Experimental and Clinical Transplantation最新文献

{"title":"No Association of Sex or Racial Factors With Outcomes in Adult Intestine-Only Transplant: A United Network for Organ Sharing Database Analysis.","authors":"Laura M Cogua, Connor J Tupper, Giovanni Faddoul, Meng-Hao Li, Naoru Koizumi, Jorge Ortiz","doi":"10.6002/ect.2025.0267","DOIUrl":"https://doi.org/10.6002/ect.2025.0267","url":null,"abstract":"<p><strong>Objectives: </strong>Adult intestine-only transplant is an uncommon procedure for intestinal failure. We assessed demographic factors associated with recipient mortality and graft failure rates in adult intestine-only transplant recipients.</p><p><strong>Materials and methods: </strong>Data for cases of adult intestine-only transplants diagnosed for the period 2004-2024 were collected from the United Network for Organ Sharing database. Demographic characteristics of recipients, mortality, and graft survival were evaluated among racial groups.</p><p><strong>Results: </strong>A total of 896 transplants were included. Most were White (75.2%) and were female (56.3%). There were no differences in graft failure or recipient mortality by race/ethnicity or sex. Race/ethnicity was not associated with graft survival for adult intestine-only transplant. Recipient mortality was greater with older recipients (hazard ratio = 1.022; P = .007). Basiliximab/daclizumab was associated with a higher mortality rate (hazard ratio = 1.001; P < .001). There were no racial disparities and no differences in regimens for induction immunosuppression or maintenance immunosuppression with regard to recipient mortality or graft failure.</p><p><strong>Conclusions: </strong>Recipient age and basiliximab/daclizumab may significantly influence adult intestine-only transplant recipient survival but not graft outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"7-15"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Left Ventricular Outflow Tract Obstruction in Living Donor Liver Transplant: A Case Report.","authors":"Yeiheum Park, Seon Jae Lee, Jae Hwan Kim","doi":"10.6002/ect.2025.0247","DOIUrl":"https://doi.org/10.6002/ect.2025.0247","url":null,"abstract":"<p><p>Liver transplant involves major hemodynamic changes due to hypovolemia, altered vascular resistance, and postreperfusion syndrome. Dynamic left ventricular outflow tract obstruction may occur during surgery and cause cardiovascular compromise. Early recognition is crucial to prevent adverse outcomes. A 55-year-old female patient with alcoholic liver disease underwent living donor liver transplant. Preoperative echo-cardiography showed a hyperdynamic left ventricle with preserved systolic function. During surgery, the patient developed hypotension, tachycardia, and desaturation. Transesophageal echocardiography revealed severe mitral regurgitation and turbulent flow consistent with left ventricular outflow tract obstruction. Hemodynamic stability was achieved through vasopressor therapy and volume management. The patient developed pulmonary edema but subsequently recovered and was discharged on day 35. This case demonstrates the importance of intraoperative transesophageal echo-cardiography to identify left ventricular outflow tract obstruction during liver transplant. Dynamic left ventricular outflow tract obstruction should be considered in hemodynamic collapse, and early echocardiographic assessment can guide effective intervention.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"74-77"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Custodiol-MP in Rewarming Machine Perfusion Up to Normothermia for Porcine Kidney Grafts.","authors":"Hristo Zlatev, Laura Malkus, Thomas Minor, Charlotte von Horn","doi":"10.6002/ect.2025.0261","DOIUrl":"https://doi.org/10.6002/ect.2025.0261","url":null,"abstract":"<p><strong>Objectives: </strong>Controlled oxygenated rewarming is an effective strategy to minimize tissue alterations upon reperfusion after cold preservation and ensures better graft function after transplant. Custodiol-MP, a modification of the classical HTK solution, has been further developed specifically for use in machine perfusion of organs with the intention to meet clinical standards. Here, we compared Custodiol-MP with AQIX RS-I solution for rewarming machine perfusion from hypo- up to normothermic temperature.</p><p><strong>Materials and methods: </strong>Porcine kidney grafts that were ischemically predamaged were cold stored for 18 hours in HTK solution. Kidneys were then connected to a machine perfusion device and treated with controlled oxygenated rewarming from 8 to 35 °C using either AQIX RS-I or Custodiol-MP solution. Kidneys were then evaluated using an established ex vivo reperfusion model.</p><p><strong>Results: </strong>Controlled rewarming with either AQIX RS-I or Custodiol-MP solution resulted in an overall improved kidney performance compared with simply cold storage of kidneys in terms of glomerular capacity, tubular function, and cellular damage. No major differences between rewarming with AQIX RS-I or Custodiol-MP were noted. However, controlled oxyge-nated rewarming with Custodiol-MP resulted in slight improvements in urine production, protein urea, and efficiency of oxygen utilization.</p><p><strong>Conclusions: </strong>Custodiol-MP seems to be at least equally suitable for controlled oxygenated rewarming up to normothermia versus AQIX RS-I solution, with a tendency to improved support of glomerular function and mitochondrial recovery.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"16-22"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Persistent Vitelline Vein in a Pediatric Liver Transplant Recipient: A Case Report.","authors":"Oğuzhan Şal, Cihan Karataş, Barış Demir, Altan Alim, Turan Kanmaz","doi":"10.6002/ect.2025.0179","DOIUrl":"https://doi.org/10.6002/ect.2025.0179","url":null,"abstract":"<p><p>The portal vein is crucial for supplying the liver, and its embryonic development is complex. Variations in portal vein formation can lead to significant surgical challenges, particularly in liver transplantation. Here, we report a unique case of a persistent left portal vein in a 2-year-old patient with Alagille syndrome. During the recipient hepatectomy, the portal vein was found to have an unusual course, traversing behind the pancreas with a more caudal confluence than typical. Although no adverse outcomes occurred during transplant, this variation required a longer and more angular anastomosis, potentially increasing the risk of tension, torsion, and angulation. These variations may contribute to complications, such as anastomosis failure or increased vascular injury. Although no vascular complications arose in this case, the persistence of the left portal vein underscores the importance of surgeons recognizing embryological variations. Preoperative radiological assessment is crucial for anticipating potential challenges, ensuring a safer surgical procedure, and improving patient outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"83-85"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical Fissure Vein Anatomy and Its Importance in Monosegment 3 Graft Procurement for Liver Transplant: A Missed Variable.","authors":"Giriraj Bora, Shyam Sunder Mahansaria, Ramdip Ray","doi":"10.6002/ect.2025.0139","DOIUrl":"https://doi.org/10.6002/ect.2025.0139","url":null,"abstract":"<p><p>Liver transplant in infants weighing less than 6 kg presents substantial technical challenges, prompting various innovations to enhance outcomes. To mitigate the risk of \"large-for-size syndrome,\" initial left lateral segment transplant techniques have evolved, including use of monosegment grafts procured along anatomical planes. Thorough understanding of segmental liver anatomy on radiological imaging is crucial for planning of monosegment grafts. Failure to identify anatomical variations preoperatively can lead to unexpected surgical findings and potentially affect outcomes. Here, we report a living donor liver transplant in which a segment 3 graft was used in a 5.5-kg infant with biliary atresia. We highlight 2 novel surgical issues encountered: (1) an unusual drainage pattern of the umbilical fissure vein in the donor and (2) the innovative application of a Contegra bovine jugular vein graft to reconstruct the atretic portal vein in the recipient. With adequate awareness and meticulous planning, successful outcomes can be achieved in most instances. Furthermore, the use of bovine jugular vein conduits represents an innovative approach in liver transplant. In situations where deceased donor grafts are not available, this option could potentially offer advantages over synthetic expanded polytetrafluoroethylene grafts. Our patient was discharged on postoperative day 16 with normal liver function tests and continues to have normal liver Doppler and function test results at 3 years after liver transplant.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"78-82"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PANoptosis-Based Diagnostic Model Using Single-Cell and Transcriptome RNA Sequencing to Predict Rejection in Kidney Transplant Patients.","authors":"Qian Chen, Sheng Chao, Chao Liu, Yu-Lin Niu, Lei Jia","doi":"10.6002/ect.2025.0199","DOIUrl":"https://doi.org/10.6002/ect.2025.0199","url":null,"abstract":"<p><strong>Objectives: </strong>Kidney transplantation is the most effective treatment for end-stage renal failure, but transplant rejection remains a major challenge. The role of PANoptosis in rejection is not fully understood.</p><p><strong>Materials and methods: </strong>We performed single-cell analysis of PANoptosis-related differentially expressed genes in kidney transplant rejection using data from the GEO database. We identified 7 core PANoptosis genes associated with rejection from 2 machine learning algorithms. We constructed a clinical predictive model, which we evaluated for efficacy and calibration. We predicted potential therapeutic drugs by using the DSigDB database.</p><p><strong>Results: </strong>Compared with nonrejection samples, rejection samples showed increased proportions of endothelial cells and macrophages and decreased proximal tubular cells and fibroblasts. Among 134 PANoptosis-related differentially expressed genes, 7 core genes were significantly positively correlated. The predictive model based on these genes demonstrated good accuracy and calibration. Drug prediction identified tosyllysyl chloromethane targeting NFKBIA as a promising candidate for treatment of rejection.</p><p><strong>Conclusions: </strong>Our findings provide a proof-of-concept diagnostic model that required clinical validation of 7 core PANoptosis-related genes in kidney transplant rejection through single-cell and machine learning analyses. Tosyllysyl chloromethane targeting NFKBIA emerged as a potential therapeutic agent, offering new insights into personalized diagnosis and treatment strategies for renal transplant rejection.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"23-35"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Cancer in Solid-Organ Transplant Recipients.","authors":"Funda Salgür, Altuğ Kut, Özlem Turhan İyidir, Meriç Yavuz Çolak, Mehmet Haberal","doi":"10.6002/ect.2025.0240","DOIUrl":"https://doi.org/10.6002/ect.2025.0240","url":null,"abstract":"<p><strong>Objectives: </strong>One of the best treatment methods for end-stage organ failure is solid-organ transplant. Experiences gained in the postoperative treatment and follow-up of transplant recipients continue to guide the morbidity and mortality rates of patients. Evaluations regarding the increased risk of thyroid cancer after solid-organ transplant are still controversial. In this study, we aimed to examine the incidence of thyroid cancer development in solid-organ transplants cross-sectionally.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cross-sectional study at a single center, which included 23 patients who had undergone liver and kidney transplant and were diagnosed with thyroid cancer after transplant. Among the included patients, 21 had undergone kidney transplant and 2 had undergone liver transplant. The patients' thyroid cancer types, postoperative thyroglobulin and anti-thyroglobulin levels, and whether they received radioactive iodine therapy after surgery were examined. We also investigated whether the deceased patients died primarily from thyroid cancer.</p><p><strong>Results: </strong>Among 1191 transplants were performed at our clinic, 851 were kidney transplants and 340 were liver transplants. Thyroid malignancy was detected in 23 (1.93%) of these cases. The mean age was 54.48 ± 11.41 years, ranging from 38 to 76 years. Fine needle aspiration biopsy results showed suspicious findings for malignancy in 1 case (4.35%), atypia of uncertain significance in 1 case (4.35%), and findings consistent with papillary carcinoma in 21 cases (91.30%). Seventeen patients (73.91%) had papillary carcinoma, whereas others had papillary microcarcinoma. Four patients (17.39%) in the study died, and retrospective review of the records for the primary causes of death showed that all were from causes unrelated to the thyroid.</p><p><strong>Conclusions: </strong>This study showed that the incidence of thyroid cancer has increased in solid-organ transplants, but mortality rates from thyroid cancer have not been affected.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"69-73"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Large Language Model Assistance on Evaluation of Complex Medical Living Kidney Donor Recipients: A Prospective, Role-Stratified Analysis.","authors":"Hari Shankar Meshram, Vishal Batheja, Bhavin Modasia, Saurabh Puri, Chandani Bhagat, Sreenivas Rao Gadireddy, Rajendra Prasad Mathur","doi":"10.6002/ect.2025.0233","DOIUrl":"https://doi.org/10.6002/ect.2025.0233","url":null,"abstract":"<p><strong>Objectives: </strong>Living donor kidney transplant often involves decisions that require complex recipient evaluation under substantial cognitive load. Large language models may augment clinician reasoning; however, their role in transplant assessment remains unexplored.</p><p><strong>Materials and methods: </strong>We conducted a prospective, vignette-based study evaluating ChatGPT (GPT-5, OpenAI) as a decision-support tool to assess living donor kidney transplant recipients. Fourteen nephro-logy fellows completed 22 expert-validated vignettes unaided and, after a 72-hour washout, completed vignettes with the assistance of ChatGPT. Primary outcomes were accuracy (agreement with expert reference) and completeness (coverage of critical decision elements). Secondary outcomes included unsafe potential (risk of harm from omission/error) and cognitive workload (NASA Task Load Index).</p><p><strong>Results: </strong>We analyzed 308 paired responses. Accuracy improved from 68.4% (SD 7.5) to 86.2% (SD 5.6; mean change of 17.8%, d=1.25). Completeness rose from 63.5% (SD 8.1) to 82.1% (SD 6.9; mean change of 18.6%, d=1.31). Gains were most significant in complex vignettes (change of 24.5%; P = .002). Unsafe potential was present in 18 vignettes (82%) unaided but was reduced to 5 (23%) with ChatGPT5, resulting in an absolute reduction of 59% (P < .001). Omissions fell from 6 (27%) to 2 (9%) (reduction of 18%; P = .01). NASA Task Load Index scores declined substantially, with large effect sizes in mental demand (d=3.55), effort (d=3.65), and frustration (d=2.97).</p><p><strong>Conclusions: </strong>In our study, large language model support significantly enhanced accuracy, completeness, and safety while diminishing cognitive workload among nephrology fellows. This finding highlighted that large language models can operate as both cognitive aids and safety nets in transplant evaluation. Future real-world validation and continuous audits are necessary before integration into clinical workflows.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"43-50"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donation After Circulatory Death in Simultaneous Pancreas-Kidney Transplant Lags Despite Comparable Outcomes and Growing Organ Demand.","authors":"Emily Gaine, Mohammed Rahman, Aman Pal, Jordan Loon, Omar Ali, Nicholas Ryan, Naoru Koizumi, Meng-Hao Li, Giovanni Faddoul, Jorge Ortiz","doi":"10.6002/ect.2025.0255","DOIUrl":"https://doi.org/10.6002/ect.2025.0255","url":null,"abstract":"<p><strong>Objectives: </strong>Pancreas transplant provides definitive treatment for uncontrolled insulin-dependent diabetes, yet use of donation after circulatory death pancreases remains limited due to concerns about higher complication rates and reduced graft survival versus donation after brain death. We (1) assessed circulatory death simultaneous pancreas-kidney transplants from 2015-2019 and 2020-2024, (2) reviewed donor/recipient characteristics, and (3) compared outcomes of circulatory versus brain death donation in simultaneous pancreas-kidney transplants.</p><p><strong>Materials and methods: </strong>In a retrospective cohort analysis of all adult simultaneous pancreas-kidney transplants for 2015-2024 (n = 6934; United Network of Organ Sharing), we divided recipients as donation after circulatory death (n = 219) and brain death (n = 6715). We evaluated donor, recipient, and simultaneous pancreas-kidney transplant characteristics associated with graft survival.</p><p><strong>Results: </strong>No significant difference was shown in the proportion of circulatory death transplants for 2015-2019 versus 2020-2024 (95% CI, -0.0125 to 0.004; P = .3). Circulatory death transplant recipients had a higher proportion of type 2 diabetes and were more likely to be treated at high-volume centers. Donation after circu-latory death transplants were more often from male, non-Hispanic White donors, with higher Kidney Donor Profile Indexes. Kidney delayed graft function was higher among circulatory death donors (26.50% vs 8.40%; P < .001). No significant difference in 5-year pancreas graft survival was observed between recipients of circulatory death and brain death transplants (hazard ratio = 0.88; P = .456). Higher recipient body mass index (hazard ratio = 1.04; P < .001), kidney delayed graft function (hazard ratio = 1.72; P < .001), and cytomegalovirus donor-positive/recipient-negative se-rostatus (hazard ratio = 1.29; P = .004) were independently associated with poorer graft survival.</p><p><strong>Conclusions: </strong>Donation after circulatory death simultaneous pancreas-kidney outcomes parallel results from brain death transplants, yet use remains low. Optimized donor management could expand the pancreas donor pool and enhance transplant access.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 12","pages":"763-771"},"PeriodicalIF":0.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Late Complication Occurring Due to Tacrolimus After Liver Transplant: Posterior Reversible Encephalopathy Syndrome.","authors":"Sertaç Usta, Koray Karabulut","doi":"10.6002/ect.2017.0248","DOIUrl":"10.6002/ect.2017.0248","url":null,"abstract":"<p><p>Posterior reversible encephalopathy syndrome is a rare condition of the central nervous system that may occur in adults as well as in children. Clinically, it presents with mental status changes, visual loss, headaches, seizures, or coma. The diagnosis of posterior reversible encephalopathy syndrome is based on the typical appearance in occipital and parietal lobes in radiologic imaging studies, such as computed tomography or magnetic resonance imaging of the brain, which exhibit the typical appearance due to vasogenic edema. Causative factors include hyper-tensive encephalopathy, renal failure, preeclampsia, autoimmune conditions, and the use of cytotoxic or immunosuppressive agents. Rare cases of posterior reversible encephalopathy syndrome due to treatment with tacrolimus, an immunosuppressive agent com-monly used after organ transplant, have been reported. In these patients, the tacrolimus dose is reduced or discontinued. In transplant patients with neurologic symptoms, the possibility of posterior reversible encephalopathy syndrome should be kept in mind.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":" ","pages":"842-844"},"PeriodicalIF":0.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36302253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}