Ankara Universitesi Eczacilik Fakultesi Dergisi最新文献

CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET 一种地方性丹参中提取的精油的化学成分和生物活性 greuter & burdet

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-24 DOI: 10.33483/jfpau.1416623

A. S. Çinar, S. Rizvanoğlu, Müjde Eryılmaz, Betül Demirci, Alev Önder

{"title":"CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET","authors":"A. S. Çinar, S. Rizvanoğlu, Müjde Eryılmaz, Betül Demirci, Alev Önder","doi":"10.33483/jfpau.1416623","DOIUrl":"https://doi.org/10.33483/jfpau.1416623","url":null,"abstract":"Objective: The study aimed to determine the chemical composition and antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil of Salvia absconditiflora Greuter & Burdet (an endemic species) growing wildly in Türkiye.\u0000Material and Method: The essential oil from the aerial parts of the plant was obtained by hydro-distillation (0.4%) and analyzed by GC-FID and GC-MS. In addition, the broth microdilution method was used to determine antibacterial activity. The crystal violet assay was performed for antibiofilm activity, and the reporter bacteria Chromobacterium violaceum ATCC 12472 was used in the anti-quorum sensing activity test.\u0000Result and Discussion: The major components of the essential oil were identified as 1,8-cineole (32.2%), camphor (13.6%), α-pinene (7.6%), camphene (5.5%), and viridiflorol (5.1%). The essential oil showed the best antibacterial activity against Gram-positive test bacteria, with a minimum inhibitory concentration (MIC) of 0.0078 (v/v) against Staphylococcus aureus strains. The percentage biofilm inhibition value of the essential oil was determined as 84.4%. The inhibition of violacein production by the essential oil in Chromobacterium violaceum ATCC 12472 indicated the possibility of anti-quorum sensing activity. The results of this study show that the essential oil of S. absconditiflora could be a promising alternative in fighting bacterial infections.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"56 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALZHEIMER HASTALIĞI, RİSK FAKTÖRLERİ VE TEDAVİ 阿尔茨海默病、风险因素和治疗

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-18 DOI: 10.33483/jfpau.1441827

Nejla Yildirim, Binay Can Eke

引用次数: 0

MOLECULAR DOCKING AND MOLECULAR DYNAMICS SIMULATIONS INHIBITION AGAINST OF HUMAN TELOMERASE BY NUCLEOSIDE AND NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NRTIs/NNRTIs) 分子对接和分子动力学模拟核苷酸和非核苷酸逆转录酶抑制剂（NRTIs/NNRTIs）对人类脱氧核糖核酸酶的抑制作用

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-17 DOI: 10.33483/jfpau.1444259

Dilan Konyar, Muhammed Tılahun Muhammed

{"title":"MOLECULAR DOCKING AND MOLECULAR DYNAMICS SIMULATIONS INHIBITION AGAINST OF HUMAN TELOMERASE BY NUCLEOSIDE AND NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NRTIs/NNRTIs)","authors":"Dilan Konyar, Muhammed Tılahun Muhammed","doi":"10.33483/jfpau.1444259","DOIUrl":"https://doi.org/10.33483/jfpau.1444259","url":null,"abstract":"Objective: This study investigated the anticancer effects of nucleoside and non-nucleoside reverse transcriptase inhibitors drugs by computational methods. The study aimed to evaluate the binding capacity of these drugs on the telomerase essential N-terminal (TEN) domain of telomerase reverse transcriptase (TERT). Molecular docking was used to assess the drugs' binding potential to the TEN domain. The stability of the protein-drug combination obtained from the docking method was assessed using molecular dynamics (MD) modeling. \u0000Material and Method: The TEN domain of TERT's crystal structure was obtained from the Protein Data Bank (PDB). The crystal structure identified by the PDB code 2B2A has a resolution of 2.2 Å. The molecular docking was performed using AutoDock Vina. The complexes were visualized using Biovia Discovery Studio. The MD simulation was conducted using GROMACS 2020 as indicated. An MD simulation was conducted for 200 ns on both the complexes and the free protein. The RMSD (root mean square deviation) of the protein and the molecules in relation to the protein, RMSF (root mean square fluctuation), and Rg (radius of gyration) were shown via Qt Grace.\u0000Result and Discussion: Doravirine, Etravirine, Rilpivirine showed higher binding affinity to the TEN domain compared to the reference TERT inhibitor, BIBR1532, based on the docking investigation. The MD simulation analysis showed that the protein-Doravirine complex had the highest stability in remaining within the protein's binding pocket. On the contrary, the protein-Rilpivirine complex decreased stability, potentially causing the ligand to not stay within the binding site. Doravirine was found to inhibit the TEN domain in the computational study. Therefore, the design and synthesis of novel doravirin derivatives is being considered because of the potential anticancer activity of doravirin in inhibiting the TEN domain of TERT.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OKÜLER İLAÇ TAŞIYICI SİSTEM OLARAK LİPİT BAZLI NANOPARTİKÜLLER 脂质纳米颗粒作为眼部给药系统

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-16 DOI: 10.33483/jfpau.1420064

Heybet Kerem Polat, Eren Aytekin, Nasıf Fatih Karakuyu, Nihat Kurt, Yonca Yazıksız

{"title":"OKÜLER İLAÇ TAŞIYICI SİSTEM OLARAK LİPİT BAZLI NANOPARTİKÜLLER","authors":"Heybet Kerem Polat, Eren Aytekin, Nasıf Fatih Karakuyu, Nihat Kurt, Yonca Yazıksız","doi":"10.33483/jfpau.1420064","DOIUrl":"https://doi.org/10.33483/jfpau.1420064","url":null,"abstract":"Amaç: Bu derleme kapsamında, oküler kullanımdaki katı lipit nanopartikül (KLN) ve nanoyapılı lipit taşıyıcı (NLT) sistemlerine, bu formülasyonların sterilizasyonuna ve tasarımla kalite (QbD) hakkında yapılan son araştırmaları tartışmak amaçlanmıştır.\u0000Sonuç ve Tartışma: Göze ilaç taşınması son yıllardaki gelişmelere rağmen hala karmaşık bir sorun olarak devem etmekte ve etkili ilaç taşınabilmesi için yenilikçi yaklaşımlara ihtiyaç duyulan bir alandır. Bu derlemede, yenilikçi yaklaşımlardan olan KLN’ler ve NLT’lerin oftalmik ilaç uygulamalarında sağladıkları üstünlükler güncel literatür örnekleriyle tartışılmıştır. KLN’ler oda sıcaklığında katı halde bulunan lipitlerin genellikle eritilmesi ya da çeşitli solvanlarda çözündürülmesi ile hazırlanan lipit partiküllerdir. NLT’ler ise yapısında katı lipitlerle birlikte oda sıcaklığında sıvı halde bulunan lipitleri de içermektedir. Oküler ilaç uygulamalarında kritik aşamalardan biri de sterilizasyon basamağıdır. Uygun sterilizasyon işleminin seçiminde, kullanılan lipitlerin erime dereceleri, serbest radikal oluşturma eğilimleri ve partikül büyüklükleri göz önünde bulundurulmalıdır. Sonuç olarak, KLN ve NLT’ler hem biyouyumluluk hem de etkililik anlamında oküler tedaviler için umut vadeden ilaç taşıyıcı sistemlerdir. Derleme kapsamında incelenen literatür çalışmaları da bu çıkarımı desteklemektedir. Ancak saklama süresince karşılaşılabilen stabilite sorunları ve tekrarlanabilir büyük ölçekte üretim konusunda yaşanan sıkıntılar nedeniyle klinik tedavide yeterince kullanılamamaktadır. Bu sorunların çözümü aşamasında QbD’nin etkili olacağı düşünülmektedir.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"5 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A STUDY ON JOB ANALYSIS IN COMMUNITY PHARMACIES: CASE OF ANKARA 社区药房工作分析研究：安卡拉案例

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-14 DOI: 10.33483/jfpau.1403130

Mine Zanbak Canan, M. Uzun, Gülbin Özçelikay

{"title":"A STUDY ON JOB ANALYSIS IN COMMUNITY PHARMACIES: CASE OF ANKARA","authors":"Mine Zanbak Canan, M. Uzun, Gülbin Özçelikay","doi":"10.33483/jfpau.1403130","DOIUrl":"https://doi.org/10.33483/jfpau.1403130","url":null,"abstract":"Objective: Job analysis is a method in which the duties and responsibilities in an organization are examined and researched systematically. The aim of this study is to determine both the workload of the pharmacist including the consultation to the patients and administrative works in community pharmacies, and the time allocated to these responsibilities. We are presenting advices which increase the productivity of the management.\u0000Material and Method: This study is descriptive-survey research. In this research, the survey method was used as a data collection tool. A questionnaire was prepared for the study, which was created by conducting interviews identifying the tasks that the pharmacists do in their routine. The survey was applied to a small number of pharmacists. The final version was sent by e-mail to pharmacists located in Ankara.\u0000Result and Discussion: It was determined that pharmacists spend most of their time in the pharmacy on patient counseling. Pharmacy staff assist the pharmacist with counseling, but mostly with administrative work. This study is important for the students who plan to be community pharmacists to be able to manage their pharmacies efficiently. It shows that the work awaits them in a community pharmacy and the time to do the work in the pharmacy on average basis.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140705916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANTIDEPRESSANT CONSUMPTION IN TÜRKİYE DURING THE PANDEMIC 大流行病期间土耳其的抗抑郁药消费情况

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-08 DOI: 10.33483/jfpau.1431730

Hilal Demirhan Keleş, Emrah Bilgener, Emre Keleş

引用次数: 0

PETROSELINUM CRISPUM (MILL.) FUSS (PARSLEY), A FOOD AND MEDICINALLY IMPORTANT PLANT: A REVIEW OF RECENT STUDIES BETWEEN 2013-2023 欧芹，一种重要的食用和药用植物：2013-2023 年近期研究综述

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-08 DOI: 10.33483/jfpau.1362626

Tuğba Subaş, U. Özgen, İçim Gökkaya, Gülin Renda

{"title":"PETROSELINUM CRISPUM (MILL.) FUSS (PARSLEY), A FOOD AND MEDICINALLY IMPORTANT PLANT: A REVIEW OF RECENT STUDIES BETWEEN 2013-2023","authors":"Tuğba Subaş, U. Özgen, İçim Gökkaya, Gülin Renda","doi":"10.33483/jfpau.1362626","DOIUrl":"https://doi.org/10.33483/jfpau.1362626","url":null,"abstract":"Objective: Petroselinum crispum (Mill.) Fuss is a bright green biennial medicinal and aromatic herb that grows almost all over the world. Today, it is one of the most commonly used culinary herbs. In addition to its use as food, it has been shown to possess broad pharmacological activities in several in vivo and in vitro studies. This study aimed to comprehensively summarize the current studies on the traditional use, phytochemical composition, pharmacological activities, clinical studies, toxicity, and drug interactions of parsley.\u0000Result and Discussion: According to the literature data, parsley is used as a diuretic, carminative, emmenagogue and for the prevention and treatment of kidney stone formation, the treatment of conditions such as urinary tract infections and stomach disorders. Its phytochemical composition consists of flavonoids, coumarins, phenolic compounds, organic acids, carotenoids, vitamins, minerals, fixed oil, essential oil, and other compounds. Studies on P. crispum have shown that it has a wide range of pharmacological activities, including antioxidant, antibacterial, antifungal, antidiabetic, antihypertensive, antiplatelet, analgesic, antiinflammatory, antihepatotoxic, antinephrotoxic, anticancer, antiurolithiatic, wound healing, antiobesity, estrogenic and neuroprotective effects. This review comprehensively summarizes the scientific data of the last ten years (2013-2023) on P. crispum.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"279 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DETERMINATION OF DNA DAMAGE INDUCED BY BISPHENOL A AND BISPHENOL S IN MCF7 CELL LINE 测定双酚 A 和双酚 S 在 mcf7 细胞系中诱导的 DNA 损伤

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-08 DOI: 10.33483/jfpau.1428739

Ekin Erdoğmuş, Seda Ipek, Belma Gümüşel, Y. Duydu, Aylin Üstündağ

引用次数: 0

ANTİ-APOPTOTİK PROTEİN İÇİN YENİ İNHİBİTÖRLERİN İN-SİLİKO YÖNTEMLERLE ARAŞTIRILMASI 通过内科学方法研究新型抗凋亡蛋白抑制剂

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-08 DOI: 10.33483/jfpau.1412714

M. Ünal

{"title":"ANTİ-APOPTOTİK PROTEİN İÇİN YENİ İNHİBİTÖRLERİN İN-SİLİKO YÖNTEMLERLE ARAŞTIRILMASI","authors":"M. Ünal","doi":"10.33483/jfpau.1412714","DOIUrl":"https://doi.org/10.33483/jfpau.1412714","url":null,"abstract":"Amaç: Bu araştırma makalesinin amacı, terapötik müdahale için yeni yollar keşfetmek üzere in-silico yöntemler kullanarak anti-apoptotik protein inhibitörleri incelemektir. Bununla birlikte ilaç keşif süreçlerini hızlandırmada hesaplamalı yaklaşımların potansiyelini vurgulamakta ve daha fazla deneysel doğrulama için umut verici adayları belirlemek için uygun maliyetli ve zaman açısından verimli bir strateji sunmayı hedeflemektedir.\u0000Gereç ve Yöntem: Bu çalışmada, önemli anti-apoptotik proteinleri hedef alan potansiyel inhibitörleri belirlemek için gelişmiş hesaplama teknikleri kullanılmıştır. Moleküler yerleştirmeden yararlanarak, hedef proteinlerle bağlanma ilgileri ve etkileşim modellerini tespit etmek için çeşitli kimyasal kütüphaneleri sistematik olarak taranmıştır Çalışma, potansiyel ilaç adaylarının tasarımını optimize etmek için bu etkileşimlerin yapısal inceliklerini aydınlatmaya odaklanmıştır.\u0000Sonuç ve Tartışma: Bulgularımız, yüksek bağlanma afiniteleri ve uygun farmakokinetik özelliklere sahip umut verici öncü bileşikleri ortaya çıkarmakta ve bunları daha fazla deneysel doğrulama için aday olarak sunmaktadır. Bu çalışmada elde edilen hesaplamalı içgörüler, anti-apoptotik protein inhibitörleri hakkındaki artan bilgi birikimine katkıda bulunmakla kalmayıp, aynı zamanda anormal apoptotik düzenleme ile karakterize edilen hastalıklarla mücadelede yeni terapötiklerin rasyonel tasarımı için bir temel sağlamaktadır.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"53 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS 评价用于检测环境水体中常用非甾体抗炎药物（NSAIDs）的各种已开发方法的灰度特征

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-02 DOI: 10.33483/jfpau.1425350

B. Sezgin, M. Soyseven

{"title":"EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS","authors":"B. Sezgin, M. Soyseven","doi":"10.33483/jfpau.1425350","DOIUrl":"https://doi.org/10.33483/jfpau.1425350","url":null,"abstract":"Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography (GC) and Liquid Chromatography (LC) methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites in environmental water samples.\u0000Material and Method: The evaluation of the methods' environmental impact was performed using National Environmental Methods Index Label (NEMI), Analytical Eco-scale, Analytical GREEnness Metric (AGREE), and Green Analytical Procedure Index (GAPI).\u0000Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"45 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0