPT.</p><p><strong>Methods: </strong>We presented a set of 8 frequently-asked questions about long-acting reversible contraception (LARC) to ChatGPT, repeated over three distinct days. Each question was repeated with the LARC name changed (e.g., 'hormonal implant' vs 'Nexplanon') to account for variable terminology. Two coders independently assessed the AI-generated answers for accuracy, language inclusivity, and readability. Scores from the three duplicated sets were averaged.</p><p><strong>Results: </strong>A total of 264 responses were generated. 69.3% of responses were accurate. 16.3% of responses contained inaccurate information. The most common inaccuracy was outdated information regarding the duration of use of LARCs. 14.4% of responses included misleading statements based on conflicting evidence, such as claiming intrauterine devices increase one's risk for pelvic inflammatory disease. 45.1% of responses used gender-exclusive language and referred only to women. The average Flesch readability ease score was 42.8 (SD 7.1), correlating to a college reading level.</p><p><strong>Conclusion: </strong>ChatGPT offers important information about LARCs, though a minority of responses are found to be inaccurate or misleading. A significant limitation is AI's reliance on data from before October 2021. While AI tools can be a valuable resource for simple medical queries, users should be cautious of the potential for inaccurate information.</p><p><strong>Short condensation: </strong>ChatGPT generally provides accurate and adequate information about long-acting contraception. However, it occasionally makes false or misleading claims.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"74-77"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety and accuracy of dating unwanted pregnancies and detecting ectopic pregnancy with the RCOG decision aid without routine ultrasound - a retrospective analysis form a large abortion service.","authors":"Janina Kaislasuo, Oskari Heikinheimo","doi":"10.1080/13625187.2025.2452175","DOIUrl":"10.1080/13625187.2025.2452175","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests routine pre-abortion ultrasound is unnecessary for women with regular menstrual cycles and without symptoms or risk factors for ectopic pregnancy in early gestation.</p><p><strong>Objectives: </strong>We evaluated the safety and accuracy of using the decision aid for early medical abortion without ultrasound developed by the RCOG Abortion Care group in a Finnish setting.</p><p><strong>Method: </strong>Using gestational age (GA) expected by last menstrual period (LMP), cycle irregularities, use of hormonal contraceptives, breastfeeding and self-reported symptoms indicative of possible ectopic pregnancy, women were classified into 'no ultrasound needed' and 'ultrasound needed' with a cut-off of 10 + 0 weeks or 70 days. Findings on US were then evaluated to assess classification accuracy.</p><p><strong>Results: </strong>Between September and December 2023, 494 women attending the abortion clinic at the Helsinki University Hospital were assessed. Correct classification of the necessity of an ultrasound was made in 491/494 (99.4%) cases before the women had a scan. The remaining three cases were one woman with an unexpected GA just above 10 + 0, one asymptomatic ectopic pregnancy and one asymptomatic pregnancy of unknown location with high plasma hCG, diagnosed as a partial molar pregnancy on pathology after diagnostic vacuum aspiration.</p><p><strong>Conclusions: </strong>Use of the structured flowchart developed by the RCOG highly accurately identifies women needing an ultrasound examination. The few cases that would have been undetected highlight the importance of informing women and health care providers about symptoms of ectopic or abnormal pregnancy similar to practices in wanted pregnancies not routinely examined and dated before late first trimester.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"93-96"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mandatory spousal authorisation for abortion: characteristics of countries in which it exists and the potential for modernisation of the law.","authors":"Sam Rowlands","doi":"10.1080/13625187.2024.2434844","DOIUrl":"10.1080/13625187.2024.2434844","url":null,"abstract":"<p><strong>Purpose: </strong>Spousal authorisation for abortion (SA) is in direct conflict with the right to bodily autonomy. The World Health Organisation guideline on abortion specifically recommends that abortion should be available on request without third-party authorisation. The objectives of this study were to: a) determine which countries insist by law on SA, b) describe shared characteristics of these countries, c) assess the impact of such legislation on access to abortion and d) evaluate the chances of repeal of such laws.</p><p><strong>Methods: </strong>Interrogation of known databases on global abortion laws. Grouping of countries with SA laws according to their characteristics. A literature review of material on how mandatory SA relates to reproductive rights.</p><p><strong>Results: </strong>Fifteen countries were found to require SA. Nine of these countries have low freedom and democracy scores. Three South Eastern Asian countries, Japan, South Korea and Taiwan, have high freedom and democracy scores and no dominant religion. Broader studies on third-party authorisation for abortion show delayed access to abortion and emphasise the general principle that it is the healthcare seeker alone whose consent should be required for a health intervention. A qualitative study from Türkiye showed specifically how SA requirements could impair access to abortion.</p><p><strong>Conclusions: </strong>Twelve of the countries do not appear to have the necessary government or societal conditions necessary for abortion law modernisation in the near future. In contrast, Japan, South Korea and Taiwan are prime candidates for immediate liberalisation of their abortion laws.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"104-106"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriele S Merki-Feld, Riley Bove, Lisa B Haddad, Kerstin Hellwig, Jan Hillert, Maria Houtchens, Melinda Magyari, Scott Montgomery, Manuela Simoni, Egon Stenager, Heidi Thompson, Zeliha Tulek, Kurt Marhardt, Rossella E Nappi
{"title":"Family planning and contraception in people with multiple sclerosis: perspectives for obstetricians, gynaecologists, and other health care professionals involved in reproductive planning.","authors":"Gabriele S Merki-Feld, Riley Bove, Lisa B Haddad, Kerstin Hellwig, Jan Hillert, Maria Houtchens, Melinda Magyari, Scott Montgomery, Manuela Simoni, Egon Stenager, Heidi Thompson, Zeliha Tulek, Kurt Marhardt, Rossella E Nappi","doi":"10.1080/13625187.2024.2434843","DOIUrl":"10.1080/13625187.2024.2434843","url":null,"abstract":"<p><strong>Purpose: </strong>Multiple sclerosis (MS) is often diagnosed in people of reproductive age. However, family planning counselling is not always integrated within MS care. Decisions on family planning can be further complicated by potential side effects associated with several disease-modifying therapies. While neurologists may lack training in contraceptive use and family planning counselling, obstetricians and gynaecologists (OB-GYNs) and other health care professionals involved in reproductive life planning (RHCPs) may lack detailed knowledge and experience around the use of contemporary MS treatments.</p><p><strong>Material and methods: </strong>Through a modified Delphi consensus programme, a multidisciplinary steering committee of 13 international experts developed practical clinical recommendations on contraceptive use and family planning for people with MS (PwMS). This article offers insights to help OB-GYNs and RHCPs implement these recommendations, focusing on contraceptive decision-making and MS medications.</p><p><strong>Results: </strong>The perspectives discussed emphasise providing education on MS to OB-GYNs and other RHCPs, enabling informed counselling for PwMS and their partners regarding contraception and family planning. Close collaboration among the multidisciplinary team, including neurologists, is crucial in providing reproductive care for PwMS.</p><p><strong>Conclusions: </strong>The detailed perspectives provided aim to enable OB-GYNs and other RHCPs to provide informed counselling for PwMS and their partners regarding contraception and family planning.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"59-73"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Would it be feasible for European Union countries to implement Safe Access Zones for premises providing abortion services?","authors":"Emily Ottley, Sam Rowlands","doi":"10.1080/13625187.2025.2463431","DOIUrl":"10.1080/13625187.2025.2463431","url":null,"abstract":"<p><p>Anti-abortion protestors situated near premises providing abortion services create barriers and hurdles to accessing abortion services, which violates the right of pregnant people to seek sexual and reproductive health services. There has been shown to be a need for Safe Access Zones (SAZs) to guarantee physical access to abortion services without obstruction. SAZs usually operate within a prescribed radius around premises providing abortion services and set out what behaviour is prohibited. The objective of this paper is to present a summary of the international experience of introducing and implementing SAZ laws, and to explain the lessons to be learned from this experience. SAZ legislation has been successfully enacted internationally in 22 jurisdictions (USA excluded). Countries with SAZ laws include Australia, New Zealand, the UK, and parts of Canada. Despite the Parliamentary Assembly of the Council of Europe calling for the introduction of SAZs in 2022, only two European Union (EU) countries have implemented this recommendation so far. On the basis of the medical and legal insights gained from the functioning of SAZs to date, it is the authors' opinion that it would be feasible for the 25 EU countries that do not yet have such zones to legislate for SAZs.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"107-112"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Grandi, Lia Feliciello, Alice Sgandurra, Valeria Pedrini, Gloria Guariglia, Valentina Ferrari, Nicoletta Del Duca, Antonio La Marca
{"title":"Tips and tricks for the management of contraceptive etonogestrel implant in clinical practice: an Expert Opinion.","authors":"Giovanni Grandi, Lia Feliciello, Alice Sgandurra, Valeria Pedrini, Gloria Guariglia, Valentina Ferrari, Nicoletta Del Duca, Antonio La Marca","doi":"10.1080/13625187.2024.2434846","DOIUrl":"10.1080/13625187.2024.2434846","url":null,"abstract":"<p><p>The use of long-acting reversible contraceptives (LARCs) is increasing globally due to their higher ability to effectively prevent unintended pregnancies in comparison to short-acting reversible contraceptives (SARCs), especially in adolescence. LARCs include intrauterine devices (copper- or levonorgestrel-releasing) and subcutaneous implants. For LARCs application a dedicated training is needed. Particularly, this Expert Opinion is aiming to open to expert debates on the subcutaneous implant, in particular etonogestrel (ENG)-releasing one, as a cutting-edge form of hormonal contraception. It provides up-to-date guidance about practical advice and technical tips for the ENG implant insertion/removal derived from many years of clinical experience, along with recommendations for the management of unscheduled bleeding during contraception with this method.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"78-86"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christine M Corrêa, Luiz C Zeferino, Luis Bahamondes
{"title":"Association of intrauterine device use and risk of abnormal cervical cytology.","authors":"Christine M Corrêa, Luiz C Zeferino, Luis Bahamondes","doi":"10.1080/13625187.2025.2453869","DOIUrl":"10.1080/13625187.2025.2453869","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether intrauterine device (IUD) use is associated with a significantly increased risk of abnormal cervical cytology.</p><p><strong>Methods: </strong>A retrospective cohort study was carried out at the University of Campinas, Campinas, SP, Brazil. Data came from medical records of 2,963 women from a family planning clinic who had undergone at least one cervical cytology for screening between 1990 and 2017. Women were split into three groups: users of either copper (Cu)- or the levonorgestrel 52 mg-IUD (2,305) and users of other contraceptive methods (658). The dependent variable was the cytological results as normal and abnormal, based on the Bethesda System. The most severe cytological result of each participant was considered and when all her results were normal, the last one was considered.</p><p><strong>Results: </strong>IUD use was associated with a lower risk of abnormal cervical cytology after adjusting for the number of cytology assessments per participant (RR 0.74; 95% CI 0.55;0.99; <i>p</i> = 0.049). Abnormal cervical cytology was more common in women with multiple cytology assessments and a longer duration since sexual debut. For each additional cytology test, the risk increased by 33.8% (<i>p</i> < 0.001), and for every additional year since sexual debut, the risk increased by 6.2% (<i>p</i> < 0.001). A lower incidence of abnormal cervical cytology was observed among women with a history of caesarean delivery, with a 24.9% reduction in risk per additional caesarean (<i>p</i> < 0.001). IUD users underwent more cervical cytology assessments than non-IUD users.</p><p><strong>Conclusion: </strong>We identified low risk of abnormal cervical cytology among IUD users.</p>","PeriodicalId":50491,"journal":{"name":"European Journal of Contraception and Reproductive Health Care","volume":" ","pages":"87-92"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}