Fetal and Pediatric Pathology最新文献_第4页

New Marker in the Umbilical Cord Blood of Fetuses with Fetal Growth Restriction: Serum Sortilin-1 Level. 胎儿生长受限胎儿脐带血中的新标记物：血清 Sortilin-1 水平。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-10-10 DOI: 10.1080/15513815.2024.2412846

Gulsan Karabay, Burak Bayraktar, Zeynep Seyhanli, Betul Tokguz Cakir, Gizem Aktemur, Serap Topkara Sucu, Nazan Vanlı Tonyali, Selma Ipek, Tugba Kolomuc Gayretli, Sevki Celen

{"title":"New Marker in the Umbilical Cord Blood of Fetuses with Fetal Growth Restriction: Serum Sortilin-1 Level.","authors":"Gulsan Karabay, Burak Bayraktar, Zeynep Seyhanli, Betul Tokguz Cakir, Gizem Aktemur, Serap Topkara Sucu, Nazan Vanlı Tonyali, Selma Ipek, Tugba Kolomuc Gayretli, Sevki Celen","doi":"10.1080/15513815.2024.2412846","DOIUrl":"https://doi.org/10.1080/15513815.2024.2412846","url":null,"abstract":"Objective: To determine the role of sortilin in the pathogenesis of fetal growth restriction (FGR) by examining serum sortilin levels in fetal cord blood. Methods: This prospective case-control study was conducted at Ankara Etlik City Hospital between July 2023 and January 2024. Group 1 included 44 pregnant women with late FGR; Group 2 included 44 healthy pregnant women as controls. Results: Umbilical cord blood sortilin levels were significantly higher in the FGR group [2.96 (2.43-4.01)] compared to the control group [2.12 (1.74-3.18)] (p = 0.001). Sortilin levels negatively correlated with APGAR scores at 1 min (r=-0.281, p = 0.008) and 5 min (r=-0.292, p = 0.006). A sortilin threshold of 2.58 ng/ml predicted composite adverse neonatal outcomes with 66.7% sensitivity, 53.1% specificity, and an AUC of 0.652 (95% CI: 0.529-0.775, p = 0.031). Conclusion: This study showed that sortilin levels, which are indicators of oxidation, were higher in the cord blood of newborns with late FGR.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"1-11"},"PeriodicalIF":0.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary TFE3-Rearranged Renal Cell Carcinoma in a Chinese Girl Treated for Wilms Tumor: Case Report and Literature Review 一名曾接受 Wilms 肿瘤治疗的中国女孩的继发性 TFE3 重排肾细胞癌：病例报告和文献综述

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-17 DOI: 10.1080/15513815.2024.2402383

Jing Chu, Lian Chen

引用次数: 0

Pediatric Angiosarcoma with Novel Phenotypic and Genotypic Profile in Chinese Children 具有新表型和基因型特征的中国儿童血管肉瘤

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-13 DOI: 10.1080/15513815.2024.2402395

Bo Shao, Yuan Fang, Yizhen Wang, Lian Chen

引用次数: 0

Prompt Cytopathological Diagnosis of Multiple Xanthomatous Skin Nodules in an Adolescent Girl Opening the Doors to Detection of Familial Hypercholesterolemia 少女多发性黄瘤皮肤结节的及时细胞病理学诊断为检测家族性高胆固醇血症打开了大门

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-11 DOI: 10.1080/15513815.2024.2390938

Shaivy Malik, Preeti Kandwal, Neha Kawatra Madan, Meetu Agrawal, Sunil Ranga

引用次数: 0

Assessment of Matrix Metalloprotease - 7 (MMP7) Immunohistochemistry in Biliary Atresia and Other Pediatric Cholestatic Liver Diseases. 基质金属蛋白酶-7（MMP7）免疫组织化学在胆道闭锁和其他儿童胆汁淤积性肝病中的评估。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2023-10-31 DOI: 10.1080/15513815.2023.2276780

Sandhya Biswal, Dipanwita Biswas, Santosh Kumar Mahalik, Suvendu Purkait, Suvradeep Mitra

{"title":"Assessment of Matrix Metalloprotease - 7 (MMP7) Immunohistochemistry in Biliary Atresia and Other Pediatric Cholestatic Liver Diseases.","authors":"Sandhya Biswal, Dipanwita Biswas, Santosh Kumar Mahalik, Suvendu Purkait, Suvradeep Mitra","doi":"10.1080/15513815.2023.2276780","DOIUrl":"10.1080/15513815.2023.2276780","url":null,"abstract":"Background and aims: Biliary atresia (BA) is a progressive fibro-obliterative cholangiopathy. The histopathological diagnosis is often challenging and an immunohistochemical marker is often sought as an adjunct. We evaluated MMP7 immunohistochemistry in BA and other non-BA pediatric cholestatic liver diseases. Materials and methods: MMP7 immunohistochemistry was applied in 5 age-matched normal control, 23 cases of BA and 43 cases of non-BA pediatric cholestasis including 16 cases of choledochal cyst (CC), and a multiplication score was obtained by multiplying the intensity and percentage positivity in the cholangiocytes. Results: BA showed a high mean MMP7 multiplication score which was significantly different from the normal control and other non-BA pediatric cholestatic diseases including CC (p value < 0.001). The sensitivity, specificity, positive, and negative predictive values of MMP7 immunohistochemistry were 91.3%, 93.02%, 87.5%, and 95.2% respectively. Conclusion: MMP7 immunohistochemistry may be an adjunct to histomorphology in BA.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"341-350"},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between the Expression of DNA Damage Repair Protein OGG1 and Ubiquitination Pathway Protein STUB1 in Pediatric Neuroblastoma. DNA损伤修复蛋白OGG1与泛素化途径蛋白STUB1在小儿神经母细胞瘤中表达的相关性

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-01 DOI: 10.1080/15513815.2024.2393351

Bo Shao, Yi-Zhen Wang, Yuan Fang

{"title":"Correlation Between the Expression of DNA Damage Repair Protein OGG1 and Ubiquitination Pathway Protein STUB1 in Pediatric Neuroblastoma.","authors":"Bo Shao, Yi-Zhen Wang, Yuan Fang","doi":"10.1080/15513815.2024.2393351","DOIUrl":"10.1080/15513815.2024.2393351","url":null,"abstract":"Background: Neuroblastoma, a pediatric malignancy, is significantly influenced by genetic factors. Prior research indicates that the OGG1 rs1052133 G > C polymorphism correlates with a decreased risk of neuroblastoma.Methods: We analyzed 57 neuroblastoma and 21 adrenal samples, using immunohistochemistry to measure OGG1 and STUB1 expression levels. We conducted a survival analysis to explore relationship between the expressions and neuroblastoma prognosis.Results: Notably higher OGG1 expression and significantly lower STUB1 expression in neuroblastoma. OGG1 levels were significantly correlated with patient age, tumor location, histological grade, Shimada classification, INSS stage, and risk category. A negative association was observed between OGG1 and STUB1 expressions. Higher OGG1 expression was linked to reduced PFS and OS. Lower STUB1 expression was associated with unfavorable PFS. Additionally, OGG1 expression and risk category emerged as independent predictors of prognosis.Conclusion: OGG1 potentially functions as an oncogene in NB, with its activity possibly modulated by STUB1 through the ubiquitination pathway.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"387-398"},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Effect of Maternal Iron Deficiency Anaemia on the Expression of Iron Transport Proteins in the Third Trimester Placenta. 撤回声明：孕产妇缺铁性贫血对第三孕期胎盘中铁转运蛋白表达的影响。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1080/15513815.2024.2381410

引用次数: 0

Construction of a Cancer Stem Cell Marker Genes-Related 22-Gene Signature for Overall Survival Prediction in High-Risk Wilms' Tumor. 构建癌症干细胞标记基因相关的 22 个基因特征，用于预测高风险 Wilms 肿瘤的总体生存率

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1080/15513815.2024.2382277

Lihong Duan, Wudie Xia

{"title":"Construction of a Cancer Stem Cell Marker Genes-Related 22-Gene Signature for Overall Survival Prediction in High-Risk Wilms' Tumor.","authors":"Lihong Duan, Wudie Xia","doi":"10.1080/15513815.2024.2382277","DOIUrl":"10.1080/15513815.2024.2382277","url":null,"abstract":"Background: This study aimed to investigate the comprehensive expression profile of cancer stem cell (CSC)-related genes and construct a prognostic signature for overall survival (OS) prediction in high-risk Wilms' tumor (WT). Materials and methods: Gene expression and survival data from 120 high-risk WT cases in the Therapeutically Applicable Research to Generate Effective Treatments (TARGET)-WT were used. Results: In total, 229 CSC-related genes were found to be significantly dysregulated in WT compared to tumor-adjacent normal tissues, among which 34 were associated with OS. Using LASSO regression, a 22-gene signature was developed, which exhibited excellent performance in 3-, 5-, and 10-year OS predictions (AUC > 0.86). The high-risk score group showed markedly poorer OS compared to the low-risk score group (median separation, HR = 6.41, 95% CI: 3.18-12.92, p = 3.2e - 9). The 22-gene signature was an independent prognostic factor for OS (HR = 5.086, 95% CI: 3.019-8.568, p < 0.001). Conclusion: This study identified a robust prognostic signature that can effectively support OS prediction.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"351-365"},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Compilation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Neonatal Respiratory Distress Syndrome. 关于表面活性蛋白-B (SFTPB) 多态性与新生儿呼吸窘迫综合征易感性之间关系的数据综合汇编。

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI: 10.1080/15513815.2024.2390932

Mohammad Golshan-Tafti, Reza Bahrami, Seyed Alireza Dastgheib, Mohamad Hosein Lookzadeh, Seyed Reza Mirjalili, Maryam Yeganegi, Zahra Marzbanrad, Maryam Aghasipour, Amirhossein Shahbazi, Ali Masoudi, Mahmood Noorishadkam, Hossein Neamatzadeh

{"title":"A Comprehensive Compilation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Neonatal Respiratory Distress Syndrome.","authors":"Mohammad Golshan-Tafti, Reza Bahrami, Seyed Alireza Dastgheib, Mohamad Hosein Lookzadeh, Seyed Reza Mirjalili, Maryam Yeganegi, Zahra Marzbanrad, Maryam Aghasipour, Amirhossein Shahbazi, Ali Masoudi, Mahmood Noorishadkam, Hossein Neamatzadeh","doi":"10.1080/15513815.2024.2390932","DOIUrl":"10.1080/15513815.2024.2390932","url":null,"abstract":"Background: This study aims to explore the association between variations in the Surfactant Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS).Methods: A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and CNKI databases up to February 10, 2024, to identify pertinent studies.Results: A total of seventeen studies examining the +1580 C/T polymorphism (2,058 cases and 2,596 controls) and five studies investigating the -18 A/C polymorphism (680 cases and 739 controls) were included in the analysis. The pooled data indicated that the +1580 C/T polymorphism confers a protective effect against NRDS in various populations and ethnic groups. Conversely, the -18 A/C polymorphism did not demonstrate a significant association either globally or among Asian neonates.Conclusions: The +1580 C/T variant appears to be protective against NRDS, whereas the -18 A/C polymorphism shows minimal impact on the disease's progression.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"399-418"},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Onset Inflammatory Bowel Disease Due to Immunodeficiency as a Result of ICOS Gene Homozygous Mutation. ICOS基因同源突变导致免疫缺陷引起的早发炎性肠病

IF 0.7 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2024-08-11 DOI: 10.1080/15513815.2024.2388697

Hanife Ayşegül Arsoy, Demet Hafızoğlu, Hatice Zeynep Terzi, Ezgi Işıl Turhan

引用次数: 0