Experimental and Clinical Transplantation最新文献

{"title":"Renal Transplant Outcomes in Pediatric Cystinosis Patients: A Comparative Analysis with Non-Cystinosis Controls.","authors":"Osama Gheith, Ayman Nagib, Mohamed Adel, Ahmed Denewar, Mohamed Balha, Medhat Alawady, Zakaria E Zakaria, Torki Al-Otaibi","doi":"10.6002/ect.MESOT2025.O37","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.O37","url":null,"abstract":"<p><strong>Objectives: </strong>Cystinosis is a rare autosomal recessive lysosomal storage disorder causing progressive chronic kidney disease. Limited data exist on renal transplant outcomes in transplant recipients with cystinosis. In this study, we compared clinical outcomes of pediatric renal transplant recipients with cystinosis versus those without cystinosis.</p><p><strong>Materials and methods: </strong>We conducted a retrospective comparative analysis of 143 pediatric renal transplant recipients (23 with cystinosis, 120 without cystinosis {control group } ) followed at a Kuwait kidney transplant center. Primary outcomes included graft function, patient survival, and posttransplant complications. Secondary outcomes assessed anthropometric parameters and serum creatinine trajectories.</p><p><strong>Results: </strong>Transplant recipients with cystinosis versus without cystinosis had significantly lower height at last follow -up (1.34 ± 0.18 vs 1.52 ± 0.15 cm; P = .001 )and better baseline renal function (creatinine level of 84.5 ± 36.4 vs 105.0 ± 89.0 μmol /L; P = .04 ). Graft survival at final follow -up was comparable between groups (78.3 % in cystinosis group vs 69.2 % in control group; P = .39 ). New -onset diabetes after transplant was not observed in the cystinosis group versus shown in 9.2 % of patients in the control group (P = .17 ). Viral complications, including BK viremia, BK nephropathy, and cytomegalovirus viremia, showed no significant difference between groups. Patient survival was excellent in both groups (100 % vs 98.3 % in the cystinosis vs control group; P = .55 ).</p><p><strong>Conclusions: </strong>Pediatric renal transplant recipients with cystinosis demonstrated comparable graft survival and favorable posttransplant outcomes versus recipients without cystinosis, with potential advantages, including lower incidence of new -onset diabetes after transplant and better early renal function. These findings support renal transplant as a viable treatment option for pediatric patients with cystinosis and end -stage renal disease.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"100-105"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Complications of Kidney Transplant Biopsy in Patients With Intraperitoneal and Extraperitoneal Kidney Transplants in Labbafinezhad Hospital.","authors":"Fariba Samadian, Shiva Samavat, Mahsa Hosseini Chimeh, Sahand Ameri, Mohsen Nafar, Ahmad Firouzan, Fatemeh Poorrezagholi, Taymaz Yousefzad, Nooshin Dalili, Somaye Sadat Heidary","doi":"10.6002/ect.MESOT2025.P21","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P21","url":null,"abstract":"<p><strong>Objectives: </strong>Although the extraperitoneal approach is standard in renal transplant, intraperitoneal placement is utilized in pediatric recipients and select adult cases. Concerns exist regarding the safety of percutaneous allograft biopsy in intraperitoneally placed kidneys due to potential visceral injury. We aimed to compare biopsy-related complication rates between intraperitoneal and extraperitoneal kidney transplant recipients.</p><p><strong>Materials and methods: </strong>This retrospective cohort study (2022-2024) compared biopsy-related complications in 100 transplant recipients (50 intraperitoneal, 50 extraperitoneal) at Labbafinezhad Hospital. Only 23 patients underwent ultrasonography-guided allograft biopsy (13 intraperitoneal, 10 extraperitoneal) for clinical indications. Demographic, clinical, and transplant-related variables and postbiopsy complications were evaluated.</p><p><strong>Results: </strong>The intraperitoneal group (mean age 39 ±12 years, 69% male) and the extraperitoneal group (mean age 37 ± 13 years, 60% male) were demographically comparable (P > .05). All transplants were from living donors. No significant differences were observed in baseline characteristics, including cause of end-stage renal disease, dialysis vintage, or number of previous transplants. Postbiopsy complications were rare and of minor severity in both cohorts. One patient (7.7% ) in the intraperitoneal group developed a small hematoma (grade 3), and 1 patient (7.7% ) had a minor perinephric collection (40 mL). No such events occurred in the extraperitoneal group, but this difference was not significant (P = .565). No instances of gross hematuria, clinically significant hemoglobin drop, transfusion requirement, hypotension, fistula, or need for angioembolization were recorded in either group.</p><p><strong>Conclusions: </strong>Ultrasonography-guided renal allograft biopsy appears to be a safe procedure with a similarly low complication profile in both intraperitoneal and extraperitoneal transplant recipients. Despite theoretical risks associated with intraperitoneal organ placement, our study found no evidence of increased major or minor complications, supporting the safety of percutaneous biopsy in this population when performed with image guidance.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"235-240"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Cardiac Arrest During Organ Procurement From a Donor After Brain Death.","authors":"Mark William Noble, Neusha Haque, Saman Tayba, Prassana Kumar, Nageswar Bandla","doi":"10.6002/ect.MESOT2025.P178","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P178","url":null,"abstract":"<p><p>Cardiac arrest is a rare but critical complication during the management of donors declared dead by neurological criteria (donation after brain death). We report the case of a 56)year)old male donor after brain death who developed sudden cardiac arrest shortly before planned organ procurement. Despite prolonged cardiopulmonary resuscitation and progression to asystole, organ retrieval was initiated with ongoing resuscitative measures and vasoactive support. The liver was successfully retrieved following hypothermic perfusion, demonstrated no significant histopathological injury, and was transplanted successfully. This case highlights the feasibility of organ recovery following cardiac arrest in donation after brain death donors and emphasizes the importance of preparedness, rapid multidisciplinary coordination, and robust protocols to optimize organ viability and expand the donor pool.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"451-453"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Social, Academic, and Professional Outcomes in Adults Following Pediatric Kidney Transplant: A Single-Center Study.","authors":"Alara Akdeniz, Esra Baskın, Meraj Siddiqui, Elif Şahin Eroğlu, Adem Şafak, Emre Karakaya, Sedat Yıldırım, Mehmet Haberal","doi":"10.6002/ect.MESOT2025.O41","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.O41","url":null,"abstract":"<p><strong>Objectives: </strong>Kidney transplant is the preferred treatment for end-stage renal disease in children due to superior effects on survival, growth, and quality of life versus dialysis. However, childhood kidney transplant presents unique challenges for long-term social, academic, and professional integration as recipients transition into adulthood. We assessed the educational attainment, employment status, and marital outcomes of an adult cohort of childhood kidney transplant recipients.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed all pediatric kidney transplants at Başkent University Hospital from January 2015 through December 2024. Eligibility was defined as a renal graft before the age of 18 years with subsequent follow-up into adulthood. Data were collected via a structured, voluntary questionnaire administered during telephone interviews, which captured academic qualifications, employment status, marital status, posttransplant caregiver arrangements, and demographic information of patients' parents, including education and employment.</p><p><strong>Results: </strong>We included 98 patients (mean age, 25.98 ±5.58 years; mean age at transplant, 14.12 ± 3.83 years), comprising 53 male (54.1%) and 45 female participants (45.9% ). Living-related donors were predominant. Regarding the recipients' parents, maternal education was predominantly low, and 82.7% of the maternal parents were homemakers. Paternal parents demonstrated higher employment rates (n = 47; 48.0% ) and more varied educational attainment. Educational attainment revealed that 48 patients (49.0% ) completed high school, 15 (15.3% ) attended university, and 9 (9.2% ) earned a bachelor-level degree. Employment status was reported by 47 recipients (47.9% ), with 48 (46.9% ) unemployed and 3 (3.1% ) employed part time. Seventeen participants (17.3% ) were married with at least 1 child.</p><p><strong>Conclusions: </strong>Pediatric kidney transplant recipients encounter substantial future challenges in social and professional integration as they progress through adulthood. Our cohort demonstrated moderate educational achievement and employment rates, and most were unmarried. Our findings emphasize the importance of long-term multidisciplinary support to promote successful transitions into adulthood, addressing not only medical needs but also social and occupational needs.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"106-109"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical and Jurisprudential Considerations of Stem Cell Donation in the Gulf.","authors":"Ayesha Mubarak Aldhabah Alketbi, Walaaeldeen Mohamed Ibraheem, Shaikha Ahmed Altaffaq, Hanadi Sharif Murad Mohamed, Noura Nasir Alkarbi, Fatima Saleh Mohammed Al Blooshi, Sharifa Ali Hashem Alblooshi","doi":"10.6002/ect.MESOT2025.P181","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P181","url":null,"abstract":"<p><p>Stem cell donation has become an important component of contemporary regenerative medicine, particularly in the treatment of hematological malignancies, immune deficiencies, genetic disorders, and selected metabolic diseases. However, its implementation in Muslim Gulf societies remains shaped by medical awareness, legal clarity, institutional readiness, and religious -ethical considerations. In this study, we examined community and physician perspectives on stem cell donation in the Gulf Cooperation Council context, with particular attention to Islamic jurisprudence, ethical values, and regulatory frameworks. We adopted an integrative design, combining doctrinal legal and jurisprudential analysis with 2 cross -sectional surveys. The community survey included 65 participants and examined awareness, perceived barriers, religious considerations, registration intention, and willingness to donate. The physician survey included 55 medical doctors and assessed professional knowledge, perceived therapeutic importance, institutional support, legal awareness, and policy preferences. Findings showed that both community members and physicians recognized the humanitarian and therapeutic value of stem cell donation, yet this positive perception had not translated into active registration or strong system -level engagement. Among community participants, lack of information, uncertainty regarding religious rulings, and limited awareness of registration mechanisms emerged as key barriers. Among physicians, limited familiarity with legal frameworks and inadequate institutional support were central constraints. Strengthening stem cell donation in the Gulf Cooperation Council requires coordinated educational initiatives, clear religious guidance, stronger institutional training, and legally transparent opt -in donation systems that respect cultural, ethical, and religious sensitivities.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"380-388"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of Changes in Risk Factors for Mortality and Antimicrobial Resistance in Pseudomonas species Infections in Solid-Organ Transplant Patients Over the Years.","authors":"Nuran Sarı, Özlem Kurt Azap, Hande Arslan, Adem Şafak, Mehmet Haberal","doi":"10.6002/ect.MESOT2025.P126","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P126","url":null,"abstract":"<p><strong>Objectives: </strong>Although Pseudomonas species infections have decreased since the introduction of anti -pseudomonal antibiotics, these infections still cause mortality in immunocompromised patients. This study investigated the antibiotic resistance and mortality risk factors of Pseudomonas species isolated from various materials in solid -organ transplant recipients.</p><p><strong>Materials and methods: </strong>Infections due to Pseudomonas species between 2020 and 2024 were retrospectively analyzed in solid -organ transplant recipients aged >18 years. Recurrent infections in the same patient were excluded. We analyzed resistance profiles to commonly used antibiotics, demographic and laboratory data, and risk factors affecting 30 -day hospital mortality using the SPSS version 25 statistical program.</p><p><strong>Results: </strong>Pseudomonas species infection was detected in 80 solid -organ transplant recipients: 70 % were male patients, 78 % had living donors, and 57 % were kidney transplant recipients. Pseudomonas aeruginosa was the most frequently detected species (95 % ). The most common agent was detected in body fluid samples. Thirty -day hospital mortality was 18.8 %. Mortality was significantly higher in patients with resistance to amikacin, ciprofloxacin, cefepime, and colistin, and in those with invasive procedures and mechanical ventilation, and in patients with sepsis and in intensive care. Resistance rates were higher between 2020 and 2023, when the COVID -19 pandemic was active.</p><p><strong>Conclusions: </strong>Although changes occurred over the years, antibiotic resistance increased during the COVID -19 pandemic. This increased resistance created difficulties in empirical and pathogen -targeted treatments. Amikacin and colistin are recommended for empirical treatment of Pseudomonas species infections due to their low resistance rates. In addition, unnecessary invasive procedures should be avoided, discontinuing them when the indication is no longer there. Adhering to infection prevention can reduce risk factors, as sepsis, intensive care unit stay, and invasive procedures affect mortality.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"334-339"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Extrahepatic Portal Venous Variant Leading to Graft Discard in Deceased Donor Liver Transplantation.","authors":"Evangelia Florou, Rajendran Vellaisamy, Andreas Prachalias, Kanaga Natarajan, Parthi Srinivasan","doi":"10.6002/ect.2026.0160","DOIUrl":"https://doi.org/10.6002/ect.2026.0160","url":null,"abstract":"","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 7","pages":"575-577"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Determinants in Pediatric Liver Transplant From a Single Center Performing Primarily Living Donor Transplants.","authors":"Cansu Altuntaş, Alaaddin Aydın, Eryiğit Eren, Mehmet Tokaç, Ayhan Dinçkan","doi":"10.6002/ect.MESOT2025.O64","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.O64","url":null,"abstract":"<p><strong>Objectives: </strong>Despite advances in surgical technique and postoperative care, pediatric liver transplant outcomes remain highly variable, particularly in centers with limited access to deceased donor organs. We evaluated survival rates and identified key clinical, surgical, and laboratory parameters associated with posttransplant mortality in a high -volume single center performing primarily living donor liver transplants.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 98 pediatric liver transplants performed from January 2018 to February 2024 at the Istinye University Organ Transplantation Unit, Istanbul, Türkiye. All cases were ABO compatible. Assessed variables included recipient demographic data, indications, weight, preoperative and postoperative day 7 laboratory results, graft type, and complications. Survival was defined as time from liver transplant to death from any cause. Kaplan -Meier and Cox regression analyses were used to identify predictors of survival. P < .05 was considered statistically significant.</p><p><strong>Results: </strong>Median age at transplant was 17 months; 51.0 % of patients weighed ≤10 kg. Living donor transplants accounted for 92.6 % of cases. Overall crude survival was 74.5 %. Cumulative survival rates at 6 months, 1 year, and 3 years were 78.5 %, 77.4 %, and 73.2 %, respectively. Kaplan -Meier survival analysis showed that recipients with a body weight of ≤10 kg had a significantly higher mortality rate and shorter overall survival (P = .012 ). Multivariate Cox regression identified 2 independent predictors of mortality: higher graft -to -recipient weight ratio (hazard ratio 1.498; P = .032 ) and platelet count decrease for each increment of 10 000 platelets /mm ³ on postoperative day 7 (hazard ratio 1.046; P = .004 ).</p><p><strong>Conclusions: </strong>This study highlights 3 modifiable or monitorable factors, that is, low transplant weight, high graft -to -recipient weight ratio, and early postoperative thrombocytopenia, as key predictors of reduced survival in pediatric liver transplant recipients. These findings emphasize the need for careful donor -recipient matching and early postoperative monitoring, particularly in centers that rely primarily on living donor transplants.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"183-190"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothermic Oxygenated Machine Perfusion Using a Standard Cardiopulmonary Bypass System: Clinical Outcomes and Feasibility in Extended Criteria Donor Liver Transplantation.","authors":"Alexey Vasilyevich Shabunin, Pavel Alexeevich Drozdov, Marina Gennadievna Minina, Oksana Nikolaevna Levina, Sergey Andreevich Astapovich, Evgeniy Ivanovich Zakurdaev, Dmitriy Aleksandrovich Makeev, Daniil Aleksandrovich Solomatin, Ismail Ibragimovich Kurbanov, Alexey Igorevich Yurik","doi":"10.6002/ect.MESOT2025.O26","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.O26","url":null,"abstract":"<p><strong>Objectives: </strong>Hypothermic oxygenated perfusion reduces ischemia-reperfusion injury and improves early graft function in extended criteria donor liver transplant. However, use of machine perfusion may be limited because of lack of dedicated perfusion devices. We evaluated feasibility and clinical outcomes of dual hypothermic oxygenated perfusion performed using a standard cardiopulmonary bypass system.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 87 adult recipients who underwent orthotopic liver transplant from extended criteria donors (2018 -2024 ). We compared 34 cases with static cold storage (SCS group; 2018 -2022 ) versus 53 with dual hypothermic oxygenated perfusion using a modified cardiopulmonary bypass system (D -HOPE group; 2023 -2024 ), analyzing early graft function, early allograft dysfunction, postoperative renal function, complications, and short -term survival. Morphological assessment included light and transmission electron microscopy at 3 time points: before preservation, after dual hypothermic oxygenated perfusion, and after static cold storage.</p><p><strong>Results: </strong>Dual hypothermic oxygenated perfusion was associated with significantly lower aspartate aminotransferase on postoperative day 1 (1450 {1180 -2210 }vs 2280 {1620 -3010 } U /L; P = . ⁰ ³ ³ ) and alanine aminotransferase (1180 {900 -2002 } vs 1890 {1280 -2500 } U /L; P = . ⁰ ² ⁴ ). Total bilirubin and international normalized ratio were significantly lower on postoperative days 3 and 7. Early allograft dysfunction occurred in 28.3 % of patients in the D -HOPE and 61.8 % in the SCS group (P = . ⁰ ). Reduced estimated glomerular filtration rate ( <45 mL /min /1.73 m ² ⁰ ⁴ ) was less frequent and total intensive care unit and hospital stay were significantly shorter in the D-HOPE group. Electron microscopy demonstrated better preservation of mitochondrial ultrastructure after dual hypothermic oxygenated perfusion, whereas light histology showed comparable findings across groups.</p><p><strong>Conclusions: </strong>Dual hypothermic oxygenated perfusion performed with a standard cardiopulmonary bypass system is feasible and safe and associated with improved early graft function in extended criterial donor liver transplant. This conventional platform may facilitate hypothermic oxygenated perfusion in transplant centers lacking dedicated machine perfusion systems.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"84-92"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunosuppressive Medication Adherence Among Kidney Transplant Recipients: A Qualitative Exploration of Patient Experiences.","authors":"Deniz Tasdemir","doi":"10.6002/ect.MESOT2025.P159","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P159","url":null,"abstract":"<p><strong>Objectives: </strong>Kidney transplant is a life -saving treatment for patients with end -stage renal failure. However, lifelong adherence to immunosuppressive medication is essential to prevent graft rejection. Despite its importance, nonadherence remains a common issue among transplant recipients, particularly in varying cultural and regional contexts. This study, which used a qualitative descriptive design, aimed to explore the factors affecting adherence to immunosuppressive medication among kidney transplant recipients in the Mediterranean region of Türkiye through a qualitative approach.</p><p><strong>Materials and methods: </strong>This study included 21 kidney transplant recipients through snowball sampling who were using immunosuppressive drugs. Data were collected through semi -structured in -depth interviews. The interviews were analyzed using thematic content analysis to identify key categories, themes, and sub -themes related to medication adherence behavior.</p><p><strong>Results: </strong>Four main categories emerged from the data: individual factors, social support, health system -related factors, and psychological aspects. Themes included knowledge and awareness about medications, emotional responses to drug use, quality of communication with health care providers, and the presence or absence of social support. Subthemes such as fear of organ loss, forgetfulness, family encouragement, and depressive symptoms were also identified. Participant narratives reflected how personal beliefs, emotional burden, and systemic support played a crucial role in adherence behavior.</p><p><strong>Conclusions: </strong>This study highlighted the multifaceted nature of medication adherence in kidney transplant recipients. Findings underscored the need for individualized education, psychosocial support, and stronger patient -provider communication to enhance long -term adherence. Incorporating culturally sensitive strategies within follow -up care may contribute to more successful transplant outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"363-370"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}