Explore-The Journal of Science and Healing最新文献

{"title":"Herbal prescription Siryeongtang and acupuncture treatment for gait disturbance due to idiopathic normal pressure hydrocephalus: A case report.","authors":"Moon-Young Ki, Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon","doi":"10.1016/j.explore.2024.103097","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103097","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic normal-pressure hydrocephalus (iNPH), characterized by unexplained normal-pressure hydrocephalus, primarily presents with symptoms such as gait disturbances, cognitive impairment, and urinary incontinence. Currently, cerebrospinal fluid (CSF) drainage via shunting is the only effective treatment for iNPH.</p><p><strong>Case presentation: </strong>A 56-year-old Asian woman visited our hospital with a worsening gait disturbance and a history of recurrent falls over the past 2 years. She was diagnosed with iNPH using brain computed tomography. Notably, her gait disturbances continued to worsen despite undergoing a ventriculoperitoneal (VP) shunt. The patient was prescribed the herbal medicine Siryeongtang along with acupuncture and electroacupuncture. Subsequently, the changes in gait balance and speed were objectively assessed during the treatment period using the WIN-TRACK evaluation tool. The symmetry index for step length improved after 42 days of treatment, reaching 111 %, 71 %, and 37 % on days 15, 24, and 42, respectively. The symmetry index for step speed also decreased from 77 % on day 15 to 5 % on day 42. In addition, the time required to walk 5 m was reduced to 13, 10, and 9 s on days 15, 24, and 42, respectively.</p><p><strong>Conclusions: </strong>Treatment with Korean medicine improved gait balance and speed in a patient with iINPH whose symptoms did not improve following shunt surgery.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"103097"},"PeriodicalIF":1.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study.","authors":"Anuradha Majumdar, Mungara Anjaneya Venkata Vara Prasad, Satish Reddy Gandavarapu, Kalakata Sudhir Kumar Reddy, Varun Sureja, Dharmeshkumar Kheni, Vishal Dubey","doi":"10.1016/j.explore.2024.103099","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103099","url":null,"abstract":"<p><strong>Background and aim: </strong>Chronic lower back pain (CLBP) is a major condition that leads to disability and reduced quality of life (QoL). This randomised, double-blind, placebo-controlled clinical study evaluated the efficacy and safety of a novel Boswellia serrata and Curcuma longa combination (CL20192) for the treatment of CLBP.</p><p><strong>Material and methods: </strong>Participants with CLBP were randomised to receive either a 300 mg CL20192 capsule (n = 45) or placebo capsule (n = 45) once daily for 90 days. Efficacy was evaluated using the Descriptor Differential Scale and Oswestry Disability Index scores for pain, unpleasantness, and disability. Additionally, the 36-item short form questionnaire was used for QoL evaluation. Frequency of painkiller use, serum levels of inflammatory biomarkers (tumour necrosis factor-α, interleukin-6, and high-sensitivity C-reactive protein), and phytoconstituents (total boswellic acids and curcuminoids) were determined. Therapy satisfaction was assessed using the Physician and Patient Global Assessment Scales.</p><p><strong>Results: </strong>All randomised participants completed the study. CL20192 supplementation significantly reduced Descriptor Differential Scale pain, unpleasantness, and Oswestry Disability Index scores compared with the placebo group (p < 0.001 for all parameters). Critical QoL scores greatly improved in the CL20192 group. Serum phytoconstituent levels were elevated in the CL20192-treated group. This group demonstrated a significant reduction in inflammatory biomarker levels (tumour necrosis factor-α, interleukin-6, and high-sensitivity C-reactive protein), confirming efficacy in abating CLBP compared with the placebo. Moreover, therapy satisfaction scores were significantly high in the CL20192-treated group, and intervention with CL20192 was well tolerated.</p><p><strong>Conclusion: </strong>Intervention with 300 mg CL20192 capsules, containing a novel combination of Boswellia serrata and Curcuma longa extracts, effectively alleviated pain, unpleasantness, and disability in patients with CLBP compared with the placebo. This outcome was consistent with a decrease in serum inflammatory markers and improved therapy assessment scores.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"103099"},"PeriodicalIF":1.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intentionally-treated water on cell migration of human glioblastoma cells.","authors":"Chang-Tze Ricky Yu, Dean I Radin, Chen-Yu Chu, Yung-Jong Shiah","doi":"10.1016/j.explore.2024.103100","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103100","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated if human glioblastoma cancer cells (U87MG cell line) cultured in intentionally treated water could reduce cell migration, a prerequisite for metastasis, as compared to the same cells cultured in untreated (control) water.</p><p><strong>Design: </strong>Three Buddhist monks entered a meditative state and directed their awareness to bottles of ultrapure water while holding the intention that the water would cause beneficial changes in U87MG. The study was conducted double-blind whereby all aspects of the study involving cell growth and migration measures, as well as all subsequent statistical evaluations, were performed without knowledge of the type of water being used. Cell cultures were incubated in growth mediums prepared with treated and untreated water, and a wound healing assay was employed to measure cell migration.</p><p><strong>Results: </strong>U87MG cells incubated with treated water migrated less efficiently than the same cells in untreated water. A repeated measures ANOVA, spanning four time periods (0, 3, 6, and 9 h), determined that the time × water condition interaction was associated with p < 0.005.</p><p><strong>Conclusion: </strong>Intentioned awareness appeared to change as-yet unknown properties of ultrapure water, resulting in a reduction of U87MG cells migration activity. Further research is warranted to replicate these results and to investigate the underlying protein expression mechanisms in influencing cell migration.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"103100"},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving cupping therapy combined with acupoint bloodletting for plaque psoriasis: A case report.","authors":"Xia Qiao, Chunyan Yang, Wenxin Yang, Yan Li","doi":"10.1016/j.explore.2024.103098","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103098","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic inflammatory skin disease that can present in various phenotypes, with the most common form being plaque psoriasis. Currently, no type of psoriasis can be cured, and existing treatment options are associated with certain safety concerns. In recent years, traditional Chinese medicine has achieved great results in treating psoriasis. Cupping therapy is a widely used method in China. In this case, the combination of moving cupping therapy and acupoint bloodletting has demonstrated a favorable therapeutic effect on plaque psoriasis.</p><p><strong>Case presentation: </strong>A 35-year-old male diagnosed with plaque psoriasis for 20 years, presented with generalized itchy, erythematous, and scaly skin. The patient underwent moving cupping therapy combined with acupoint bloodletting once every other day, three times per week, for a total duration of 8 weeks. After treatment, the erythema, plaques, and scales on the patient's entire body had mostly resolved. The Psoriasis Area and Severity Index (PASI) score decreased from 50 to 5, the Body Surface Area (BSA) improved from 60 % to 4 %, and the Dermatology Life Quality Index (DLQI) decreased from 17 to 2 points. No relapse was observed during the 6-month follow-up.</p><p><strong>Conclusion: </strong>This case demonstrates that moving cupping therapy combined with acupoint bloodletting is well tolerated and effective in relieving skin lesion symptoms and improving the quality of life in patients with plaque psoriasis. As a cost-effective adjunctive therapy, moving cupping therapy combined with acupoint bloodletting holds promise as a non-pharmacological treatment option for plaque psoriasis.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"103098"},"PeriodicalIF":1.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You….. And Me…..and a Cup of Tea: Eight insights we've gleaned from enlightened masters.","authors":"Jeb Barton, Marjorie Woollacott","doi":"10.1016/j.explore.2024.103096","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103096","url":null,"abstract":"<p><p>This Reflection piece offers eight insights that have been gleaned from enlightened masters related to the nature of consciousness, awareness and experience. These insights are elucidated in ways that can help in the evaluation of the usefulness of our values and beliefs, and how these dictate the way we respond to our life experiences. In this way the essay points to the importance of cultivating and refining one's own awareness because it is the level of our awareness that controls the flow of creativity and experience, both into and out of our lives.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"103096"},"PeriodicalIF":1.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective treatment of non-union after internal fixation of femoral neck fracture using integrated traditional Chinese and western medicine.","authors":"Xianzhe Zhang, Xiaoming Du, Jie Xiang, Qifa Shu, Haoyun Huang, Yi Guo, Tao Wang, Yimei Hu, Junzhi He","doi":"10.1016/j.explore.2024.103095","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103095","url":null,"abstract":"<p><strong>Background: </strong>Hip fractures, particularly femoral neck and intertrochanteric fractures, represent approximately 6.37 % of all fractures, with incidence rates showing an upward trend annually.</p><p><strong>Case presentation: </strong>This report presents a case of a 55-year-old female with a femoral neck fracture who underwent internal fixation. One-year post-surgery, the patient continued to experience hip pain, and computed tomography (CT) scans revealed non-union of the fracture. The patient received an integrated treatment approach combining traditional Chinese and Western medicine, involving the alternating administration of osteopeptide tablets and Guijia Jiangu capsules, a proprietary herbal formulation. No additional pharmacological or surgical interventions were employed. Seven months after initiating the treatment, digital radiography (DR) examinations showed that the fracture had largely healed. At the seven-month follow-up, and nearly four years thereafter, the patient reported no discomfort in the hip region. Subsequent DR examinations revealed no signs of avascular necrosis of the femoral head, and no adverse events were noted. The internal fixation device was removed five years post-fracture.</p><p><strong>Conclusion: </strong>The results indicate that integrated traditional Chinese and Western medicine may effectively treat non-union after internal fixation of femoral neck fractures, though further studies are warranted to confirm these outcomes.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"103095"},"PeriodicalIF":1.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic effect of two different massages on the sleep quality of orthopedic surgery patients: A randomized controlled study","authors":"Morteza Hojat Ansari ,&nbsp;Seyedeh Zahra Aemmi ,&nbsp;Abbas Farhadi Faruji ,&nbsp;Habibollah Esmaily","doi":"10.1016/j.explore.2024.103084","DOIUrl":"10.1016/j.explore.2024.103084","url":null,"abstract":"<div><h3>Objective</h3><div>Poor sleep quality due to pain, anxiety, and other surgical complications is a common challenge in postoperative patients. The present study aims to investigate the effect of postoperative slow-stroke back and hot stone massage therapy on the sleep quality of orthopedic surgery patients.</div></div><div><h3>Methods</h3><div>This randomized and controlled clinical trial was conducted on 99 patients in the postoperative period of orthopedic surgery. The participants were randomly distributed into three groups (slow-stroke back massage, hot stone massage, and routine care). On the first or second day after the surgery, one group received a slow-stroke back massage, and another received a hot stone massage in the morning and afternoon for 10-15 minutes. Demographic surveys and the Richard-Campbell Sleep Questionnaire (RCSQ) were used for data collection. Chi-square, Kruskal-Wallis, and Wilcoxon tests were used for analysis, and the desired significance level was considered &lt; 0.05.</div></div><div><h3>Results</h3><div>There was a significant improvement in sleep quality scores of patients in the slow-stroke back or hot stone massage groups compared with the routine care group (p &lt; 0.001) and also before intervention (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The results suggest that slow-stroke back and hot stone massages can improve sleep quality in patients with orthopedic surgery in the postoperative period.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103084"},"PeriodicalIF":1.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Rosa damascena extract capsule on the sexual function of menopausal women: A randomized clinical trial","authors":"Zohreh Gholinezhad ,&nbsp;Fatemeh Zahra Karimi ,&nbsp;Hassan Rakhshandeh ,&nbsp;Seyed Reza Mazloum","doi":"10.1016/j.explore.2024.103082","DOIUrl":"10.1016/j.explore.2024.103082","url":null,"abstract":"<div><h3>Objective</h3><div>Although the prevalence of sexual dysfunction is high in menopausal women and it can cause many problems for them, it has been largely overlooked. The present study aimed to determine the effect of <em>Rosa damascena</em> extract capsules on the sexual function of menopausal women.</div></div><div><h3>Materials and methods</h3><div>This randomized, triple blinded clinical trial was conducted on 82 menopausal women who were randomly divided into two groups. In the intervention group, women took a capsule of <em>Rosa damascena</em> extract every 12 h for 8 weeks, while women in the placebo group took similar capsules without medicinal effects. The Female Sexual Function Index (FSFI) was evaluated before and after the intervention (4 and 8 weeks). The data were analyzed by SPSS software and statistical tests such as independent <em>t</em>-test, Mann‒Whitney U test, and Chi-square, with a significance level of 0.05.</div></div><div><h3>Results</h3><div>The use of <em>Rosa damascena</em> extract capsules significantly improved the total FSFI score four (<em>P</em> = 0.016) and eight weeks after the intervention (<em>P</em> &lt; 0.001). The positive changes in FSFI domains in the intervention group were as follows: arousal, lubrication, satisfaction, and pain during intercourse four and eight weeks after the intervention. Additionally, desire and orgasm significantly increased eight weeks after the intervention (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The results of this study indicate that <em>Rosa damascena</em> can improve sexual function in menopausal women. However, further studies are needed.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103082"},"PeriodicalIF":1.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of aromatherapy with sweet orange oil (Citrus sinensis L.) in relieving pain and anxiety during labor","authors":"Jessica C. Nascimento ,&nbsp;Vitória S. dos S. Gonçalves ,&nbsp;Bruna R.S. Souza ,&nbsp;Laranda de C. Nascimento ,&nbsp;Betina M.R. de Carvalho ,&nbsp;Paulo C.L. Nogueira ,&nbsp;José P.S. Santos ,&nbsp;Lysandro P. Borges ,&nbsp;Tiago C. Goes ,&nbsp;Jessiane Bispo de Souza ,&nbsp;Henrique D.M. Coutinho ,&nbsp;Adriana G. Guimarães","doi":"10.1016/j.explore.2024.103081","DOIUrl":"10.1016/j.explore.2024.103081","url":null,"abstract":"<div><h3>Introduction</h3><div>Need to improve the quality of vaginal birth in a humanized and non-invasive way, contributing to pain and anxiety during labor. Integrative and complementary practices, such as aromatherapy, have been an important tool for managing natural birth. To evaluate the effects of Citrus sinensis L. aroma on pain and anxiety during labor.</div></div><div><h3>Methods</h3><div>Single-blind randomized clinical trial with pregnant women was performed in a city of Brazilian northwest. The pregnant women were divided (n=42/group) into an experimental group (inhalation of 250 μL of <em>C. sinensis</em> essential oil) and a placebo group (250 μL of distilled water), and submitted to the evaluation of pain intensity through Visual Analogic Scale, anxiety (STAI-E), physiological parameters, as well as fetal heart rate.</div></div><div><h3>Results</h3><div>Aromatherapy significantly reduced pain intensity over time (p=0.0411), especially for pregnant women in stage 1 dilatation and primiparous (p=0.0022). In addition, essential oil inhalation also reduced anxiety (p&lt;0.0001), showing significant positive correlations (r=0.3147; p=0.3129) with pain intensity. Exposure to the aroma of sweet orange also reduced mean blood pressure, heart rate, respiratory rate of pregnant women and fetal heart rate (p&lt;0.0001).</div></div><div><h3>Discussion</h3><div>The active compounds present in the essential oil used, especially limonene, are capable of modulating neurotransmission systems associated with pain and anxiety, being effective in reducing these symptoms during labor.</div></div><div><h3>Conclusion</h3><div>It was shown that <em>C. sinensis</em> essential oil reduces pain and anxiety during labor, indicating the potential of this type of intervention and its possible applicability in good labor practices.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103081"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials","authors":"Zhao Peng,&nbsp;Duo Li,&nbsp;Na Wu,&nbsp;Xiao-Yuan Wang,&nbsp;Gai-Xia Sun,&nbsp;Hui-Bin Gao,&nbsp;Hai-Xia Li","doi":"10.1016/j.explore.2024.103083","DOIUrl":"10.1016/j.explore.2024.103083","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to systematically evaluate the safety and efficacy of curcumin as an adjunctive treatment for patients with ulcerative colitis (UC) and to assess the methodological quality of the published studies.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase, and CENTRAL databases for randomized controlled trials published up to August 18, 2023. Two independent reviewers screened studies based on predefined criteria. Meta-analysis was performed using a random-effects model with RevMan 5.4. Heterogeneity was assessed using Cochran's Q test and I² statistic.</div></div><div><h3>Results</h3><div>Eight randomized controlled trials involving 482 patients were included. Seven studies reported clinical remission, and three reported endoscopic remission. Compared to the placebo group, adjunctive curcumin therapy significantly improved clinical remission (RR=2.33, 95 % CI: 1.25 to 4.34; <em>P</em> = 0.008; I²=80 %). Although endoscopic remission showed an increasing trend, it was not statistically significant (RR=4.17, 95 % CI: 0.63 to 27.71; <em>P</em> = 0.14; I²=80 %). Significant improvements were also observed in clinical improvement (RR=1.93, 95 % CI: 1.10 to 3.36; <em>P</em> = 0.02; I²=56 %) and endoscopic improvement (RR=1.76, 95 % CI: 1.12 to 2.77; <em>P</em> = 0.01; I²=62 %) in the curcumin group. No serious adverse events were reported. Subgroup analysis indicated a positive correlation between treatment efficacy and dosage, with no significant impact of administration method or follow-up duration on the pooled results or heterogeneity.</div></div><div><h3>Conclusion</h3><div>Curcumin as an adjunctive treatment shows promise in improving clinical and endoscopic outcomes in UC patients without significant adverse effects. However, due to the limited number of studies and substantial heterogeneity, further large-scale randomized controlled trials are necessary to confirm these findings.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103083"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}