F1000Research最新文献

{"title":"Absent in Melanoma 2 Gene Associated Periodontitis and Coronary Heart Disease","authors":"Z. Daily, Batool H Al-Ghurabi","doi":"10.12688/f1000research.151954.1","DOIUrl":"https://doi.org/10.12688/f1000research.151954.1","url":null,"abstract":"Aims To study the association between AIM2 gene polymorphisms and the tendency for periodontal infection and coronary heart disease, and to determine whether males or females are more susceptible to these diseases. Additionally, we examined its association with the features of periodontal disease. Methods 140 patients were enrolled in this study, and those who took part were divided into four groups as follows: healthy (c), periodontal disease (P), coronary heart disease with intact periodontium (AS-C), and coronary heart disease with periodontal disease (AS-P). Information on entrants, including age, sex, body mass index, and indicators of periodontal disease severity, was documented. Blood samples were collected, and AIM2 gene polymorphisms were evaluated by polymerase chain reaction test, gel phase, and sequences. Results Genetic analysis of AIM2 G/T (rs2793845) revealed a high frequency of the (T) allele and (GT and TT) genotypes that were detected in the periodontal disease and coronary heart disease groups in males. The Hardy-Weinberg equilibrium of alleles and genotypes did not differ significantly between the study groups. Gene polymorphisms were also significantly correlated with indicators of periodontal disease severity. Conclusion High frequenting of (T) alleles and (GT, TT) genotypes in AIM2 single nucleotide polymorphisms (SNP) were associated with an increased tendency to develop periodontal disease and coronary heart disease. It can be supposed that it has a causative function in the pathophysiology of both disorders, and the validity of SNP as a potential genomic factor for the risk of both disorders in Iraqi males.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141830970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selfies, narcissism and oral health a cross - sectional study among adolescents and young adults in Mangaluru - India.","authors":"Preeti Prabhu, M. Pai, Shweta Yellapurkar, S. Natarajan, A. V. Mahuli","doi":"10.12688/f1000research.153818.1","DOIUrl":"https://doi.org/10.12688/f1000research.153818.1","url":null,"abstract":"Background Selfies have been defined as “a photograph that one has taken of oneself, and are a continuing growing trend among Millennials. Narcissism refers to the personality trait of an extraordinary self-awareness and adoration. Studies have shown a close relationship between selfie-taking behaviour, narcissism and oral health. Hence, a study was conducted with aim of the influence of selfie-taking behavior and narcissism on oral health. Methods An analytical cross-sectional questionnaire study was designed using relevant literature for collating information on sociodemographic characteristics, frequency of dental visits, selfie-taking behavior and perceived oral health. Oral health examination was performed to assess decay and plaque. Narcissism was assessed using The Five-Factor Narcissism Inventory Short Form Results The study included a sample of 163 participants. The associations between selfies taken per day and perceived oral health was statistically significant (p value 0.047*). Binary logistic regression models were constructed, which were significant for perceived oral health and grandiose fantasy. Plaque Scores showed significant corelations between indifference, manipulativeness, thrill seeking and age. Step forward binary regression demonstrated a significant odds ratio for grandiose narcissism followed by selfie-taking behavior Conclusion This study revealed a correlation between perceived oral health and selfie-taking behaviour. Further studies are required to assess selfie-taking behaviour and oral health.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Championing health systems management with digital innovation and applications in the age of artificial intelligence: protocol for a research program","authors":"Ericles Andrei Bellei, Ana Carolina Bertoletti De Marchi","doi":"10.12688/f1000research.152543.1","DOIUrl":"https://doi.org/10.12688/f1000research.152543.1","url":null,"abstract":"Health systems are experiencing increasing pressures worldwide due to heightened service demands, demographic aging, stringent regulations, and economic constraints, making efficiency and efficacy in health management critical aspects. At the heart of this complexity, health managers seek to optimize resources and improve care delivery at a time when the adoption of digital technologies, including artificial intelligence (AI), becomes increasingly imperative. This necessity reflects not only the pursuit of innovation but also the urgency to adapt to an ever-evolving environment. However, the effective characterization, availability, and incorporation of these technologies as support tools still represent an emerging challenge that is insufficiently explored in the literature. In response, this project proposes the development of a framework of theoretical and practical guidelines for the implementation and management of digital tools in health systems in the age of AI. Adopting a mixed-methods approach that includes systematic review, analyses of commercial off-the-shelf solutions, and qualitative studies with health managers and practitioners, the aim is to map current technology use, identify gaps and best practices, and provide a guide for future direction. This project also intends to develop in co-creation with professionals in the field to ensure the relevance and practical applicability of the developed guidelines. The results are expected to not only contribute to the scientific literature but also offer an evidence-based guide to optimizing the use of digital technologies in health management, promoting a significant transformation in the development and adoption of innovative digital solutions.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141837637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of Microorganisms and Effectiveness of Biodegradation Techniques on LDPE Plastics: A Systematic Review","authors":"Jorge Guillermo Morales Ramos, Leydy Mekinley Fernández Tarrillo, Anghelly Xiomara Guevara Bravo, Marilin Sánchez-Purihuamán, Carmen Rosa Carreño Farfán, Carolina Susana Loayza Estrada, E. G. Llontop Ynga, Horacio De La Cruz Silva","doi":"10.12688/f1000research.151338.1","DOIUrl":"https://doi.org/10.12688/f1000research.151338.1","url":null,"abstract":"Introduction The aim of the research was to demonstrate the efficiency of microorganisms and the effectiveness of biodegradation techniques on Low-density polyethylene (LDPE) plastics. The research question was: What is the efficiency of LDPE-degrading microorganisms and the effectiveness of biodegradation techniques? Methods The systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Articles were obtained from Scopus, Web of Science (WOS), Embase, and Google Scholar. The DeCS/Mesh search terms were: Low-density polyethylene, efficiency, biodegradation, microbial consortia, fungi, bacteria. Inclusion criteria were: scientific articles that included bacteria, fungi, and microbial consortia reported as LDPE degraders that report the percentage of weight loss; articles published from January 2010 to October 2022, and publications in Spanish and English with open access. Exclusion criteria were: studies that do not report gravimetry, the biodegradation time of LDPE, and the genus or species of the polyethylene-degrading microorganism. Results Out of 483 studies found, 50 were included in this Systematic Review (SR). The most frequent study techniques were scanning electron microscopy (SEM), gravimetry, and fourier transform infrared spectroscopy (FTIR), and in the case of microorganisms, the most studied belonged to the genus Pseudomonas, Bacillus, and Aspergillus. Regarding the isolation place, the most frequent mentioned in the reviewed articles were landfill soil and sanitary landfill soil. The efficiency of LDPE-degrading microorganisms was higher in bacteria such as Enterobacter spp., Pantoea spp., Pseudomonas spp., Escherichia coli, and Bacillus spp., which obtained a range of DE of 9.00-70.00%, 24.00-64%, 1.15 – 61.00%, 45.00%, and 1.5-40% with DT of 4-150, 120, 4-150, 30, and 30-120 days, respectively; in the case of fungi, the main microorganisms are Neopestalotiopsis phangngaensis, Colletotrichum fructicola, and Thyrostroma jaczewskii with efficiencies of 54.34, 48.78, and 46.34%, in 90 days, respectively; and the most efficient microbial consortia were from Enterobacter spp. and Pantoea sp. with 38.00 – 81.00%, in 120 days; and, Pseudomonas protegens, Stenotrophomonas sp., B. vallismortis and Paenibacillus sp. with 55. 00 – 75.00% in 120 days. Conclusions The most efficient microorganisms in LDPE degradation are Enterobacter spp., Pantoea spp., Pseudomonas spp., Escherichia coli, and Bacillus spp.; in fungi Neopestalotiopsis phangngaensis, Colletotrichum fructicola, and Thyrostroma jaczewskii; and in microbial consortia, those formed by Enterobacter spp. and Pantoea sp., and that of P. protegens, Stenotrophomonas sp., B. vallismortis and Paenibacillus sp.; and the most effective techniques used in LDPE biodegradation are SEM, gravimetry, and FTIR.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141837604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of sleep hygiene education and lavender essential oil inhalation on the sleep quality and overall well-being of athletes who undergo late-evening training: a randomized controlled trial  ","authors":"Atef Salem, K. Trabelsi, M. Boujelbane, Ahlem Belgacem, Mohamed Kerkeni, Manel Kerkeni, O. Boukhris, Haithem Jahrami, Jordan M. Glenn, A. Ammar, Wolfgang I. Schöllhorn, Hamdi Chtourou","doi":"10.12688/f1000research.150977.1","DOIUrl":"https://doi.org/10.12688/f1000research.150977.1","url":null,"abstract":"Background Sleep hygiene education (SHE) and lavender essential oil (LEO) inhalation are two effective strategies aimed at enhancing sleep quality and mood states. This study investigated the effects of a single SHE session combined with nightly LEO inhalation for 7 days of late-evening resistance training sessions on sleep quality and mood states in trained athletes. Methods Forty-two athletes were randomly assigned to four groups: a control group (CG), a SHE group (SHEG), a LEO group (LEOG), and a SHE + LEO group (CSLG). CG and LEOG maintained their sleep habits during the intervention, while SHEG and CSLG followed SHE recommendations. Additionally, LEOG and CSLG inhaled LEO nightly before sleep. Sleep patterns were recorded via actigraphy. The Brunel Mood Scale and the Hooper questionnaires were completed before and after the intervention. Results Sleep latency was lower in SHEG (p=0.001) and CSLG (p=0.012) compared to the CG. The subjective sleep score improved in SHEG, LEOG, and CSLG (p < 0.001), with greater improvement observed in SHEG (p = 0.002) and CSLG (p < 0.001) compared to CG at post-intervention. Additionally, significant improvements were observed in the Hooper index in the SHEG (p=0.048) and CSLG (p=0.027), with CSLG demonstrating higher scores compared to CG at the post-intervention assessment (p=0.026). Furthermore, the subjective fatigue score significantly decreased in the CSLG (p=0.009). Conclusions Combining SHE and LEO inhalation could be an effective strategy to enhance sleep latency, subjective sleep quality, and overall wellness, and reduce feelings of fatigue in trained athletes following late-evening resistance training sessions.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘What seems to be missing is actual reality’ Why don’t postdocs engage with career-focused professional development?","authors":"Mollie Etheridge, Jessica Hampton, Becky Ioppolo, Lara Abel, Noam Tal-Perry, Katherine Dawson, Marie Collier, Zoe Matthews, Kate Murray, Sylvia Osborn, Liz Simmonds, Steven Wooding","doi":"10.12688/f1000research.151211.1","DOIUrl":"https://doi.org/10.12688/f1000research.151211.1","url":null,"abstract":"Background The relationship dynamics between postdoctoral researchers and their managers – typically Principal Investigators (PIs) - can directly and indirectly impact the professional development activities that postdocs participate in. Although career and development (C&D) conversations can be a platform through which both parties communicate about the postdoc’s development needs and career aspirations, it is unclear how frequently postdocs are having these types of conversations. Evidence from across the UK indicates that this group receive little feedback on their performance. Methods To explore interventions that could empower postdocs to initiate C&D conversations, we conducted a pilot study at the University of Cambridge where current postdocs were offered workshops utilizing two widely available professional development tools. Both workshops included 360-degree feedback interventions, and we hypothesized that the feedback gathered through these tools could give postdocs both a launching pad for facilitating a conversation with their PI and address the aforementioned feedback shortfall. Results Although most of the participant sample reported already having C&D conversations, those who did not report as such demonstrated mixed feelings about whether facilitating these types of discussions is even part of the PI role. Insights from participants’ engagement with the 360-degree feedback tools also show that participants were mindful of time constraints when seeking feedback, indicating that the usefulness of such interventions may be inhibited by wider cultural issues in the sector. Conclusions Through the development of what we call ‘the researcher development framework, this study highlights the shortcomings of using professional development interventions to address cultural issues.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and health care provider factors influencing stroke self-management behavior: A cross-sectional study","authors":"Yurike Septianingrum, A. Yusuf, Ika Yuni Widyawati, Nunik Purwanti, Nety Mawarda Hatmanti, Shelly Nursofya Lestari, Andis Yuswanto","doi":"10.12688/f1000research.143731.1","DOIUrl":"https://doi.org/10.12688/f1000research.143731.1","url":null,"abstract":"Background This study aimed to examine individual- and health service provider-related factors that influence the self-management behavior of patients with stroke. Methods This cross-sectional study investigated a cohort of 110 ischemic stroke patients in the neurology outpatient department of Universitas Airlangga Hospital from February 2023 to May 2023. Data were obtained using the following three distinct questionnaires: the general demographic questionnaire, health care provider questionnaire, and modified stroke self-management behavior questionnaire. Results Chi-square test results indicated a significant correlation between age (p = 0.023) and information availability (p = 0.000) with self-management behavior in patients with stroke. However, no significant correlations were observed between gender (p = 1.107), residence (p = 0.859), availability of access (p = 0.093), availability of health facilities (p = 0.065), and collaboration among health workers (p = 0.641) with self-management behavior in patients with stroke. Ordinal logistic regression analysis results indicated that age significantly influenced self-management behavior in patients with stroke (p = 0.034; OR = 2.49). Discussion The presence of reliable information within the hospital setting is expectedly complemented by a strong level of literacy among patients with stroke, thereby facilitating the enhancement of their self-management practices.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140963577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep geological disposal of plastic waste: Pros and cons","authors":"Hayk Minasyan","doi":"10.12688/f1000research.149702.1","DOIUrl":"https://doi.org/10.12688/f1000research.149702.1","url":null,"abstract":"Plastic production is growing, plastic waste is accumulating, and current waste management methods (recycling, incineration, etc.) are not yet able to solve this waste problem. Proposals and projects aimed at solving or facilitating the problem of plastic waste are therefore relevant. This article proposes a deep geological disposal method for plastic waste projects. The prototype for this project was the deep geological disposal of nuclear waste. Although plastic waste and nuclear waste are fundamentally different, the adequacy of this approach is justified by the fact that plastic waste, such as nuclear waste, has a a long degradation period and poses great danger to the environment, animals, and humans. The article is conceptual and examines the aspects necessary for the implementation of the project, such as the establishment of a special international UN agency for plastic waste management, specific sources of funding, giving plastic waste a monetary value, applying free market principles, and using existing potential opportunities for deep geological disposal of plastic waste. This article also discusses the proposed concept for finding more optimal options.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability, validity, and minimal clinically important differences for the Thai-version of the Aberdeen Varicose Vein Questionnaire (AVVQ-Thai) in patients with chronic venous disease","authors":"Boonying Siribumrungwong, Pinit Noorit, Termpong Reanpang, Chawanan Pornwaragorn, Chumpon Wilasrusmee, Suchat Wongsuwanich, Kanoklada Srikuea, Saritphat Orrapin, Thoetphum Benyakorn, Andrew Malcolm Garratt, Kittipan Rerkaserm","doi":"10.12688/f1000research.147716.1","DOIUrl":"https://doi.org/10.12688/f1000research.147716.1","url":null,"abstract":"Background Patient-reported outcome measures (PROMs) are essential for assessing the health of patients with chronic venous disease (CVD). Therefore, we aimed to translate the Aberdeen Varicose Vein Questionnaire into Thai language (AVVQ-Thai) and evaluate its reliability and validity. Minimal clinically important differences (MCID) of the AVVQ-Thai also be estimated. Methods International standards for PROM translation were followed including the forward-backwards translation of the AVVQ. Patients with Clinical-Etiology-Anatomy-Pathophysiology (CEAP) C2-C6 with truncal reflux were prospectively included. Venous interventions were used to treat reflux and varicosities. Patients’ characteristics, venous clinical severity scores (VCSS), EuroQol EQ-5D, and AVVQ-Thai were collected pre- and one-month post-intervention. AVVQ-Thai was also collected one to two weeks after the initial visit by reply-paid postal questionnaire. Results The study included 119 patients (30% C2, 29% C3, 28% C4, 11% C5, and 2% C6). The AVVQ-Thai had good internal consistency with Cronbach’s alpha of 0.783 and moderate reliability with the intraclass correlation coefficient of 0.67 (95%CI: 0.50, 0.79). The AVVQ-Thai was significantly correlated with VCSS and was able to discriminate patients with different levels of health problems as assessed by EQ-5D at both pre-and post-intervention, demonstrating good construct and discriminative validity. The median AVVQ scores improved significantly after intervention from 15.4 (IQR 8.3, 24.2) to 4.2 (IQR 1.3, 8.4) in C2-C3, and 18.9 (IQR 14.1, 25.5) to 7.3 (IQR 4.6, 16.3) in C4-C6. The MCID of the AVVQ was 6.21 on the 0-100 scale, which equates to the level of difference necessary to be clinically meaningful. Conclusions AVVQ-Thai has satisfactory evidence for internal consistency, reliability, validity, and responsiveness to change and is recommended for application in Thailand.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic and macroscopic evaluation","authors":"Ludwig Andribert Powantia Pontoh, Jessica Fiolin, Ismail Hadisoebroto Dilogo, Marcel Prasetyo, Radiana Dhewayani Antarianto, Alida Harahap, Angela Jennifer Tantry, Trevino Aristakus Pakasi, Bambang Pontjo Priosoeryanto, Tri Isyani Tungga Dewi","doi":"10.12688/f1000research.147309.1","DOIUrl":"https://doi.org/10.12688/f1000research.147309.1","url":null,"abstract":"Background Current treatment of osteoarthritis (OA) mainly focused on treating symptoms. Exosome from Adipose-derived Mesenchymal Stem Cell (Ad-MSC) have been shown to delay degenerative process. This study aimed to investigate the clinical, radiological and histological impact of combined intra-articular (IA) hyaluronic acid (HA) and exosome Ad-MSCs in-vivo using a larger animal model with low-grade OA. Methods Eighteen male Ovies aries sheep underwent total lateral meniscectomy and conventional radiography was performed to confirm low-grade OA after 6 weeks. The sheep were divided into three groups, Group 1 (G1; n=6) received thrice exosome injections, G2 (n=6) received twice HA injection, and G3 (n=6) received both treatments with a 1-week interval after 10 days of meniscectomy. Clinical evaluations were conducted using the Clinical Lameness Score (CLS), radiographic with X-ray using OA score by Innes et al, while macroscopic evaluation by Osteoarthritis Research Society International (OARSI) scores. Results Lameness parameter scored lowest in G3 significantly (2.0±0.0 VS 2.7±0.52 VS 2.7±0.52; p=0.024) at the second month although the overall CLS score did not significantly differ at the 3rd month. The best improvement of conventional total OA radiographic score at the 3rd month compared to all groups (5.2±1.17 vs 6.3±0.82 vs 6.7±1.03; p=0.053). Macroscopic OARSI evaluation showed no difference (p=0.711). Conclusions Combined repeated exosome Ad-MSC and HA IA injection proven to delay OA progression, however longer duration of follow up is required to evaluate its long-term effect.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}