Experimental and Clinical Transplantation最新文献

{"title":"Mean Systemic Filling Pressure Trends in Liver Transplant Recipients: An Observational Pilot Study.","authors":"Karthik Ponnappan Thirumurugan, Udit Dhingra, Anil Yogendra Yadav, Amal Francis Sam, Viniyendra Pamecha","doi":"10.6002/ect.2024.0183","DOIUrl":"10.6002/ect.2024.0183","url":null,"abstract":"<p><strong>Objectives: </strong>Mean systemic filling pressure is a key determinant of venous return and cardiovascular function, with potential implications for hemodynamic stability in surgical interventions, such as liver transplantation. In this prospective observational pilot study, we investigated changes in mean systemic filling pressure in patients undergoing living related donor liver transplant (primary outcome) and its correlation with various hemodynamic and intraoperative parameters (secondary outcomes).</p><p><strong>Materials and methods: </strong>This study was conducted at a tertiary care hospital between May 2020 and October 2020. We obtained 193 mean systemic filling pressure values from 20 adult patients (aged 18-65 y) undergoing living related donor liver transplant. We analyzed mean systemic filling pressure, heart rate, central venous pressure, mean arterial pressure, cardiac output, systemic vascular resistance, and stroke volume variation measured at baseline and during surgery. Mean systemic filling pressure was assessed by using the arm technique.</p><p><strong>Results: </strong>The baseline mean systemic filling pressure was 35.7 ± 8.6 mm Hg. During dissection (n = 114 mean systemic filling pressure results), anhepatic (n = 39 results), and neo-hepatic (n = 40 results) phases, mean systemic filling pressure was 31.1 ± 8.3, 26.7 ± 5.8, and 27.9 ± 6.1 mm Hg, respectively (P = .002). Among the hemodynamic variables, mean systemic filling pressure was positively correlated with central venous pressure (r = 0.69, P = .001) and negatively correlated with cardiac output (r = -0.53, P = .015).</p><p><strong>Conclusions: </strong>Mean systemic filling pressure values tended to decrease during the anhepatic phase and increase during the neo-hepatic phase. Although we observed strong positive correlation between mean systemic filling pressure and central venous pressure throughout surgery,the expected positive correlation between mean systemic filling pressure and cardiac output was not observed.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"43-51"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parvovirus B19-Induced Pure Red Cell Aplasia Several Years After Kidney Transplantation and Following a Transition From Everolimus to Tacrolimus.","authors":"Theodoros Eleftheriadis, Maria Divani, Tzanis Leontaridis, Christina Poulianiti, Maria-Anna Polyzou-Konsta, Evangelos Lykotsetas, Ioannis Stefanidis","doi":"10.6002/ect.2024.0267","DOIUrl":"10.6002/ect.2024.0267","url":null,"abstract":"<p><p>A 57-year-old male patient, who underwent a preemptive living donor renal transplant from his mother 22 years earlier, was switched from everolimus to tacrolimus after 21 years because of development of proteinuria. Four months after transition of medication, the patient presented with anemia and reduced reticulocyte count, whereas leukocyte and platelet counts remained within normal limits. Investigation into the cause of anemia ruled out deficiencies in iron, folate, or vitamin B12, as well as inflammation, monoclonal gammopathy, hemolysis, and hypothyroidism. Gastroscopy and colonoscopy revealed no abnormalities. The patient showed a gradual increase in serum creatinine levels. Serological testing for human parvovirus B19 revealed a positive immunoglobulin M result. The patient was treated with intravenous immunoglobulin, after which hemoglobin levels began to rise within a few days. Three weeks after treatment, hemoglobin levels returned to baseline, and serum creatinine levels improved. A follow-up polymerase chain reaction test for human parvovirus B19 was negative. This case highlights the importance of maintaining vigilance for pure red cell aplasia caused by human parvovirus B19 infection, even long after kidney transplant, particularly when interventions are implemented that may increase the intensity of immunosuppression.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"67-71"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Bacterial Infection After Liver Transplant: A Systematic Review and Meta-Analysis.","authors":"Jie Yu, Yaxuan Xu, Jichang Jiang, Jinlong Huo, Tingting Luo, Lijin Zhao","doi":"10.6002/ect.2024.0238","DOIUrl":"10.6002/ect.2024.0238","url":null,"abstract":"<p><strong>Objectives: </strong>Bacterial infection is an important cause of early death after liver transplant. This meta-analysis aimed to determine the risk factors for bacterial infection after liver transplant.</p><p><strong>Materials and methods: </strong>We searched for relevant studies published in PubMed,Web of Science, Embase, The Cochrane Library, China National Knowledge Infrastructure, Wan Fang Database, Chinese Science and Technology Journal Database, and China Biomedical Literature Database up to May 2024. After literature screening, we used the Newcastle-Ottawa Scale to evaluate the quality of included studies. The fixed-effect or random-effect model was used to calculate the combined odds ratio and corresponding 95% CI. We used the I 2 test to evaluate whether there was heterogeneity among studies.</p><p><strong>Results: </strong>The 23 included articles reported on 6426 adult liver transplant patients and 1427 cases of bacterial infection. Preoperative hepatic encephalopathy (odds ratio = 2.55; 95% CI, 1.48-4.41), Model for End-Stage Liver Disease score (odds ratio=2.09; 95% CI, 1.10-3.97), Child-Pugh C score (odds ratio = 4.87; 95% CI, 3.22-7.37), hypoproteinemia (odds ratio = 2.88; 95% CI, 1.84-4.50), use of antibiotics (odds ratio = 3.62; 95% CI, 1.83-7.17), intraoperative blood transfusion (odds ratio = 2.14; 95% CI, 1.04-4.38), intraoperative bleeding (odds ratio = 2.74; 95% CI, 1.53-4.90), ventilator time (odds ratio = 3.24; 95% CI, 1.88-5.57), stay in intensive care unit (odds ratio = 5.17; 95% CI, 3.35-7.99), and hospitalization time (odds ratio = 1.03; 95% CI, 3.06-7.61) were influencing factors but not age.</p><p><strong>Conclusions: </strong>Further strict and well-designed studies with sufficient sample size are needed to identify risk factors to address the limitations of our study. Strengthening the assessment and screening of risk factors and effective intervention as soon as possible are conducive to improving the clinical outcomes of liver transplant recipients.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"1-11"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonogram-Guided Continuous Quadratus Lumborum Block as Pain Management in Pediatric Kidney Transplant Recipients: A Case Series.","authors":"Barry Immanuel Kambey, Andi Ade Wijaya Ramlan, Rahendra Rahendra, Nathasha Brigitta Selene","doi":"10.6002/ect.2024.0205","DOIUrl":"10.6002/ect.2024.0205","url":null,"abstract":"<p><p>Adequate perioperative analgesia is essential to optimize recovery in pediatric transplant surgery. Regional anesthesia techniques, such as continuous quadratus lumborum block, have been identified as effective and safe options for managing perioperative pain in pediatric abdominal surgeries. However, data on its use in pediatric kidney transplants are limited. We present a case series of 8 pediatric patients who underwent kidney transplant between January 2022 and April 2024 at our institution because of stage V chronic kidney disease of various etiologies. Four patients had received hemodialysis and 2 had received continuous ambulatory peritoneal dialysis before transplant. After induction of general anesthesia, quadratus lumborum block was performed before the surgical incision. Patients were positioned in the left lateral decubitus position. Patients had ultrasonographic imaging using the subcostal approach to visualize the lateral abdominal muscle layers. Once the psoas major muscle was identified, an 18-gauge Tuohy needle was inserted 1 to 2 cm lateral to the ultrasonograph probe, targeting the quadratus lumborum muscle. A catheter was subsequently inserted anterior to the quadratus lumborum muscle. Each patient received continuous quadratus lumborum block with either 0.125% bupivacaine at a rate of 4 to 6 mL/hour for 24 hours or 0.2% ropivacaine at a rate of 6 mL/hour as part of a multimodal perioperative pain management protocol. The perioperative pain was effectively managed with minimal need for rescue analgesics, and no substantial adverse events were reported. Quadratus lumborum block is an accessible and safe technique with great potential to facilitate postoperative pain management, especially in pediatric patients undergoing kidney transplant.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"72-77"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Tirzepatide in Solid-Organ Transplant Recipients: Experience of a Quaternary Care Center in the Middle East.","authors":"Omar El Khatib, Maguy Chiha, Rabih Hijazi, Ola Jarad, Cynthia Salloum, Khaled El Baba, Ruba Dajani, Salma Al Shaqfa, Sandra El Hajj","doi":"10.6002/ect.2024.0284","DOIUrl":"10.6002/ect.2024.0284","url":null,"abstract":"<p><strong>Objectives: </strong>Diabetes constitutes a prevalent condition posttransplant, imposing a substantial burden on solid organ transplant recipients, including increased risk of graft loss and reduced overall survival. Consequently, the implementation of effective glycemic control strategies is vital. Tirzepatide, the first dual glucosedependent insulinotropic polypeptide/glucagon-like peptide-1 receptor coagonist, represents a novel therapeutic option in the general population; however, further data are needed to support its use in solid-organ transplant recipients.</p><p><strong>Materials and methods: </strong>In this retrospective chart review, we examined a cohort of 41 heterogenous patients who were undergoing tirzepatide therapy after solid-organ transplant in Abu Dhabi, United Arab Emirates, from January 2017 to January 2024.</p><p><strong>Results: </strong>Within our study cohort, the median time elapsed from transplant to tirzepatide therapy commencement was 2.91 years (range, 1.04-4.38 y), with use that lasted for a median follow-up duration of 11 months (range, 7-13 mo) until date of data collection. Tirzepatide facilitated optimal glycemic control, elicited significant weight reductions, and improved renal function without adversely affecting graft function or patient survival, showing an adverse effect profile similar to that of the general population, as shown in the literature.</p><p><strong>Conclusions: </strong>Tirzepatide represents a promising therapeutic avenue for management of posttransplant diabetes mellitus and type 2 diabetes mellitus in solidorgan transplant recipients.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"12-20"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avascular Necrosis in Renal Transplant Patients.","authors":"Bulent Kaya, Saime Paydas, Mustafa Balal, Burak Mete, Tolga Kuzu","doi":"10.6002/ect.2022.0345","DOIUrl":"10.6002/ect.2022.0345","url":null,"abstract":"<p><strong>Objectives: </strong>Kidney transplant recipients are at increased risk for avascular necrosis due to steroid use and accompanying comorbidities. Concerning risk factors, uncertainty still exists. We evaluated the clinical characteristics and risk factors of avascular necrosis in kidney transplant recipients.</p><p><strong>Materials and methods: </strong>Symptomatic avascular necrosis was found by magnetic resonance imaging in 33 of 360 kidney transplant patients between 2005 and 2021. The patients' clinical characteristics, biochemical testing, and medications were evaluated.</p><p><strong>Results: </strong>We found the frequency of avascular necrosis to be 9.7% during the follow-up period. If the total steroid dosage used was more than 4 g in the first 3 months, the risk of developing avascular necrosis increased 4.08 times, and the presence of cytomegalovirus disease increased the risk by 4.03 times. Avascular necrosis was observed bilaterally in 60.6% of cases and at the femoral head in 66.7%. The frequency of avascular necrosis was highest in the first and second years posttransplant.</p><p><strong>Conclusions: </strong>We found that avascular necrosis appears most frequently in the first 2 years after kidney transplant and the most important risk factors are cumulative steroid dose and cytomegalovirus disease. In the follow-up of kidney transplant patients, it is important to use low-dose steroid doses if possible. Of note, preventing the development of cytomegalovirus disease by screening and prophylaxis for cytomegalovirus is also important in reducing the development of avascular necrosis.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":" ","pages":"21-28"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Clinical Entity: Staphylococcus-Related Glomerulonephritis.","authors":"Numune Aliyeva, Erol Demir, Yasar Caliskan, Halil Yazici, Alaattin Yildiz","doi":"10.6002/ect.2016.0066","DOIUrl":"10.6002/ect.2016.0066","url":null,"abstract":"<p><p>Staphylococcus aureus is a rare cause of postinfectious glomerulonephritis, and Staphylococcus-related glo-merulonephritis primarily occurs in middle-aged or elderly patients. Patients with Staphylococcus-related glomerulonephritis also present with hematuria, proteinuria of varying degrees, rising serum creatinine levels, and/or edema. The severity of renal insufficiency is proportional to the degree of proliferation and crescent formation. Here, we present a diabetic patient admitted with a history of 1 week of left elbow pain. Laboratory results revealed that erythrocyte sedimentation rate was 110 mm/hour, serum creatinine level was 1 mg/dL, C-reactive protein level was 150 mg/L, and magnetic resonance imaging showed signal changes in favor of osteomyelitis at the olecranon level, with diffuse edematous appearance in the elbow skin tissue and increased intra-articular effusion. After diagnosis of osteomyelitis, ampicillin/sulbactam and teicoplanin were administered. After day 7 of admission, the patient developed acute kidney injury requiring hemodialysis under antibiotic treatment. Kidney biopsy was performed to determine the underlying cause, which showed Staphylococcus-related glomerulonephritis. Recovery of renal func-tions was observed after antibiotic and supportive treatment.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":" ","pages":"78-80"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34861079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Hospital Stay Predicts Worse Outcomes After Pancreas Transplantation: An Analysis of the SRTR Database.","authors":"Yanfang Mei, Yunxi Lu, Chaochao Jiang","doi":"10.6002/ect.2024.0242","DOIUrl":"10.6002/ect.2024.0242","url":null,"abstract":"<p><strong>Objectives: </strong>Postoperative length of hospital stay is a crucial predictor of short-term outcomes, yet few studies have explored the effects of length of hospitalization on prognosis following pancreas transplant.</p><p><strong>Materials and methods: </strong>We analyzed data from the Scientific Registry of Transplant Recipients (January 2000-December 2014) for first-time pancreas transplant recipients. Patients were categorized into normal (<20 days) and prolonged (≥20 days) length of hospital stay groups. The relationship between length of stay and graft and patient survival was examined.</p><p><strong>Results: </strong>Our study included 15047 first-time pancreas transplant patients, with 1465 having prolonged length of stay and 13582 having normal length of stay. Graft and patient survival rates were significantly lower in the prolonged compared with the normal length of stay group (P < .001). Patient survival rates at 1, 3, and 5 years were 91.8%, 85.5%, and 78.5% in the prolonged and 97.7%, 94.3%, and 89.6% in the normal length of stay groups, respectively. Graft survival rates at 1, 3, and 5 years were 80.7%, 74.4%, and 69.5% in the prolonged and 93.4%, 87.4%, and 82.6% in the normal length of stay groups, respectively. Prolonged length of stay was a risk factor for 1-year graft survival (hazard ratio = 2.301; 95% CI, 1.920-2.757). Longer lengths of hospital stay were significantly associated with poorer survival (P < .001).</p><p><strong>Conclusions: </strong>Prolonged length of hospital stay was significantly related to reduced graft and patient survival rates after pancreas transplant. Optimizing factors that may lead to prolonged length of stay and providing targeted adjuvant therapy can potentially mitigate associated adverse effects and reduce postoperative expenses.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"52-59"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recipient Aortic Dissection After Orthotopic Heart Transplant: A Case Report.","authors":"Denyan Mansuroglu, Ali Dogan, Oguz Konukoglu, Kenan Sever, Mehmet Balkanay","doi":"10.6002/ect.2024.0272","DOIUrl":"10.6002/ect.2024.0272","url":null,"abstract":"<p><p>Aortic dissection following orthotopic heart transplant is a rare but life-threatening event and typically occurs at the donor-recipient aortic anastomosis. In the case described here, a 40-year-old male patient, 10 years after he had received a heart transplant to treat dilated cardiomyopathy, presented with chest pain and dyspnea. Imaging revealed a chronic dissection that originated from the suture line between the donor and recipient aortas and extended to the iliac arteries. Notably, a mismatch was observed between the donor and recipient aortas during the initial transplant surgery. Although most cases reported in the literature involve dissections in the donor aorta, this dissection occurred in the recipient aorta. Surgical management included replacement of the ascending aorta with a Dacron graft and reinforcement of the anastomosis line. The postoperative course was uneventful, and follow-up imaging showed complete thrombosis of the false lumen. Aortic dissection after heart transplant, although rare, requires immediate surgical intervention due to its high mortality risk. Surgical precision during the initial transplant, especially with regard to the donor-recipient aortic mismatch, and vigilant long-term follow-up are crucial to prevent such complications and thereby facilitate improved patient outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"81-84"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Viral Challenges: A 5-Year Review of Infections in Solid-Organ Transplant Patients.","authors":"Nuran Sari, Başak Bacı, Mehmet Said Canlı, Oguz Çınar, Sarp Utku Durgut, Zümra Olcar, Çaglar Sel, Erdem Yıldırım, Emre Karakaya, Özlem Kurt Azap, Atilla Sezgin, Mehmet Haberal","doi":"10.6002/ect.2024.0307","DOIUrl":"10.6002/ect.2024.0307","url":null,"abstract":"<p><strong>Objectives: </strong>Solid-organ transplant recipients are prone to infections due to intensive immunosuppression treatments after transplant. Incidence of viral infections is gradually increasing. During the COVID-19 pandemic, transplant patients were shown to be at increased risk of infections. We investigated viral infections in transplant patients before and during the pandemic to guide patient follow-up.</p><p><strong>Materials and methods: </strong>We collected data of solid-organ transplant recipients ≥18 years old who experienced viral infections during 2019-2023. We analyzed demographic data, transplant types, and clinical outcomes with SPSS software (version 25.0); P < .05 was statistically significant.</p><p><strong>Results: </strong>We analyzed 238 patients (mean age 43.9 ± 14.9 years; 69.7% male) diagnosed with viral infections: 79.8% received kidney transplants, 16.4% liver, and 3.8% heart. The most prevalent virus was SARS-CoV-2 (64.7%), followed by influenza (18.1%) and cytomegalovirus (7.6%). Mean age for heart transplant was lower than among other transplant types (P = .015). Fever, cough, and sputum production were common in influenza infections (P = .012, P = .041, and P = .009, respectively); myalgia and dyspnea were common with SARS-CoV-2 (P = .029 and P = .013, respectively). Rates of bacteremia and intensive care unit admission were high for cytomegalovirus infections (P = .002, P = .031). Thrombocytopenia and bacteremia were detected more frequently for liver transplants (P = .004 and P = .013, respectively). Empirical antibiotic treatment was started in 17.2% of patients. Twenty-nine patients were monitored in the intensive care unit, and 12.1% died. Mortality was significantly higher in patients >65 years old and in the presence of bacteremia (P = .001).</p><p><strong>Conclusions: </strong>Vaccination, early detection, and preventive strategies play pivotal roles to manage viral infections in solid-organ transplant recipients. Future research should focus on optimized prophylaxis and individualized care plans.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 1","pages":"60-66"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}