Explore-The Journal of Science and Healing最新文献

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Scholarly Appraisal of“Improving cognitive function in older adults through mind-body qigong exercise at senior daycare centers: the role of sleep as a moderator and mediator” “在老年日托中心通过身心气功锻炼改善老年人认知功能:睡眠在调节和调节中的作用”的学术评价
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-06-17 DOI: 10.1016/j.explore.2025.103197
Parth Aphale , Himanshu Shekhar , Shashank Dokania
{"title":"Scholarly Appraisal of“Improving cognitive function in older adults through mind-body qigong exercise at senior daycare centers: the role of sleep as a moderator and mediator”","authors":"Parth Aphale , Himanshu Shekhar , Shashank Dokania","doi":"10.1016/j.explore.2025.103197","DOIUrl":"10.1016/j.explore.2025.103197","url":null,"abstract":"","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103197"},"PeriodicalIF":1.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out of body experiences: Scoping review 灵魂出窍:范围审查
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-06-04 DOI: 10.1016/j.explore.2025.103196
Jenny Moix , Samantha Baldaccini , Marta Isern
{"title":"Out of body experiences: Scoping review","authors":"Jenny Moix ,&nbsp;Samantha Baldaccini ,&nbsp;Marta Isern","doi":"10.1016/j.explore.2025.103196","DOIUrl":"10.1016/j.explore.2025.103196","url":null,"abstract":"<div><h3>Background</h3><div>Despite the growing body of scientific research on Out of Body Experiences (OBEs), a scoping review has not yet been conducted.</div></div><div><h3>Method</h3><div>A search was conducted across six databases. Studies published between 1987 and 2024 were included, resulting in the selection of 87 publications. The analyzed factors included deliberate inducing, predisposing, precipitating, consequential, phenomenological, and physiological factors.</div></div><div><h3>Results</h3><div>OBEs can occur spontaneously, be self-induced, or induced through different methods. Experiences such as sleep paralysis, or lucid dreaming can facilitate OBEs. They can be triggered in various situations. The reactions to OBEs vary widely: some individuals fear their recurrence, while others welcome these experiences. OBEs are highly idiosyncratic, often accompanied by a strong sense of reality. Explanatory hypotheses for the nature of OBEs include psychological, physiological, and non-local consciousness perspectives.</div></div><div><h3>Conclusions</h3><div>OBEs are a complex phenomenon that requires further understanding to normalize and expand the current conception of consciousness.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103196"},"PeriodicalIF":1.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of laughter yoga in reducing postpartum depression symptoms: A randomized controlled study 笑声瑜伽减少产后抑郁症状的有效性:一项随机对照研究
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-06-02 DOI: 10.1016/j.explore.2025.103195
Hacer Unver Koca , Didem Simsek Kucukkelepce , Osman Kucukkelepce , Aysegul Kocyigit
{"title":"Effectiveness of laughter yoga in reducing postpartum depression symptoms: A randomized controlled study","authors":"Hacer Unver Koca ,&nbsp;Didem Simsek Kucukkelepce ,&nbsp;Osman Kucukkelepce ,&nbsp;Aysegul Kocyigit","doi":"10.1016/j.explore.2025.103195","DOIUrl":"10.1016/j.explore.2025.103195","url":null,"abstract":"<div><h3>Aim</h3><div>We aimed to evaluate the positive effects of laughter yoga on many diseases and postpartum depression.</div></div><div><h3>Method</h3><div>The study was randomized and controlled with a pretest-posttest control group and was conducted with 104 women. Data were collected with an introductory information form and Edinburgh Postpartum Depression Scale.</div></div><div><h3>Results</h3><div>It was determined that Laughter Yoga (LY) significantly reduced postpartum depression symptoms (t <sub>(102)</sub> =-14.007; p=0.000&lt;0,05).</div></div><div><h3>Conclusion</h3><div>Laughter Yoga has been found effective in alleviating depression symptoms among postpartum women following six sessions of application. Given the sensitivity of the postpartum period and women's reluctance to use medications due to concerns about their newborns, it is advisable to promote the adoption of LY and similar alternative medicine practices.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103195"},"PeriodicalIF":1.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Floating needle therapy for the treatment of ureteral calculi: A case report 浮针疗法治疗输尿管结石1例
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-26 DOI: 10.1016/j.explore.2025.103194
Kun Xue , Kuian Qu
{"title":"Floating needle therapy for the treatment of ureteral calculi: A case report","authors":"Kun Xue ,&nbsp;Kuian Qu","doi":"10.1016/j.explore.2025.103194","DOIUrl":"10.1016/j.explore.2025.103194","url":null,"abstract":"<div><h3>Background</h3><div>Ureteral calculi are a prevalent urological disorder typically managed by surgery or pharmacotherapy, which are associated with risks and patient anxiety. Floating Needle Therapy (FNT), a minimally invasive technique targeting subcutaneous connective tissue, has shown efficacy in pain management and muscle-related conditions. This case report describes the first documented use of FNT for treating a distal ureteral calculus, exploring its potential to facilitate stone passage through myofascial relaxation and improved local circulation.</div></div><div><h3>Methods</h3><div>A 53-year-old male with right distal ureteral lithiasis (5 × 2 mm) and mucosal edema presented with severe abdominal pain (VAS score 8) and hematuria. Declining surgery, he received FNT targeting myofascial trigger points in the rectus abdominis, oblique, adductor longus, gracilis, and iliocostalis muscles. A 3.5-cm Fu’s needle was inserted subcutaneously, followed by horizontal sweeping manipulation for 5 min daily for three days.</div></div><div><h3>Results</h3><div>After the first session, pain reduced to VAS 3, and hematuria resolved. The second session led to complete pain resolution and spontaneous stone passage overnight. Follow-up ultrasounds confirmed no residual calculus, with no recurrence at 1-month follow-up.</div></div><div><h3>Conclusions</h3><div>This case suggests FNT may promote ureteral stone passage by relieving myofascial tension, enhancing microcirculation, and reducing edema. While these findings are promising, large-scale randomized controlled trials are needed to validate its efficacy across diverse patient populations and stone characteristics.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103194"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of acupressure and acupuncture on sleep quality in cancer patients with insomnia: A systematic review and meta-analysis 穴位按压和针刺对癌症失眠患者睡眠质量的影响:系统回顾和荟萃分析
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-23 DOI: 10.1016/j.explore.2025.103192
Yasamin Khosravaninezhad , Reza Moshfeghinia , Leila Liaghat , Hamid Ghazipoor , Yasamin Kaheni , Amin Javidan , Yeganeh Mirzaee , Adib Azadmehr , Yussef Hashemi , Mehdi Pasalar
{"title":"Effect of acupressure and acupuncture on sleep quality in cancer patients with insomnia: A systematic review and meta-analysis","authors":"Yasamin Khosravaninezhad ,&nbsp;Reza Moshfeghinia ,&nbsp;Leila Liaghat ,&nbsp;Hamid Ghazipoor ,&nbsp;Yasamin Kaheni ,&nbsp;Amin Javidan ,&nbsp;Yeganeh Mirzaee ,&nbsp;Adib Azadmehr ,&nbsp;Yussef Hashemi ,&nbsp;Mehdi Pasalar","doi":"10.1016/j.explore.2025.103192","DOIUrl":"10.1016/j.explore.2025.103192","url":null,"abstract":"<div><h3>Introduction</h3><div>Cancer patients frequently experience insomnia, adversely affecting their quality of life. This study aimed to systematically review and analyse the effectiveness and safety of acupressure and acupuncture in improving sleep quality among cancer patients suffering from insomnia, providing evidence for non-pharmacological treatment options.</div></div><div><h3>Methods</h3><div>Several digital databases (Scopus, PubMed, Embase, Web of Science, Medline, Cochrane library, PsycINFO, CINAHL complete, and Google Scholar) were examined for English-language records. Inclusion criteria involved randomized controlled trials assessing the impact of acupressure or acupuncture on cancer patients with insomnia. The Cochrane Collaboration's instrument was employed to evaluate the quality of the encompassed studies. For meta-analysis, a model that accounts for variability among studies was favoured, and statistical analysis was conducted using Stata software version 17.</div></div><div><h3>Results</h3><div>This review analysed 13 randomized controlled trials involving 806 cancer patients. The analysis indicated that sleep quality didn’t differ significantly between treatment and control groups. However, sleep efficacy was significantly higher in the treatment group (SMD [95 % CI] = 0.43 [0.21, 0.65]). Additionally, total sleep time showed a significantly higher extent in the treatment group (SMD [95 % CI] = 0.58 [0.24, 0.92]). No significant differences were found for depression or sleep onset latency between groups, while anxiety levels were lower in the treatment group (SMD [95 % CI] = -0.52 [-0.90, -0.15]).</div></div><div><h3>Conclusion</h3><div>The review suggests that acupressure and acupuncture enhance sleep quality in cancer patients suffering from insomnia, showing notable benefits during follow-up, especially among Asian participants.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103192"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of acupressure applied to hemodialysis patients on fatigue: a systematic review and meta-analysis 穴位按压对血液透析患者疲劳的影响:系统回顾和荟萃分析
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-21 DOI: 10.1016/j.explore.2025.103193
Derya Tülüce , Zehra Bayram , Songül Karadağ
{"title":"Effect of acupressure applied to hemodialysis patients on fatigue: a systematic review and meta-analysis","authors":"Derya Tülüce ,&nbsp;Zehra Bayram ,&nbsp;Songül Karadağ","doi":"10.1016/j.explore.2025.103193","DOIUrl":"10.1016/j.explore.2025.103193","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the effect of acupressure application to hemodialysis patients on fatigue and to provide guidance to future studies.</div></div><div><h3>Methods</h3><div>Between 2004 and May 2022, the PubMed, EBSCO (Medline, CINAHL), EMBASE (OVID) Web of Science, Türkiye Clinics (Turkey citation index), and TR Index were searched considering the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. It included randomized and non-randomized controlled trials. It also covered meta-analysis-related studies in Turkish and English and evaluated them based on the Joanna Briggs Institute checklist. The study used ('hemodialysis' OR 'dialysis' OR 'renal dialysis') AND ('fatigue' OR 'tiredness' OR 'weariness' OR 'exhaustion') AND ('acupressure') as the keywords and utilized RewMan5 and CMA programs for analysis. Heterogeneity was expressed through I<sup>2</sup> and Q statistics. Random effect model was used, and Kendall’s Tau were used for publication bias.</div></div><div><h3>Results</h3><div>The meta-analysis that covered five (5) research articles published between 2004 and 2022 consisted of 475 study samples (intervention: control: placebo). Two independent researchers evaluated the full texts of these articles for quality purposes. Considering the hemodialysis patients, there was no significant difference between their average scores in studies that utilized the fatigue VAS scale (<em>Z</em> = 1.28; 95 % CI = –1.69, 0.36; <em>p</em> = 0.20), whereas there was a positive change in average PFS scores of the acupressure applied group in studies that performed the Piper Fatigue Scale (PFS) (<em>Z</em> = 3.58; 95 % CI = –1.15, –0.34; <em>p</em> = 0.0003).</div></div><div><h3>Conclusion</h3><div>The systematic review and meta-analysis concluded that the acupressure applied to hemodialysis patients revealed an effective outcome on fatigue.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103193"},"PeriodicalIF":1.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auricular acupressure for chemotherapy-related insomnia in cancer patients: A systematic review and meta-analysis 耳穴按压治疗癌症患者化疗相关失眠:系统回顾和荟萃分析
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-19 DOI: 10.1016/j.explore.2025.103188
Chunping Zhang , Yiwen Zhang , Tongyun Li , Chuanzhu Yan , Hong Guan
{"title":"Auricular acupressure for chemotherapy-related insomnia in cancer patients: A systematic review and meta-analysis","authors":"Chunping Zhang ,&nbsp;Yiwen Zhang ,&nbsp;Tongyun Li ,&nbsp;Chuanzhu Yan ,&nbsp;Hong Guan","doi":"10.1016/j.explore.2025.103188","DOIUrl":"10.1016/j.explore.2025.103188","url":null,"abstract":"<div><h3>Background</h3><div>Cancer patients undergoing chemotherapy are prone to experiencing sleep disturbances. Research has shown that auricular acupressure may be beneficial in relieving these symptoms, but high-quality evidence is lacking. This study was designed to systematically evaluate the efficacy of auricular acupressure for relieving chemotherapy-related insomnia.</div></div><div><h3>Methods</h3><div>This review was reported in accordance with the PRISMA framework. A total of 4 English databases (PubMed, Embase, Web of Science, The Cochrane Library) and 4 Chinese databases (CNKI, Wanfang, VIP, CBM) were searched from inception to October 31, 2024 to identify randomized clinical trials (RCTs) examining the use of auricular acupressure for the treatment of chemotherapy-related insomnia. The methods recommended by the Cochrane collaboration group were applied to evaluate the quality of the methodology. Cochrane Review Manager 5.4 was used for the meta-analysis.</div></div><div><h3>Results</h3><div>This meta-analysis included 1073 patients from 14 randomized controlled trials. We mainly compared auricular acupressure with routine nursing or sham auricular acupressure. The results showed that auricular acupressure could alleviate chemotherapy-related insomnia(MD<strong>(</strong>PSQI<strong>)</strong>=-3.68, 95 %CI [-4.74,-2.62], <em>P</em> &lt; 0.00001), anxiety(SMD=-1.07, 95 %CI [-1.57,-0.57], <em>P</em> &lt; 0.0001), depression (SMD=-1.14, 95 %CI [-1.78–0.50], <em>P</em> = 0.0005&lt;0.05) and fatigue (SMD = -1.14, 95 % CI [-1.78 to 0.50], <em>P</em> = 0.0005) more effectively than sham auricular acupressure and routine nursing.</div></div><div><h3>Conclusion</h3><div>This meta-analysis found that auricular acupressure can relieve chemotherapy-related insomnia, anxiety, depression and fatigue, and improve the quality of life of patients. However, the current relevant literature has low quality and is highly heterogeneous, which reduces the credibility of the research results. Therefore, more rigorously designed randomized controlled trials are needed to verify these conclusions.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103188"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional Chinese medicine as an alternative therapy for chronic immune thrombocytopenia in children: A case report 中医药作为儿童慢性免疫性血小板减少症的替代疗法:1例报告
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-17 DOI: 10.1016/j.explore.2025.103190
Hsin Tan , Shi-Chen Ou , Tung-Ti Chang
{"title":"Traditional Chinese medicine as an alternative therapy for chronic immune thrombocytopenia in children: A case report","authors":"Hsin Tan ,&nbsp;Shi-Chen Ou ,&nbsp;Tung-Ti Chang","doi":"10.1016/j.explore.2025.103190","DOIUrl":"10.1016/j.explore.2025.103190","url":null,"abstract":"<div><h3>Introduction</h3><div>Treating children with chronic, refractory immune thrombocytopenia (ITP) remains a challenging issue. Conventional treatments, such as glucocorticoids and intravenous immunoglobulin (IVIG), are commonly used; however, some patients exhibit a poor response to these interventions. Throughout the history of traditional Chinese medicine (TCM), numerous texts have documented the use of herbal decoctions to treat hematologic diseases; thereby offering an alternative management strategy for children with chronic ITP.</div></div><div><h3>Case presentation</h3><div>This report describes a 6-year-and-1-month-old girl with chronic ITP who showed limited response to glucocorticoids and IVIG. Following complementary therapy with a traditional Chinese medicine formula, she achieved a sustained platelet response that was maintained within a safe range, averaging 50,000/μL, over the subsequent three years, with no signs of bleeding.</div></div><div><h3>Discussion</h3><div>The pathophysiology of ITP is linked to antiplatelet antibodies and a lack of immune suppression. Scientific studies have shown that TCM formulations, such as Guipi Decoction, Ziyin Jianghou Decoction, and Shengxuexiaoban Capsules, possess immunoregulatory effects that help restore platelet production while exerting anti-inflammatory and hematopoietic properties. For pediatric patients with chronic or refractory ITP, integrative approaches, including TCM, may offer additional therapeutic benefits by enhancing platelet counts.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103190"},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herbal hazards: Unveiling the dark side of unknown botanical remedies 草药危害:揭开未知植物疗法的阴暗面
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-17 DOI: 10.1016/j.explore.2025.103191
Agnelo Lucamba , Ricardo Grillo , Luzolo Filipe , Mariana Aparecida Brozoski
{"title":"Herbal hazards: Unveiling the dark side of unknown botanical remedies","authors":"Agnelo Lucamba ,&nbsp;Ricardo Grillo ,&nbsp;Luzolo Filipe ,&nbsp;Mariana Aparecida Brozoski","doi":"10.1016/j.explore.2025.103191","DOIUrl":"10.1016/j.explore.2025.103191","url":null,"abstract":"<div><h3>Objective</h3><div>In some areas, patients often turn to traditional remedies, including local herbs, due to the lack of medical resources. However, the flora in many regions remains largely uncataloged, posing significant risks due to the unknown properties and potential toxicities of these plants.</div></div><div><h3>Case report</h3><div>The case report presented describes a female patient from Angola who suffered severe facial disfigurement and visual impairment after using <em>filanganga</em> to treat an odontogenic abscess. The herb's corrosive effects underscore the dangers of unverified traditional remedies. This case highlights the critical need for healthcare professionals to be aware of the potential risks associated with unclassified herbs, particularly in regions where traditional medicine is prevalent.</div></div><div><h3>Conclusion</h3><div>The article advocates for comprehensive research to catalog local flora and for public health campaigns to educate patients on the risks of using unverified herbal treatments. The conclusion emphasizes the importance of balancing respect for cultural practices with the need for scientific validation to ensure patient safety.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103191"},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical chamomile oil as a novel therapeutic intervention for diabetic neuropathy: A randomized double-blind controlled clinical trial 局部洋甘菊油作为糖尿病神经病变的一种新的治疗干预:一项随机双盲对照临床试验
IF 1.9 4区 医学
Explore-The Journal of Science and Healing Pub Date : 2025-05-16 DOI: 10.1016/j.explore.2025.103189
Mohammad Amiri , Mohammad Hossein Imani , Amir Hossein Imani , Hanieh Bazrafshan , Mehdi Bazrafshan , Hossein Molavi Vardanjani , Mohammad Ebrahim Zohalinezhad
{"title":"Topical chamomile oil as a novel therapeutic intervention for diabetic neuropathy: A randomized double-blind controlled clinical trial","authors":"Mohammad Amiri ,&nbsp;Mohammad Hossein Imani ,&nbsp;Amir Hossein Imani ,&nbsp;Hanieh Bazrafshan ,&nbsp;Mehdi Bazrafshan ,&nbsp;Hossein Molavi Vardanjani ,&nbsp;Mohammad Ebrahim Zohalinezhad","doi":"10.1016/j.explore.2025.103189","DOIUrl":"10.1016/j.explore.2025.103189","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic neuropathy, a prevalent complication of diabetes mellitus, significantly impairs quality of life due to chronic pain and sensory deficits. Conventional pharmacotherapies, while effective, are often limited by systemic adverse effects. Chamomile (<em>Matricaria chamomilla L</em>.) oil, renowned for its anti-inflammatory, antioxidant, and analgesic properties, presents a promising topical alternative for mitigating neuropathic symptoms.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the efficacy of topical chamomile oil in improving neuropathy indices among patients with controlled diabetes, as measured by validated clinical tools.</div></div><div><h3>Methods</h3><div>A randomized, double-blind, placebo-controlled trial was conducted involving 72 participants with diabetic neuropathy. Participants were allocated to either the intervention group (chamomile oil) or the control group (placebo), with both groups continuing standard gabapentin therapy. Neuropathy outcomes were assessed using Neurothesiometer scores, the Michigan Neuropathy Screening Instrument (MNSI), and the DN4 questionnaire at baseline and post-intervention. ANCOVA was employed to analyze intergroup differences, adjusting for baseline covariates.</div></div><div><h3>Results</h3><div>The chamomile oil group exhibited statistically significant improvements in neuropathy indices compared to the placebo group (<em>p</em> &lt; 0.05). Post-intervention, reductions in Neurothesiometer scores (mean difference: −1.14 ± 0.42), MNSI (−1.89 ± 0.31), and DN4 (−1.97 ± 0.28) were observed in the intervention group, with no comparable changes in controls. ANCOVA confirmed the robustness of these findings (<em>F</em> = 6.72, <em>p</em> = 0.012).</div></div><div><h3>Conclusion</h3><div>Topical chamomile oil significantly alleviates neuropathic symptoms in diabetic patients, offering a safe and adjunctive therapeutic option. Its mechanism may involve modulation of oxidative stress and inflammatory pathways, warranting further investigation into long-term benefits and molecular targets.</div></div><div><h3>Trial registration</h3><div>This trial was registered at the Iranian Registry of Clinical Trials (IRCT), registration number <strong>IRCT20240611062090N1</strong>. The full protocol is available at <span><span>www.irct.ir</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 4","pages":"Article 103189"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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