Drug-related problems associated to antibiotic use in cesarean delivery: a retrospective analysis in a secondary care hospital.

Katherine Romero Viamonte, Adrian Salvent Tames, A. Bustillos, María Victoria Rojo Manteca, Ana Martín-Suárez
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Abstract

Background/Objectives A drug-related problem (DRP) is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. The aim of this study is to identify and categorize the DRPs associated with the use of antibiotics in women undergoing cesarean delivery and to analyze the causes of these problems, making an improvement proposal of preoperative antibiotic prophylaxis (PAP) use in accordance with international guidelines. Methods Observational, retrospective, descriptive study of 814 women undergoing cesarean delivery. Prescription adequacy was assessed based on the selection, administration, dose and duration of the antibiotic therapy. DRP analysis and characterization was conducted using the Pharmaceutical Care Network Europe (PCNE) Classification V 9.1. Results DRPs were detected in all women (1125, 1.38 DRPs/patient), the most frequent ones associated to failure to administer PAP (30.10% of patients) and to unnecessary postsurgical antibiotic (100%). Of the 1935 possible causes for DRPs identified, most of them were related to inappropriate drug selection. Cefazolin was administered to 98.07% of women with PAP and 71.45% of patients received postsurgical cefalexin, with 13 different antibiotics being used in total. Conclusions The implementation of therapeutic protocols and early identification of DRPs is proposed in order to optimize antibiotic use in the institution.
与剖腹产使用抗生素相关的药物问题:一家二级医院的回顾性分析。
背景/目的 与药物相关的问题(DRP)是指涉及药物治疗的事件或情况,实际或潜在地干扰了预期的健康结果。本研究旨在识别和分类与剖宫产产妇使用抗生素相关的 DRP,并分析这些问题的原因,根据国际指南提出术前抗生素预防(PAP)使用的改进建议。方法 对 814 名接受剖宫产手术的产妇进行观察性、回顾性和描述性研究。根据抗生素治疗的选择、给药、剂量和持续时间来评估处方的充分性。采用欧洲药品护理网络(PCNE)分类 V 9.1 对 DRP 进行了分析和定性。结果 在所有妇女(1125 人,每名患者 1.38 例)中都发现了 DRP,其中最常见的是未使用 PAP(30.10% 的患者)和不必要的术后抗生素(100%)。在已确定的 1935 个可能导致 DRP 的原因中,大多数与药物选择不当有关。98.07%的 PAP 妇女使用了头孢唑啉,71.45%的患者术后使用了头孢氨苄,总共使用了 13 种不同的抗生素。结论 建议实施治疗方案并及早识别 DRP,以优化该机构的抗生素使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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