Eye & Contact Lens-Science and Clinical Practice最新文献

{"title":"Sjögren Disease and the Corneal Surface.","authors":"Reiko Kobayashi, Shizuka Koh","doi":"10.1097/ICL.0000000000001261","DOIUrl":"10.1097/ICL.0000000000001261","url":null,"abstract":"<p><strong>Abstract: </strong>Dry eye in Sjögren disease is characterized by lacrimal gland dysfunction, often resulting in decreased lacrimal fluid secretion, tear film thinning, epithelial cell damage, and ocular surface inflammation. Beyond lacrimal gland impairment, corneal nerves play a crucial role in the disease, with patients exhibiting a spectrum of symptoms depending on structural and functional nerve abnormalities. Two phenotypes are recognized in patients with Sjögren disease: one with diminished symptoms despite worsening clinical signs (neurotrophic aspect), and another with heightened symptoms such as hyperalgesia or photoallodynia that are disproportionate to clinical findings (neuropathic aspect). A comprehensive understanding of corneal nerve status may enable more personalized treatment approaches.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"328-331"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Sensitivity Recovery After Eyelid Malposition Surgery: A Clinical Perspective.","authors":"Francisco Calleja-Casado, Amparo Lanuza García, Sergio Obiol Ferrando, Elena Navarro Hernández, Antonio Miguel Duch Samper","doi":"10.1097/ICL.0000000000001280","DOIUrl":"10.1097/ICL.0000000000001280","url":null,"abstract":"","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"347"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Neuropathic Pain: A Clinician's Approach.","authors":"Deborah S Jacobs","doi":"10.1097/ICL.0000000000001295","DOIUrl":"10.1097/ICL.0000000000001295","url":null,"abstract":"<p><strong>Abstract: </strong>Ocular neuropathic pain (ONP) can be defined as \"pain\" or \"discomfort\" projected to eye because of a lesion or disease or physiological dysfunction of the nervous system. The diagnosis of ONP is a clinical one; history, eye examination, the anesthetic challenge, and in vivo confocal microscopy providing supportive roles in helping to distinguish nociceptive, nociplastic, and neuropathic pain. Multimodal treatment involving local agents and interventions, along with systemic agents, is often required.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"338-342"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotrophic Keratopathy in Herpes Zoster Ophthalmicus.","authors":"Bennie H Jeng","doi":"10.1097/ICL.0000000000001252","DOIUrl":"10.1097/ICL.0000000000001252","url":null,"abstract":"<p><strong>Abstract: </strong>Neurotrophic keratopathy (NK) is a serious condition that can lead to significant visual morbidity. One of the greatest challenges of treating NK is that there are a wide variety of underlying conditions that affect the corneal nerves, and the root cause of the NK for any given individual is necessary in order to provide the best possibility of treatment success. NK is noted to be frequently caused by herpetic disease, including herpes zoster ophthalmicus (HZO), and studies have demonstrated that the risk of developing NK increases with recurrences of HZO. As such, vaccination to prevent HZO, as well as suppressive valacyclovir to reduce the chance of multiple recurrences of HZO in individuals who have had HZO, can decrease the risk of NK from HZO as well as the subsequent vision loss. These preventative therapies are therefore highly recommended.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"324-327"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden in Plain Sight: The Miscoding of Chronic Postsurgical Pain as Dry Eye Disease.","authors":"Nathan Goturi, Deborah S Jacobs, Eric A Moulton","doi":"10.1097/ICL.0000000000001285","DOIUrl":"10.1097/ICL.0000000000001285","url":null,"abstract":"<p><strong>Abstract: </strong>Chronic postsurgical pain (CPSP) is a complication of cataract surgery. It is underrecognized and may be misdiagnosed as dry eye disease (DED). This retrospective case series presents three patients with no history of DED who developed CPSP after cataract surgery, but were misdiagnosed with DED for months or years. Despite these patients continuing to complain of persistent eye pain, their symptoms were dismissed as DED, delaying appropriate management. These cases highlight the challenges in recognizing CPSP and detrimental consequences of misdiagnosis as DED. In addition, these cases demonstrate that International Classification of Diseases codes for DED can serve as proxies allowing retrospective identification and investigation of CPSP in large databases, which in turn, may contribute to identification of risk factors, improved use of resources, and better outcomes for patients with CPSP after cataract surgery.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"343-346"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Sensory Nerves and Corneal Epithelial Cells Are in a Codependent Relationship.","authors":"Mary Ann Stepp, Sonali Pal-Ghosh","doi":"10.1097/ICL.0000000000001253","DOIUrl":"10.1097/ICL.0000000000001253","url":null,"abstract":"<p><strong>Abstract: </strong>The intraepithelial corneal nerves are a dense collection of sensory axons that consist of the intraepithelial basal nerves and intraepithelial nerve terminals. The plasma membranes of corneal epithelial cells ensheathe the nerves providing them mechanical support. The nerves, in turn, release trophic factors that nourish the epithelial cells. The corneal nerves grow continuously, and homeostasis is maintained by the diurnally regulated shedding the terminals. In response to injury, severed fragments of sensory axons and terminals along with their mitochondria are internalized by corneal epithelial cells. Some of these axonal mitochondria function metabolically within the corneal epithelium. The health of the corneal epithelium during homeostasis and in response to injury depends on the health of its sensory nerves, and the stability of the sensory nerves depends on the insulation and support provided by the corneal epithelial cells. This mini review describes the unique features of the corneal epithelium and its sensory nerves, highlights their importance, and summarizes how their nomenclature is evolving to reflect recent research findings.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"332-337"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Cyanoacrylate Tissue Adhesive in Management of Multidrug-Resistant Fusarium Keratitis: A Case Report.","authors":"Cezmi Doğan, Fatma Burcu Özdemir, Oğuzhan Kılıçarslan, Zeynep Yazgan, Gökhan Aygün","doi":"10.1097/ICL.0000000000001283","DOIUrl":"10.1097/ICL.0000000000001283","url":null,"abstract":"<p><strong>Purpose: </strong>This report discusses a case of multidrug-resistant fungal keratitis associated with contact lens use, complicated by corneal perforation and managed with cyanoacrylate tissue adhesive application.</p><p><strong>Case report: </strong>A 51-year-old previously healthy female patient with a history of extended-wear soft contact lens use for approximately five years was referred to our clinic due to decreased vision in her left eye over three weeks. Her visual acuity was 20/20 in the right eye and hand motion in the left eye. Slitlamp examination revealed an expansive infiltrate involving all layers of the cornea of the left eye. The infectious pathogen was identified as Fusarium . After one week of medical treatment, corneal perforation occurred in the left eye, leading to the application of cyanoacrylate tissue adhesive to ensure globe integrity in the short term. After six months, slitlamp examination revealed no reactivation, prompting the removal of the cyanoacrylate from the corneal surface. Approximately one year later, tectonic penetrating keratoplasty and phacoemulsification surgeries were performed for visual rehabilitation. Subsequent vision improvement was observed, with the final best-corrected visual acuity (logMAR) of the left eye reaching 0.3.</p><p><strong>Conclusion: </strong>This case study demonstrates the complexity of managing multidrug-resistant fungal keratitis. The authors would like to highlight that the application of cyanoacrylate tissue adhesive is an immediate therapeutic option, due to its anatomical effect on globe integrity and potential antifungal properties, which can help reduce the risks associated with corneal transplantation.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"318-321"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Eyelid Hygiene Improves Early Adaptation to Pediatric Orthokeratology: A Randomized Clinical Study.","authors":"Mansha He, Weihong Liu, Jiahao Liang, Yicui Weng, Can Chen, Xiaoxiao Zhang","doi":"10.1097/ICL.0000000000001278","DOIUrl":"10.1097/ICL.0000000000001278","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of daily eyelid wipes on ocular-surface health and comfort during the early adaptation period of orthokeratology (Ortho-K) wear in children.</p><p><strong>Methods: </strong>This single-masked, randomized clinical study was conducted at a tertiary eye hospital from July to October 2025. Fifty-eight myopic children (aged 8-12 years) initiating Ortho-K were randomly assigned to an eyelid-wipe group or a control group. The examiner was masked to group allocation. Baseline and 1-month measurements included noninvasive tear breakup time, lipid-layer thickness, tear meniscus height, meibomian gland expressibility, corneal fluorescein staining, matrix metalloproteinase-9 levels, and Ocular Surface Disease Index.</p><p><strong>Results: </strong>After 1 month, noninvasive tear breakup time and lipid-layer thickness showed no significant between-group differences in change ( P =0.12 and P =0.07, respectively). Meibomian gland expressibility improved more in the eyelid-wipe group (2.5±0.9-1.9±0.8) than in controls (2.4±0.8-2.3±0.9), with a significant between-group difference in change ( P =0.002). Corneal fluorescein staining at the 1-month visit was lower in the eyelid-wipe group than in controls (0.9±0.8 vs. 1.3±0.9, P =0.03). Ocular Surface Disease Index scores showed a greater reduction in the eyelid-wipe group than in controls ( P =0.02). Tear meniscus height and matrix metalloproteinase-9 levels did not differ significantly between groups. All participants continued wipe use, and no adverse events were reported.</p><p><strong>Conclusions: </strong>Daily sterile eyelid wipes safely improved meibomian gland function and comfort without inducing inflammation, suggesting a simple adjunctive approach to enhance early ocular-surface adaptation in pediatric Ortho-K wearers.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"286-290"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Optical Defocus-Induced Myopia Model for Guinea Pigs Using Rigid Gas Permeable Contact Lenses.","authors":"So Goto, Sarah Singh, Qiurong Zhu, Sonal Aswin Vyas, Christine Wildsoet","doi":"10.1097/ICL.0000000000001279","DOIUrl":"10.1097/ICL.0000000000001279","url":null,"abstract":"<p><strong>Objectives: </strong>Guinea pigs are a widely used mammalian model for studies of myopia and early ocular growth regulation more generally. The study reported here covers the development of rigid gas permeable (RGP) contact lenses (CLs) for guinea pigs, as an alternative to spectacle lenses for imposing optical defocus, recognized as an important modulator of eye elongation in young animals.</p><p><strong>Methods: </strong>New Zealand pigmented guinea pigs ( Cavia porcellus ) were used in this study, with the RGP lens design based on developmental corneal shape profiles derived from anterior segment optical coherence tomography data collected across a range of ages, as typically encountered in such studies. The validity of this CL-based approach was examined in a follow-up study, in which the ocular effects of -10, 0, and +5 diopters [D] RGP lenses, applied as continuous monocular optical defocus treatments, were tracked over 2 weeks, with the fellow untreated eyes of experimental animals serving as contralateral controls. Pretreatment baseline spherical equivalent refractive errors (RE) and axial length (AL) of both eyes were measured, along with follow-up weekly measurements over the wearing period.</p><p><strong>Results: </strong>There were no differences in any of the ocular parameters between the three groups at baseline, while after two weeks of lens wear, there were significant differences between the -10 D group compared with 0 D and +5 D groups in both RE ( P <0.001) and AL ( P <0.05). Importantly, myopia was observed in all of the guinea pigs fitted with -10 D lenses, and overall, eyes fitted with -10 D lenses showed increased ALs and relative myopia compared with their fellows, while those fitted with +5 D lenses showed reduced ALs and relative hyperopia; the plano lens group fell in between (treated-fellow eyes: -10, 0, and +5 D lenses: -8.25, -1.0, and +0.5 D, and +0.16, +0.08, and -0.02 mm, respectively). Also importantly, no significant CL-related adverse ocular effects were observed.</p><p><strong>Conclusions: </strong>This study provides proof of principle that defocusing RGP CLs are a feasible alternative to spectacle lenses for studies of eye growth regulation in young guinea pigs and experimental myopia specifically, with potential application in investigations into novel approaches for controlling myopia progression and underlying mechanisms.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"306-314"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identify the Relationships Between Orthokeratology Lens Decentration and Myopia Control Efficacy in Children by Using Pentacam.","authors":"Yu-Kai Kuo, Lan-Hsin Chuang, Hung-Chi Chen, Ling Yeung, Ho-Min Chen, Jui-Yen Lin, Yih-Shiou Hwang, Chi-Chun Lai, Chun-Fu Liu","doi":"10.1097/ICL.0000000000001262","DOIUrl":"10.1097/ICL.0000000000001262","url":null,"abstract":"<p><strong>Purpose: </strong>To determine orthokeratology (ortho-k) lens decentration and its relationships with annual axial length (AL) changes in children treated with ortho-k.</p><p><strong>Methods: </strong>This retrospective study included children aged 9 to 15 years treated with ortho-k for at least 1 year. Lens decentration was measured using Pentacam based on the relative positions of the corneal thinnest point, pupil center, and visual center. Annual AL change was analyzed using regression models adjusted for age and target power.</p><p><strong>Results: </strong>In total, 71 eyes from 37 patients (mean age, 10.9 years) were included in the final analysis. The mean follow-up time was 35.0 months. The mean annual AL change was 0.11 mm. According to the customized formula based on the pupil or visual center, greater horizontal and vertical vectors and a larger total distance of decentration were associated with less annual AL change.</p><p><strong>Conclusion: </strong>Greater temporal and inferior vectors, as well as a larger total distance of decentration, are associated with greater myopia control efficacy. These findings will help to facilitate the prescription and future design of ortho-k lenses to improve myopia control efficacy.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"274-279"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}