Experimental and Clinical Transplantation最新文献

{"title":"Evaluation of the Risk Factors for De Novo Intraocular Pressure Elevation after Penetrating Keratoplasty.","authors":"Yonca Asfuroğlu, Emine Esra Karaca, Mahmut Asfuroglu, Cenk Zeki Fikret, Özlem Evren Kemer","doi":"10.6002/ect.2025.0161","DOIUrl":"https://doi.org/10.6002/ect.2025.0161","url":null,"abstract":"<p><strong>Objectives: </strong>We analyzed prevalence, ocular risk factors, and medical/surgical management of eyes with de novo intraocular pressure elevation following penetrating keratoplasty.</p><p><strong>Materials and methods: </strong>In this retrospective study, we assessed 400 patients who underwent penetrating keratoplasty from January 2018 to August 2024 for de novo intraocular pressure elevation during the postoperative follow-up period. We evaluated patient demographics, ocular risk factors, indications for penetrating keratoplasty, topical steroid use, peak and regulated intraocular pressure, need for antiglaucomatous medication/surgery, and mean follow-up time.</p><p><strong>Results: </strong>After exclusion of eyes with preexisting glaucoma, 55 of 400 patients (13.7 % ) showed intraocular pressure elevation. Postoperatively, mean peak intraocular pressure was 31.92 ± 6.24 mm Hg. To achieve intraocular pressure control, an average of 2.12 ± 0.84 topical antiglaucoma medications were administered. Eleven patients (20 % ) required surgical intervention. Eyes with peripheral anterior synechiae had an increased risk of the need for antiglauc-omatous surgery (P = .03; odds ratio 0.175; 95% CI, 0.035-0.868 ). In addition, significantly higher prevalence of peripheral anterior synechiae was demonstrated among eyes with intraocular pressure elevation occurring within the first 24 weeks postoperatively (P = .03 ). Peak intraocular pressure levels were higher in aphakic eyes (P = .04; odds ratio 0.87; 95 % CI, 0.77 -0.99 ). Furthermore, the peak (P = .02; odds ratio 0.85; 95 % CI, 0.74 -0.98) and regulated (P = .02; odds ratio 0.7; 95 % CI, 0.51 -0.95) intraocular pressures in the postoperative period were significantly higher in eyes that had undergone tectonic penetrating keratoplasty.</p><p><strong>Conclusions: </strong>Eyes with preexisting peripheral anterior synechiae, aphakia and eyes undergoing penetrating keratoplasty for tectonic reasons are more vulnerable to postoperative intraocular pressure elevation/glaucoma. Early onset of intraocular pressure issues may be linked to preexisting inflammation and extended use of strong topical steroids, which highlights the importance of proactive care and effective management to prevent complications.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 3","pages":"268-273"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tacrolimus Dose Adjustment Table and Rules for Treating Lung Transplant Patients: The Tacrolimus Dose Finder.","authors":"Macé M Schuurmans, Jérôme Bonzon, René Hage","doi":"10.6002/ect.2025.0301","DOIUrl":"https://doi.org/10.6002/ect.2025.0301","url":null,"abstract":"","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 3","pages":"289-292"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical Risk Predictors and Recovery Trajectories for Estimated Glomerular Filtration Rate Among Indian Living Kidney Donors: A Retrospective Cohort Analysis.","authors":"Hari Shankar Meshram, Khushboo Saxena, Vivek Kute, Sudeep Desai, Sanshriti Chauhan","doi":"10.6002/ect.2025.0156","DOIUrl":"https://doi.org/10.6002/ect.2025.0156","url":null,"abstract":"<p><strong>Objectives: </strong>In the Indian subcontinent, data on clinical outcomes of living kidney donors remain scarce. We aimed to evaluate renal outcomes after kidney donation using estimated glomerular filtration trajectory-based analysis.</p><p><strong>Materials and methods: </strong>In this retrospective single-center study, we analyzed 300 living kidney donors who underwent nephrectomy between January 1 and December 31, 2019, at a tertiary transplant center. Only donors who completed at least 2 years of follow-up were studied. Primary outcome measures were new-onset hypertension, proteinuria, and decline of estimated glom erular filtration below 60 mL/min. Secondary outcomes were estimated glomerular filtration rate trajectories stratified by sex for baseline levels, systolic blood pressure, body mass index, and peak creatinine during admission. Predictors of proteinuria were investigated by Cox regression.</p><p><strong>Results: </strong>At median follow-up of 25.7 months, 14.3% of donors developed de novo hypertension, 9.3% developed proteinuria, and 6.0% had estimated glomerular filtration rate <60 mL/min/1.73 m². Trajectory analysis showed a biphasic pattern of estimated glomerular filtration rate trend, characterized by an initial decline followed by stabilization after 6 to 12 months. Donors with elevated systolic blood pressure and obesity demonstrated a steeper drop in estimated glomerular filtration rate and flatter recovery slopes compared with donors with normal systolic blood pressure. Male donors with higher perioperative peak serum creatinine showed delayed recovery. In contrast, donors with low systolic blood pressure and normal body mass index had better trajectory estimated glomerular filtration rate after donation.</p><p><strong>Conclusions: </strong>In this first Indian study to use trajectory-based modeling for stratifying risk in living kidney donors after donation, kidney donation practices remain safe but also call for structured and personalized follow-up protocols for candidates with increased risk.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"119-128"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single Incision for Simultaneous Liver and Kidney Transplant With Right-Side Nephrectomy for Polycystic Liver and Autosomal Dominant Polycystic Kidney Disease.","authors":"Emadoddin Rezaei, Marcos Vinicius Perini, Ruelan Furtado, John Whitlam, Bulang He","doi":"10.6002/ect.2025.0279","DOIUrl":"https://doi.org/10.6002/ect.2025.0279","url":null,"abstract":"<p><p>We describe a new surgical approach for simultaneous liver and kidney transplant in which we utilized the same reverse L incision used for liver transplant to perform ipsilateral native nephrectomy and kidney transplant. The 48-year-old male patient had auto-somal dominant polycystic kidney and significant polycystic liver disease. He underwent multidisciplinary assessment and was listed for simultaneous liver and kidney transplant. The liver and kidney graft were donated from a donor after neurological determination of death. After hepatectomy and orthotopic liver transplant, a right native nephrectomy was performed followed by kidney transplant using the same incision. The transplanted kidney was placed on the right-hand side, with renal artery anastomosed to the external iliac artery, the renal vein anastomosed to the external iliac vein, and the ureter anastomosed to the end of the retained distal native ureter (ureteroureterostomy). Both liver and kidney graft had immediate function after transplant. This case highlights the feasibility and efficiency of a single reverse L incision approach for simultaneous liver and kidney transplant combined with a right-side nephrectomy.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"189-192"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Evolving Landscape of Randomized Clinical Trials in Transplantation: An Analysis of Output and Trends.","authors":"Badi Rawashdeh, Haneen Al-Abdallat, Ayham Asassfeh, Emily Cooper, Karim Halazun, Matthew Cooper","doi":"10.6002/ect.2025.0046","DOIUrl":"https://doi.org/10.6002/ect.2025.0046","url":null,"abstract":"<p><strong>Objectives: </strong>Randomized controlled trials are considered the fundamental basis of evidence-based medi-cine, especially in the field of organ transplantation. Given the increasing demand for organs and the distinct challenges associated with this topic, our aim was to systematically analyze and characterize the randomized controlled trial landscape in solid-organ transplantation and to identify dominant research trajectories and influential thematic areas.</p><p><strong>Materials and methods: </strong>Using a bibliometric approach, we extracted randomized controlled trials specific to solid-organ transplantation from the Scopus database. After application of exclusionary criteria, 3581 rando-mized controlled trials were included in our analyses.</p><p><strong>Results: </strong>A significant emphasis on kidney transplantation was observed, with 48.6% of randomized controlled trials addressing kidney transplant. Immunosuppressive strategies, particularly those centered around agents such as tacrolimus, cyclosporine, and mycophenolic acid emerged as dominant research foci.</p><p><strong>Conclusions: </strong>Our results showed the continual growing significance of immunosuppression in the field of transplant research, indicating that immunosuppression will continue to be a central focus of study in the foreseeable future. Subsequent to reaching its peak in 2005, we noted a significant consistent yearly reduction in the quantity of randomized controlled trials; this trend necessitates further exploration and discussion, emphasizing the importance of continued rigorous research to drive future advancements in transplantation.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"101-110"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Effectiveness of Spironolactone to Reduce Proteinuria in Kidney Transplant Recipients During a 5-Year Follow-Up.","authors":"João Antônio Pessoa de Freitas, Marcos Vinicius de Sousa, Marilda Mazzali","doi":"10.6002/ect.2025.0132","DOIUrl":"https://doi.org/10.6002/ect.2025.0132","url":null,"abstract":"<p><strong>Objectives: </strong>Objectives: Posttransplant proteinuria is a biomarker of renal injury, negatively affecting graft function and survival. Aldosterone is involved in renal allograft damage, and its blockade can be beneficial. This study analyzed the long-term effect of spironolactone on proteinuria and graft function in kidney transplant recipients.</p><p><strong>Materials and methods: </strong>We conducted a retrospective single-center study of kidney transplant recipients ≥18 years old with persistent posttransplant proteinuria (measured as urine protein-to-creatinine ratio >0.5 for more than 6 months), who were treated with spirono-lactone and followed for 5 years. Patients were grouped by initial proteinuria as mild (<1), moderate (1-3), and severe (>3). Effects of spironolactone alone or combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were analyzed.</p><p><strong>Results: </strong>Among 138 included patients, 119 received spironolactone monotherapy: 23 (19.%) had mild proteinuria, 75 (63.0%) were moderate, and 21 (17.7%;) were severe. In the moderate group, proteinuria significantly reduced from 1.4 (1.0-2.6) to 0.8 (0.2-7.7) at month 1 and 0.7 (0.1-3.8) at month 5. In the severe group, proteinuria also significantly reduced at year 1 from 5.4 (3.2-9.1) to 1.4 (0.2-11.6) (P < .05) and at year 5 to 0.5 (0.1-3.1) (P < .05). Nineteen patients received spironolactone associated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers: 12 (63.1%) had moderate proteinuria and 7 (36.9%) had severe proteinuria. In the moderate group, proteinuria significantly decreased to 0.9 (0.1-5.2) after 2 years compared with baseline of 1.6 (1.0-2.4), reaching 0.6 (0.1-3.5) in year 5. In the severe group, proteinuria decreased during 2 years from 5.6 (3.3-8.9) to 1.5 (0.9-3.7) (P < .01) and reached 1.7 (0.3-3.1) in year 5. Renal function remained stable, and graft survival rate was similar among groups.</p><p><strong>Conclusions: </strong>Long-term treatment with spironolactone effectively reduced posttransplant proteinuria in kidney transplant recipients with initial proteinuria >1, preserving graft function.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"111-118"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Early Postoperative Stay in the Intensive Care Unit and Rehabilitation Requirements in Liver Transplant Recipients With Hepatocellular Carcinoma Versus Decompensated Cirrhosis.","authors":"Xiuli Chen, Yiming Wu, Kangning Zhang, Yuanyuan Liu, Peng Du, Yuqi Ou, Guanghua Liu","doi":"10.6002/ect.2025.0080","DOIUrl":"https://doi.org/10.6002/ect.2025.0080","url":null,"abstract":"<p><strong>Objectives: </strong>This study compared early postoperative duration of stay in the intensive care unit and rehabilitation requirements between patients with hepatocellular carcinoma and patients with decom-pensated cirrhosis after liver transplant.</p><p><strong>Materials and methods: </strong>Patients were divided into 3 groups: hepatocellular carcinoma with mild-to-mode-rate cirrhosis, hepatocellular carcinoma with severe cirrhosis, and decompensated cirrhosis. We collected data on demographics and etiology, Child-Pugh classification, preoperative blood and biochemical profiles, cardiopulmonary function, and postoperative recovery milestones (eg, extubation time, drain removal, catheter removal, first bowel movement). We also obtained data on quadriceps muscle strength, rehabilitation sessions, and duration of stay in the intensive care unit. We conducted comparative analyses among groups and used linear regression to identify factors influencing stay duration in the intensive care unit.</p><p><strong>Results: </strong>Our study included 110 liver transplant patients. Preoperatively, the decompensated cirrhosis group had the highest proportion of patients with Child-Pugh class C and disease duration of >3 years. Postoperatively, groups with hepatocellular carcinoma had earlier weaning, catheter, and drain removal compared with the decompensated cirrhosis group, which had longer stays in the intensive care unit and more rehabilitation sessions. Regression analysis showed that preoperative total bilirubin and albumin levels and postoperative drain and catheter removal times were the main determinants of stay duration in the intensive care unit.</p><p><strong>Conclusions: </strong>Patients with hepatocellular carcinoma had better preoperative conditions, leading to faster postoperative recovery, shorter stays in the intensive care unit, and reduced rehabilitation requirements compared with those with decompensated cirrhosis. Etiology-specific recovery patterns and predictive models support individualized rehabilitation management.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"134-143"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Health After Kidney Transplantation: Insights Into Infertility and Assisted Techniques.","authors":"Tabassum Elahi, Saima Ahmed, Muhammed Mubarak","doi":"10.6002/ect.2026.0004","DOIUrl":"https://doi.org/10.6002/ect.2026.0004","url":null,"abstract":"<p><p>Fertility challenges are significantly more prevalent among individuals with chronic kidney disease compared with healthy populations. Kidney transplant often restores reproductive potential and makes parenthood attainable for many recipients; however, a considerable proportion remains infertile. This infertility is multifactorial, arising from sexual dysfunction, hormonal disturbances, and uremia-induced gonadal toxicity. Patients should be counseled on potential adverse effects of medications for fertility, pregnancy progression, and fetal health. Interdisciplinary care is particularly important for infertile graft recipients, especially women, to safeguard both transplant function and maternal well-being during pregnancy. Evidence indicates that, with appropriate management, parenthood after transplant can be safe and successful, and the risk of congenital anomalies in children of male recipients is comparable to baseline population rates. Assisted reproductive technologies, including in vitro fertilization, have demonstrated effectiveness in this group, although tailored protocols are essential to prevent complications such as ovarian hyperstimulation syndrome. Current evidence on use of assisted repro-ductive technology in kidney transplant recipients is largely limited to case reports and small studies, underscoring the need for larger, standardized investigations. Here, we provide an overview of reproductive challenges in kidney transplant patients, with a focus on infertility, and highlight emerging strategies in fertility preservation and management aimed at improving clinical outcomes.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"87-100"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Follow-up of Panel Reactive Antibodies From Diagnosis Until Completion of Therapy Including Allogeneic Stem Cell Transplantation Among Patients With Acute Leukemia.","authors":"Didem Sahin Eroglu, Klara Dalva, Ender Kalaci, Selami Kocak Toprak, Sinem Civriz Bozdag, Pervin Topcuoglu, Taner Demirer, Gunhan Gurman, Meltem Kurt Yuksel","doi":"10.6002/ect.2020.0524","DOIUrl":"10.6002/ect.2020.0524","url":null,"abstract":"<p><strong>Objectives: </strong>Existence of panel reactive antibodies is the limiting step in both solid-organ and hematopoietic stem cell transplantation. There are hypotheses related to panel reactive antibody formation, but there is no knowledge about its formation in acute leukemia at diagnosis and during the chemotherapy period, in which there is a strong myelosuppression and immunosuppression. We aimed to determine the panel reactive antibodies positivity in acute leukemia patients at diagnosis and during the entire therapy period, including stem cell transplantation.</p><p><strong>Materials and methods: </strong>In this single-center pros-pective study, we enrolled 35 patients with acute leukemia (8 with acute lymphoblastic leukemia, 27 with acute myeloid leukemia). Serum samples were obtained before induction therapy and every 3 months thereafter until the last follow-up or death, for a median of 369 days (minimum-maximum, 9-725 days). Panel reactive antibodies were defined with single-antigen bead assays on a Luminex platform.</p><p><strong>Results: </strong>A total of 10 patients (29%) were found to have panel reactive antibodies at any time point. At diagnosis, 5 patients (14.3%) had antibodies of either class I (n = 2) or II (n = 1) or both (n = 2), and in 4 patients these persisted during median follow-up of 168 days (minimum-maximum, 9-322 days). Among the remaining 30 patients, an additional 5 (17%) developed de novo antibodies. Incidence rate of development of de novo antibodies was 5.5 per 10 000 person-days. There was no effect of transfusion load on the development of panel reactive antibodies. Differences in percentages in males versus females, blood type mismatch, and graft-versus-host disease were higher in patients who had de novo antibodies after transplantation. Positivity at any time had no statistically significant effect on overall survival (P = .71).</p><p><strong>Conclusions: </strong>Panel reactive antibodies do not occur frequently in the acute leukemia setting despite intensive transfusions.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":" ","pages":"165-172"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38934499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Anesthetic Management of Orthotopic Liver Transplant in a Patient with Deoxyguanosine Kinase Deficiency: A Case Report.","authors":"Nedim Çekmen, Denada Haka, Adnan Torgay, Emre Karakaya, Adem Şafak, Sedat Yıldırım, Mehmet Haberal","doi":"10.6002/ect.2025.0218","DOIUrl":"https://doi.org/10.6002/ect.2025.0218","url":null,"abstract":"<p><p>Deoxyguanosine kinase deficiency is a rare autosomal recessive mitochondrial DNA depletion syndrome characterized by severe progressive hepatic failure and neurologic involvement in infancy or early childhood. The disease often progresses to end-stage liver disease, necessitating liver transplant in selected patients. We present the anesthetic management of a 17-year-old female patient with end-stage liver disease due to deoxyguanosine kinase deficiency who was scheduled for liver transplant. Liver transplant is currently the only definitive treatment option for hepatic failure associated with deoxyguanosine kinase deficiency, although perioperative morbidity and mortality remain high. Anesthesia management of patients with deoxyguanosine kinase deficiency who undergo liver transplant requires aggressive blood glucose and lactic acidosis monitoring. Comprehensive preoperative assessment, with careful consideration of systemic manifestations and underlying mitochondrial dysfunction, is essential. Successful anesthetic mana-gement requires a multidisciplinary team approach, meticulous perioperative planning, and watchful intraoperative monitoring to optimize outcomes and improve prognosis in this high-risk population.</p>","PeriodicalId":50467,"journal":{"name":"Experimental and Clinical Transplantation","volume":"24 2","pages":"193-196"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}