Experimental and Clinical Transplantation最新文献

{"title":"Extrahepatic Liver Metastasis in the Follow-Up of Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma: Single-Center Experience.","authors":"Osman Aydın, Muhammet Kadri Çolakoğlu, Dilara Turan Gökçe, Volkan Öter, Yiğit Mehmet Özgün, Derya Arı, Nesrin Turhan, Rıza Sarper Ökten, Meral Akdoğan Kayhan, Erdal Birol Bostancı","doi":"10.6002/ect.2023.0111","DOIUrl":"10.6002/ect.2023.0111","url":null,"abstract":"<p><strong>Objectives: </strong>Hepatocellular carcinoma is a common type of primary liver cancer and a major cause of cancer-related deaths worldwide. Liver transplantation is the choice of treatment for patients with hepatocellular carcinoma within the Milan criteria. Extrahepatic metastasis is a particularly concerning complication of hepatocellular carcinoma recurrence after liver transplant, associated with poor prognosis, and has limited treatment options. We analyzed our results in the incidence and management of extrahepatic metastasis in patients transplanted for hepatocellular carcinoma.</p><p><strong>Materials and methods: </strong>Between 1999 and 2022, 61 patients underwent liver transplant for hepatocellular carcinoma at our center and were included in the study. At our outpatient department, patients who underwent liver transplant for hepatocellular carcinoma had follow-up and tumor surveillance examinations at specific intervals posttransplant. Examinations included physical examination, ultrasonography of the abdomen and liver, radiographic examination of the chest, serum laboratory tests with α-fetoprotein, and ultrasonography-guided liver biopsy.</p><p><strong>Results: </strong>The 61 patients followed up for hepatocellular carcinoma were between 22 and 65 years old; 8 (14.1%) were women. Chronic hepatitis B infection was observed in 36 patients (59%). Extrahepatic metastases were observed in 13 patients during follow-up. The mean recurrence time in the 13 patients who developed extrahepatic hepatocellular carcinoma recurrence was 21 months posttransplant. Extrahepatic recurrence included lung, bone, and spleen metastasis in 7 patients, isolated lung metastasis in 3 patients, seeding metastasis in 2 patients, and isolated bone metastasis in 1 patient. Twenty of the 58 patients included in the study received local ablative therapy before transplant.</p><p><strong>Conclusions: </strong>Hepatocellular carcinoma beyond Milan criteria and microvascular invasion are risk factors for extrahepatic hepatocellular carcinoma recurrence; a multimodal approach is used to manage recurrent disease.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"133-137"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Elderly Donors on Long-Term Outcomes of Liver Transplantation: A Retrospective Cohort Study.","authors":"Ying Xu, Xiao-Feng Wu, Yuan Liu, Yu-Na Zhi, Zhao-Bo Liu, Zhen-Shun Wang, Guang-Ming Li, Dong-Dong Lin","doi":"10.6002/ect.2024.0241","DOIUrl":"10.6002/ect.2024.0241","url":null,"abstract":"<p><strong>Objectives: </strong>Transplant centers are increasingly using livers from donors aged >60 years, but long-term outcomes remain unclear.</p><p><strong>Materials and methods: </strong>We collected data from 957 adult deceased donor liver transplant recipients (conducted at our center from January 2015 through October 2023). The cohort was divided into early, middle, and late transplant era groups, each covering a 3-year interval based on transplant date. We compared 183 donors aged ≥60 years (older group [average age 64.9 ± 3.4 y]) versus 774 donors aged 18 to 59 years (young group), which we also compared after propensity score matching. We compared outcomes of older organs transplanted into older recipients versus older organs transplanted into young recipients. We conducted multivariate logistic regression analysis to identify potential factors influencing liver transplant outcomes.</p><p><strong>Results: </strong>Over the time period, average donor age increased significantly, cold ischemia time and warm ischemia time decreased, postoperative complications decreased among older donor liver transplant recipients, and cumulative recipient and graft survival rates improved. The older donor group had fewer male donors, more donors with diabetes, and lower average donor liver weight versus the young donor group. Recipients in the older donor group had significantly lower body mass index and higher prevalence of alcoholic cirrhosis versus recipients in the young donor group. Three-month postoperative mortality rate was significantly higher in the older donor group. Subgroup analysis showed significant differences in outcomes between older donors assigned to older recipients and older donors assigned to young recipients, including higher incidence of major postoperative complications and lower 3-month mortality rate. Recipient-donor age differences, early transplant era, and postoperative peak bilirubin level may affect differences.</p><p><strong>Conclusions: </strong>Livers from older donors can yield positive outcomes for young and old recipients. Use of organs from older donors is a viable approach to mitigate organ shortages, including for younger recipients.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"120-132"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Effect of Brain Death Etiologies on Organs Transplanted Per Donor.","authors":"Arman Hasanzade, Seyed Mohammad Reza Nejatollahi, Mojtaba Mokhber Dezfouli, Dorsa Najari, Masoud Jamali, Seyed Khashayar Mirbahaeddin, Fariba Ghorbani","doi":"10.6002/ect.2024.0255","DOIUrl":"10.6002/ect.2024.0255","url":null,"abstract":"<p><strong>Objectives: </strong>We assessed effects of brain death etiology on organ donation, particularly focusing on the number of organs transplanted per donor.</p><p><strong>Materials and methods: </strong>We evaluated 934 actual donors from 982 brain death cases at our center from April 2016 to July 2023. We analyzed donor cause of death, donor age, sex, blood group, time to consent, and hospital characteristics.</p><p><strong>Results: </strong>Among 934 actual brain death donors (63.6% male), mean age was 41.44 years. Cause of death was nontraumatic intracranial hemorrhage in 43.3% of cases, followed by trauma, hypoxia, cerebrovascular accident, toxicity, and brain tumor, respectively. Kidney, liver, heart, and lung donations occurred in 696 cases (74.5%), 809 (86.6%), 146 (15.6%), and 25 (3.4%), respectively. Donor cause of death significantly affected kidney donation (P < .001), with highest rates in trauma (83.7%), followed by brain tumors. Although cause of death did not affect liver transplant rates (P = .26), the highest rate was associated with trauma (89.9%), followed by toxicity. Difference in heart transplant rates among different causes of death was significant (P < .001), with highest rates in trauma cases. Similar to liver transplant, lung transplant was similar among different causes of death (P = .3). Organs transplanted per donor averaged 2.52 ± 1.13, with highest numbers associated with trauma (2.88 ± 1.07), followed by drug toxicity, brain tumors, hypoxia, nontraumatic intracranial hemorrhage, and cerebrovascular accident (P < .001). Compared with trauma, differences in organs transplanted per donor were significant for nontraumatic intracranial hemorrhage (mean difference 0.56; 95% CI, 0.39-0.74; P < .001), cerebrovascular accident (mean difference 0.58; 95% CI, 0.29-0.87; P < .001), and hypoxia (mean difference 0.50; 95% CI, 0.26-0.76; P = .002).</p><p><strong>Conclusions: </strong>Understanding how cause of death influences donation can help improve organ donation practices and potentially increase the number of organs available for transplant.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"103-110"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of the Brain Death Organ Donor: Results of a Comprehensive Bibliometric Analysis on Research, 1992-2024.","authors":"Xiaohang Chen, Li Pan, Wei Zhou, Shaojun Ye, Chongxiang He, Yan Xiong, Cheng Zeng, Qifa Ye, Yan Xu, Xin Zhou","doi":"10.6002/ect.2024.0235","DOIUrl":"10.6002/ect.2024.0235","url":null,"abstract":"<p><strong>Objectives: </strong>Organ transplant is widely regarded as the optimal treatment for patients with end-stage organ failure; however, the scarcity of organs has evolved into a substantial medical and social dilemma. To gain insight into recent advancements in global research on brain death organ donor management, we compiled relevant literature for a comprehensive bibliometric analysis of the field.</p><p><strong>Materials and methods: </strong>We used the CiteSpace (6.2.R3) tool to perform a visualization analysis of the literature on management of organ donors after brain death, which we conducted with the Web of Science database.</p><p><strong>Results: </strong>Using a time period from 1992 to 2024, we examined annual publication volume, countries, research institutions, authors, and journals associated with the management of organ donors after brain death. The 269 research articles originated from 37 countries and regions. The United States was the foremost country in publishing articles on the management of brain dead donors. Harvard University emerged as the leading publisher in this field of research. We noted the top 3 authors by publication volume as K. J. Wood, B. Gridelli, and T. Kawai. Visualization of hotspots and frontiers encompassed kidney transplant, intestinal failure, graft dysfunction, and organ donor evaluation, among other areas.</p><p><strong>Conclusions: </strong>Our comprehensive overview of the organ donation management field can serve as a valuable resource for researchers looking to delve deeper into the specific aspects, thereby contributing to the ongoing advancement of brain death organ donor management.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"87-96"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Everolimus in Lung Transplant Recipients Undergoing Surveillance Bronchoscopy with Transbronchial Forceps Biopsy and Cryobiopsy: A Retrospective Cohort Study.","authors":"René Hage, Carolin Steinack, Fabrizio Pumo, David Hoier, Jérôme Bonzon, Macé M Schuurmans","doi":"10.6002/ect.2024.0321","DOIUrl":"10.6002/ect.2024.0321","url":null,"abstract":"<p><strong>Objectives: </strong>Managing posttransplant immunosuppression in lung transplant recipients is crucial yet complex. Everolimus, a mechanistic target of rapamycin inhibitor, offers benefits such as reduced chronic rejection and improved management of donor-specific antibodies. However, its potential to impair wound healing raises concerns, particularly with minimally invasive procedures like surveillance bronchoscopy with cryobiopsy. We evaluated whether everolimus use in lung transplant recipients increases the risk of complications, particularly bleeding, during bronchoscopy.</p><p><strong>Materials and methods: </strong>Our retrospective cohort study analyzed data from lung transplant recipients at the University Hospital Zurich (2022-2023). We categorized patients based on immunosuppressive regimen: patients on everolimus and patients on standard calcineurin inhibitor-based regimens. We reviewed outcomes from 105 bronchoscopies, involving both forceps biopsies and cryobiopsies. For primary outcomes, we examined bleeding incidence, with severity graded with the Nashville Bleeding Scale. We conducted statistical analyses by using the X² test, with significance set at P < .05.</p><p><strong>Results: </strong>We examined 41 bronchoscopies in patients on everolimus and 64 bronchoscopies in patients who were not treated with everolimus. No significant difference in bleeding incidence was shown between groups (P > .05). No bleeding occurred in 68.3% of patients with everolimus and 60.9% of patients without everolimus. Grade 2 bleeding occurred in 26.8% of patients with everolimus and in 34.4% of patients without everolimus, with no significance difference. No grade 4 bleeding or life-threatening complications were recorded, and a minor pneumothorax was observed in only 1 patient in the group without everolimus.</p><p><strong>Conclusions: </strong>Everolimus use in lung transplant recipients did not increase the risk of bleeding or other complications during surveillance bronchoscopy with forceps and cryobiopsies. We suggest that everolimus therapy can be safely continued during such procedures, supporting its uninterrupted application in lung transplant patients.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"138-145"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living Donor Renal Transplant After Ex Vivo Partial Nephrectomy for Incidentally Detected Small Renal Mass: A Case Series.","authors":"Brij Mohan Joshi, Pragnesh Desai, Gaurav Dwivedi, Satish Ranjan, Anant Kumar","doi":"10.6002/ect.2024.0291","DOIUrl":"10.6002/ect.2024.0291","url":null,"abstract":"<p><strong>Objectives: </strong>Because of the risk of tumor implantation, a kidney with a small renal mass is not accepted as a donor in the kidney transplant program. Here, we evaluated the long-term outcomes of transplantation of kidneys with small renal mass.</p><p><strong>Materials and methods: </strong>We reviewed 14 donors who had been incidentally diagnosed with a small renal mass during standard donor evaluation. All donors underwent laparoscopic donor nephrectomy followed by bench resection of the mass. The negative margins were confirmed on the frozen section.</p><p><strong>Results: </strong>On histopathological examination, 6 masses were reported as renal cell carcinoma, 4 were angiomyolipomas, 2 were oncocytoma, and 2 were papillary adenoma. After a median follow-up of 30 months, no recurrences were shown in the recipients. All recipients showed stable graft function.</p><p><strong>Conclusions: </strong>When no other donor is available, a kidney with a small renal mass can be considered for living related kidney transplant. Bench excision of the mass was oncologically safe, with recipients having good long-term outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"116-119"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental and Focal Glomerulosclerosis Secondary to MELAS Syndrome and Long-Term Outcomes After Kidney Transplant: Case Report and Literature Review.","authors":"Marcos Vinicius de Sousa, Giovana Mariani, Maria Almerinda Vieira Fernandes Ribeiro Alves, Marilda Mazzali","doi":"10.6002/ect.2025.0006","DOIUrl":"10.6002/ect.2025.0006","url":null,"abstract":"<p><p>Mitochondrial disease is a heterogeneous group of disorders with variable clinical and laboratory manifestations. The most common mitochondrial DNA defect is the transition of adenine to guanine at position 3243 (m.3243A≥G) on the MT-TL1 gene, causing a systemic syndrome known as MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). The kidney is particularly susceptible to mitochondrial diseases due to its high oxygen consumption and abundance of mitochondria. Tubular cells and podocytes can be affected by these diseases, resulting in diverse clinical and laboratory manifestations. We reported a case of a 31-year-old female patient with bilateral sensorineural deafness diagnosed with the m.3243A≥G sequence variant in adulthood. At the time of diagnosis, she had end-stage renal disease secondary to focal segmental glomerulosclerosis. Her sister was diagnosed with MELAS syndrome, and mitochondrial disease was investigated. After 27 months on dialysis, our patient received a kidney transplant from a deceased donor and presented nonnephrotic range proteinuria within the first month after transplant. Despite developing de novo donor-specific antibodies after COVID-19, the function of the transplanted kidney remained stable. With adjustment to the maintenance immunosuppression therapy, there was a gradual decrease in the mean fluorescence intensity of de novo donor-specific antibodies. The graft function and proteinuria remained stable throughout a 5-year follow-up, which is similar to a follow-up reported in the literature. The kidney is especially vulnerable to mitochondrial diseases. In this report, posttransplant outcomes were satisfactory in a 5-year follow-up, similar to those reported by other authors.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"146-150"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Only Intestinal Retransplant Is Associated With Higher Rates of Graft Failure, Acute Rejection, and Mortality: A United Network for Organ Sharing Database Analysis.","authors":"Laura M Cogua, Connor J Tupper, Meng-Hao Li, Naoru Koizumi, Jorge Ortiz","doi":"10.6002/ect.2025.0021","DOIUrl":"10.6002/ect.2025.0021","url":null,"abstract":"<p><strong>Objectives: </strong>Adult intestinal retransplant has increased substantially during the past decade, outpacing the rate of primary transplants to become the fourth most common reason for intestinal transplant. Although intestinal retransplant is a viable option for patients with failed transplants, long-term survival is often lower. We compared intestinal retransplant to primary intestinal transplant for rates of graft failure, acute rejection, and mortality.</p><p><strong>Materials and methods: </strong>We collected data from the United Network for Organ Sharing database for intestinal retransplant and first-time intestinal transplant for the period from 2010 to 2024. We compared recipient and deceased donor characteristics of primary intestinal transplant alone and intestinal retransplant via Pearson chi-square tests. We contrasted graft failure, mortality, and acute rejection by using log-rank tests, multivariate Cox analysis, and logistic regression analysis.</p><p><strong>Results: </strong>We selected 741 patients; 60 (8.1%) were intestinal retransplant recipients. On log-rank tests, intestinal retransplant showed 20% higher rate of graft failure and mortality after 5 years (P < .001). Regression analysis showed that retransplant was associated with 61% higher rate of graft failure (hazard ratio = 1.615, P = .002), 107% higher rate of acute rejection (odds ratio = 2.072, P = .049), and an 82% increase in mortality (hazard ratio = 1.823, P < .001). No associations between sex, race and ethnicity, or induction or maintenance regimens and graft failure or mortality for intestinal retransplant were shown.</p><p><strong>Conclusions: </strong>Adult intestinal retransplant was associated with higher rates of graft failure related to rejection and infection, and retransplant status was associated with higher rates of graft failure and mortality. No associations between different regimens of induction or maintenance and graft failure or mortality were shown. Race/ethnicity and sex did not affect graft failure or mortality. Further research of intestinal retransplant will improve knowledge of risk factors associated with negative outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"97-102"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of Traumatic External Iliac Artery Dissection Due to Vascular Clamping.","authors":"Mahir Kırnap, Ümit Özçelik, Aydıncan Akdur, Ebru H Ayvazoğlu Soy, İclal Işıklar, Feza Yarbuğ Karakayalı, Gökhan Moray, Mehmet Haberal","doi":"10.6002/ect.2016.0091","DOIUrl":"10.6002/ect.2016.0091","url":null,"abstract":"<p><p>Traumatic external iliac artery dissection after renal transplant is a rare complication, but it should be urgently managed due to its devastating effects on graft and lower limb circulation. External iliac artery dissection is seen more in recipients with diabetes mellitus and comorbid disease. Recipients with external iliac artery dissection should be treated immediately by percutaneus angioplasty or surgical reconstruction. In this study, we reported the management of 2 kidney transplant cases with external iliac artery dissection due to vascular clamping of the artery. External iliac artery dissection was diagnosed by ultrasonography in both cases. After failed percu-taneous interventional angioplasty, we reconstructed the external iliac artery dissection surgically and replaced the external iliac artery with polytetra-fluoroethylene grafts in both patients. Both patients were discharged with normal functioning grafts showing 0.9 and 0.8 mg/dL serum creatinine levels at month 3 posttransplant. Close monitoring of recipients after transplant is mandatory for early diagnosis and early management of external iliac artery dissection to prevent graft loss and preserve lower limb circulation. Routine Doppler ultrasonography is an inexpensive and useful tool for early diagnosis in cases of sudden cessation or decrease in urine. In cases of failed percutaneous interventional angioplasty, recon-struction with synthetic vascular grafts can be safely applied in external iliac artery dissection.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":" ","pages":"154-157"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35577168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Laboratory Features of Geriatric Patients Undergoing Transplantation: A Single-Center Experience.","authors":"Funda Salgür, Cihat Burak Sayin, Damlanur Tunçay, Meriç Yavuz Çolak, Mehmet Haberal","doi":"10.6002/ect.2025.0012","DOIUrl":"10.6002/ect.2025.0012","url":null,"abstract":"<p><strong>Objectives: </strong>Organ transplant is a life-saving treatment for patients with end-stage organ failure. Today, with the increase in the healthy aging geriatric population, transplant cases in elderly patients are also increasing. This study examined the effects of age differences on morbidity and mortality in kidney and liver transplant patients.</p><p><strong>Materials and methods: </strong>A total of 33 patients aged 65 years and over (elderly group) and 31 patients aged 25 to 64 years (younger group) were selected from 1273 kidney and 532 liver transplants performed at Başkent University Ankara Hospital between January 2000 and December 2023. In this descriptive study, we retrospectively compared graft survival and laboratory values between kidney and liver transplant patients in the elderly versus younger group.</p><p><strong>Results: </strong>The mean age was 73.67 ± 5.57 years in the elderly group and 57.77 ± 10.47 years in the younger group. Among patients with kidney transplant, the elderly group consisted of 4 female (19%) and 17 male (81%) patients, and the younger group consisted of 6 female (33%) and 12 male (67%) patients. Among patients with liver transplant, the elderly group consisted of 3 female (27%) and 8 male (73%) patients, and the younger group consisted of 2 female (15%) and 11 male (85%) patients. No significant differences were shown in graft survival duration between elderly and younger kidney transplant patients (P = .443). Liver transplant recipients in the elderly group had significantly higher aspartate aminotransferase levels at month 1 versus patients in the younger group (P = .012). Among kidney transplant patients, the younger group had urine protein and creatinine values at month 3 and creatinine values at month 12 that were significantly higher than in the elderly group (P = .016; P = .043).</p><p><strong>Cconclusions: </strong>Transplant had positive contributions in reducing mortality and morbidity in patients in the elderly group. Transplant studies of geriatric patients will benefit surgeons working with elderly patients and the literature in this field.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"23 2","pages":"111-115"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}