Explore-The Journal of Science and Healing最新文献

{"title":"Intractable cough and hiccups after resuscitation and acute coronary syndrome treatment successfully treated using the Kampo medicine bukuyoingohangekobokuto: A case report","authors":"Shin Takayama ,&nbsp;Tamon Yamanaka","doi":"10.1016/j.explore.2024.04.005","DOIUrl":"10.1016/j.explore.2024.04.005","url":null,"abstract":"<div><h3>Background</h3><p>Even in patients who survive resuscitation through multidisciplinary treatment, minor persistent symptoms can make hospital discharge difficult. Herein, we report a case of myocardial infarction with intractable symptoms following resuscitation, which were successfully treated using Kampo medicine.</p></div><div><h3>Case presentation</h3><p>A 71-year-old man experienced intractable cough and hiccups following resuscitation for acute myocardial infarction. Despite successful invasive treatment for his cardiac condition, the patient's persistent symptoms hindered his recovery and discharge from hospital. The patient was diagnosed with qi and blood deficiency, qi stagnation, and fluid retention, before being prescribed the Kampo medicine “bukuryoingohangekobokuto (BRIHK)”. Within days of treatment initiation, his symptoms notably improved, allowing him to be discharged.</p></div><div><h3>Conclusion</h3><p>This case highlights the potential of Kampo medicine for addressing post-resuscitation symptoms that are refractory to conventional treatments, and emphasizes the importance of integrating Kampo medicine with Western medical practices to enhance patient care and quality of life.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1550830724000648/pdfft?md5=d9bbb9e3190e165a9d1c1890fdc2fd96&pid=1-s2.0-S1550830724000648-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosound Therapy as a treatment for long COVID patients: A pre-post pilot study","authors":"Colleenia Korapatti ,&nbsp;Lauren Vera ,&nbsp;Keith Miller","doi":"10.1016/j.explore.2024.04.004","DOIUrl":"10.1016/j.explore.2024.04.004","url":null,"abstract":"<div><h3>Background</h3><p>43 % of people who are diagnosed with COVID-19 will experience persistent symptoms, also known as “long COVID,” which lasts past the recovery of the acute infection. Long COVID symptoms overlap with symptoms that the Biosound Therapy System (BTS) has been shown to improve. The BTS is a multimodal treatment that includes biofeedback, vibroacoustic therapy synchronized with music that plays binaural beats, and video content. This study aimed to determine feasibility for a future full-scale Randomized Controlled Trial (RCT) and explore the impact of the BTS on long COVID symptoms.</p></div><div><h3>Methods</h3><p>This pre-post pilot study was conducted in an outpatient mental health clinic. Adults aged 20–65 years old with persistent COVID-19 symptoms were screened and randomly assigned to the intervention or control group. The intervention group was given 8 Biosound Therapy sessions during a period of 4 weeks. All participants were assessed at baseline and at post-intervention using the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder 7-item scale (GAD-7), Cambridge Brain Sciences (CBS) tasks, and the COVID-19 Persistent Symptom Questionnaire. The feasibility outcomes were recruitment rates, retention rates, and open-ended questions about participants’ experiences.</p></div><div><h3>Results</h3><p>15 participants enrolled in the study and 13 completed the study (9 intervention, 4 control). Trial recruitment ended prematurely due to the emergence of the Omicron variant of COVID-19. Participants responded to open-ended questions with only positive remarks and made no comments on the study not being feasible. A Wilcoxon signed-rank test indicated that compared to baseline, participants in the intervention group had significant improvement in their GAD-7 score, PHQ9 score, 2 Cambridge Brain Science tasks (“Odd” and “Double Trouble”), fatigue, and difficulties in concentrating or remembering (<em>p</em> &lt; 0.05; 95 % CI).</p></div><div><h3>Conclusion</h3><p>The intervention group showed promising improvement without reported side effects. A full-scale RCT is feasible as long as the recruitment setting is changed to a location that allows access to more patients with long COVID. Results were limited due to the small sample size; therefore, a full-scale trial is needed.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1550830724000636/pdfft?md5=c052e97262c17f7a24fceaaee83737c7&pid=1-s2.0-S1550830724000636-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meanings of indigenous land-based healing and the implications for water governance","authors":"John Bosco Acharibasam ,&nbsp;Margot Hurlbert ,&nbsp;Ranjan Datta ,&nbsp;Kevin wâsakâyâsiw Lewis","doi":"10.1016/j.explore.2024.04.002","DOIUrl":"10.1016/j.explore.2024.04.002","url":null,"abstract":"<div><p>The continuous process of settler colonialism in Canada has profoundly impacted Indigenous Peoples' relationship with the Land and water, which holds immense significance in their healing journey. Reconnecting with the land and water through culturally rooted practices has far-reaching implications for the health and well-being of Indigenous communities. Maintaining a strong bond with the land and water is integral to Indigenous healing traditions. To gain insights into this connection we used a relational theoretical framework and engaged with Ministikwan Lake Cree Nation, a remote Indigenous community. Our approach centred around community-based participatory research, utilizing methods like deep listening, cultural camps and story-sharing to collect wisdom from community members, knowledge keepers, and Elders. The research findings show understanding the connection between Land-based healing practices and Indigenous-led water governance is critical to solving the water crises within remote Indigenous communities. This knowledge is indispensable for reshaping current water governance systems and ensuring the well-being of Indigenous communities across Canada.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1550830724000600/pdfft?md5=e794d4f8e6fc04497f94d8d19f0db72b&pid=1-s2.0-S1550830724000600-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupotomy combined with Korean medicine treatment in a patient with acute sacroiliac pain unresponsive to conventional therapy: A case report","authors":"Gawon Choe ,&nbsp;Ji Hye Hwang","doi":"10.1016/j.explore.2024.04.003","DOIUrl":"10.1016/j.explore.2024.04.003","url":null,"abstract":"<div><h3>Rationale</h3><p>Acute injury to the sacroiliac joint (SIJ) can result from high-energy external forces that cause a combination of axial loading and sudden rotational movements, resulting in severe pain that cannot be relieved by regular nonsteroidal anti-inflammatory drugs. The treatment includes injections of steroids and local anesthetics to reduce pain and promote healing. Here, we report the case of a patient with acute sacroiliac pain who did not respond to conventional injection therapy.</p></div><div><h3>Patient concerns</h3><p>A 58-year-old male patient who did not exercise regularly experienced pain in his left groin and difficulty walking while kicking on his right leg. He received two injections and manual therapy at a local orthopedic clinic; however, his symptoms did not improve despite taking painkillers.</p></div><div><h3>Diagnoses</h3><p>Radiographic images showed no abnormalities. After confirming the cause of onset, pain pattern, physical examination, and tenderness, the patient was diagnosed with an acute SIJ sprain (static blood).</p></div><div><h3>Interventions</h3><p>At the first visit, a single acupotomy was performed on the seven treatment points identified during the physical examination, and immediate improvement in symptoms was confirmed. From then on, Korean medicine (KM) treatments, such as acupuncture, cupping, chuna, and bee venom pharmacopuncture, were performed.</p></div><div><h3>Outcomes</h3><p>Immediately after acupotomy, groin pain improved by 80 %, gait immediately normalized, and the patient showed no symptoms at the 9th visit.</p></div><div><h3>Lessons</h3><p>For SIJ-type groin pain that does not respond to existing treatments, immediate relief is achieved after a single acupotomy at the exact treatment point. Therefore, in the future, the importance of identifying a precise treatment point for SIJ pain should be recognized, and the use of Korean medicine treatment techniques, including acupotomy, should be considered.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1550830724000624/pdfft?md5=bcf1d2a3867de24801dc0e625f1dc561&pid=1-s2.0-S1550830724000624-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140600151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized homeopathic medicines in preventing the progression from pre-diabetes to diabetes: A double-blind, randomized, placebo-controlled, parallel-arm trial","authors":"Aryabrata Banerjee ,&nbsp;Subhasish Ganguly ,&nbsp;Sangita Saha ,&nbsp;Pulakendu Bhattacharyya ,&nbsp;Satyajit Naskar ,&nbsp;Debraj Mukherjee ,&nbsp;Shuvadip Ghosh ,&nbsp;Prosenjit Maji ,&nbsp;Subhranil Saha ,&nbsp;Abdur Rahaman Shaikh ,&nbsp;Priyanka Ghosh ,&nbsp;Chandrima Chatterjee ,&nbsp;Munmun Koley ,&nbsp;Shyamal Kumar Mukherjee","doi":"10.1016/j.explore.2024.03.003","DOIUrl":"10.1016/j.explore.2024.03.003","url":null,"abstract":"<div><h3>Context</h3><p>Pre-diabetes is a significant public health problem worldwide. India has a very high rate of progression from pre-diabetes to diabetes, 75–78 per thousand persons per year.</p></div><div><h3>Objective</h3><p>To study the efficacy of individualized homeopathic medicinal products (HMPs) against placebos in preventing the progression from pre-diabetes to diabetes.</p></div><div><h3>Design</h3><p>Six-month, double-blind, randomized (1:1), two parallel arms, placebo-controlled trial.</p></div><div><h3>Setting</h3><p>Outpatient departments of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal, India.</p></div><div><h3>Patients</h3><p>Sixty participants with pre-diabetes.</p></div><div><h3>Interventions</h3><p>Verum: HMPs plus yoga therapy (YT; <em>n</em> = 30); control: identical-looking placebos plus YT (<em>n</em> = 30).</p></div><div><h3>Main outcome measures</h3><p>The primary efficacy endpoint was the proportion of participants progressing from pre-diabetes to diabetes, measured after three and six months. Secondary outcomes comprised of fasting blood glucose (FBS), oral glucose tolerance test (OGTT), glycated hemoglobin percentage (HbA1c%), lipid profile, liver enzymes (alanine transaminase, aspartate transaminase), urea and creatinine, and Measure Yourself Medical Outcome Profile version 2 (MYMOP-2); all measured after 3 and 6 months.</p></div><div><h3>Results</h3><p>The proportion of participants converted from pre-diabetics to diabetics (<em>n</em>/<em>N; n</em> = diabetics, <em>N</em> = prediabetics) was significantly less in the verum group than control: HbA1C% (month 3: verum – 2/30 versus control – 11/30, <em>p</em> = 0.003; month 6: 3/30 vs. 2/30, <em>p</em> = 0.008), OGTT (month 3: 0/30 vs. 8/30, <em>p</em> = 0.015; month 6: 0/30 vs. 1/30, <em>p</em> = 0.008), but not according to FBS (month 3: 1/30 vs. 1/30, <em>p</em> = 0.779; month 6: 1/30 vs. 3/30, <em>p</em> = 0.469). Several secondary outcomes also revealed significant improvements in the verum group than in placebo: HbA1C% (<em>p</em> &lt; 0.001), OGTT (<em>p</em> = 0.001), serum ALT (<em>p</em> = 0.031), creatinine (<em>p</em> = 0.012), and MYMOP-2 profile scores (<em>p</em> &lt; 0.001). <em>Sulphur, Bryonia alba</em>, and <em>Thuja occidentalis</em> were the most frequently indicated medicines. Thus, HMPs outperformed placebos by successfully preventing the progression of pre-diabetes to diabetes.</p></div><div><h3>Trial registration</h3><p>Clinical Trials Registry – India CTRI/2022/04/042,026; UTN: U1111–1277–0021</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of traditional healing practices from Mexico by U. S. women of Mexican origin: A systematic review","authors":"Caroline E. Ortiz,&nbsp;Suzanne C. Smeltzer","doi":"10.1016/j.explore.2024.04.001","DOIUrl":"10.1016/j.explore.2024.04.001","url":null,"abstract":"<div><p>Hispanics are 18.7 % of the U.S. population, and people of Mexican origin are 61.4 % of that Hispanic community. National health surveys indicate that utilization of traditional medicine among Hispanics is low compared to non-Hispanic Whites. However, many researchers have described their use in Hispanic populations as commonplace. Objective: This review analyzed studies about traditional healing practices from Mexico (THPM) used by women of Mexican origin in the U.S. for a greater understanding of traditional health practices within U.S. communities of Mexican origin. Data Sources: Journal databases were searched for studies between January 1, 1990 and December 31, 2020. Study Selection: The Whittemore and Knafl and Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) methods were used to analyze the studies. Data Extraction: Seven themes emerged: A) foundations, B) medical pluralism, C) non-disclosure and patient satisfaction, D) remedies and rituals, E) healers, F) affinity, and G) what clinicians need to know. Four subthemes were identified: G1) cultural sensitivity, G2) communication skills, G3) leveraging the influence of THPM, and G4) scientific inquiry. Data Synthesis: U.S. women of Mexican origin reported continued use of THPM for health promotion, influenced by their understanding of health and illness, community ties, and personal experiences. Study authors recommended strategies for improving patient-provider communication and understanding patients’ use of traditional health and healing practices. Conclusion: Further explorations of THPM are needed to build awareness of culturally-tied health beliefs and behaviors that improve medical care experiences and quality for Hispanics of Mexican origin.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140600204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and testing of a new Tibetan medicine constitutional self-assessment tool","authors":"Samdrup Tsomo (Sanzhi Cuomao),&nbsp;Pakmo Tso (Bomao Cuo),&nbsp;Dondrup Namgyal (Dongzhu Nanjia),&nbsp;Rigzin Gyal (Renzeng Jia),&nbsp;Lumo Tsering (Limao Cairang),&nbsp;Druktse Gyal (Zhouze Jia),&nbsp;Ogyan Kyab (Ruojian Jia),&nbsp;Ngodrup Tso (Yezhi Cuo),&nbsp;Kunchok Gyaltsen (Gongque Jianzan)","doi":"10.1016/j.explore.2024.03.004","DOIUrl":"10.1016/j.explore.2024.03.004","url":null,"abstract":"<div><p>Previous studies have attempted to develop measurement tools for constitutional identification in Traditional Tibetan Medicine (TTM), but they have limitations. We developed a new constitution self-assessment tool that is more firmly grounded in the <em>Gyüzhi</em>, the foundational text of Tibetan Medicine. This new self-assessment tool takes the form of a questionnaire in which the items represent the diagnostic criteria of the three central elemental dynamics of Tibetan medicine (<em>rLung, Tripa, Béken</em>) and are related to the body, psychology, and diet preferences. We tested versions of the new questionnaire in three samples of Tibetan adults (total <em>n</em> = 973) in Qinghai Province and evaluated its validity in 90 respondents randomly selected from the main samples. These respondents completed the questionnaire and were independently evaluated by Tibetan Medicine experts using traditional methods of constitution identification. A comparison of the results led us to revise the original questionnaire. Based on expert advice, we combined similar and overlapping items to simplify and improve the scale. Cronbach's alpha was used to assess internal consistency and indicated that the final scale is reliable. There was 80–93 % agreement between experts’ identifications and self-assessment responses in the survey when both types of data were available. The Traditional Tibetan Medicine (TTM) constitution scale developed in this paper has a strong basis in theory and TTM practice. It can be used by Tibetan medical practitioners, other health care providers, researchers, and the lay public to identify individual constitution and help determine appropriate treatment.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1550830724000594/pdfft?md5=5a9ccbecffd5674a221e955ef82b1e93&pid=1-s2.0-S1550830724000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bee venom acupuncture and herbal medicine for hand eczema: Two case reports and an in vivo study","authors":"Soobin Jang ,&nbsp;Hyo In Kim ,&nbsp;Jae Woo Jung ,&nbsp;Mina Boo ,&nbsp;Soo-Hyun Sung ,&nbsp;Jinbong Park ,&nbsp;Sungha Kim","doi":"10.1016/j.explore.2024.03.002","DOIUrl":"10.1016/j.explore.2024.03.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Eczema and contact dermatitis are relatively common, non-life-threatening disease, but can reduce the patient's quality-of-life when it becomes chronic. This study describes two cases of bee venom acupuncture (BVA) and herbal medicine (San Wu Huangqin decoction; SWH) co-treatment for hand eczema and contact dermatitis, then confirms the effect of the combination therapy in an in vivo model of eczema.</p></div><div><h3>Case presentation</h3><p>A 56-year-old female (case 1) and a 33-year-old male (case 2) presented to the clinic with symptoms of itching and erythema (case 1), and scaliness (case 2) on both hands. Both were diagnosed with hand eczema and contact dermatitis based on examination of the erythema and scaliness. They were treated with BVA and SWH for three months. The lesions were healed and had not recurred after 1 and 3 years of follow-up. A mouse study was conducted by repeated application of 2,4-dinitrochlorobenzene (DNCB) to induce eczema-like contact dermatitis in Balb/c mice. In a DNCB-induced eczema-like contact dermatitis model, BVA and SWH co-administration synergistically improved clinical symptoms seen in eczema. Also, they improved histological changes of the skin, suppressed immune cell infiltration, and decreased inflammatory cytokines and immunoglobulin E in the serum.</p></div><div><h3>Conclusion</h3><p>This study suggests BVA and SWH could be an alternative treatment for eczema and contact dermatitis.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1550830724000570/pdfft?md5=312f4d2e4f2b0b6e8252d9a1c6184943&pid=1-s2.0-S1550830724000570-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140276881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of reiki application on menopausal symptoms","authors":"Fatma Hikmet Yeşil ,&nbsp;Diğdem Lafcı Bakar","doi":"10.1016/j.explore.2024.03.001","DOIUrl":"10.1016/j.explore.2024.03.001","url":null,"abstract":"<div><h3>Objective</h3><p>The present study was conducted in order to determine the effects of Reiki on the menopausal symptoms of women.</p></div><div><h3>Methods</h3><p>This study having a randomized controlled experimental design was carried out involving 48 individuals (24 in Reiki, 24 in control). Study data were collected between November 2018 and February 2019 by using a personal information form, The Menopause Rating Scale.</p></div><div><h3>Results</h3><p>The mean menopausal symptoms score of women decreased after Reiki intervention and the difference was found to be statistically significant (<em>p</em> &lt; 0.05). Reiki reduced the menopausal symptoms levels of women having menopause.</p></div><div><h3>Conclusion</h3><p>It has been found that distant Reiki application is effective in reducing somatic, psychological and urogenital complaints in women during menopause.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial","authors":"Maryam Delfan ,&nbsp;Parastou Kordestani-Moghaddam ,&nbsp;Mohammad Gholami ,&nbsp;Khadije Kazemi ,&nbsp;Rasool Mohammadi","doi":"10.1016/j.explore.2024.02.008","DOIUrl":"10.1016/j.explore.2024.02.008","url":null,"abstract":"<div><h3>Introduction</h3><p>Mild cognitive impairment is the middle level of natural cognitive impairment during primary steps of dementia. There are a few studies about improving the cognitive performance and sleep quality in patients with a limited dementia. So, this study was conducted to evaluate the effects of <em>Bacopa monnieri</em> on cognitive performance and sleep quality of patients with mild cognitive impairment.</p></div><div><h3>Materials and methods</h3><p>In this study, 62 patients with mild cognitive impairment were categorized into two groups of control and intervention. The intervention group received one pill of 160 mg <em>Bacopa monnieri</em> extract in 2 months, and the control group received a pill containing starch powder. The cognitive impairment and sleep quality was assessed using a questionnaire containing demographic information, Montreal Cognitive Assessment, and the Pittsburg Sleep Quality Index in three time-points of before the study, one months after the intervention and 2 months after the intervention (the end of study).</p></div><div><h3>Results</h3><p>The results showed no statistically significant difference between two groups in all three time-points in overall cognitive performance score and its 6 parameters (<em>P</em> &gt; 0.05). While in the field of attention at the end of the first month (<em>P</em> = 0.033) and the end of the second month (<em>P</em> = 0.004), it was significant difference between the study groups. Also, in the field of verbal fluency at the end of the second month, this difference was significant (<em>P</em> = 0.003). The cognitive performance overall score showed no significant difference between two groups in first (<em>P</em> = 0.939) and second time-points (<em>P</em> = 0.661), although it was significant at third time-point (<em>P</em> = 0.029). There was no statistically significant difference between two groups in all time-points for sleep quality overall score (<em>P</em> &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>The results showed that <em>Bacopa monnieri</em> can improve the cognitive performance overall score and some of its parameters, but it had no effect on sleep quality.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140046993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}