Experimental and Clinical Transplantation最新文献

{"title":"Comparison of Radiation Dose Between Low-Dose Postoperative and Standard-Dose Preoperative Abdominal Computed Tomography in Living Liver Donors.","authors":"Sunyoung Lee, Kyoung Won Kim, Heon-Ju Kwon, Sang Hyun Choi, Young-In Yoon, Gi-Won Song, Sung-Gyu Lee","doi":"10.6002/ect.2025.0277","DOIUrl":"https://doi.org/10.6002/ect.2025.0277","url":null,"abstract":"<p><strong>Objectives: </strong>Although contrast-enhanced abdominal computed tomography is frequently used to detect possible postoperative complications in living liver donors, radiation exposure remains a major concern. For this reason, we used low-dose postoperative computed tomography scans. We compared radiation doses of low-dose postoperative computed tomog-raphy with those of standard-dose preoperative computed tomography in living liver donors.</p><p><strong>Materials and methods: </strong>This retrospective study included 80 living liver donors (median age of 28.0 years; 40 male participants) who underwent standard-dose preoperative and low-dose postoperative abdo-minal computed tomography scans between 2023 and 2024. Scanning parameters of tube voltage peak, effective tube current, and rotation time were, respectively, 100 kVp, 200 mA·s, and 0.5 s for preoperative computed tomography and 100 kVp, 40 mA·s, and 0.5 s for low-dose postoperative computed tomography. We compared radiation doses, including dose length product and effective dose, for preoperative versus postoperative portal venous phase abdominal computed tomography scans with paired Wilcoxon signed-rank tests. We assessed correlations between the radiation dose and body mass index with the Spearman correlation coefficient.</p><p><strong>Results: </strong>The median dose length product and effective dose with low-dose postoperative computed tomog-raphy were significantly lower than with standard-dose preoperative computed tomography (72.6 vs 371.0 mGy·cm and 1.1 vs 5.6 mSv, respectively; all P < .001). The dose length product and effective dose of preoperative and postoperative computed tomography scans showed very strong positive correlations with body mass index (ρ = 0.919 and 0.909, respectively; all P < .001). In all subgroups based on body mass index, the median dose length product and effective dose of postoperative computed tomog-raphy were significantly lower versus preope-rative computed tomography (all P < .001).</p><p><strong>Conclusions: </strong>Low-dose postoperative computed tomography scans can significantly reduce radiation dose in living liver donors.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"144-148"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ Donation: Knowledge, Attitudes, and Willingness Among Patients, Their Families, and Society About Lung Transplant.","authors":"Fatmanur Çelik Başaran, Sinan Türkkan, Mehmet Furkan Şahin, Muhammet Ali Beyoğlu, Emre Yılmaz, Alkın Yazıcıoğlu, Erdal Yekeler","doi":"10.6002/ect.2023.0118","DOIUrl":"https://doi.org/10.6002/ect.2023.0118","url":null,"abstract":"<p><strong>Objectives: </strong>Organ transplantation is a life-saving treatment. The higher the awareness about organ donation in a society, the higher the number of lives saved through organ transplant. We evaluated the knowledge, attitudes, and willingness concerning organ donation among patients who had received a lung transplant and their family members as well as the wider population.</p><p><strong>Materials and methods: </strong>Study participants were divided into the following 3 groups: 56 transplant patients, 69 family members of the included transplant patients, and 77 community members. An online questionnaire was sent to all of the participants to enquire about their knowledge of and attitudes toward organ donation and their willingness to engage in organ donation. Answers from the 3 groups were evaluated comparatively.</p><p><strong>Results: </strong>Study participants were generally knowled-geable about organ donation and wanted to donate, but they did not do so for various reasons. The most common ones were distrust of the health care system, lack of knowledge of donation procedures, and the possibility that the recipient was not a \"good\" person (that is, not someone who is useful to society and humanity). The study observed that, as the participants' level of education increased, the number of people who were willing to donate decreased.</p><p><strong>Conclusions: </strong>With the increased number of people with chronic diseases and needing organ transplant, thousands of patients on organ transplant wait lists die every year. Individuals should be accurately informed about organ donation, and they should be encouraged to donate.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"182-188"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Efficacy and Safety of the Glucagon-Like-Peptide-1 Receptor Agonists Tirzepatide and Semaglutide in Solid-Organ Transplant Recipients.","authors":"Omar El Khatib, Maguy Chiha, Ola Jarad, Cynthia Salloum, Khaled El Baba, Ruba Dajani, Salma Al Shaqfa, Sandra El Hajj","doi":"10.6002/ect.2025.0180","DOIUrl":"https://doi.org/10.6002/ect.2025.0180","url":null,"abstract":"<p><strong>Objectives: </strong>Diabetes mellitus, including new-onset diabetes after transplant, is a prevalent complication in solid-organ transplant recipients, often necessitating complex glycemic management. Glucagon-like peptide-1 receptor agonists, including semaglutide and tirzepatide, have shown promising outcomes in the general population, but comparative data in solid-organ transplant recipients are limited. In this study, we evaluated and compared the efficacy and safety of semaglutide and tirzepatide in a diverse cohort of solid-organ transplant recipients.</p><p><strong>Materials and methods: </strong>This retrospective chart review study involved 73 solid-organ transplant recipients treated with semaglutide (n = 39) or tirzepatide (n = 34) at a quaternary care center in the United Arab Emirates. Efficacy endpoints included changes in weight, body mass index, hemoglobin A1c, fasting plasma glucose, insulin requirements, and serum triglycerides. As safety outcomes, we assessed adverse effects, immunosuppressant levels, and allograft function.</p><p><strong>Results: </strong>Both agents significantly improved weight, body mass index, hemoglobin A1c, fasting plasma glucose, and triglyceride levels. Tirzepatide led to a greater reduction in median triglyceride levels compared with semaglutide, despite a significantly shorter treatment duration. Adverse events were more frequent in the semaglutide group, including gastrointestinal intolerance and infections, despite being confounded by disparities in follow-up duration. No significant changes in tacrolimus levels, graft function, or mortality were observed in either group.</p><p><strong>Conclusions: </strong>Tirzepatide and semaglutide were shown to be both effective and generally safe for mana-gement of diabetes mellitus in solid-organ transplant recipients. Tirzepatide may offer advantages in tolerability and rapid glycemic control. Prospective studies are warranted to confirm these findings in larger, controlled cohorts.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"173-181"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Pattern of Changes in Hepatic Artery Resistive in Patients Undergoing Deceased Donor Liver Transplantation.","authors":"Mohsen Aliakbarian, Fahimeh Hoseinzadeh, Maryam Salari, Rozita Khodashahi, Amir Mahmoud Ahmadzadeh","doi":"10.6002/ect.2025.0270","DOIUrl":"https://doi.org/10.6002/ect.2025.0270","url":null,"abstract":"<p><strong>Objectives: </strong>Postoperative hepatic artery resistive index is strongly influenced by perioperative hemodynamics and graft-related factors. However, evidence linking prognostic variables to early postoperative hepatic artery resistive index remains limited and hete-rogeneous. This study explored changes in hepatic artery resistive index and whether changes were associated with patient-level exposures and prog-nostic variables.</p><p><strong>Materials and methods: </strong>We analyzed retrospective data from 323 patients who underwent deceased donor liver transplant at the Montaserieh Transplant Center Registry of Mashhad University of Medical Sciences between 2014 and 2021. Patient demographic charac-teristics and clinical assessments were analyzed. Doppler sonographies performed before and during the first 3 days posttransplant were used to measure hepatic artery resistive index. We used SPSS version 27 and R-Studio version 4.5.1 for analyses.</p><p><strong>Results: </strong>Mean age of patients was 48.71 ± 1.022 years. Mean hepatic artery resistive index increased among patients aged ≤50 years from day 0 (0.762 ± 0.149) to day 1 (0.789 ± 0.141), showed continuous upward trend in patients aged >50 years, increasing from day 0 (0.778 ± 0.136) to day 3 (0.835 ± 0.105), and was significantly higher in patients aged >50 years on day 2 (0.031; P = .012) and day 3 (0.044; P < .001) compared with patients aged ≤50 years. Older deceased donor age was associated with increased mean hepatic artery resistive index over time (0.083, P = .029). Although baseline resistive index and liver injury markers were significantly associated with subsequent changes in hepatic artery resistive index, no significant association was observed for Model for End-Stage Liver Disease score.</p><p><strong>Conclusions: </strong>With an association shown between age and higher hepatic artery resistive index, trend analysis may help identify high-risk groups for arterial thrombosis. Further research is needed to better clarify the relationships between Model for End-Stage Liver Disease scores and clinical outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"158-164"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and Outcomes of Pregnancy After Kidney Transplant: A Single-Center Retrospective Study from Azerbaijan.","authors":"Rashad Sholan, Ulduz Hashimova, Nargiz Bakhshaliyeva, Malahat Sultan","doi":"10.6002/ect.2025.0303","DOIUrl":"https://doi.org/10.6002/ect.2025.0303","url":null,"abstract":"<p><strong>Objectives: </strong>Kidney transplant restores fertility in female recipients with end-stage renal disease; however, pregnancy in this population is classified as a high-risk condition. Data regarding pregnancy outcomes in kidney transplant recipients within the Azerbaijani population remain limited.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on female living donor kidney transplant recipients at the State Security Service Military Hospital in Baku, Azerbaijan, from 2017 to 2024. The study evaluated demographics, immunosuppression adjust-ments, renal function, and obstetric compli-cations.</p><p><strong>Results: </strong>Among 208 transplant cases, 13 pregnancies were identified in 10 recipients. The median age at conception was 28.3 years, with a median post-transplant interval of 32.7 months. All patients discontinued mycophenolate mofetil at 6 weeks prior to conception. Renal function remained stable, with no significant differences in serum creatinine levels between pre-pregnancy (1.05 mg/dL) and 3 months postpartum (1.07 mg/dL), and no acute rejection episodes occurred. Maternal complications included gestational hypertension (30.8%), urinary tract infections (23.1%), and physiological hydronephrosis (23.1%). The live birth rate was 92.3% (12 of 13 births). All deliveries were via cesarean section; 38.5% were premature (<37 weeks). Neonatal outcomes were positive, with no major congenital anomalies.</p><p><strong>Conclusions: </strong>Pregnancy after kidney transplant is feasible and safe for both mother and graft under a strict multidisciplinary follow-up regimen. Despite risks of prematurity and hypertension, vigilant monitoring ensures high live birth rates without compromising graft stability.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"129-133"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous Immunoglobulin-Associated Heart Block in a Kidney Transplant Recipient: A Rare Cardiac Complication.","authors":"Saurabh Puri, Nidhi Yadav, Vishal Batheja, Bhavin Modasia, Aditi Sharma, Hari Shankar Meshram, Rajendra Prasad Mathur","doi":"10.6002/ect.2025.0276","DOIUrl":"https://doi.org/10.6002/ect.2025.0276","url":null,"abstract":"","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"197-198"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft and Recipient Survival Analysis of Renal Transplantation in Rheumatic Diseases: A Retrospective Case-Control Study.","authors":"Vural Taner Yılmaz, Tahir Saygın Öğüt, Abdullah Kısaoğlu, Hüseyin Koçak, Bülent Aydınlı, Mert Ünal, Veli Yazısız","doi":"10.6002/ect.2023.0267","DOIUrl":"https://doi.org/10.6002/ect.2023.0267","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, we aimed to evaluate the long-term outcomes of renal transplant in patients with rheumatic diseases.</p><p><strong>Materials and methods: </strong>In this retrospective case-control study, we analyzed and compared outcomes of 187 patients who underwent renal transplant because of rheumatic disease-associated renal failure between the years 1994 and 2020 versus a control transplant group (n = 325), matched for age, sex, body mass index, and follow-up duration.</p><p><strong>Results: </strong>Among patients in the rheumatic disease group, AA amyloidosis was the most common renal pathology leading to kidney transplant. Delayed graft function, acute rejection, and mortality were more common in the rheumatic disease group. Survival rates in recipients at 1, 5, 10, and 15 years were lower in the rheumatic disease group than in the control group (log-rank 0.046), whereas graft survival rates were found to be similar (log-rank 0.206). Recipient survival rates at 1, 5, 10, and 15 years in patients in the rheumatic disease group with AA amyloidosis were significantly worse compared with patients in the rheumatic disease group with glomerulonephritis (log-rank 0.006). Advanced recipient age and graft loss were found to be independent risk factors for mortality in the Cox regression analysis.</p><p><strong>Conclusions: </strong>Delayed graft function, acute rejection, and mortality rates were higher in patients who had kidney transplants because of rheumatic diseases. Patients with secondary amyloidosis associated with rheumatic disease had worse long-term renal transplant outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"36-42"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Hepatic Ischemia-Reperfusion Injury Model in Rats: the Optimum Ischemia and Reperfusion Durations.","authors":"Ender Fakıoğlu, Gamze Bilgili, Binnaz Handan Özdemir, Meriç Yavuz Çolak, Lütfi Hakan Güney, Emre Karakaya, Yaprak Yalçın, Pınar Baysan Çebi, Fatma Belgin Ataç","doi":"10.6002/ect.2025.0122","DOIUrl":"https://doi.org/10.6002/ect.2025.0122","url":null,"abstract":"<p><strong>Objectives: </strong>Hepatic ischemia-reperfusion injury is a major contributor to posttransplant liver graft dysfunction and postoperative complications. Although rat models are commonly used in hepatic ischemia-reperfusion injury research, standardized durations for ischemia and reperfusion remain undefined. Here, we aimed to identify optimal ischemia and reperfusion durations for a reliable and reproducible experimental hepatic ischemia-reperfusion injury model in rats.</p><p><strong>Materials and methods: </strong>We randomly assigned 45 male Wistar rats into groups with 100% hepatic perfusion blockade for 45 or 90 minutes, followed by reperfusion periods of 3, 6, 12, 24, and 48 hours. We evaluated survival rates, histopathologic liver damage (Suzuki scoring) with neutrophilic infiltration, and biochemical parameters. We excluded rats that underwent 90 minutes of ischemia or >6 hours of reperfusion (which experienced high mortality) from further analyses.</p><p><strong>Results: </strong>The 45-minute ischemia/6-hour reperfusion group exhibited significant liver injury compared with the sham and 3-hour groups, with elevated serum alanine aminotransferase and aspartate ami-notransferase, reduced hepatic ATP, and increased levels of total oxidant status, myeloperoxidase, and tumor necrosis factor-α (P < .05). Histopathological findings confirmed higher vacuolization and neutrophilic infiltration in this group. Three-hour reperfusion yielded only mild elevations in myeloperoxidase and tumor necrosis factor-α without significant tissue injury.</p><p><strong>Conclusions: </strong>The model of 45 minutes of ischemia followed by 6 hours of reperfusion reliably induced hepatic ischemia-reperfusion injury in rats, supported by both biochemical and histological parameters. This standardized model balances reproducibility and animal survivability, offering a robust foundation for future hepatic ischemia-reperfusion injury research.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"51-58"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic Regional Perfusion in Organ Transplantation: Trends, Key Topics, and Evolving Research Focus.","authors":"Badi Rawashdeh, Noor Haj Mohammad, Haneen Al-Abdallat, Emily Cooper, Parker Schimmers, Ayham Hussein, Ayham Asassfeh, Matthew Cooper","doi":"10.6002/ect.2025.0181","DOIUrl":"https://doi.org/10.6002/ect.2025.0181","url":null,"abstract":"<p><strong>Objectives: </strong>Normothermic regional perfusion is an emerging technique used to reduce warm ischemic injury during organ recovery in donation after circulatory death. The use of normothermic regional perfusion has become increasingly common as a method to improve the viability and function of organs, particularly for liver, kidney, heart, and lung transplantation. In this study, we performed a bib-liometric analysis of normothermic regional perfusion-related research to understand publication trends, key topics, and areas of focus in the field.</p><p><strong>Materials and methods: </strong>On July 8, 2025, we conducted a comprehensive search using the Web of Science database to identify relevant studies on normothermic regional perfusion. The analysis included 372 studies published between 2014 and 2025. We used VOSviewer and Microsoft Excel to analyze annual trends, countries, institutions, journals, co-occurring key words, and articles. We performed manual screening to refine data on authors and institutions with significant publication and citation frequencies.</p><p><strong>Results: </strong>Analyses of the 372 studies revealed a 22.35% annual growth rate in publication volume and a cumulative citation count of 7552. The United States led in publication output with 146 total documents, and the United Kingdom recorded the highest citation count at 2914 citations. The top 5 key words were \"outcomes\" (79 occurrences), \"donors\" (63 occurrences), \"pre-servation\" (56 occurrences), \"liver transplantation\" (55 occurrences), and \"experience\" (51 occurrences). Recent discussions focused on \"outcomes,\" \"experience,\" and \"heart transplantation,\" and earlier research emphasized \"kidney transplantation,\" \"delayed graft function,\" and \"biliary complications.\"</p><p><strong>Conclusions: </strong>The present bibliometric analysis emphasized the growing interest in normothermic regional perfusion, highlighting its evolving focus from kidney and liver related complications to heart transplantation, offering valuable insights for optimi-zing future organ transplant practices.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"59-68"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy Outcomes Among Women With Kidney Allografts in Brazil: An Integrative Review.","authors":"Marcos Vinicius de Sousa, Luís Marcos Campelo Carneiro, Marilda Mazzali, Fernanda Garanhani Surita, Maria Laura Costa, José Paulo de Siqueira Guida","doi":"10.6002/ect.2025.0256","DOIUrl":"10.6002/ect.2025.0256","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic kidney disease can reduce fertility, but fertility may improve after transplant. Posttransplant pregnancy carries risks like preeclampsia, miscarriage, and prematurity. Although pregnancy is an immune-tolerant state, changes in immunosuppressive drugs during pregnancy can increase graft rejection risk. This study evaluated maternal and fetal outcomes in Brazilian kidney transplant recipients with post-transplant pregnancies.</p><p><strong>Materials and methods: </strong>We conducted an integrative review of articles from PubMed/Medline databases, analyzing study periods, study design, immunosup-pressive regimens, and the prevalence of preeclampsia and/or eclampsia, preterm births, pregnancy loss, graft rejection, and graft failure within 2 years after pregnancy.</p><p><strong>Results: </strong>Nine articles were included after we screened titles, abstracts, and full texts, covering studies from 1968 to 2019. Among studies, most patients received azathioprine and steroids, and cyclosporine was the most used calcineurin inhibitor. The overall incidence of preeclampsia was 26.3%. Rates of pregnancy loss varied, with losses higher with graft dysfunction, hypertension, and first-year pregnancies. Preterm birth exceeded 50% in most studies. Graft rejection was 4.7%, with most recipients maintaining functio-ning grafts at 2 years.</p><p><strong>Conclusions: </strong>The incidence of preeclampsia in most studies included in this review were higher than those reported by other research, possibly due to inadequate control of comorbidities. Pregnancy loss observed in this study was similar to other studies, and overall graft rejection rate was also comparable, although causes of graft loss were not specified. The occurrence of preeclampsia in most studies of Brazilian transplant pregnancies was higher than in other studies. Other maternal and fetal outcomes were similar to those previously reported.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 1","pages":"1-6"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}