Experimental and Clinical Transplantation最新文献

筛选
英文 中文
Parathyroid Hormone Threshold Effect and Parathyroid Hormone-to-Vitamin D Ratio as Determinants of Bone Mineral Density in Long-Term Kidney Transplant Recipients: A Cross-Sectional Analytical Study>. 甲状旁腺激素阈值效应和甲状旁腺激素与维生素D比值是长期肾移植受者骨矿物质密度的决定因素:一项横断面分析研究[b]。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-08-01 DOI: 10.6002/ect.2026.0203
Tran Ngoc Nguyen, Tam Tran Minh Than, Noor Haj Mohammad, Uyen Thi Phuong Nguyen, Thanh Kien Lam
{"title":"Parathyroid Hormone Threshold Effect and Parathyroid Hormone-to-Vitamin D Ratio as Determinants of Bone Mineral Density in Long-Term Kidney Transplant Recipients: A Cross-Sectional Analytical Study>.","authors":"Tran Ngoc Nguyen, Tam Tran Minh Than, Noor Haj Mohammad, Uyen Thi Phuong Nguyen, Thanh Kien Lam","doi":"10.6002/ect.2026.0203","DOIUrl":"https://doi.org/10.6002/ect.2026.0203","url":null,"abstract":"<p><strong>Objectives: </strong>Persistent hyperparathyroidism and calcitriol deficiency coexist in most long -term kidney transplant recipients, yet the combined skeletal effects of these presentations have not been formally quantified.</p><p><strong>Materials and methods: </strong>In this cross -sectional analytical study at People's Hospital 115 (Ho Chi Minh City, Vietnam ), we studied 135 kidney transplant recipients (mean age 51.0 ± 11.3 years; 66.7 % male; mean time posttransplant 71.4 ± 28.1 months ) who underwent simultaneous measurement of serum intact parathyroid hormone, 1,25 -dihydroxyvitamin D, and dual -energy x -ray absorptiometry at 3 skeletal sites. A prespecified piecewise ordinary least -squares model characterized the relationship between parathyroid hormone and bone mineral density; a confirmatory sensitivity analysis used KDIGO -motivated breakpoint of 65 pg /mL for parathyroid hormone. We evaluated parathyroid hormone -to -vitamin D ratio as a prespecified secondary exposure measure.</p><p><strong>Results: </strong>Bone loss (worst -site T score of < -1.0 ) was present in 103 participants (76.3 % ) and osteoporosis in 27 (20.0 % ). The confirmatory piecewise model at 65 pg /mL demonstrated that above -threshold parathyroid hormone was inversely associated with T -score composite ( β = -0.00367 per pg /mL; bootstrap 95 % CI, -0.0066 to -0.0013; P < .001 ), a 100 pg /mL increment above the threshold corresponded to a -0.37 T -score decrement. Body mass index was the strongest predictor (β = +0.129 per kg /m ²; P < .001 ). The ratio of parathyroid hormone to vitamin D (ρ = -0.262; P = .002 ) provided modestly better model fit than parathyroid hormone alone (R ² = 0.247 vs 0.229; change in Akaike Information Criterion = 3.2 ).</p><p><strong>Conclusions: </strong>Parathyroid hormone exerted a threshold -dependent inverse effect on bone mineral density in long -term kidney transplant recipients, confirmed at the KDIGO lower boundary of 65 pg /mL. The ratio of parathyroid hormone to vitamin D captured the combined mineral burden more efficiently than parathyroid hormone level alone, warranting further prospective evaluation as a monitoring target in posttransplant mineral disease.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 8","pages":"589-599"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red Cell Distribution Width and Its Association With Inflammatory Burden and Proteinuria in Kidney Transplant Recipients. 肾移植受者红细胞分布宽度及其与炎症负担和蛋白尿的关系。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-08-01 DOI: 10.6002/ect.2025.0272
Mehmet C Güneri, Celalettin Usalan, Şeyda Çevik Güneri
{"title":"Red Cell Distribution Width and Its Association With Inflammatory Burden and Proteinuria in Kidney Transplant Recipients.","authors":"Mehmet C Güneri, Celalettin Usalan, Şeyda Çevik Güneri","doi":"10.6002/ect.2025.0272","DOIUrl":"https://doi.org/10.6002/ect.2025.0272","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate whether red cell distribution width can serve as an indicator of subclinical inflammation in kidney transplant recipients by examining its relationship with inflammatory markers, renal functional parameters, bone mineral metabolism, and urinary protein excretion.</p><p><strong>Materials and methods: </strong>We retrospective examined 120 adult kidney transplant recipients followed at our center. We obtained demographic characteristics, immunosuppressive regimens, and laboratory values from hospital records. Biochemical measurements included complete blood count, blood urea nitrogen, serum creatinine, albumin, electrolytes, calcium, phosphorus, parathyroid hormone, 25 -hydroxyvitamin D, glycosylated hemoglobin, high-sensitivity C -reactive protein, and urine protein -to -creatinine ratio. We categorized patients into 2 groups by mean value of red cell distribution width ( <14.5 vs ≥14.5 ). We analyzed correlations between red cell distribution width and laboratory parameters using appropriate statistical methods. P < .05 was considered significant.</p><p><strong>Results: </strong>Mean age of kidney transplant recipients was 40.9 years, and 52 were women. Overall mean red cell distribution width value was 14.5. Red cell distribution width showed significant positive correlations with parathyroid hormone (r = 0.305; P = .001 ), high -sensitivity C -reactive protein (r = 0.189, P = 0.037 ), and glycosylated hemoglobin (r = 0.192, P = .034 ) and a borderline correlation with urine protein -to -creatinine ratio (r = 0.177; P = .052 ). Patients with red cell distribution width ≥14.5 had higher parathyroid hormone, high -sensitivity C -reactive protein, and urine protein -to -creatinine ratio values and lower 25 -hydroxyvitamin D levels compared with those with red cell distribution width <14.5 (all P < .01 ).</p><p><strong>Conclusions: </strong>Increased red cell distribution width values in stable kidney transplant recipients were associated with increased inflammatory markers, greater proteinuria, and alterations in bone mineral metabolism. Red cell distribution width may serve as an accessible indicator of subclinical inflammation and metabolic dysfunction in this population; however, prospective studies are needed to confirm findings.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 8","pages":"619-625"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Persistent Proteinuria After Kidney Transplant as a Predictor of Long-Term Graft Outcomes: A Retrospective Cohort Study. 肾移植后早期持续性蛋白尿作为长期移植预后的预测因子:一项回顾性队列研究。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-08-01 DOI: 10.6002/ect.2025.0149
Mihriban Gungor, Gizem Kumru, Rezzan Eren Sadioglu, Merve Aktar, Sayeste Akkan Eren, Sule Sengul, Kenan Keven
{"title":"Early Persistent Proteinuria After Kidney Transplant as a Predictor of Long-Term Graft Outcomes: A Retrospective Cohort Study.","authors":"Mihriban Gungor, Gizem Kumru, Rezzan Eren Sadioglu, Merve Aktar, Sayeste Akkan Eren, Sule Sengul, Kenan Keven","doi":"10.6002/ect.2025.0149","DOIUrl":"10.6002/ect.2025.0149","url":null,"abstract":"<p><strong>Objectives: </strong>The source and clinical significance of early proteinuria following kidney transplantation are complex, as proteinuria may be transient or may derive from native kidneys. This study evaluated the effects of early persistent proteinuria on long -term kidney allograft outcomes.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of 312 kidney transplant recipients who received transplants between 2009 and 2020. Persistent proteinuria was defined as a spot urine protein -to -creatinine ratio ≥500 mg /g documented in at least 2 consecutive assessments within the first 24 months posttransplant. We compared graft survival according to proteinuria status.</p><p><strong>Results: </strong>Among 312 study patients, proteinuria was detected in 46.3 % of patients at a single visit and 16.0 % met criteria for persistent proteinuria. Nineteen patients (6.1 % ) experienced graft loss. Single -visit proteinuria was associated with a 2 -fold increased risk of graft loss, whereas persistent proteinuria demonstrated a stronger independent association (hazard ratio 4.68; 95 % CI, 1.56 -14.07; P = .006 ). Proteinuria documented at least twice at the 6 -, 12 -, and 24 -month visits was related to an approximately 9 -fold higher probability of graft loss (hazard ratio 8.63; 95 % CI, 2.06-36.22; P = .003 ). Graft survival progressively declined with increasing levels of proteinuria.</p><p><strong>Conclusions: </strong>Early persistent proteinuria is strongly and independently associated with adverse long -term graft outcomes. Frequent assessment of proteinuria can yield important prognostic insights and can help identify recipients who require enhanced monitoring and additional diagnostic evaluation.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 8","pages":"600-607"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ABO-Incompatible Kidney Transplantation as a Strategic Expansion Tool in Low- and Middle-Income Countries. abo血型不相容肾移植作为中低收入国家的战略扩展工具。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.MESOT2025.L16
Mohamed Mongi Bacha, Aziz El Matri, Ezzedine Abderrahim
{"title":"ABO-Incompatible Kidney Transplantation as a Strategic Expansion Tool in Low- and Middle-Income Countries.","authors":"Mohamed Mongi Bacha, Aziz El Matri, Ezzedine Abderrahim","doi":"10.6002/ect.MESOT2025.L16","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.L16","url":null,"abstract":"<p><p>The persistent disparity between organ supply and demand remains the principal limitation to kidney transplantation worldwide. ABO-incompatible kidney transplant has progressively evolved from an experimental procedure to an established strategy for expanding the living donor pool. This review critically evaluated whether ABO-incompatible kidney transplant represents a justified, effective, and feasible solution in low- and middle-income countries. We conducted a structured review of international registry data, meta-analyses, and major cohort studies to assess epidemiology, historical evolution, immunologic principles, clinical outcomes, desensitization protocols, economic implications, and complication profiles associated with ABO-incompatible kidney transplant. Our results showed that global transplant activity fulfills <10% of estimated needs. ABO-incompatible kidney transplant procedures have increased living donor availability by approximately 25% to 33% in countries adopting this strategy. Contemporary data showed that graft and patient survival rates approached rates of compatible transplant, although early risks of antibody-mediated rejection, infection, and bleeding remain higher. Advances in B-cell depletion therapy, immunoadsorption techniques, and modern immunosuppressive regimens have markedly improved outcomes. The primary limitation in low- and middle-income settings is financial cost, particularly related to antibody removal technologies; however, validated cost-reduction strategies exist. ABO-incompatible kidney transplantation is no longer experimental and should be considered a mature, evidence-supported strategy. When implemented in experienced centers with appropriate protocols and cost-adaptation measures, this method constitutes a reasonable and potentially transformative approach to mitigating organ shortages in selected low- and middle-income countries.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"10-13"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology in Transplantation: Emerging Mechanisms, Clinical Applications, and Future Directions. 纳米技术在移植中的应用:新兴机制、临床应用和未来方向。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.MESOT2025.L36
Hassan Argani
{"title":"Nanotechnology in Transplantation: Emerging Mechanisms, Clinical Applications, and Future Directions.","authors":"Hassan Argani","doi":"10.6002/ect.MESOT2025.L36","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.L36","url":null,"abstract":"<p><p>Nanotechnology has rapidly evolved into a transformative platform in transplant medicine, offering sophisticated tools for targeted drug delivery, organ preservation, precision diagnostics, and tolerance induction. Engineered nanoparticles enable localized and sustained delivery of immunosuppressive agents while minimizing systemic toxicity, thus allowing long-standing limitations of conventional immunosuppression to be addressed. Diverse nanomedicine platforms, including liposomes, polymeric nanoparticles, dendrimers, magnetic nanoparticles, and inorganic systems, enhance drug bioavailability, reduce off-target effects, and allow integration of imaging and therapeutic functions. This review synthesized current progress in nanoparticle-enabled therapeutics, diagnostics, machine-perfusion-based delivery, gene editing, and personalized nano-immunotherapy, highlighting their potential to reduce rejection, ischemia-reperfusion injury, and chronic graft dysfunction. Insights from recent advances.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"26-31"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of the Management of Gastric and Duodenal Ulcers in Individuals With Advanced Chronic Kidney Disease. 晚期慢性肾脏疾病患者胃和十二指肠溃疡的处理特点
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.MESOT2025.P52
Farhod A Khadjibaev, Pulat K Sultanov, Dmitriy L Kim, Dilshod N Ergashev, Mirkamol A Hashimov, Nurbek B Iskhakov, Ruslan K Sadikov, Jur'at A Djuraev, Aziz A Ismatov
{"title":"Characteristics of the Management of Gastric and Duodenal Ulcers in Individuals With Advanced Chronic Kidney Disease.","authors":"Farhod A Khadjibaev, Pulat K Sultanov, Dmitriy L Kim, Dilshod N Ergashev, Mirkamol A Hashimov, Nurbek B Iskhakov, Ruslan K Sadikov, Jur'at A Djuraev, Aziz A Ismatov","doi":"10.6002/ect.MESOT2025.P52","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P52","url":null,"abstract":"<p><p>Peptic ulcer disease in patients with end -stage chronic kidney disease presents a complex clinical problem due to metabolic disturbances, impaired mucosal regeneration, polypharmacy, and limitations in the use of standard medications. In this study, we conducted a comparative analysis of conservative and surgical (kidney transplant ) management of gastric and duodenal ulcers in patients with end -stage renal disease versus patients without renal dysfunction. Among the 34 patients who were examined, findings showed that kidney transplant contributed to rapid ulcer healing, normalization of biochemical parameters, and reduction in recurrence rates. The study highlighted the necessity of individualized treatment strategies for patients with end -stage renal disease and emphasized the importance of restoring renal function to improve gastrointestinal outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"287-290"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of 25-Hydroxyvitamin D and Bone Turnover Markers Levels With Bone Mineral Density Measurement in Renal Transplant Patients. 肾移植患者骨密度测定与25-羟基维生素D和骨转换标志物水平的关系
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.MESOT2025.O78
Melike Beyin, Gülşah Sasak
{"title":"Association of 25-Hydroxyvitamin D and Bone Turnover Markers Levels With Bone Mineral Density Measurement in Renal Transplant Patients.","authors":"Melike Beyin, Gülşah Sasak","doi":"10.6002/ect.MESOT2025.O78","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.O78","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic kidney disease is associated with mineral and bone disorders, including abnormalities in calcium, phosphorus, parathyroid hormone, and vitamin D metabolism, as well as bone diseases like renal osteodystrophy. Although renal transplant can improve some bone mineral disorders, osteoporosis and altered bone metabolism remain important issues due to factors like corticosteroid use and persistent hyperparathyroidism. Bone biopsies are the gold standard for diagnosing bone disorders but are invasive, leading to the exploration of noninvasive methods such as bone turnover markers and bone mineral density measurements. In this study, we aimed to investigate whether there is a relationship between bone turnover markers and bone mineral densities measured by dual -energy X -ray absorptiometry.</p><p><strong>Materials and methods: </strong>This study evaluated 121 renal transplant patients categorized as normal, with osteopenia, or with osteoporosis based on dual -energy X -ray absorptiometry measurements. Biochemical markers (parathyroid hormone, alkaline phosphatase, calcium, phosphorus, vitamin D, beta -CrossLaps, and osteocalcin ) were analyzed for their relationship with bone mineral density.</p><p><strong>Results: </strong>Osteoporosis was more common in women (34.09 % ) than in men (9.09 % ), likely because of postmenopausal hormonal changes. No significant correlation between bone mineral density and bone turnover markers was observed, and none of the biochemical markers demonstrated strong predictive value for osteoporosis.</p><p><strong>Conclusions: </strong>Findings suggested that bone mineral density alone is insufficient to fully evaluate bone health, as bone turnover can vary significantly among individuals. A more comprehensive assessment combining bone mineral density, bone turnover markers, and clinical findings is necessary for a better understanding of bone health in renal transplant patients. However, the study's limitations, including a relatively small sample size, single -point measurements, and lack of follow -up, underscore the need for larger, longitudinal studies. Such studies are essential to better understand bone turnover dynamics and to develop optimized screening and treatment strategies for this patient population.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"204-212"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric Review of Türkiye-Based Publications on Organ Donation and Transplantation Between 2000 and 2025: A Thematic and Network-Based Approach. 2000年至2025年间基于<s:1> rkiye期刊的器官捐献和移植出版物的文献计量学综述:主题和网络方法。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.MESOT2025.P26
Ayse Meydanlıoğlu, Büşra Nur Temür, Nilgün Aksoy
{"title":"Bibliometric Review of Türkiye-Based Publications on Organ Donation and Transplantation Between 2000 and 2025: A Thematic and Network-Based Approach.","authors":"Ayse Meydanlıoğlu, Büşra Nur Temür, Nilgün Aksoy","doi":"10.6002/ect.MESOT2025.P26","DOIUrl":"https://doi.org/10.6002/ect.MESOT2025.P26","url":null,"abstract":"<p><strong>Objectives: </strong>A systematic analysis of organ donation -related publications can enable assessment of the existing knowledge base and can help inform future policy development Here, we analyzed scientific publications addressing public awareness on organ donation and transplantation between 2000 and 2025 by bibliometric method.</p><p><strong>Materials and method: </strong>We conducted a descriptive study based on bibliometric analysis. We obtained data using EkşiVeri 1.0.5 R -Shiny Integrated Smart Data Analysis and Analytics Application. We obtained sources from an open access database known as (TR Index, a national database developed by TÜBİTAK ULAKBİM in accordance with international standards to provide researchers with access to national and scientific content in electronic environment ). We searched publications using the key words \"organ donation\" and \"transplantation.\" We evaluated relationships between concepts using network metrics such as modularity, centrality and average path length.</p><p><strong>Results: </strong>Data were obtained from 63 research articles published by Turkish authors. Word networks with 23 nodes and 54 links at the title level and 20 nodes and 59 links at the subject level were created. Analysis of the title word network showed that the terms organ, donation, and transplantation were positioned as thematic centers with high degree and betweenness centrality values. In addition, broader and interdisciplinary concepts such as \"medicine,\" \"services,\" \"ethics,\" and \"policy\" characterized the subject area. Publications often focused on students, health care professionals, and patient groups and revolved around themes of knowledge, attitudes, and behaviors.</p><p><strong>Conclusions: </strong>Title searches for \"organ\" and \"transplantation\" showed publications originating from Türkiye that not only focused on organ donation and transplantation but also encompassed a broader and systemic context. Future studies should focus on different groups and increase initiatives aimed at raising public awareness of organ transplantation.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"268-274"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early and Late Reperfusion Injury in Liver Transplant: A Case Series and Anesthetic Management Strategies. 肝移植早期和晚期再灌注损伤:一个病例系列和麻醉管理策略。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.MESOT2025.P102
Mark William Noble, Rathnavelu Kanganavelu
{"title":"Early and Late Reperfusion Injury in Liver Transplant: A Case Series and Anesthetic Management Strategies.","authors":"Mark William Noble, Rathnavelu Kanganavelu","doi":"10.6002/ect.MESOT2025.P102","DOIUrl":"10.6002/ect.MESOT2025.P102","url":null,"abstract":"<p><p>Postreperfusion syndrome is a recognized complication of liver transplant, characterized by acute cardiovascular instability following graft reperfusion . We present a case series of 2 deceased-donor liver transplant recipients who developed distinct patterns of reperfusion injury: a patient with early reperfusion syndrome and another patient with delayed (late) reperfusion instability. Both cases manifested significant hypotension and bradycardia or low cardiac output, requiring prompt anesthetic intervention with vasopressors and inotropes. Timely recognition, vigilant intraoperative monitoring, and tailored anesthetic management resulted in hemodynamic stabilization and favorable graft outcomes. This series highlights the importance of proactive anesthetic strategies for management of ischemia-reperfusion injury during liver transplant.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 Suppl 2","pages":"428-429"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral Blood Next-Generation RNA Sequencing as an Adjunctive Tool in the Evaluation of Borderline T-Cell-Mediated Rejection in BK Virus Nephropathy. 外周血下一代RNA测序作为评估BK病毒肾病临界t细胞介导的排斥反应的辅助工具。
IF 0.7 4区 医学
Experimental and Clinical Transplantation Pub Date : 2026-07-01 DOI: 10.6002/ect.2026.0075
Rajeev Sharma, Siarhei Dzedzik, Nasir Khan, Abhinav Seth, Vishy Chaudhary
{"title":"Peripheral Blood Next-Generation RNA Sequencing as an Adjunctive Tool in the Evaluation of Borderline T-Cell-Mediated Rejection in BK Virus Nephropathy.","authors":"Rajeev Sharma, Siarhei Dzedzik, Nasir Khan, Abhinav Seth, Vishy Chaudhary","doi":"10.6002/ect.2026.0075","DOIUrl":"10.6002/ect.2026.0075","url":null,"abstract":"<p><p>Distinguishing BK virus nephropathy from T -cell -mediated rejection remains a clinicopathological challenge in kidney transplants, because the 2 entities may share overlapping histological features while requiring opposite therapeutic approaches. We report a kidney transplant recipient with biopsy -proven BK virus nephropathy who later underwent repeat biopsy showing low -level BK virus nephropathy with borderline T -cell -mediated rejection. Despite histological concern for rejection, the broader clinical picture did not support clinically significant T -cell -mediated rejection; specifically, serum creatinine remained stable, BK viral load showed marked improvement, donor -specific antibodies were negative, and there were no vascular or microvascular features of active rejection. A peripheral blood next-generation RNA sequencing gene expression profile yielded a low -risk acute rejection score of 6. Antirejection therapy was deferred, immunosuppression was not escalated, and the patient remained clinically stable. This case highlights the potential adjunctive role of peripheral blood RNA profiling for resolution of histologically ambiguous cases of BK virus nephropathy and borderline T -cell-mediated rejection.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 7","pages":"569-574"},"PeriodicalIF":0.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书