Demographics of Limbal Stem Cell Deficiency: A Literature Review.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-04-10 DOI:10.1097/ICL.0000000000001184

Daniel Fraser, Meghan M Brown, Joshua H Hou

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引用次数: 0

Abstract

Purpose: To evaluate the demographics of limbal stem cell deficiency (LSCD) and to report the prevalence, identifiable etiologies, and treatment outcomes as described in the literature.

Methods: A literature review performed by querying published studies evaluating the demographics and/or epidemiology of LSCD. Three large retrospective studies from the University of Minnesota (UMN), Cincinnati Eye Institute (CEI), and LV Prasad Eye Institute (LV Prasad) were compared.

Results: Average age at diagnosis for the UMN and CEI cohorts was 53.2 and 42.9 years old, respectively, whereas the median age was much younger at 24 years old in the LV Prasad cohort. The LV Prasad cohort revealed a 2:1 male predominance. Both the LV Prasad and UMN cohorts reported similar rates of unilateral vs. bilateral LSCD, whereas the CEI cohort reported bilateral LSCD in 70% of their cases. The leading cause of LSCD was ocular burns (53.7%) in the LV Prasad cohort, congenital aniridia (30.9%) in the CEI cohort, and chemical/thermal burns (18.7%) in the UMN cohort. Only the UMN study reported a disease prevalence rate, which was 4.25%.

Conclusions: There is great regional variability in the demographics of patients with LSCD. This may contribute to the difficulty in establishing accurate disease prevalence rates.

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角膜缘干细胞缺乏症的人口统计学：文献综述。

目的：评估角膜缘干细胞缺乏症（LSCD）的人口统计学特征，并报告文献中描述的患病率、可识别的病因和治疗结果。方法：通过查询已发表的评估LSCD人口统计学和/或流行病学的研究进行文献综述。我们比较了来自明尼苏达大学（UMN）、辛辛那提眼科研究所（CEI）和LV Prasad眼科研究所（LV Prasad）的三个大型回顾性研究。结果：UMN和CEI队列的平均诊断年龄分别为53.2岁和42.9岁，而LV Prasad队列的中位年龄要小得多，为24岁。LV Prasad队列显示2:1的男性优势。LV Prasad组和UMN组报告的单侧和双侧LSCD发生率相似，而CEI组报告的双侧LSCD发生率为70%。LSCD的主要原因是眼部烧伤（53.7%），CEI组为先天性无虹膜（30.9%），UMN组为化学/热烧伤（18.7%）。只有UMN研究报告了疾病患病率，为4.25%。结论：LSCD患者的人口统计学存在很大的地区差异。这可能导致难以确定准确的疾病流行率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.