测定双酚 A 和双酚 S 在 mcf7 细胞系中诱导的 DNA 损伤

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-08 DOI:10.33483/jfpau.1428739

Ekin Erdoğmuş, Seda Ipek, Belma Gümüşel, Y. Duydu, Aylin Üstündağ

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引用次数: 0

摘要

研究目的本研究旨在确定双酚 A（BPA）和双酚 S（BPS）对 MCF7 细胞株 DNA 的损伤：采用 COMET 法测定 MCF7 细胞株在 0.1、0.5、1、5、10 和 50 μM 双酚 A 和双酚 S 浓度下的 DNA 损伤：与对照组相比，所有研究浓度（0.1、0.5、1、5、10 和 50 μM）的双酚 A 和双酚 BPS 都能明显诱导 MCF7 细胞系的 DNA 损伤（p<0.05）。在研究的 3 个最高浓度（5、10 和 50 μM）下，双酚 A 诱导的 DNA 损伤明显高于双酚 BPA（p<0.05）。这项研究表明，双酚衍生物也会像双酚 A 一样造成 DNA 损伤。

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DETERMINATION OF DNA DAMAGE INDUCED BY BISPHENOL A AND BISPHENOL S IN MCF7 CELL LINE

Objective: This study aimed to determine the DNA damage induced by Bisphenol A (BPA) and Bisphenol S (BPS) on MCF7 cell line. Material and Method: DNA damage was determined by COMET assay in MCF7 cell line at 0.1, 0.5, 1, 5, 10 and 50 μM concentrations of BPA and BPS. Result and Discussion: All BPA and BPS concentrations studied (0.1, 0.5, 1, 5, 10 and 50 μM) significantly induced DNA damage on MCF7 cell line compared with control (p<0.05). BPS significantly induced DNA damage more than BPA at the 3 highest concentrations studied (5, 10 and 50 μM) (p<0.05). This study shows that bisphenol derivatives can also cause DNA damage like BPA.

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Ankara Universitesi Eczacilik Fakultesi Dergisi

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