Experimental and Clinical Transplantation最新文献

{"title":"Relationship Between Pulse Wave Velocity and Cognitive Impairment in Kidney Transplant Recipients.","authors":"Ahmet Kürşat Soyer, Necmi Eren, Şeyda Gül Özcan, Metin Ergül, Nuriye Yıldız, Sibel Gökçay Bek, Erkan Dervişoğlu, Betül Kalender Gönüllü","doi":"10.6002/ect.2024.0293","DOIUrl":"https://doi.org/10.6002/ect.2024.0293","url":null,"abstract":"<p><strong>Objectives: </strong>Kidney transplant recipients are at higher risk of developing atherosclerosis compared with the general population. Arterial stiffness, a key feature of atherosclerosis, is common in these patients. Cognitive impairment is also more prevalent among kidney transplant recipients and may be linked to the atherosclerotic process. We evaluated the relationship between arterial stiffness and cognitive impairment in kidney transplant recipients.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 112 kidney transplant recipients and 112 healthy controls aged 18 years or older. Arterial stiffness was assessed using pulse wave velocity measured between the carotid and femoral arteries. Cognitive function was evaluated with the Montreal-Cognitive Assessment and the Mini-Mental State Examination. We analyzed demographic data, comorbidities, medical history, medications, and laboratory results for transplant recipients.</p><p><strong>Results: </strong>Cognitive impairment was detected in 14% of kidney transplant recipients based on the Mini-Mental State Examination and in 31% based on the Montreal-Cognitive Assessment; no people in the control group showed impairment on MMSE, and only 7% scored below normal on MoCA. A significant correlation was observed between pulse wave velocity and cognitive function test scores. Higher pulse wave velocity was independently associated with an increasedrisk of cognitive impairment, as determined by the Mini-Mental State Examination.</p><p><strong>Conclusions: </strong>To our knowledge, this study is the first to demonstrate a relationship between pulse wave velocity and cognitive function as measured by the Mini-Mental State Examination and the Montreal-Cognitive Assessment in kidney transplant recipients. These results suggest that cerebrovascular disease may contribute to cognitive impairment in this population.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 6","pages":"400-405"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Breast Cancer After Kidney Transplant: Case Report and Literature Revue.","authors":"Hanen Chaker, Soumaya Yaich, Hanen Abid, Souhir Khemiri, Slim Charfi, Mondher Masmoudi, Mohamed Ben Hmida, Tahya Boudawara, Afef Khanfir, Khawla Kammoun","doi":"10.6002/ect.2025.0083","DOIUrl":"https://doi.org/10.6002/ect.2025.0083","url":null,"abstract":"<p><p>Long-term immunosuppression can lead to malignant tumors after kidney transplant. In this case study, we report a rare case of breast cancer occurring in a man after 33 years of kidney transplant. This 55-year-old kidney transplant patient presented with a right breast mass. The biopsy showed an infiltrating carcinoma. The immunohistochemical study was positive for estrogen. The patient underwent a right mastectomy with axillary dissection. Chemotherapy based on docetaxel and radiotherapy was started. Adjuvant treatment with tamoxifen and a switch from azathioprine to sirolimus were conducted. Follow-up showed that the patient died 24 months after presentation. Through this case, we emphasize the importance of vigilance about this rare cancer, often diagnosed at a late stage, which can negatively affect prognosis. Screening for risk factors is crucial.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 6","pages":"431-434"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic Next-Generation Sequencing Provides a Reliable Method for Early Diagnosis of Pneumocystis jirovecii Pneumonia After Kidney Transplant: A Single-Center Retrospective Cohort Study.","authors":"Jiangwei Zhang, Yang Li, Jin Zheng, Xiaoming Ding","doi":"10.6002/ect.2024.0250","DOIUrl":"https://doi.org/10.6002/ect.2024.0250","url":null,"abstract":"<p><strong>Objectives: </strong>Pneumocystis jirovecii pneumonia, a common pulmonary infection after kidney transplant, cannot be detected by conventional culture methods, and limitations have been shown with lung tissue biopsy, sputum collection, and sample smear staining. Early diagnosis is key as long-term survival is decreased in patients with Pneumocystis jirovecii pneumonia who are not treated in a timely and effective manner.</p><p><strong>Materials and methods: </strong>From January 2018 to January 2023, our study enrolled 110 patients with pulmonary infection seen at the First Affiliated Hospital of Xi'an Jiaotong University (China). Of these patients, 46 had confirmed Pneumocystis jirovecii pneumonia per metagenomic next-generation sequencing or conventional detection methods. We compared percentages of positive tests, other pathogen species, and other factors between the 2 test methods. Clinical characteristics of patients with (n = 46) and without (n = 64) Pneumocystis jirovecii were analyzed retrospectively.</p><p><strong>Results: </strong>Overall incidence of PJP was 2.3% (46/1977). Among 46 patients diagnosed with Pneumocystis jirovecii pneumonia, average time of onset post-transplant was 7.21 ± 2.55 months; 42 patients were cured, and 4 patients died. Thirty-three patients had mixed pulmonary infections, with Pneumocystis jirovecii and human cytomegalovirus being the most common pathogen combination, and 13 patients had monotypic pulmonary infections. Sixteen patients were Pneumocystis jirovecii positive according to conventional pathogen detection, for a detection rate of 34.8% (16/46), with significant difference shown between detection methods (χ2 = 92.0, P < .01). Patients who were treated with tacrolimus had insufficient use of sulfamethoxazole-trimethoprim and previous cytomegalovirus infection, and patients with acute rejection were more likely to develop Pneumocystis jirovecii pneumonia (P < .05).</p><p><strong>Conclusions: </strong>Metagenomic next-generation sequencing showed more advantages in early diagnosis of Pneumocystis jirovecii pneumonia. Precision medicine can be adopted to reduce costs and improve cure rates based on results of metagenomic next-generation sequencing.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"334-341"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthotopic Kidney Transplant in a Patient with Augmented Bladder and Diseased Iliac Vessels: A Surgical Challenge With Successful Outcome.","authors":"Abdul Khalique, Hamza Bashir, Shariq Bin Yousuf, Shuah Ullah, Tanzeel Ur Rehman, Bux Ali, Tahir Aziz, Ziad Sophie, Adeeb Ul Hassan Rizvi","doi":"10.6002/ect.2025.0075","DOIUrl":"https://doi.org/10.6002/ect.2025.0075","url":null,"abstract":"<p><p>Kidney transplantation offers superior outcomes compared with dialysis but requires alternative approaches in complex cases. We present a 24-year-old male patient with end-stage renal disease, neurogenic bladder, and iliac vessel thrombosis who underwent orthotopic kidney transplant with concurrent native nephrectomy.Despite challenges, including postoperative double J stent migration requiring reexploration, the patient achieved stable graft function at 14-month follow-up. This case highlights the feasibility of orthotopic transplant in high-risk patients when performed at experienced centers. Successful outcomes depend on meticulous surgical technique and multidisciplinary management.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"379-382"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Kidney Transplant Recipient Treated With Migalastat for Fabry Disease for 33 Months.","authors":"Theodoros Eleftheriadis, Maria Divani, Christina Poulianiti, Maria-Anna Polyzou-Konsta, Evangelos Lykotsetas, Andriani Balatsouka, Ioannis Ioannidis, Ioannis Stefanidis","doi":"10.6002/ect.2025.0063","DOIUrl":"https://doi.org/10.6002/ect.2025.0063","url":null,"abstract":"<p><p>Fabry disease is an X-linked lysosomal storage disorder characterized by impaired glycosphingolipid metabolism as a result of deficient or absent α-galactosidase A activity.This enzymatic defect leads to the progressive accumulation of glycosphingolipids within various tissues, resulting in multisystem involvement, including renal dysfunction, cardiovascular pathology, cerebrovascular complications, andperipheral neuropathy.This report presents the case of a 57-year-old female who underwent kidney transplant 5 years earlier because of end-stage renal disease of unknown etiology. Genetic screening identified the GLA gene variant c.937G>T (D313Y). The patient exhibited symptoms, including vertigo,tinnitus,headaches, andupperlimbparesthesia, alongside findings of left ventricular hypertrophy and microangiopathic white matter lesions. Initiation of migalastat therapy led to symptomatic improvement without adverse effects orthe need for modifications in her immunosuppressive regimen. After 33 months of migalastat therapy, renal function remained stable, left ventricular hypertrophy resolved, and no progression of cerebral white matter lesions was observed. Thus, migalastat was shown as a well-tolerated and effective therapeutic option for Fabry disease in kidney transplant recipients with amenable GLA mutations.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"383-387"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsatile Normothermic Perfusion With Cardiopulmonary Bypass for Thoracic Organ Recovery in Donation After Uncontrolled Circulatory Death: A Feasible Strategy for Expanding the Donor Pool.","authors":"Sam Zeraatiannejaddavani, Mohammadamin Shahrbaf, Nazafarin Kamalzadeh, Yazdan Shafikhani","doi":"10.6002/ect.2025.0089","DOIUrl":"https://doi.org/10.6002/ect.2025.0089","url":null,"abstract":"<p><strong>Objectives: </strong>Donation after circulatory death offers a promising solution to expand the thoracic organ donor pool, yet its application remains limited because of warm ischemia and technical barriers, especially in uncontrolled donation after circulatory death. We aimed to evaluate a pulsatile normothermic car-diopulmonary bypass-based strategy for thoracic organ recovery of uncontrolled donors after circulatory death and the effects of this strategy on graft function and recipient outcomes.</p><p><strong>Materials and methods: </strong>In this prospective single-center study, we studied thoracic organs recovered from uncontrolled donors after circulatory death after ≥60 minutes of unsuccessful cardiopulmonary resuscitation. After heparinization and pharmacologic optimization, donors underwent median sternotomy and were connected to a cardiopulmonary bypass circuit with pulsatile flow. Organ assessment was performed in vivo. Donor, graft, and recipient functional data were recorded, with follow-up results studied through at least 1 year.</p><p><strong>Results: </strong>Forty-two donors were included. All hearts (n = 42) and 40 lungs (from 84 donors) were successfully transplanted. Despite prolonged cardiopulmonary resuscitation, no graft failure or recipient mortality occurred. One year survival for both heart and lung recipients was 100%. Heart grafts showed progressive improvement in functional status, including left ventricular ejection fraction, lactate levels, and New York Heart Association classification; lungs demonstrated sustained gains in gas exchange, pulmonary function tests, and 6-minute walk distance. Mild primary graft dysfunction (grade 1-2) occurred in 10% of lung recipients (all unilateral transplants). Pericardial effusion increased, likely because of trauma before procurement, but resolved without effects on function.</p><p><strong>Conclusions: </strong>Pulsatile normothermic cardiopulmonary bypass enables successful procurement of thoracic organs from uncontrolled donors after circulatory death with excellent outcomes. This low-cost physiological approach may offer a viable strategy to expand availability of donors in resource-limited settings.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"317-327"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric Oxygen Therapy Has the Potential to Extend Cold Ischemia Time by Reducing Inflammation and Apoptosis in Rat Livers.","authors":"Başak Büyük, Özlem Öztopuz, Neslihan Düzenli","doi":"10.6002/ect.2024.0080","DOIUrl":"https://doi.org/10.6002/ect.2024.0080","url":null,"abstract":"<p><strong>Objectives: </strong>Preserving allograft function is crucial for the success of organ transplantation. Although static cold storage helps reduce organ damage, its effectiveness is limited. This study aimed to investigate the effects of early and short-term hyperbaric oxygen therapy applied to cold-stored rat liver tissues on inflammation and apoptosis and the potential to extend the tolerable cold ischemia time.</p><p><strong>Materials and methods: </strong>We collected Wistar rat livers after perfusion and placed them in static cold storage alone or treated them with hyperbaric oxygen for 60 or 120 minutes immediately after placing them in cold storage. Samples were kept in cold storage for 24 hours. We evaluated histological changes by hematoxylin and eosin staining, expression levels of tumor necrosis factor-alpha and interleukin 10 by immunohistochemistry, interleukin 6 gene by reverse transcriptase-polymerase chain reaction, and apoptotic index by terminal deoxynucleotidyl transferase dUTP nick end-labeling methods.</p><p><strong>Results: </strong>Hyperbaric oxygen therapy reduced development of sinusoidal dilatation but not hydropic degeneration. This treatment also reduced the apoptotic index and expression levels of tumor necrosis factor-alpha, interleukin 10, and interleukin 6 gene (interleukin 6 mRNA). Exceptforinterleukin 6 gene expression, the decreases were more pronounced with hyperbaric oxygen therapy applied for 120 versus 60 minutes. Hyperbaric oxygen therapy partially mitigated histopathological changes in cold-stored livers and exhibited antiapoptotic and cytokine-mediated antiinflammatory effects proportional to the duration of administration.</p><p><strong>Conclusions: </strong>Hyperbaric oxygen therapy in addition to static cold storage, even for a limited period, may contribute to an expanded cold ischemia time and increased allograft survival.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"371-378"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portal Vein Stenosis Management in the Long-Term After Living Donor Liver Transplant.","authors":"Konstantin Semash, Timur Dzhanbekov, Azimjon Usmonov","doi":"10.6002/ect.2025.0027","DOIUrl":"https://doi.org/10.6002/ect.2025.0027","url":null,"abstract":"<p><strong>Objectives: </strong>Portal vein stenosis occasionally occurs as a postoperative complication of a living donor liver transplant. Portal vein stenosis decreases the portal venous blood supply to the liver graft and increases extrahepatic portal venous pressure, which may lead to liver dysfunction, splenomegaly, gastrointestinal bleeding, cytopenia, and ascites.</p><p><strong>Materials and methods: </strong>From November 2021 to February 2024, we treated 6 patients at our center who presented with clinical features of bilirubinemia and signs of portal hypertension (cytopenia, ascites) that occurred in the long-term after liver transplant. In all cases, portal vein stenosis was diagnosed by ultrasonography and contrast-enhanced computed tomography. The results of endovascular interventions on the portal vein were assessed.</p><p><strong>Results: </strong>All patients were treated with percutaneous transhepatic correction of portal vein stenosis with balloon venoplasty. In all cases, an ultrasonography guided percutaneous approach to the portal vein was performed. Balloon venoplasty was performed in all cases, and no stents were used. No postoperative complications occurred. Signs of portal hypertension and graft dysfunction regressed after an average of 1 month of observation. There were no recurrences during 15 months of follow-up.</p><p><strong>Conclusions: </strong>Our case series highlighted the importance of considering portal vein stenosis in the differential diagnosis of late-onset portal hypertension or liver graft dysfunction symptoms following liver transplant. The optimal treatment method is endovascular intervention.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"347-353"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing a Systematic Quality Improvement Strategy to Reduce Cytomegalovirus Infection Following Kidney Transplantation.","authors":"Zain Ul Abideen, Muhammad Shahzar Malik, Emily Ko, Andrew Connor, Imran Saif","doi":"10.6002/ect.2024.0333","DOIUrl":"https://doi.org/10.6002/ect.2024.0333","url":null,"abstract":"<p><strong>Objectives: </strong>Cytomegalovirus is a common oppor-tunistic infection affecting kidney transplant reci-pients that adversely affects allograft function and patient well-being. The risk of infection is highest during the first 6 months posttransplant. Infection surveillance and antiviral drug prophylaxis strategies vary in transplant centers, often stratified based on clinical risk, with strategies ranging from universal antiviral prophylaxis to preemptive viral monitoring. Using a multifaceted approach, we conducted a successful quality improvement project to reduce cytomegalovirus infection rates during the first 6 months after kidney transplantation.</p><p><strong>Materials and methods: </strong>For the improvement project, we conducted an initial baseline audit and 2 plan-do-study-act cycles between August 2021 and April 2023. After the baseline audit, we devised the following series of interventions: incorporating the Cockcroft Gault creatinine clearance (for valganciclovir dosing) into our electronic renal software for easy availability in clinics, printing dosing cards for clinics, improving awareness of health care professionals, offering valganciclovir prophylaxis to recipients seropositive for cytomegalovirus immunoglobulin G, and actively considering reduction of immunosuppression in suitable kidney transplant recipients after multidis-ciplinary transplant team approval.</p><p><strong>Results: </strong>With the quality improvement project, overall cytomegalovirus infection rate within 6 months posttransplant decreased from 22.5% to 5.8%, with rates reduced in donor-positive/recipient-negative, donor-positive/recipient-positive, and donor-negative/recipient-positive risk categories. Accuracy of valganciclovir dosing in clinics increased according to the Cockcroft Gault creatinine clearance.</p><p><strong>Conclusions: </strong>Our work shows how multiple factors need to be addressed to reduce the occurrence of cytomegalovirus infection post kidney transplantation. We reduced the incidence of cytomegalovirus infection within 6 months after kidney transplantation, in all cytomegalovirus risk categories, by adopting a multifaceted quality improvement strategy targeting key factors identified on a baseline audit. Transplant centers should regularly survey cytomegalovirus infection rates and adopt a quality improvement strategy to reduce infection rates given its complexity and detrimental outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"328-333"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Donor Sex on Graft Outcomes After Living Donor Kidney Transplant.","authors":"Sajid Shakeel, Taqi T Khan, Nadeem Ahmad, Naveed Khan, Qaiser Iqbal, Muneeb Hassan, Lajward Asnath, Abdullah Shah","doi":"10.6002/ect.2025.0045","DOIUrl":"https://doi.org/10.6002/ect.2025.0045","url":null,"abstract":"<p><strong>Objectives: </strong>Transplant is increasingly recognized as a better alternative to dialysis for patients with endstage renal disease, with living donor transplants generally showing better outcomes. Despite insights into the influence of various donor and recipient factors, the role of donor sex in transplant outcomes remains underexplored. We evaluated recipient outcomes of female donor kidneys compared with outcomes of male donor kidneys in living donor kidney transplant.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analytic cohort study involving 250 patients 18 years and older who underwent living donor kidney transplant. All transplants were performed between related individuals (up to fourth degree). Participants were categorized based on donor-recipient sex combinations, and outcome measures included immediate graft function, delayed graft function, slow graft function, rejection rates, and post-transplant serum creatinine trends.We used Kaplan-Meier survival curves to assess graft and patient survival. We used statistical software for data analysis, incorporating chi-square tests, t tests, analysis of variance, Cox proportional hazards modeling, and log-rank tests.</p><p><strong>Results: </strong>Among the 250 transplants analyzed, donor demographics revealed near equality in male and female donors (124 female vs 126 male donors), with a significant majority of male recipients (n = 213). The study found no significant differences between male and female donors concerning graft function and post-transplant serum creatinine levels. However, male recipients consistently exhibited higher serum creatinine levels versus female recipients. Although graft and patient survival rates did not differ significantly across sex combinations,female recipients demonstrated consistently better outcomes.</p><p><strong>Conclusions: </strong>Our study indicated that female donors do not negatively affect immediate graft function or short-term outcomes in living donor kidney transplants.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 5","pages":"342-346"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}