Experimental and Clinical Transplantation最新文献

{"title":"Literature Review: Nutritional Status of Hemodialysis Patients in the Azerbaijan Republic:A Retrospective Analysis.","authors":"Hikmet Ismayilov, Zemfira Hasanova, Ilham Hamidov, Mirhashim Jalalov","doi":"10.6002/ect.MESOT2025.P190","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P190","url":null,"abstract":"<p><strong>Objectives: </strong>Nutritional status is a vital predictor of survival in chronic hemodialysis patients. Protein -energy wasting and micronutrient deficiencies are associated with increased morbidity and mortality. In this study, we evaluated the prevalence of malnutrition and seasonal nutritional fluctuations among patients who were receiving hemodialysis in the Azerbaijan Republic.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of 126 patients undergoing chronic hemodialysis in 2024. Assessments included serum biochemical markers (albumin, hemoglobin, ferritin, vitamin D ), body mass index, and dietary records.</p><p><strong>Results: </strong>Among 126 patients, hypoalbuminemia was observed in 49 patients (39 % ) and 55 patients (44 %) presented with body mass index <20 kg /m2. Micronutrient deficiencies were frequent, with iron deficiency in 45 patients (36 % ) and vitamin D deficiency in 60 patients (48 %). Seasonal variations significantly affected protein and caloric intake (P < .05 ).</p><p><strong>Conclusions: </strong>Malnutrition is a significant burden in Azerbaijani hemodialysis units. Implementation of regular monitoring and individualized dietary counseling is essential to optimize patient outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"44-46"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-Labeled Diethylenetriamine Pentaacetic Acid Unveils a Hernia: Renal Scintigraphy in Late Transplant Obstruction.","authors":"Mahsa Hosseini Chimeh, Shiva Samavat, Samaneh Hosseinzadeh, Sahand Ameri, Mohsen Nafar, Ahmad Firouzan, Fatemeh Poorrezagholi, Fariba Samadian, Nooshin Dalili","doi":"10.6002/ect.MESOT2025.P45","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P45","url":null,"abstract":"<p><p>Ureteral obstruction is a frequent urologic complication after kidney transplant and usually occurs in the early postoperative period. Inguinal herniation of the transplanted ureter is a rare but potentially correctable cause of late obstructive uropathy. We report a 57-year-old male kidney transplant recipient who presented with hydronephrosis and acute kidney injury. Ultrasonography showed moderate to severe hydronephrosis of the renal allograft. Renal scintigraphy with 99mTc-diethylenetriamine pentaacetic acid revealed delayed tracer transit and abnormal radiotracer accumulation inferior to the urinary bladder, suggestive of distal ureteral obstruction. Abdominopelvic computed tomography confirmed herniation of the distal transplanted ureter into a right inguinal hernia. This case highlights the diagnostic value of 99mTc-diethylenetriamine pentaacetic acid renal scintigraphy for identification of uncommon causes of late ureteral obstruction in kidney transplant recipients. Inguinal herniation of the transplanted ureter should be considered in patients with posttransplant hydronephrosis and compatible clinical findings.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"406-408"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Transplant and Neurogenic Bladder.","authors":"Nasser Simforoosh","doi":"10.6002/ect.MESOT2025.L21","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.L21","url":null,"abstract":"<p><p>This work presents open and laparoscopic cystoplasty of different types and kidney transplants in patients with augmented bladder. The timing of kidney transplant before augmentation in patients with neurogenic bladder or with a previously augmented neurogenic bladder and results of these procedures are discussed, as well as urinary voiding problems in patients who have undergone kidney transplant. This report reinforces the conclusion that appropriately managed neurogenic bladder does not preclude successful kidney transplant.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"14-19"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiopoietins and Angiopoietin-Like Proteins as New Biomarkers in Posttransplant Diabetes Mellitus: A Single-Center Study From Kuwait.","authors":"Mohamed Jahromi, Torki Al-Otaibi, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Kawthar Jahrami, Osama Gheith","doi":"10.6002/ect.MESOT2025.P191","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P191","url":null,"abstract":"<p><strong>Objectives: </strong>Posttransplant diabetes mellitus is a chronic metabolic complication that often develops in kidney transplant recipients and is an inflammatory disease that directly affects a patient's immune system. Angiopoietin and angiopoietin -like proteins are intrinsic mediators of immune cells. We assessed the relationship between circulating angiopoietin proteins ANGPT ¹ and ANGPT ²and angiopoietin-like proteins ANGPTL ³, ANGPTL ⁴, ANGPTL ⁶, ANGPTL ⁷, and ANGPTL ⁸ in kidney transplant recipients who develop posttransplant diabetes mellitus (experimental group) versus recipients who do not develop diabetes after transplant (control group).</p><p><strong>Materials and methods: </strong>We included 154 age-matched and sex-matched participants (38 with posttransplant diabetes mellitus) and 155 control participants. We collected 3 mL of venous blood from each patient. Plasma levels of angiopoietin proteins ANGPT ¹ and ANGPT ² and angiopoietin-like proteins ANGPTL ³, ANGPTL ⁴, ANGPTL ⁶, ANGPTL ⁷, and ANGPTL ⁸ were determined by enzyme-linked immunosorbent assay. We determined the correlation between plasma levels of ANGPT ¹and ANGPT ² and ANGPTL ³, ANGPTL ⁴, ANGPTL ⁶, ANGPTL ⁷, and ANGPTL ⁸in our posttransplant diabetes mellitus group and the control group.</p><p><strong>Results: </strong>There were highly significant differences between kidney transplant recipients with diabetes versus control participants with regard to plasma levels of ANGPT ¹, ANGPTL ⁶, ANGPTL ⁷, and ANGPTL ⁸ (P < . ⁰⁰¹, P = . ⁰⁰¹, P < . ⁰⁰¹, and P =.⁰⁴, respectively). No significant statistical association was found for ANGPT2, ANGPTL3, and ANGPTL4 in our posttransplant diabetes mellitus cohorts.</p><p><strong>Conclusions: </strong>Plasma levels of ANGPT¹, ANGPTL⁶, ANGPTL⁷, and ANGPTL ⁸ may correlate with disease severity and chronicity in transplant patients who develop posttransplant diabetes mellitus. Thereby these may serve as potential biomarkers of the disease severity with possible early intervention in the management strategy especially with modifiable risk factors such as immunosuppression regimen, antidiabetic medications, and follow-up of the complications of posttransplant diabetes mellitus.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"395-402"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Renal Transplantation: Current Innovations and Future Horizons.","authors":"Morteza Okhovvat, Saeid Amirkhanlou, Naser Simforoosh, Fatemeh Poor-Reza Gholi","doi":"10.6002/ect.MESOT2025.O55","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.O55","url":null,"abstract":"<p><strong>Objectives: </strong>This study critically examined the evolving role of artificial intelligence (AI ) in kidney transplantation, aiming to bridge the gap between theoretical promise and clinical implementation. The study evaluated AI -driven innovations across the transplant continuum, from pretransplant matching to posttransplant care, while identifying key barriers, including training gaps, ethical considerations, and system integration challenges. The objective was to propose actionable strategies to optimize the effect of AI on graft survival, equity in organ access, and long -term patient outcomes.</p><p><strong>Materials and methods: </strong>We conducted a systematic review of AI integration in kidney transplant using PubMed, Web of Science, Cochrane, and Google Scholar databases up to December 2024. Search terms included \"artificial intelligence\" and \"renal transplantation.\" We used a 2 -phase screening process for relevance filtering and QUADAS -2 critical appraisal. We categorized AI algorithms by architecture and clinical application, with quantitative synthesis of performance metrics and qualitative analysis of implementation barriers, ethics, and stakeholder acceptance.</p><p><strong>Results: </strong>AI in kidney transplant required general, not deep, technical expertise from health care professionals. Semi -supervised learning offered a promising, scalable approach by reducing data labeling by 40% with maintained accuracy. AI algorithms were shown to improve donor -recipient matching, reduce rejection, and enhance postoperative care. Deep learning models showed strong performance in predicting graft survival (concordance index 0.65-0.72 ) and delayed graft function (receiver operating characteristic area under the curve of 0.82 ). Furthermore, AI -powered digital pathology reduced organ discard rate by 37 % through better tissue analysis.</p><p><strong>Conclusions: </strong>AI represents a transformative opportunity to personalize kidney transplantation and improve patient outcomes, functioning best as an augmentative tool rather than replacement for clinical expertise. A 3 -tiered integration model is proposed: cultivating general AI familiarity, understanding kidney transplant -specific capabilities, and providing practical training in AI tools. Continued research remains essential to address limitations and ensure safe, ethical, and effective clinical integration.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"143-150"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Principal Component Analysis to Discover Distinct Patterns of Serologic Class II Subtypes With WHO Specificity.","authors":"Nabil Mohsin, Isabelle Wood, Indira Guleria, Edgar Milford, Melissa Y Yeung","doi":"10.6002/ect.MESOT2025.L33","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.L33","url":null,"abstract":"<p><strong>Objectives: </strong>Patient serum for anti-HLA antibodies are tested with purified antigens covalently affixed to beads as targets. Serologic nomenclature from the World Health Organization (WHO) is currently used to specify the reactivity of antibodies, although target antigens are defined at a finer allelic level. We investigated whether different reactivity patterns could be present at the allele level of a single WHO serologic antigen.</p><p><strong>Materials and methods: </strong>We analyzed 2389 serum samples from 1215 patients waiting for solid-organ transplant by using class II single antigen beads for detection of HLA antibodies. We used principal component analysis to identify unique antibody reactivity patterns against the beads. We particularly focused on patterns within a WHO antigen that suggested the presence of new serologic class II HLA specificities. We used the HLA DQ7 data to illustrate the principle of the discovery methodology. Four assay target beads representing different DQA1 alleles were classified as DQ7.</p><p><strong>Results: </strong>Two principal components accounted for about 98.6%of the DQ7 data variance. The dominant principal component, which accounted for 83.9% of the variance, represented a reaction pattern in which sera reacted equally with all 4 beads. The second principal component (14.7% of the variance) represented sera that reacted selectively with DQA1*03:01, DQB1*03:01. Four of 10 DR and 6 of 7 DQ WHO serologic specificities that were studied showed more than 5% nonconcordant patterns revealed by principal component analysis.</p><p><strong>Conclusions: </strong>Principal component analysis revealed differential reactivity patterns of the alleles of single WHO serological specificity. This method could be a powerful tool for identifying patterns of reactivity, which may represent new serological specificities.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"57-62"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Late Versus Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients.","authors":"Osama Gheith, Mohamed Abdul-Moneem, Mohamed Shaker, Nabil Alserwy, Mohamed Adel, Ahmed Denewar, Ayman Maher, Mohamed Dahab, Khalid Abdultawab, Medhat Alawady, Torki Al-Otaibi","doi":"10.6002/ect.MESOT2025.P56","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P56","url":null,"abstract":"<p><strong>Objectives: </strong>Late and chronic active antibody -mediated rejection represents distinct phenotypes after kidney transplant, yet their comparative outcomes remain poorly defined. This study compared clinical outcomes, treatment patterns, and long -term graft survival between late and chronic active antibody -mediated rejection.</p><p><strong>Materials and methods: </strong>This single -center retrospective cohort study included 111 kidney transplant recipients with biopsy-proven antibody -mediated rejection (50 late, 61 chronic active ) between 2009 and 2024. Groups were matched on baseline demographics, donor type, comorbidities, and maintenance immunosuppression. Outcomes included treatment intensity, complications, renal function, and 5 -year graft survival.</p><p><strong>Results: </strong>Both groups had comparable baseline characteristics. Patients with late antibody-mediated rejection received significantly more intensive therapy: higher rituximab use (52.0 % vs 34.4 %; P = . ⁰⁰¹ ), more plasma exchange sessions (5.04 vs 2.11; P < . ⁰⁰¹ );, and higher rituximab doses (513.4 vs 252.6 mg; P = . ⁰⁰⁴ ). Patients with late antibody -mediated rejection showed trends toward higher BK viremia (6.0 % vs 1.6 % ), whereas patients with chronic active antibody -mediated rejection had more new -onset diabetes after transplant (21.3 % vs 8.0 % ). At presentation, patients with chronic active antibody-mediated rejection had worse graft function (creatinine 176 vs 139 μmol /L; P = .013 ). Despite divergent initial management, both groups converged at 5 years with no significant difference in graft function or survival; overall graft loss exceeded 70% in both groups (P > .05 ).</p><p><strong>Conclusions: </strong>Late and chronic active antibody -mediated rejection received different treatment intensities based on perceived acuity, yet both groups had similarly poor 5 -year outcomes with >70 % graft failure. These findings challenge current therapeutic paradigms and emphasize the urgent need for earlier diagnosis and more effective agents beyond standard regimens of steroids, plasma exchange, intravenous immunoglobulin, and rituximab.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"298-303"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Recovery After Parathyroid Cell Transplantation Using a Novel Scoring System.","authors":"Beyza Goncu, Harika Salepcioglu Kaya, Rumeyza Kazancioglu, Yeliz Emine Ersoy, Adem Akcakaya","doi":"10.6002/ect.MESOT2025.P133","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P133","url":null,"abstract":"<p><strong>Objectives: </strong>Permanent hypoparathyroidism is a lifelong condition and characterized by chronic hypocalcemia and dependence on calcium and active vitamin D therapy. Parathyroid cell transplantation has emerged as a potential restorative treatment, yet standardized tools for assessment of posttransplant recovery are lacking. This study aimed to evaluate clinical recovery following parathyroid cell transplant using a novel functional scoring system.</p><p><strong>Materials and methods: </strong>This retrospective, single -center (in Istanbul, Türkiye ), longitudinal study included 40 consecutive parathyroid cell transplants performed between 2019 and 2024 in patients with permanent hypoparathyroidism. A 5 -level recovery scoring system (score 0 to 4 ) integrating serum calcium levels, medication requirements, and hypocalcemia -related symptoms was developed to assess outcomes. Patients were followed for up to 4 years. Clinically meaningful recovery was defined as score ≥3, corresponding to a ≥50 % reduction in calcium and/or active vitamin D supplementation.</p><p><strong>Results: </strong>Recovery scores improved progressively over time posttransplant. Most patients demonstrated early biochemical benefit within the first 2 months, followed by stabilization and sustained improvement. By 6 months, a substantial proportion achieved clinically meaningful recovery (score ≥3 ), characterized by marked reduction in supplementation requirements and symptomatic improvement. A limited subset of patients achieved score 4, indicating complete independence from replacement therapy. Serum calcium levels showed a significant time -dependent increase, although interindividual variability in response persisted.</p><p><strong>Conclusions: </strong>Parathyroid cell transplant can provide sustained functional improvement in patients with permanent hypoparathyroidism. The proposed recovery scoring system offers a practical, clinically meaningful tool that integrates biochemical parameters, medication dependence, and symptoms, enabling standardized monitoring of posttransplant outcomes. This approach may facilitate long -term treatment management strategies for this challenging disease.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"345-351"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Immunosuppression in Kidney Transplantation: A Comprehensive Review.","authors":"Hassan Argani","doi":"10.6002/ect.MESOT2025.L35","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.L35","url":null,"abstract":"<p><p>Individualized immunosuppression represents a paradigm shift in kidney transplant from traditional \"trial-and-error\" dosing strategies toward individualized regimens. Precision immunosuppression is informed by pharmacogenetics, biomarkers, therapeutic drug monitoring, and recently artificial intelligence-based prediction models, although stratified risk assessment of patients is still mandatory. This review investigated the current evidence on individualized induction and maintenance immunosuppression. In addition, the roles of pharmacokinetics, pharmacogenomics, and emerging biomarker platforms were reviewed and future pathways for tailored posttransplant care were outlined. In summary, the data indicate that optimized immunosuppressive therapy improves graft outcomes, reduces toxicity, and enables targeted minimization strategies in selected recipients.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"20-25"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health-Related Quality of Life in Heart Transplant Recipients: A Comparative Study.","authors":"Yasemin Sezgin, Mehtap Bilgin Çetin, İdil Özerkliğ, Batuhan Bakırarar, Şule Bulut, Atilla Sezgin","doi":"10.6002/ect.MESOT2025.P112","DOIUrl":"10.6002/ect.MESOT2025.P112","url":null,"abstract":"<p><strong>Objectives: </strong>Oral health problems can have potential effects beyond the oral cavity. The aim of this study was to evaluate the oral health -related quality of life in heart transplant recipients, compare the results with systemically healthy individuals, and investigate the effects of periodontal clinical parameters and periodontal and oral status on oral health-related quality of life.</p><p><strong>Materials and methods: </strong>For this retrospective study, we included heart transplant recipients who had previously undergone periodontal evaluation and age -and sex -matched systemically healthy individuals. Oral health -related quality of life was measured using the Oral Health Impact Profile -14. Periodontal status and oral health status were assessed using the following parameters: plaque index, bleeding on probing, probing depth, clinical attachment loss, gingival recession, and decayed, missing, and filled teeth index. We used the Mann -Whitney U test, χ2 test, and logistic regression analyses for statistical analyses.</p><p><strong>Results: </strong>No significant differences were observed in total Oral Health Impact Profile -14 scores between heart transplant recipients and healthy individuals (P > . ⁰⁵ ). However, mean probing depth, gingival recession, clinical attachment loss, and plaque index scores were significantly higher among heart transplant recipients than among healthy individuals. The number of missing teeth were also significantly higher (P < . ⁰⁵ )in the transplant group. Logistic regression analysis did not identify any variable with a significant impact on oral health -related quality of life.</p><p><strong>Conclusions: </strong>Although periodontal disease parameters appeared more pronounced in heart transplant recipients, this was not reflected in oral health -related quality of life scores. The asymptomatic nature of periodontal deterioration and pretransplant dental procedures may contribute to this outcome. Our results underscored the importance of preventive, structured, and interdisciplinary oral care in this medically vulnerable population.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"327-333"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}