黑色素瘤 2 基因缺失与牙周炎和冠心病有关

Z. Daily, Batool H Al-Ghurabi
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引用次数: 0

摘要

目的 研究 AIM2 基因多态性与牙周感染和冠心病发病倾向之间的关系,并确定男性或女性更易患这些疾病。此外,我们还研究了其与牙周病特征的关系。方法 本研究共招募了 140 名患者,并将参加研究的患者分为以下四组:健康组(C)、牙周病组(P)、冠心病伴牙周完整组(AS-C)和冠心病伴牙周病组(AS-P)。记录入选者的信息,包括年龄、性别、体重指数和牙周病严重程度指标。采集了血液样本,并通过聚合酶链反应测试、凝胶相和序列对 AIM2 基因多态性进行了评估。结果 AIM2 G/T(rs2793845)基因分析表明,在男性牙周病组和冠心病组中,检测到(T)等位基因和(GT 和 TT)基因型的频率较高。研究组之间等位基因和基因型的哈代-温伯格平衡差异不大。基因多态性与牙周病严重程度指标也有显著相关性。结论 AIM2 单核苷酸多态性(SNP)中(T)等位基因和(GT, TT)基因型的高频率出现与牙周病和冠心病发病倾向的增加有关。可以认为,SNP 在这两种疾病的病理生理学中具有致病功能,SNP 作为伊拉克男性罹患这两种疾病风险的潜在基因组因素是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Absent in Melanoma 2 Gene Associated Periodontitis and Coronary Heart Disease
Aims To study the association between AIM2 gene polymorphisms and the tendency for periodontal infection and coronary heart disease, and to determine whether males or females are more susceptible to these diseases. Additionally, we examined its association with the features of periodontal disease. Methods 140 patients were enrolled in this study, and those who took part were divided into four groups as follows: healthy (c), periodontal disease (P), coronary heart disease with intact periodontium (AS-C), and coronary heart disease with periodontal disease (AS-P). Information on entrants, including age, sex, body mass index, and indicators of periodontal disease severity, was documented. Blood samples were collected, and AIM2 gene polymorphisms were evaluated by polymerase chain reaction test, gel phase, and sequences. Results Genetic analysis of AIM2 G/T (rs2793845) revealed a high frequency of the (T) allele and (GT and TT) genotypes that were detected in the periodontal disease and coronary heart disease groups in males. The Hardy-Weinberg equilibrium of alleles and genotypes did not differ significantly between the study groups. Gene polymorphisms were also significantly correlated with indicators of periodontal disease severity. Conclusion High frequenting of (T) alleles and (GT, TT) genotypes in AIM2 single nucleotide polymorphisms (SNP) were associated with an increased tendency to develop periodontal disease and coronary heart disease. It can be supposed that it has a causative function in the pathophysiology of both disorders, and the validity of SNP as a potential genomic factor for the risk of both disorders in Iraqi males.
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