Ankara Universitesi Eczacilik Fakultesi Dergisi最新文献_第2页

DEVELOPMENT OF A FAST LIQUID CHROMATOGRAPHY METHOD WITH A CHEMOMETRIC APPROACH BASED ON BOX-BEHNKEN DESIGN FOR THE DETERMINATION OF ANTIDEPRESSANTS IN PHARMACEUTICAL FORMULATIONS 基于方框-贝肯设计的化学计量学方法开发快速液相色谱法，用于测定药物制剂中的抗抑郁药

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-01 DOI: 10.33483/jfpau.1425340

Sercan Yıldırım, Tuğçe Özyiğit

{"title":"DEVELOPMENT OF A FAST LIQUID CHROMATOGRAPHY METHOD WITH A CHEMOMETRIC APPROACH BASED ON BOX-BEHNKEN DESIGN FOR THE DETERMINATION OF ANTIDEPRESSANTS IN PHARMACEUTICAL FORMULATIONS","authors":"Sercan Yıldırım, Tuğçe Özyiğit","doi":"10.33483/jfpau.1425340","DOIUrl":"https://doi.org/10.33483/jfpau.1425340","url":null,"abstract":"Objective: The objective of this work was to develop a liquid chromatographic method for the quantification of antidepressants, namely duloxetine (DXN), fluoxetine (FXN), citalopram (CIT), paroxetine (PXN), and sertraline (SRN), by a chemometric approach based on Box-Behnken design.\u0000Material and Method: After initial experiments to determine significant parameters, a Box-Behnken design consisting of 17 experiment sets was carried out. All separations were conducted using an Agilent Poroshell 120 EC-C18 analytical column (75 mm × 4.6 mm × 2.7 µm). \u0000Result and Discussion: The optimum levels of pH, acetonitrile ratio, and flow rate were determined with the desirability function as 2.7, 38%, and 1.1 ml/min, respectively. The differences (<8%) between predicted optimum responses and experimentally obtained results proved the model's suitability. Limits of detection and limits of quantification values were in the ranges of 0.17-0.29 µg/ml and 0.53-0.89 µg/ml, respectively. The feasibility of the technique was proven by analyzing PXN and DXN formulations.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"41 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LIQUID AND SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) CONTAINING VALSARTAN: STABILITY ASSESSMENT AND PERMEABILITY STUDIES 含有缬沙坦的液体和固体自乳化给药系统（SEDDS）：稳定性评估和渗透性研究

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-03-28 DOI: 10.33483/jfpau.1385707

Gülbeyaz Yıldız Türkyılmaz, Mine Diril, Eda Gülmezoğlu, Y. Karasulu

{"title":"LIQUID AND SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) CONTAINING VALSARTAN: STABILITY ASSESSMENT AND PERMEABILITY STUDIES","authors":"Gülbeyaz Yıldız Türkyılmaz, Mine Diril, Eda Gülmezoğlu, Y. Karasulu","doi":"10.33483/jfpau.1385707","DOIUrl":"https://doi.org/10.33483/jfpau.1385707","url":null,"abstract":"Objective: Valsartan (VST) is a Biopharmaceutical classification system (BSC) class II active ingredient with a bioavailability of approximately 25% and is utilized to treat high blood pressure (hypertension). This study aimed was to showcase the stability and increase the permeability of VST by developing self-emulsifying drug delivery systems (SEDDS) and solidified SEDDS (S-SEDDS) formulations.\u0000Material and Method: The ratios of the components were determined by the pseudo-ternary phase diagram, and the characterization studies were conducted in the previous study. Stability was performed in long-term (25±2˚C, 60±5% relative humidity) and accelerated (40±2˚C, 75±5% relative humidity) conditions. The intestinal permeability of SEDDS formulations was evaluated by Caco-2 cells.\u0000Result and Discussion: Formulations for 12 month, droplet sizes were found to be 67.52 ± 5.26 nm and 176.93 ± 17.34 nm for SEDDS of VST (VST-SEDDS) and S-SEDDS of VST (VST-S-SEDDS), respectively. During this period, polydispersity indexes were: VST-SEDDS, 0.56±0.1; VST-S-SEDDS, 0.58±0.05. Both formulations increased VST permeability across Caco-2 cells: VST-SEDDS by 2.32x (powder) and 2.18x (commercial); VST-S-SEDDS by 1.38x (powder) and 1.30x (commercial). The formulation components did not have cytotoxic effects. These results demonstrated that newly developed VST-SEDDS and VST-S-SEDDS formulations with high permeability may be a desirable approach for antihypertensive therapy.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"35 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IN SILICO APPROACHES ON PHENYLALANINE HYDROXYLASE INHIBITOR-RELATED COMPOUNDS USED IN PARKINSON’S DISEASE TREATMENT 用于帕金森病治疗的苯丙氨酸羟化酶抑制剂相关化合物的硅学方法

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-03-26 DOI: 10.33483/jfpau.1380350

Hatice Akkaya, E. Sümer

{"title":"IN SILICO APPROACHES ON PHENYLALANINE HYDROXYLASE INHIBITOR-RELATED COMPOUNDS USED IN PARKINSON’S DISEASE TREATMENT","authors":"Hatice Akkaya, E. Sümer","doi":"10.33483/jfpau.1380350","DOIUrl":"https://doi.org/10.33483/jfpau.1380350","url":null,"abstract":"Objective: In Parkinson’s disease, Levodopa with Carbidopa addresses dopamine deficiency. Phenylalanine hydroxylase catalyzes phenylalanine to tyrosine conversion crucial for dopamine synthesis. Inhibiting phenylalanine hydroxylase may enhance Carbidopa's effects, preventing peripheral dopamine synthesis. The study used virtual scanning, molecular docking, and dynamics simulation to explore phenylalanine hydroxylase interactions with Carbidopa and similar ligands. ADME/T assessments and drug similarity tests were conducted to evaluate therapeutic potential in biological systems.\u0000Material and Method: A molecular docking study was performed on the structures obtained from the PubChem database and human PAH (PDB ID: 6PAH) using Autodock Vina within Chimera 1.16. Furthermore, the ligands underwent ADME/T assays, which are crucial aspects in drug development.\u0000Result and Discussion: The study suggests that 2-(2-Aminohydrazinyl)-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid shows promise as a phenylalanine hydroxylase inhibitor for Parkinson's disease treatment, but further research is needed to assess its safety, efficacy, and specificity, particularly in extracerebral regions, while also exploring its potential to improve the effectiveness of Levadopa/Carbidopa combination therapy.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"124 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KİMYASAL SİLAHLARA VE BİYOTERÖRE KARŞI TEDAVİDE KULLANILAN UYGULAMALAR 在处理化学武器和生物恐怖主义方面的应用

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-02-27 DOI: 10.33483/jfpau.1363452

Sibel İLBASMIŞ TAMER, İlkay ERDOĞAN ORHAN

{"title":"KİMYASAL SİLAHLARA VE BİYOTERÖRE KARŞI TEDAVİDE KULLANILAN UYGULAMALAR","authors":"Sibel İLBASMIŞ TAMER, İlkay ERDOĞAN ORHAN","doi":"10.33483/jfpau.1363452","DOIUrl":"https://doi.org/10.33483/jfpau.1363452","url":null,"abstract":"Objective: In the present study, the chemical and physical properties of various chemical warfare agents, general information about medical protection methods, current analysis methods equipment, decontamination techniques and pharmaceutical formulations used when exposed to chemical agents will be discussed.\u0000Result and Discussion: Among weapons of mass destruction, chemical warfare agents are one of the most brutal dangers posed to humanity compared to biological and nuclear weapons. These war agents can be produced easily, cheaply and can cause mass casualties in small amounts with chemicals that are easily obtained in our daily lives, even by small terrorist groups. Chemical warfare agents can enter the body through various routes; and symptoms may vary accordingly. When inhaled, gases, vapors and aerosols can be absorbed through any part of the respiratory tract, from the mucosa of the nose and mouth to the alveoli of the lungs. The eye may able to absorb these agents directly. Liquid droplets and solid particles can be absorbed from the surface of the skin and mucous membranes. Toxic compounds that have a characteristic effect on the skin can demonstrate their effects when they accumulate on the skin as solid or liquid particles. The vapors of some volatile substances can penetrate intact skin and subsequently cause poisoning. Wounds or abrasions are more permeable than intact skin. Chemical warfare agents can contaminate food and beverages and absorbed into the gastrointestinal tract. While chemical warfare agents penetrate through various transmucosal routes, they can cause irritation or damage to the surfaces. In addition, toxic substances can pollute groundwater, leaking into the environment by soil and air and cause long-term harmful effects on living organisms.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"15 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NANOPARTICLES FOR DUAL IMAGING: PET AND FLUORESCENCE IMAGING 用于双重成像的纳米粒子：宠物和荧光成像

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-02-22 DOI: 10.33483/jfpau.1323924

E. T. Sarcan

{"title":"NANOPARTICLES FOR DUAL IMAGING: PET AND FLUORESCENCE IMAGING","authors":"E. T. Sarcan","doi":"10.33483/jfpau.1323924","DOIUrl":"https://doi.org/10.33483/jfpau.1323924","url":null,"abstract":"Objective: Molecular imaging methods are gaining popularity in clinical and preclinical fields. There are many different imaging methods such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT) and Near-infrared fluorescence (NIRF), and each has different advantages and disadvantages. Multimodal imaging methods, a combination of two or more molecular imaging modalities, have been developed to overcome the disadvantages of these molecular imaging methods. However, these imaging methods are conjugated with different vectors to improve the multimodal imaging methods used. In this field, drug delivery systems, peptides, proteins, antibodies and aptamers have been widely used for conjugation of multimodal imaging modalities to overcome some of the disadvantages that come from imaging modalities. In this review, PET and NIRF combination imaging modalities were explained and more specifically PET and NIRF nanoparticle dual imaging modalities with their pros and cons were investigated.\u0000Result and Discussion: Dual imaging modalities overcome to limitations of single imaging modalities and provide a better understanding of biological, anatomical, and physiological processes. Multimodal imaging modalities offer higher sensitivity, resolution, and specificity with\u0000lower cost and toxicity although have several disadvantages.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME 炎症性肠病与药用植物：最新综述

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-02-18 DOI: 10.33483/jfpau.1393243

Ece Bayir, Gözde ELGİN CEBE

{"title":"ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME","authors":"Ece Bayir, Gözde ELGİN CEBE","doi":"10.33483/jfpau.1393243","DOIUrl":"https://doi.org/10.33483/jfpau.1393243","url":null,"abstract":"Amaç: Enflamatuar bağırsak hastalığı (EBH), ülserasyon, kanama, sıvı ve elektrolit kaybı ile karakterize, atak ve remisyon dönemlerinden oluşan gastrointestinal sistemin (GİS) kronik enflamasyonudur. Ülseratif kolit ve Chron, etiyolojisi ve patogenezi tam olarak belli olmayan EBH’nin majör klinik formlarıdır. Son yıllarda ülkemizde ve dünyada insidansı ve prevalansı gittikçe artan EBH, bireylerin yaşam kalitesini olumsuz etkilemektedir. Bu durum hastalığın tedavisini daha da önemli hale getirmektedir. Fakat bu tedavi yöntemleri hastalığın remisyon süresinin uzatılması ve progresyonunun önlenmesi için yetersiz kalabilmektedir. Bu nedenle hastalar esas tedavilerine ek olarak farklı tamamlayıcı tedavi arayışlarına yönelmektedir. Bu yöntemler arasında hastaların en sık başvurduğu tamamlayıcı tedavi, bitkisel ürünlerdir. \u0000Sonuç ve Tartışma: Bitkisel ürünlerin kullanımı, hastalık üzerinde olumlu etkiler yapabildiği gibi olumsuz etkilere de yol açabilmektedir. Bu nedenle belli standartlara sahip ürünlerin uygun hastalıkta, uygun formda, uygun dozda ve hekim/eczacı kontrolünde kullanılması gerekmektedir. Literatürdeki çalışmalar değerlendirildiğinde; enflamatuar bağırsak hastalıklarında kullanılan tıbbi bitkilerin fazlalığına rağmen birçoğunun potansiyel etki mekanizmasının ve olumlu/olumsuz etkilerinin tam olarak ortaya konmadığı görülmektedir. Bu bitkilerin yanlış ve bilinçsizce kullanımı hastalığın seyrinin kötüleşmesine yol açabileceğinden enflamatuar bağırsak hastalıklarında kullanılan tıbbi bitkilerle ilgili daha fazla araştırmaya ihtiyaç duyulmaktadır.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"5 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

İNSAN PAPİLLOMA VİRÜSÜ (HPV) TEDAVİSİNDE YENİ YAKLAŞIMLAR: AKTİF HEKSOZ İLİŞKİLİ BİLEŞİK (AHCC®) 治疗人类乳头瘤病毒（HPV）的新方法：活性己糖相关化合物 (AHCC®)

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-02-18 DOI: 10.33483/jfpau.1364203

Zehra Keçeci̇, Cansu Bölükbaş, Hazal Eken

{"title":"İNSAN PAPİLLOMA VİRÜSÜ (HPV) TEDAVİSİNDE YENİ YAKLAŞIMLAR: AKTİF HEKSOZ İLİŞKİLİ BİLEŞİK (AHCC®)","authors":"Zehra Keçeci̇, Cansu Bölükbaş, Hazal Eken","doi":"10.33483/jfpau.1364203","DOIUrl":"https://doi.org/10.33483/jfpau.1364203","url":null,"abstract":"Amaç: İnsan papilloma virüsü (HPV) alt tiplerine bağlı olarak cilt ve mukoza zarlarında siğil ve kanser oluşumuna sebep olabilen cinsel yolla bulaşan en yaygın viral enfeksiyon olması sebebi ile ciddi bir halk sağlığı problemi oluşturmaktadır. Günümüzde HPV tedavisinde hastalığın eradikasyonunu sağlamayan, sadece dışa doğru büyüyen siğillerin uzaklaştırılmasını ve semptomların iyileştirilmesini amaçlayan seçenekler mevcuttur. Bu tedavilerin dışında immün sistemi destekleyici çeşitli doğal ürünlerin kullanımının da HPV tedavisinde faydalı olabileceği gösterilmiştir. Mantar ekstraktlarının bağışıklık sistemi üzerindeki kesin etkileri tam olarak aydınlatılamamış olsa da uzun yıllardan beri dünyanın farklı bölgelerinde çeşitli sağlık sorunları için kullanılmaktadır. Bu derlemede bir mantar ekstratı olan AHCC®’nin HPV enfeksiyonu üzerindeki etkilerine odaklanılmıştır.\u0000Sonuç ve Tartışma: Yenilebilir bir mantar olan Lentinula edodes'in asetillenmiş α-1,4-glukanlar bakımından zenginleştirilmiş, standartlaştırılmış, kültürlenmiş bir özütü olan AHCC® sahip olduğu çeşitli farmakolojik etkileri nedeni ile HPV tedavisinde öne çıkan alternatif tedavi seçenekleri arasında yer almaktadır. Yapılan preklinik ve klinik çalışmalar, AHCC®’nin bağışıklık sistemini destekleyerek HPV tedavisi için umut veren yeni bir seçenek olabileceğini göstermektedir.","PeriodicalId":504701,"journal":{"name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","volume":"1 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0