Explore-The Journal of Science and Healing最新文献

{"title":"Effectiveness of aromatherapy with sweet orange oil (Citrus sinensis L.) in relieving pain and anxiety during labor","authors":"Jessica C. Nascimento ,&nbsp;Vitória S. dos S. Gonçalves ,&nbsp;Bruna R.S. Souza ,&nbsp;Laranda de C. Nascimento ,&nbsp;Betina M.R. de Carvalho ,&nbsp;Paulo C.L. Nogueira ,&nbsp;José P.S. Santos ,&nbsp;Lysandro P. Borges ,&nbsp;Tiago C. Goes ,&nbsp;Jessiane Bispo de Souza ,&nbsp;Henrique D.M. Coutinho ,&nbsp;Adriana G. Guimarães","doi":"10.1016/j.explore.2024.103081","DOIUrl":"10.1016/j.explore.2024.103081","url":null,"abstract":"<div><h3>Introduction</h3><div>Need to improve the quality of vaginal birth in a humanized and non-invasive way, contributing to pain and anxiety during labor. Integrative and complementary practices, such as aromatherapy, have been an important tool for managing natural birth. To evaluate the effects of Citrus sinensis L. aroma on pain and anxiety during labor.</div></div><div><h3>Methods</h3><div>Single-blind randomized clinical trial with pregnant women was performed in a city of Brazilian northwest. The pregnant women were divided (n=42/group) into an experimental group (inhalation of 250 μL of <em>C. sinensis</em> essential oil) and a placebo group (250 μL of distilled water), and submitted to the evaluation of pain intensity through Visual Analogic Scale, anxiety (STAI-E), physiological parameters, as well as fetal heart rate.</div></div><div><h3>Results</h3><div>Aromatherapy significantly reduced pain intensity over time (p=0.0411), especially for pregnant women in stage 1 dilatation and primiparous (p=0.0022). In addition, essential oil inhalation also reduced anxiety (p&lt;0.0001), showing significant positive correlations (r=0.3147; p=0.3129) with pain intensity. Exposure to the aroma of sweet orange also reduced mean blood pressure, heart rate, respiratory rate of pregnant women and fetal heart rate (p&lt;0.0001).</div></div><div><h3>Discussion</h3><div>The active compounds present in the essential oil used, especially limonene, are capable of modulating neurotransmission systems associated with pain and anxiety, being effective in reducing these symptoms during labor.</div></div><div><h3>Conclusion</h3><div>It was shown that <em>C. sinensis</em> essential oil reduces pain and anxiety during labor, indicating the potential of this type of intervention and its possible applicability in good labor practices.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103081"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials","authors":"Zhao Peng,&nbsp;Duo Li,&nbsp;Na Wu,&nbsp;Xiao-Yuan Wang,&nbsp;Gai-Xia Sun,&nbsp;Hui-Bin Gao,&nbsp;Hai-Xia Li","doi":"10.1016/j.explore.2024.103083","DOIUrl":"10.1016/j.explore.2024.103083","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to systematically evaluate the safety and efficacy of curcumin as an adjunctive treatment for patients with ulcerative colitis (UC) and to assess the methodological quality of the published studies.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase, and CENTRAL databases for randomized controlled trials published up to August 18, 2023. Two independent reviewers screened studies based on predefined criteria. Meta-analysis was performed using a random-effects model with RevMan 5.4. Heterogeneity was assessed using Cochran's Q test and I² statistic.</div></div><div><h3>Results</h3><div>Eight randomized controlled trials involving 482 patients were included. Seven studies reported clinical remission, and three reported endoscopic remission. Compared to the placebo group, adjunctive curcumin therapy significantly improved clinical remission (RR=2.33, 95 % CI: 1.25 to 4.34; <em>P</em> = 0.008; I²=80 %). Although endoscopic remission showed an increasing trend, it was not statistically significant (RR=4.17, 95 % CI: 0.63 to 27.71; <em>P</em> = 0.14; I²=80 %). Significant improvements were also observed in clinical improvement (RR=1.93, 95 % CI: 1.10 to 3.36; <em>P</em> = 0.02; I²=56 %) and endoscopic improvement (RR=1.76, 95 % CI: 1.12 to 2.77; <em>P</em> = 0.01; I²=62 %) in the curcumin group. No serious adverse events were reported. Subgroup analysis indicated a positive correlation between treatment efficacy and dosage, with no significant impact of administration method or follow-up duration on the pooled results or heterogeneity.</div></div><div><h3>Conclusion</h3><div>Curcumin as an adjunctive treatment shows promise in improving clinical and endoscopic outcomes in UC patients without significant adverse effects. However, due to the limited number of studies and substantial heterogeneity, further large-scale randomized controlled trials are necessary to confirm these findings.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103083"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of randomized controlled trials examining the efficacy and safety of elemene in combination with chemotherapy for the treatment of gastric cancer","authors":"Yige Liu ,&nbsp;Feng Du ,&nbsp;Bo Chen ,&nbsp;Sanjay Rastogi ,&nbsp;Yanhua Huang","doi":"10.1016/j.explore.2024.103076","DOIUrl":"10.1016/j.explore.2024.103076","url":null,"abstract":"<div><h3>Background</h3><div>Elemene is a naturally occurring chemical derived from plants of the Zingiberaceae family, and it finds application in several cancer-related contexts. Nevertheless, there is a dearth of comprehensive assessment about the combined effectiveness and safety of chemotherapy in gastric cancer (GC).</div></div><div><h3>Objective</h3><div>To investigate the safety and effectiveness of elemene in conjunction with chemotherapy for the treatment of Gastric cancer.</div></div><div><h3>Methods</h3><div>A comprehensive search of Medline, EMBASE, Scopus, and Cochrane Library identified peer-reviewed journal papers. OR and RR were calculated, along with their 95 % confidence ranges. We assessed heterogeneity using Cochrane Q and I2 statistics and the relevant P-value. The analysis used RevMan 5.3.</div></div><div><h3>Results</h3><div>Current meta-analysis includes 11 RCTs with 726 GC patients, 364 of whom received elemene paired with treatment and 362 received standard chemotherapy. Elemene-coated chemotherapy improves ORR (RR 1.43, 95 % CI 1.22–1.67, p &lt; 0.00001), reduces blood system toxicity (OR 0.49, 95 % CI 0.35–0.69, p &lt; 0.0001), nausea and vomiting (RR 0.65, 95 % CI 0.55–0.77), diarrhea (RR 0.73, 95 % CI 0.58–0.90), and liver problems (RR 0.64, 95 % CI 0.49–0.83).Subgroup analysis showed that both oral and intravenous administration improved ORR statistically, and a network diagram with consistent connectivity, well-defined network architecture, and high-quality evidence shows that elemene combined with chemotherapy has significant therapeutic efficacy.</div></div><div><h3>Conclusion</h3><div>Elemene may possess the capacity to enhance the effectiveness and mitigate the adverse effects of gastric cancer chemotherapy. Nevertheless, due to the restricted number of studies incorporated, additional research studies utilizing sizable samples are required to validate the aforementioned findings</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103076"},"PeriodicalIF":1.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of traditional Chinese medicine in the conservative management of complete small intestinal obstruction post-gastric cancer surgery: A case report","authors":"Weipeng Zhao ,&nbsp;Jian Xun ,&nbsp;Xinyu Yuan ,&nbsp;Jinchang Huang ,&nbsp;Jing Bai","doi":"10.1016/j.explore.2024.103080","DOIUrl":"10.1016/j.explore.2024.103080","url":null,"abstract":"<div><div>In this case report, we describe the successful treatment of a patient with complete small bowel obstruction following gastric cancer surgery, employing an integrated approach of traditional Chinese medicine and Western medicine. Initial treatment consisted of conventional biomedical interventions, including intestinal obstruction catheterization, but after 16 days without improvement, surgical intervention was recommended. The patient, however, refused surgery and opted for treatments based on traditional Chinese medicine. Comprehensive traditional Chinese medicine therapies such as acupuncture, moxibustion, flash cupping, oral administration of compound herbal formulas, and enemas using Chinese herbal medicine were implemented alongside modern medical care. The obstruction resolved, and the patient was discharged without requiring surgery. Follow-up revealed no recurrence of the condition. This case highlights the potential of integrating traditional Chinese medicine with Western medical practices in the conservative management of complete small bowel obstruction, offering a reference for clinical application.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103080"},"PeriodicalIF":1.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double-blind, randomized, placebo-controlled trial of individualized homeopathic medicinal products in the treatment of nocturnal enuresis in children","authors":"Junayed Akram ,&nbsp;Arpita Basu ,&nbsp;Md. Sakhawat Hossain ,&nbsp;Soumya Bhattacharyya ,&nbsp;Saima Shamim ,&nbsp;Pintu Debnath ,&nbsp;Rizwana Rahaman ,&nbsp;Sourav Goswami ,&nbsp;Usashi Nag ,&nbsp;Priyanka Ghosh ,&nbsp;Abdur Rahaman Shaikh ,&nbsp;Chandrima Chatterjee ,&nbsp;Munmun Koley ,&nbsp;Subhranil Saha ,&nbsp;Sangita Saha ,&nbsp;Shyamal Kumar Mukherjee","doi":"10.1016/j.explore.2024.103077","DOIUrl":"10.1016/j.explore.2024.103077","url":null,"abstract":"<div><h3>Context</h3><div>Nocturnal enuresis (NE) is a very common problem in childhood. The prevalence rate varies from 3.5% to 56.4% in different geographical regions and countries.</div></div><div><h3>Objective</h3><div>Homeopathy is claimed to be a safe and effective mode of complementary and alternative therapy; however, robust research evidence supporting the efficacy or effectiveness of homeopathy in NE is scarce. This trial aimed at detecting the group differences between homeopathy and placebo in the treatment of NE in children.</div></div><div><h3>Design</h3><div>Three-month, double-blind, randomized (1:1), placebo-controlled trial.</div></div><div><h3>Setting</h3><div>Pediatric outpatient department of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal.</div></div><div><h3>Patients</h3><div>One hundred and forty children suffering from NE.</div></div><div><h3>Interventions</h3><div>Active treatment (individualized homeopathic medicinal products, IHMPs plus concomitant care, CC; <em>n</em> = 70) versus control (identical-looking placebos, plus CC; <em>n</em> = 70).</div></div><div><h3>Main outcome measures</h3><div>Primary – the frequency of bedwetting events between groups; secondary – the pediatric quality of life inventory (PedsQL, version 4.0) questionnaire and its subscales – child-rated and parent-rated versions; all were measured at baseline, and every month, up to 3 months.</div></div><div><h3>Results</h3><div>After 3 months of intervention, group differences were statistically significant in the primary outcome favoring IHMPs against placebo (median difference: 2.4, interquartile range -4 to 9.7, Mann Whitney <em>U</em> = 1956.5, <em>p</em> = 0.039). Although the intra-group median reductions were higher in the IHMPs group than in placebos, the differences were statistically non-significant in the secondary outcome – PedsQL total child report version (<em>p</em> = 0.224) and PedsQL total parent report version (<em>p</em> = 0.942). <em>Sulphur</em> (<em>n</em> = 26, 18.6%), <em>Calcarea phosphorica</em> (<em>n</em> = 20, 14.3%), <em>Calcarea carbonica</em> and <em>Kreosotum</em> (<em>n</em> = 9 each, 6.4%)<em>,</em> and <em>Mercurius solubilis</em> (<em>n</em> = 8, 5.7%) were the most frequently prescribed medicines. Thus, IHMPs were found superior to placebos in reducing the frequency of bedwetting events in children. Independent replications are warranted to substantiate the findings.</div><div>Clinical Trials Registry – India CTRI/2022/04/042009.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103077"},"PeriodicalIF":1.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ancestral healing rituals and the significance of Taky Samy in andean spirituality","authors":"Shairy Quimbo ,&nbsp;Lorena de la Torre Parra","doi":"10.1016/j.explore.2024.103075","DOIUrl":"10.1016/j.explore.2024.103075","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Ñukami Taky Samy ñan kani, Taky Samy shimika ñukapak Ñawpa Kichwa shimimi kan, Taky nishpaka ñuka kikin shimiwan takini, takinakunawanpash takini, wiwakunapash, pishkukunapash, takinkunami, Samy, ushay samy, kawsay samy, shinchi samy, jampi samy. Takysamywanka nanaykunata, llakikunata, piñaykunata jampita ushanchik, ñukanchipak allpa kamashkata jampinata ushanchik, llaki kawsayta, wakcha kawsaytapash jampita ushanchik. Taky Samytak takipashunchik, jukipushunchik, arawishunchik, tushushunchik, willkarishunchik. Kari Karilla, wawakuna, wambrakuna, kuitrsakuna wiñarishunchik, mushukyashunchik. Taky Samywanmi, ñukanchik wawakunatak shutichipashunchik, warachipashunchik, sawachipashunchik, Hawa pachaman Wantiyayta takishpa, muyushpa tikrapashunchik, allpa mamaman willkapashunchik, Inti Raymipik Tushupashunchik, chashnami tsirwikunawan, Manka shimikunawan, sampoñakunawan, pallakunawan, kuntur pinkullukunawan, wankarkunawan, tuntullikunawan, tinyakunawan, kenakunawan, churukunawan, kipakunawan, chillchillkunawan kuyaylla, munaylla, kushilla, punchalla kawsana kapanchik kay mushuk pachapi, tukuilla pachamamawan mushukyaspa kawsapashunchik. shina kachun tukuy llactakunamanta runakuna.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Taky Samy is an ancestral Andean healing practice of our physical, mental, emotional, spiritual, and auric bodies. Taky Samy practices connect us with plants, animals, birds and Mother Earth, through the language of instruments made of ceramic, bamboo, deer, and condor feathers and bones. These practices are guided by the sacred word of prayer, mantras and songs that connect with the Great Ordering Spirit Pachakamak, and the Great Mystery Tunupa Tixi Wirakocha, so that we can return to the order of life in harmony with all the beings of Mother Earth. Mother Earth has her order and that order guides all the activities of our lives. This order is represented in the cycles of the cultivation of our crops: corn in the first order, accompanied by potatoes, beans, quinua, chochos, pumpkins, and so on. Mother Earth cycles lead all Raymi and Andean rituals and festive celebrations, such as the solar dances that are accompanied by corn chicha, this includes the practice of Taky Samy ceremonies, music and dances. Taky Samy is more than musical therapy, it is harmony of life. Its therapeutic attributes and sacred language can heal an array of ailments and can also prevent adverse personal and family situations. Taky Samy celebrates social harmony and wards off illnesses and bad luck. It ultimately connects society with the Buen Vivir or Good Living, the Sumak Kawsay, which is a legacy of our Andean ancestors. This paper touches on the origins, purpose and practices of Taky Samy as important elements of the tapestry of ancestral Andean healing rituals. It focuses on Tayta Shairy Quimbo's (this paper's first author) Taky Samy path and practices. Taky Samy sacred instruments and spaces, as well as healing word and practices, connect us with spiritual worlds,","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 6","pages":"Article 103075"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masthead page","authors":"","doi":"10.1016/j.explore.2024.103090","DOIUrl":"10.1016/j.explore.2024.103090","url":null,"abstract":"","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 6","pages":"Article 103090"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the impact of COVID-19 on yoga instruction: Examining teaching methodology, class components, and injury patterns in the Northeastern US","authors":"SoJung Kim ,&nbsp;June Solow ,&nbsp;Donald H. Lein ,&nbsp;Harshvardhan Singh","doi":"10.1016/j.explore.2024.103079","DOIUrl":"10.1016/j.explore.2024.103079","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to examine the impact of COVID-19 on the perspectives of yoga instructors (YIs) regarding teaching methodology, class components, and yoga-related injuries among their clients</div></div><div><h3>Design</h3><div>A cross-sectional design in this study.</div></div><div><h3>Setting</h3><div>A total of 407 YIs from Northeastern United States completed a customized, web-based survey.</div></div><div><h3>Main outcome measures</h3><div>Chi-square tests were carried out to determine changes in yoga teaching format before and during the pandemic, as well as the counts of yoga related injuries between face-to-face (FtoF) and online teaching format. Independent t tests were used to compare the characteristics of yoga teaching elements.</div></div><div><h3>Results</h3><div>During the pandemic, 47 % of YIs adopted online teaching, followed by a mixed (45.9 %) format and FtoF (7.1 %) instruction. Both online and FtoF classes showed similar trends, with most reporting class sizes of 4–6, followed by 7–9 and then 1–3 students. Regardless of the teaching format, most YIs performed sun salutations and practiced mixed yoga styles. Among the YIs teaching yoga online, 84.6 % expressed their willingness to continue offering online classes post-pandemic and perceived the quality of online yoga teaching as high. Importantly, the number of injuries was low, and there were no significant differences in injury counts between FtoF (3.6 %) and online (4.2 %) teaching formats (<em>p</em> &gt; 0.05). The most common injury in all forms of teaching yoga was a sprain/strain (42.9 %).</div></div><div><h3>Conclusions</h3><div>These findings could inform the development of research studies to examine the long-term feasibility and effectiveness of delivering online yoga since short-term benefits, safety, and YI acceptance appear favorable.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 6","pages":"Article 103079"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlocal Mind: Curing the Fear of Death","authors":"Barry Cottrell","doi":"10.1016/j.explore.2024.103074","DOIUrl":"10.1016/j.explore.2024.103074","url":null,"abstract":"<div><div>The aim of this article is to critique the contemporary scientific reduction of mind to brain, a dogma which is shown to be philosophically unsound and empirically unproven. The world of physical phenomena is understood to be encompassed by other subtle transphysical worlds accessed after death of the physical body.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 6","pages":"Article 103074"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective treatment of refractory oral ulcers using a compound Chinese herbal mouthwash: A report of two cases","authors":"Na Lin,&nbsp;Yan Zhang,&nbsp;Qiao ding Dai,&nbsp;Li-ping Xu","doi":"10.1016/j.explore.2024.103073","DOIUrl":"10.1016/j.explore.2024.103073","url":null,"abstract":"<div><div>Oral ulcers are a prevalent oral mucosal disorder, characterized by benignancy and self-limiting progression. However, a subset of these ulcers exhibits resistance to conventional therapeutic interventions, necessitating alternative treatment strategies. In this study, we present two cases of refractory oral ulcers that demonstrated limited responsiveness to standard treatments but achieved significant therapeutic benefits following the application of a compound Chinese herbal mouthwash. Case 1 involved a 60-year-old female patient diagnosed with Behçet's syndrome. Initial treatment with glucocorticoids and immunosuppressants yielded limited improvement in her oral ulcers; however, combination therapy involving the Chinese herbal mouthwash resulted in significant improvement and complete healing after a 2-week period. Case 2 presented a 48-year-old female patient with chronic tongue ulceration pain persisting for one year without any detectable systemic etiology. Despite receiving oral vitamin supplementation and local analgesic jelly, her symptoms remained unalleviated. A 3-week treatment regimen involving the administration of the Chinese herbal mouthwash in conjunction with thalidomide led to the complete resolution of her oral ulcers. The findings from this study suggest that the compound Chinese herbal mouthwash may serve as an adjuvant therapeutic approach for managing chronic oral ulcers that are resistant to conventional treatment.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 6","pages":"Article 103073"},"PeriodicalIF":1.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}