Eye & Contact Lens-Science and Clinical Practice最新文献

{"title":"Corneal Perforation Two Years After Mitomycin Intravascular Chemoembolization.","authors":"Trakanta Wannapanich, Raven Diacou, Vishal Jhanji","doi":"10.1097/ICL.0000000000001290","DOIUrl":"10.1097/ICL.0000000000001290","url":null,"abstract":"<p><strong>Abstract: </strong>Mitomycin intravascular chemoembolization (MICE) is a potential treatment for corneal neovascularization (NV) with encouraging early outcomes. We describe a case of focal corneal perforation occurring two years after MICE. A 65-year-old man with a history of penetrating keratoplasty performed 30 years earlier underwent MICE for treatment of corneal NV. Two years later, he presented with acute visual decline in the left eye. At presentation, the visual acuity was 20/200 improving to 20/50 with pinhole in the right eye and counting fingers improving to 20/400 in the left eye. Examination revealed a pinpoint Seidel-positive corneal perforation near the graft-host junction, occurring at the same site previously treated with MICE and adjacent to an area of prior corneal NV and lipid deposition. No trauma, infection, or autoimmune disease was identified. After three attempts of corneal gluing failed, a therapeutic corneal patch graft was performed. Postoperatively, the patient was treated with topical moxifloxacin four times daily and topical prednisolone acetate four times daily. The pinhole visual acuity improved to 20/250 with the pinhole. The anterior chamber remained formed and quiet. Although causality cannot be established, this case raises the possibility of delayed stromal weakening after MICE in a structurally vulnerable cornea and highlights the importance of long-term surveillance following this procedure.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"315-317"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premyopia Management in China: From Biometrics to Clinical Management.","authors":"Lizhen Chen, Li Sun, Hiu Ying Leung, Jingfa Zhang, Dennis S C Lam","doi":"10.1097/ICL.0000000000001282","DOIUrl":"10.1097/ICL.0000000000001282","url":null,"abstract":"<p><strong>Abstract: </strong>Myopia represents a major global public health challenge, with prevalence rising particularly among children in China, imposing a substantial socioeconomic burden. Premyopia, defined by the International Myopia Institute as spherical equivalent refraction ≤ +0.75 D and >-0.50 D, represents a pivotal intervention window. This review summarizes evidence on premyopia management in China, including (1) biometric predictors such as hyperopic reserve, axial length (AL), and AL to curvature radius ratio (AL/CR ratio); (2) interventions including outdoor time, optical interventions, low-concentration atropine (LCA), combination therapy of optical intervention and LCA, and repeated low-level red-light therapy; and (3) a risk-stratified clinical management framework integrating biometric parameters for individual interventions. Despite promising results, challenges remain with compliance, safety, and regulatory approval for some treatments. A structured, evidence-based approach combining biometric monitoring and tiered interventions is essential to curb the myopia epidemic in China.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"263-273"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-Month Changes in Accommodation and Vergence in Juvenile Myopes Wearing Multifocal Soft Contact Lenses.","authors":"HuiLing Lin, Stephen J Vincent, Fan Jiang, Yunqing Deng, Lijuan Deng, Jun Jiang","doi":"10.1097/ICL.0000000000001281","DOIUrl":"10.1097/ICL.0000000000001281","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate 6-month changes in accommodation and vergence in juvenile myopes wearing multifocal soft contact lenses (MFSCLs) versus single-vision spectacles (SVLs).</p><p><strong>Methods: </strong>A prospective, matched cohort study was conducted involving 49 myopic children aged 8 to 14 years. Participants were divided into two groups: those fitted with MFSCLs (n=26) and those with SVLs (n=23). Measurements of accommodation (e.g., lag, microfluctuations, facility, relative accommodation) and vergence (e.g., phoria, vergence range, accommodative convergence/accommodation [AC/A] ratio) were taken at baseline, 1, and 6 month.</p><p><strong>Results: </strong>Multifocal soft contact lenses significantly reduced accommodative lag (F=13.75) and increased microfluctuations (F=30.93; both P <0.001) compared with SVLs throughout the study. Initial exophoric shift and decreased AC/A ratio at baseline (both P <0.001) were transient and not sustained at 1- or 6-month follow-ups. Over 6 months, the MFSCLs showed significant changes in accommodative lag, amplitude, facility, phoria, and AC/A ratio (all P <0.05). Notably, accommodative lag, phoria, and AC/A ratio changed from baseline to 1 month, then stabilized with continued wear.</p><p><strong>Conclusions: </strong>These findings demonstrate rapid binocular adaptation to MFSCL in juvenile myopes, with key parameters stabilizing within the first month despite sustained effects on accommodative lag and microfluctuations over 6 months.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry: ChiCTR-OOC-17012103. Registered July 23, 2017, http://www.chictr.org.cn/showproj.aspx?proj=20622 .</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"291-298"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Treatment Zone Decentration With Axial Length Elongation During 2 Years of Orthokeratology Treatment.","authors":"Shuaixi Pan, Yifei Meng, Bohua Jiang, Yuankang Ma, Quan Li, Zhipeng Yan","doi":"10.1097/ICL.0000000000001286","DOIUrl":"10.1097/ICL.0000000000001286","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between treatment zone decentration and axial length elongation in myopic children during 2-year orthokeratology (Ortho-K) treatment.</p><p><strong>Method: </strong>This retrospective study analyzed clinical data from myopic children who underwent Ortho-K treatment. The magnitudes and direction of Ortho-K treatment zone decentration were recorded along with axial length measurement at baseline and 2-year follow-up. Right eye data were collected for statistical analysis.</p><p><strong>Results: </strong>Sixty subjects were enrolled and divided into three groups according to the distance of treatment zone decentration: 12 eyes in the mild (<0.5 mm), 30 eyes in the moderate (0.5-1.0 mm), and 18 eyes in the severe decentration group (>1.0 mm). Axial length elongation was significantly slower in both severe (0.28 ± 0.21 mm) and moderate decentration group (0.36 ± 0.20 mm) compared with that of the mild decentration group (0.55 ± 0.24 mm) at 2-year follow-up ( P < 0.05). Multivariate regression analysis showed that magnitudes of Ortho-K treatment zone decentration were associated with the axial length elongation ( P = 0.013).</p><p><strong>Conclusion: </strong>Greater treatment zone decentration was associated with less axial length elongation. Moderate Ortho-K treatment zone decentration should be optimal choice for safety and efficiency of myopia control in myopic children.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"280-285"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Specific Efficacy of MiSight Dual-Focus Soft Contact Lenses and Orthokeratology Lenses for Myopia Control in Pediatric Patients: A Retrospective Comparative Study.","authors":"Hye Jin Hong, Dong Wook Kim, Hui June Kim, Younghee Kim, Jiwon Jeong","doi":"10.1097/ICL.0000000000001289","DOIUrl":"10.1097/ICL.0000000000001289","url":null,"abstract":"<p><strong>Objectives: </strong>To assess age-specific effectiveness of dual-focus soft contact lenses (MiSight) and orthokeratology (Ortho-K) in slowing myopia progression over 18 months in pediatric patients, emphasizing axial length (AL) changes.</p><p><strong>Methods: </strong>Retrospective analysis of 239 eyes from 123 myopic pediatric patients (aged 8-18 years) (MiSight: 137 eyes; Ortho-K: 102 eyes), stratified by age (younger: ≤10 vs. older: >10 years). Primary outcome was AL elongation measured by IOL Master. Secondary outcomes included spherical equivalent (SE), keratometry, and cylinder power (CYL) through autorefraction. Orthokeratology measurements were taken during treatment without washout, limiting direct refractive comparisons. Linear mixed models were used for intragroup changes, and general linear model adjustment was applied for baseline imbalances in AL and CYL.</p><p><strong>Results: </strong>Despite significant baseline imbalances (MiSight group had longer AL and more myopic SE), GLM-adjusted analysis showed modestly lower overall annualized AL elongation with MiSight (0.20 mm/year) compared with Ortho-K (0.24 mm/year). In older children (older than 10 years), MiSight was associated with lower AL progression, particularly between 6 to 12 months (0.07 vs. 0.11 mm/6-months, P =0.012). In younger children (10 years and younger), adjusted AL elongation rates were comparable between groups. MiSight maintained relatively stable refractive parameters, while Ortho-K induced corneal flattening but progressive worsening of CYL.</p><p><strong>Conclusions: </strong>This age-stratified retrospective comparison demonstrated modestly lower axial elongation with MiSight after adjustment for baseline differences, particularly in older children (older than 10 years). These findings suggest potential age-dependent differences in treatment response between the two modalities and highlight the importance of individualized myopia management strategies.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"299-305"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supervised Machine Learning Models for Ocular Sagittal Height Prediction Incorporating Corneoscleral Profile Data.","authors":"Timoteo González-Cruces, Miriam Carrillo-Pulido, Francisco Javier Aguilar-Salazar, Antonio Cano-Ortiz, Razvan Ionut Ghinea, Sonia Ortiz-Peregrina","doi":"10.1097/ICL.0000000000001277","DOIUrl":"10.1097/ICL.0000000000001277","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop supervised machine learning (ML) models to predict ocular sagittal height (OC-SAG), using anterior eye data derived from topography and tomography.</p><p><strong>Method: </strong>ology: A retrospective cohort of 100 eyes provided data such as keratometry, eccentricity, white-to-white distance, and corneoscleral junction (CSJ) metrics through anterior segment optical coherence tomography (CASIA 2). Four supervised ML models were developed to predict OC-SAG at 10 mm and 14 mm chord lengths, using either topographical data alone or both topographical and tomographical data.</p><p><strong>Results: </strong>The model with the strongest predictive accuracy for the validation sample was the Random Forest, both for the 10-mm chord (r=0.88; MAE=28.16±26.81 μm) and the 14-mm chord (r=0.77; MAE=73.56±61.31 μm; flat corneal meridian, topography-based model). The inclusion of tomographic data, such as measurements related to the CSJ, did not significantly improve the performance of the models compared with using topographic data alone.</p><p><strong>Conclusions: </strong>Adding tomographic predictors did not significantly improve model performance. Despite reduced performance for longer chords, the observed error could be considered clinically acceptable for soft contact lens fitting. The study demonstrated the potential of ML in predicting OC-SAG, providing an accessible estimation method for all clinicians to support decision-making.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"227-236"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Reservoir Characteristics in Established Scleral Lens Wear, Part II: Evaluation of Tear Exchange and Midday Fogging.","authors":"Jennifer Swingle Fogt, Ellen Shorter, Jennifer S Harthan, Cherie Nau, Amy Nau, Muriel Schornack","doi":"10.1097/ICL.0000000000001271","DOIUrl":"10.1097/ICL.0000000000001271","url":null,"abstract":"<p><strong>Objectives: </strong>Tear exchange is less robust with scleral lenses compared to other modalities. This study evaluates tear exchange with scleral lens wear and examines relationships between tear exchange and optical density of the fluid reservoir and patient-reported midday fogging in established scleral lens wearers.</p><p><strong>Methods: </strong>Participants reported if they experienced midday fogging. Tear exchange was evaluated by observing sodium fluorescein uptake into the post-lens fluid reservoir after 10 seconds, and 1, 2.5, and 5 minutes. Optical density of the fluid reservoir was measured using Scheimpflug imaging. Sensitivity, specificity, and negative and positive predictive value (NPV and PPV) of tear exchange as a predictor for fogging were calculated.</p><p><strong>Results: </strong>Tear exchange occurred within 5 minutes in 64% of eyes. The difference in fluid reservoir optical density for eyes with and without tear exchange was greatest when tear exchange occurred within 10 seconds. Tear exchange between 1-5 minutes was not predictive for fogging. Tear exchange occurring within 10 seconds showed low sensitivity and NPV, but high specificity (87%) and PPV (71%) for predicting fogging.</p><p><strong>Conclusion: </strong>Tear exchange occurred in a majority of eyes in this study. Scleral lens wearers with a rapid tear exchange rate were more likely to report midday fogging.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"223-226"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Scleral Contact Lenses Affect Pupillary Light Response in Patients With Keratoconus?","authors":"Büşra Dilara Yıldırım Erdal, Burcu Kazancı","doi":"10.1097/ICL.0000000000001273","DOIUrl":"10.1097/ICL.0000000000001273","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of scleral lenses on ocular aberrations, static and dynamic pupil functions in patients with keratoconus.</p><p><strong>Methods: </strong>Thirty-nine eyes from 31 patients diagnosed with moderate to severe keratoconus. Ocular aberration measurements (Pentacam AXL wave) and pupillometry measurements using automated pupillometry were recorded for all patients, both before and after the wearing of scleral lenses.</p><p><strong>Results: </strong>After the application of scleral lenses, considerable improvements were noted in best-corrected visual acuity (BCVA), lower-order aberration (LOA), higher-order aberration (HOA), vertical coma, horizontal coma, and spherical aberration values in ocular aberration ( P <0.05). In static and dynamic pupillometry, significant decreases were observed in high photopic pupil diameter (PD), low photopic PD, mesopic PD, scotopic PD, contraction velocity, and dilation velocity ( P =0.039, P <0.001, P <0.001, P =0.023, P =0.001, and P =0.016, respectively). The change in BCVA after scleral lenses correlated with the change in LOA, HOA, vertical coma, spherical aberration, low photopic PD, and mesopic PD values ( P <0.05).</p><p><strong>Conclusions: </strong>Scleral lenses cause notable changes in static and dynamic pupil functions. Besides neutralizing LOA and HOA, the decrease in low-photopic and mesopic PD might contribute to improved BCVA and enhanced visual quality after the use of scleral lenses.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"237-244"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Ascorbic Acid for Corneal Endothelial Cell Density Enhancement, Protection, and Recovery in Fuchs Dystrophy After Complicated Cataract Surgery.","authors":"Yu-Lin Chen, Yi-Hsing Chen, Chun-Fu Liu, Yi-Jen Hsueh, Wei-Chi Wu, Yih-Shiou Hwang, Hung-Chi Chen","doi":"10.1097/ICL.0000000000001276","DOIUrl":"10.1097/ICL.0000000000001276","url":null,"abstract":"<p><strong>Abstract: </strong>We report a case highlighting the potential of topical ascorbic acid (AA) as an adjunctive strategy for supporting corneal endothelial stability in Fuchs endothelial corneal dystrophy (FECD) after complicated cataract surgery. A 74-year-old man with bilateral FECD presented with progressive vision loss. Baseline endothelial cell density (ECD) was 1,996 cells/mm2 in the right eye and 1,988 cells/mm2 in the left eye. After 15 months of AA treatment, ECD increased to 3,079 and 3,008 cells/mm2, respectively. The left eye underwent uncomplicated cataract surgery with minimal ECD loss (9.61%). The right eye suffered posterior capsule rupture requiring vitrectomy, causing a 67.08% ECD loss (to 1,036 cells/mm2) and corneal edema. With continued AA treatment for 64 months, the ECD in the right eye improved to 2,080 cells/mm2. Corneal clarity and stability were also clinically improved. This case suggests that topical AA may improve endothelial stability in FECD eyes, even after complicated surgeries. The intrapatient comparison provides observational support for a potential association between topical AA use and endothelial stability.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":"52 6","pages":"259-262"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Binocular Diplopia With Prism Incorporated Ocular Impression-Based Scleral Lenses With and Without Wavefront-Guided Optics.","authors":"John D Gelles, Angelina Weng, Victoria Vought, Rita Vought, Isis Zhang, Larry P Frohman, Steven A Greenstein","doi":"10.1097/ICL.0000000000001275","DOIUrl":"10.1097/ICL.0000000000001275","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to report the efficacy of prism-incorporated impression-based scleral lenses (pibSL) in the management of binocular diplopia.</p><p><strong>Methods: </strong>This case series includes seven patients with various etiologies of binocular diplopia, including congenital and acquired conditions, that were managed with pibSLs. Of the seven patients, two had corneal irregularity. Visual acuity (VA), diplopia resolution, and subjective patient reports on comfort and cosmetics were assessed. Wavefront-guided (wfg) optics were incorporated in select cases where poor visual quality was reported.</p><p><strong>Results: </strong>All patients experienced resolution of diplopia with VA improving to 20/20 or better with pibSLs. Wfg optics reduced residual higher-order aberrations, resulting in subjective improvement in vision quality and balanced VA. Patients reported high levels of satisfaction with pibSL.</p><p><strong>Conclusions: </strong>PibSLs are an effective, well-tolerated alternative to traditional prism spectacles for managing binocular diplopia and can address multiple comorbidities. The addition of wfg optics further improved visual quality in patients with complex visual needs.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"245-251"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}