F1000Research最新文献

{"title":"Digital sensors (non-invasive) for early detection of risk factors for recurrent stroke: A systematic review","authors":"I. M. Kariasa, Elly Nurachmah, S. Setyowati, R. Koestoer","doi":"10.12688/f1000research.17627.2","DOIUrl":"https://doi.org/10.12688/f1000research.17627.2","url":null,"abstract":"Background Improving awareness in patients with stroke to detect risk factors of recurrent stroke has recently become a major challenge for all health professionals in preventing recurrence among stroke survivors. Utilization of advanced technology, such as digital sensors, (a non-invasive device) is among the breakthroughs in detecting the risk of disease and promotes more effective prevention and improves quality of care. This study aims to conduct a systematic review on studies addressing early detection of the risk factors of recurrent stroke through the utilization of digital sensors. Methods A literature search was carried out on articles published between 2011 - 2018 on EBSCO, Elsevier, Science Direct, ProQuest, Springer link, PubMed, MEDLINE, PLoS, and the Journal of Community Nursing. The search identified quantitative research studies on the utilization of digital sensors in cases of hypertension, diabetes mellitus, hypercholesterolemia, and cardiac disorders that contributed to stroke recurrence. Each study’s bias was assessed using Review Manager 5. Results Ten articles were analyzed through data extraction. Robust assessment of independent risk factors which provoke recurrent stroke such as hypertension, diabetes mellitus, hypercholesterolemia, and heart diseases could lead to conservation of health resources. It is very important to monitor these factors. With the development of technology, the potential use of non-invasive monitoring for hypertension, diabetes mellitus, hypercholesterolemia, and heart diseases as risk factors for recurrent stroke events is considered effective because it is easy, simple, low cost, sensitive, and does not cause additional suffering for patients. Conclusion A practical and non-invasive method for early detection and monitoring of risk factors may reduce the risk of stroke recurrence among stroke survivors.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish oil-containing edible films with active film incorporated with extract of Psidium guajava leaves: preparation and characterization of double-layered edible film","authors":"Aji Sukoco, Yukihiro Yamamoto, Hiroyuki Harada, Atsushi Hashimoto, Tomoyuki Yoshino","doi":"10.12688/f1000research.153383.1","DOIUrl":"https://doi.org/10.12688/f1000research.153383.1","url":null,"abstract":"Background The utilization of zein and gum arabic has grown in an attempt to formulate wall materials based on protein–polysaccharide complexes. This mixture provides a versatile shelter for hydrophilic (guava leaf extract, GLE) or lipophilic (fish oil, FO) bioactive compounds from unwanted environmental factors, and it can be used as an edible film-forming polymer. This study was undertaken to characterize FO-containing edible films that were double-layered with a film containing GLE. Methods Modified zein and gum arabic solutions (MG complex) were mixed at a ratio of 1:1.5 (v/v), adjusted to pH 5, added with glycerol (20% of the complex) and FO (5% of the complex), and finally adjusted to pH 5. This was prepared as the bottom/lower layer. The upper/active layer was prepared by mixing MG complex, glycerol, and GLE (1, 3, and 5% w/v of the complex). Physical, mechanical, microstructural, thermal, microbiological, and oxidative measurements were also performed. Results The total phenolic and flavonoid contents in GLE were 15.81 mg GAE/g extract and 6.99 mg QE/g extract, respectively. The IC50 of the DPPH radical scavenging activity of GLE was 26.86 ppm with antibacterial activity against Bacillus subtilis and Escherichia coli of 9.83 and 12.55 mm. The total plate counts of films double-layered with a film containing GLE were retained below 3 log CFU/g during 28-day storage. The peroxide values of these films were dimmed for no more than 9.08 meq/kg sample on day 28 of storage. Thickness (872.00-971.67 μm), water vapor transmission rate (12.99-17.04 g/m2/day), tensile strength (1.56-2.02 kPa), elongation at break (61.53-75.41%), glass transition (52.74-57.50°C), melting peak (131.59-142.35°C), inhibition against B. subtilis (33.67-40.58 mm), and inhibition against E. coli (2.05-9.04 mm) were obtained by double-layer films. Conclusions GLE can be successfully incorporated into the active layer of a double-layer film to improve its characteristics while significantly slowing down the microbial contamination and oxidation rate.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141820846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Climate-Smart Agriculture Practices Adoption and Crop Productivity among Smallholder Farmers in Nyimba District, Zambia","authors":"chavula petros, Samuel Feyissa, Million Sileshi, C. Shepande","doi":"10.12688/f1000research.144332.1","DOIUrl":"https://doi.org/10.12688/f1000research.144332.1","url":null,"abstract":"Background The profound impacts of climate change on the environment, economy, and society are anticipated to significantly influence smallholder farmers, whose livelihoods and traditional ways of life are inextricably intertwined with the natural environment. This comprehensive study delves into the multifaceted factors shaping the adoption of climate-smart agricultural practices and their subsequent effects on crop productivity among the small-scale farming communities in Nyimba District, situated within Zambia. Methods The study collected data from 194 smallholder farmer households across 12 villages in 4 agricultural camps of Nyimba District between June and July 2022. A logistic regression model was utilized to assess the factors influencing crop production and the adoption of climate-smart agricultural practices in response to climate change and variability within the study area. Furthermore, propensity score matching was performed to evaluate the impacts of adopting climate-smart agriculture by comparing adopter households with their non-adopter counterparts. Results The logit regression model’s findings from the research indicate that several factors influence smallholder farmer households’ adoption of climate-smart agricultural techniques and crop productivity. These factors include the farmer’s educational level, household size, fertilizer utilization, the household head’s age and gender, farming experience duration, livestock ownership status, annual household income, farmland size, the household head’s marital status, and access to climate-related information. Additionally, the propensity score matching analysis revealed that crop yields among smallholder farmers who adopted climate-smart agricultural practices were 20.20% higher compared to non-adopters. Furthermore, the analysis showed that implementing such practices in the study area led to a 21.50% increase in maize yields for adopter households relative to their non-adopter counterparts. Conclusion The findings of this research offer valuable insights to policymakers, guiding them in enhancing farmers’ climate change adaptation strategies and formulating relevant policies. Nevertheless, these initiatives and concerted efforts possess the potential to mitigate the detrimental impacts posed by climate change and climatic variability. This manuscript is an extract from my master of science degree in climate-smart agriculture from Haramaya University titled ‘Climate-Smart Practices: Effects of Agroforestry and Conservation Agriculture on Selected Physicochemical Properties of Soils and Crop Productivity among Smallholder Farmers, in Nyimba, Zambia.’ Please refer to this link; http://ir.haramaya.edu.et/hru/bitstream/handle/123456789/6402/PETROS%20CHAVULA.pdf?isAllowed=y&sequence=1","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-related problems associated to antibiotic use in cesarean delivery: a retrospective analysis in a secondary care hospital.","authors":"Katherine Romero Viamonte, Adrian Salvent Tames, A. Bustillos, María Victoria Rojo Manteca, Ana Martín-Suárez","doi":"10.12688/f1000research.153567.1","DOIUrl":"https://doi.org/10.12688/f1000research.153567.1","url":null,"abstract":"Background/Objectives A drug-related problem (DRP) is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. The aim of this study is to identify and categorize the DRPs associated with the use of antibiotics in women undergoing cesarean delivery and to analyze the causes of these problems, making an improvement proposal of preoperative antibiotic prophylaxis (PAP) use in accordance with international guidelines. Methods Observational, retrospective, descriptive study of 814 women undergoing cesarean delivery. Prescription adequacy was assessed based on the selection, administration, dose and duration of the antibiotic therapy. DRP analysis and characterization was conducted using the Pharmaceutical Care Network Europe (PCNE) Classification V 9.1. Results DRPs were detected in all women (1125, 1.38 DRPs/patient), the most frequent ones associated to failure to administer PAP (30.10% of patients) and to unnecessary postsurgical antibiotic (100%). Of the 1935 possible causes for DRPs identified, most of them were related to inappropriate drug selection. Cefazolin was administered to 98.07% of women with PAP and 71.45% of patients received postsurgical cefalexin, with 13 different antibiotics being used in total. Conclusions The implementation of therapeutic protocols and early identification of DRPs is proposed in order to optimize antibiotic use in the institution.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A guide to selecting high-performing antibodies for Synaptotagmin-1 (Uniprot ID P21579) for use in western blot, immunoprecipitation, immunofluorescence and flow cytometry","authors":"M. Biddle, Charles Alende, Maryam Fotouhi, Carolyn Jones, Riham Ayoubi, K. Southern, C. Laflamme, H. Virk","doi":"10.12688/f1000research.154034.1","DOIUrl":"https://doi.org/10.12688/f1000research.154034.1","url":null,"abstract":"Synaptotagmin-1 is a synaptic vesicle transmembrane protein that senses calcium influx via its tandem C2-domains, triggering synchronous neurotransmitter release. Disruption to SYT1 is associated with neurodevelopmental disorders, highlighting the importance of identifying high-quality research reagents to enhance understanding of Synaptotagmin-1 in health and disease. Here we have characterized thirteen Synaptotagmin-1 commercial antibodies for western blot, immunoprecipitation, immunofluorescence and flow cytometry using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. These studies are part of a larger, collaborative initiative seeking to address antibody reproducibility issues by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. While use of antibodies and protocols vary between laboratories, we encourage readers to use this report as a guide to select the most appropriate antibodies for their specific needs.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing comparative politics education in the Asia-Pacific region: A study on the effectiveness of Chinese checkers game for strategy and negotiation learning","authors":"Mario de la Puente, Heidy Rico, Elkyn Rafael Lugo Arias, Jose Torres","doi":"10.12688/f1000research.151777.1","DOIUrl":"https://doi.org/10.12688/f1000research.151777.1","url":null,"abstract":"<ns3:p>xx.</ns3:p>","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141826977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the landscape of digital servitization: A systematic review","authors":"Hendri Ginting, Hamidah Nayati Utami, Riyadi Riyadi, Benny Hutahayan","doi":"10.12688/f1000research.150946.1","DOIUrl":"https://doi.org/10.12688/f1000research.150946.1","url":null,"abstract":"Background Digital servitization is a strategic transformation where companies adopt a service-focused approach in response to the prevailing trend of digitalization. Utilizing digital technology, businesses manage product and service operations and develop new value propositions. Further research into digital servitization is essential for maintaining competitiveness and meeting evolving market demands globally. This study aims to comprehend the evolution of digital services from theoretical and practical viewpoints and examines how these challenges are tackled. Methods Utilizing a systematic literature review methodology, the study adopts the PRISMA approach to identify 26 pertinent articles from a pool of 340 papers obtained through a SCOPUS database search. These papers were published between 2019 and 2024 and were retrieved using the keywords (‘digitalization OR digital AND servitization OR servitization’). The selection process involved scrutinizing titles, abstracts, and keywords based on predefined criteria. Results The findings reveal that current digital servitization research emphasizes five determinant variables: digitization, servitization, manufacturing servitization, process innovation, and product innovation. Additionally, response variables influenced by digital servitization were identified, including firm competitiveness, firm performance, financial performance, firm profitability, and sustainable performance. Discussion The results of this review point to inconsistencies, underscoring the necessity for additional research into the factors influencing digital servitization across companies beyond the manufacturing sector. This highlights the importance of gaining a deeper understanding of digital servitization strategies and their impacts across various industries. By expanding the scope of research to include a broader range of sectors, researchers can provide more comprehensive insights into the complexities and nuances of digital servitization adoption. This broader perspective enables a more thorough examination of the challenges and opportunities associated with implementing digital servitization strategies, ultimately contributing to a richer understanding of its implications for businesses across diverse industries.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Floristic Diversity of Natural Forest Patches Across Agroclimatic Zones in Northwestern Ethiopian","authors":"Melkamu Kassaye, Yonas Derebe, Mulugeta Tamir, Amsalu Nigatu, Bahiru Gedamu, Estegenet Emiru, Meseret Chanie, Mebratu Yigzaw","doi":"10.12688/f1000research.150296.1","DOIUrl":"https://doi.org/10.12688/f1000research.150296.1","url":null,"abstract":"Background Natural forest resources in northwestern Ethiopia are currently under threat, requiring immediate conservation measures and a management strategy. Thus, an understanding of the present floristic diversity status is required. There is lack of such type of studies specific to fragmented forest patches and across environmental factors. Consequently, this study aimed to examine the existing state of these resources to apply sustainable forest management practices. Methods To achieve this, transects with 200 square plots measuring 400 m2 were set up at nine forest patches with 200m spacing between plots and transects. Vegetation and environmental data were collected and analyzed using R version 4.1. Results Significant variations (p 0.008) were found in vegetation features along the slope, forest patches, and agroclimatic zone. When compared to other forest patches, highland, and mid-altitude forest patches had the highest species diversity (2.48) and stocking (2578 trees/ha). The gentle slope has the most species diversity (2.83). The species similarity between highland and mid-altitude forest habitats was found significant (69%). The vegetation cover in the mid-altitude forest patches was also high (abundance: 5-12%). In all the forest patches examined, tree life forms exceeded shrubs, climbers, and herbs. Conclusions According to the study’s findings, the state of forest resources varies considerably across different environmental variations. Despite the impression of entire forest patches from the outside, the interiors are open, with only huge and mature trees covering the canopy. This state has been triggered by deforestation, degradation, and inappropriate human and grazing operations.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clean innovation ecosystems: Lifting distressed communities in Appalachia with clean energy","authors":"William Paolillo, Benjamin Cross, Charles Zelek, Donald Wingate, Adam Berkebile","doi":"10.12688/f1000research.150557.1","DOIUrl":"https://doi.org/10.12688/f1000research.150557.1","url":null,"abstract":"The U.S. government has invested in distressed communities in the 21st century but with minimal effect. Regarding income, poverty, joblessness, and vacancy rates, the average distressed zip code in 2018 showed no improvement compared to its standing relative to the average prosperous zip code in 2000. We have discovered the formation of unique business clusters funded by public-private partnerships have the potential to make a difference in lifting distressed communities. Our research of literature and artifacts (photographs, videos, documents, digital media - websites or social media posts) suggests the discovery of a Clean Innovation Ecosystem (CIE). CIE refers to the network of social entrepreneurs, organizations, institutions, and individuals that work together to promote sustainable technologies and practices. As of the 4th quarter of 2023, manufacturing annual run rate construction spending has skyrocketed to over $200 billion. There are another $600 billion of Voltage Valley projects announced that have not yet been built. Over the past two decades, private investment has been between $20 billion and $100 billion annually in U.S. manufacturing infrastructure. Governments are making unprecedented investments in clean energy - which include approximately $400 billion in funding from the Inflation Reduction Act (IRA), $8 billion to establish 6–10 regional Hydrogen Hubs in the U.S., investments in carbon capture, renewable energy technologies, and other investments in clean energy sectors and technologies. All these investments come with the condition that the investment lifts distressed communities. This article explains why investing in Appalachia and geographic regions with similar characteristics will maximize the social benefit of public investment in a Clean Innovation Ecosystem. Our case study covers the Greater Central Appalachian Voltage Valley (GCAVV) – the states of Kentucky, West Virginia, Ohio, Upstate New York, and Michigan, as well as the Central Appalachian region as defined by 56 of the 85 distressed communities of Appalachia.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141830602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of association between early menarche and anxiety in undergraduate  students","authors":"Poorva Bakshi, Sharanya B. Shetty, Abira Shrama, Vasudha K G, Keshava Pai, Radhika K, P. D'Souza, Reshma N S","doi":"10.12688/f1000research.149757.1","DOIUrl":"https://doi.org/10.12688/f1000research.149757.1","url":null,"abstract":"Background Anxiety has been reported to be one of the most common epidemics in recent years. The present study focused on understanding the association between early menarche and the prevalence of anxiety and anxiety symptoms among adult undergraduate students. Methods This was an observational, case-control study. The sample included 146 young female adults aged more than or equal to 18 years pursuing the Bachelor of Medicine and Bachelor of Surgery (MBBS) and Bachelor of Dental Sciences (BDS). Using an online questionnaire, participants were asked to recall and enter the age at which they attained menarche. We used the Generalized Anxiety Disorder 7- Item Questionnaire (GAD-7) to measure the severity of their present anxiety symptoms. Results The results showed a significant increase in anxiety symptoms in participants who had early menarche compared to those who did not have early menarche. The mean score on the GAD-7 Questionnaire for the cases was 9.93 and the control group was 6.89. The GAD-7 scores among the cases group were significantly higher in the GAD-7 scores than in the control group. Conclusions This study concluded that early menarche is associated with higher anxiety levels in young adults.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}