Clinicopathological Features of Diffuse Hemispheric Glioma, H3G34-Mutant.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2025-02-28 DOI:10.1080/15513815.2025.2460560

Juan Cao, Yongxian Chen, Guocheng Yang, Xiaoxiao He, Hailun Chen, Zaoling Luo, Jingting Liao, Zhihui Huang, Weiguo Cao

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引用次数: 0

Abstract

Objective: To investigate the clinical manifestations, radiographic features, and pathological characteristics of three cases of diffuse hemispheric gliomas, H3G34-mutant (H3G34 DHG).

Methods: This study used a single-center retrospective cohort approach to analyze 45 pediatric-type diffuse high-grade glioma cases.

Results: Histologically, case 1 and case 2 had glioblastoma structures, and case 3 had primitive neuroectodermal tumor (PNET) morphology with ganglion cell differentiation. Immunohistochemical staining revealed diffuse expression of H3G34R and P53, but no expression of Olig2, ATRX, IDH1/2 and BRAF V600E in tumor cells in all three cases.

Conclusions: H3 G34 DHG occurs more significantly in younger patients, and nearly all lesions are located in the cerebral hemisphere. MRI showed mass effects, edema and mild enhancement. The histological type showed glioblastoma structure and PNET morphology. Immunohistochemistry showed that the expression of H3G34R was more significant in PNET morphology.

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.