Genes Brain and Behavior最新文献_第8页

TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample TTLL11基因与持续注意力表现和大脑网络相关:一项健康中国人样本的全基因组关联研究

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-12-13 DOI: 10.1111/gbb.12835

Hejun Liu, Xiaoyu Zhao, Gui Xue, Chuansheng Chen, Qi Dong, Xuping Gao, Li Yang, Chunhui Chen

{"title":"TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample","authors":"Hejun Liu, Xiaoyu Zhao, Gui Xue, Chuansheng Chen, Qi Dong, Xuping Gao, Li Yang, Chunhui Chen","doi":"10.1111/gbb.12835","DOIUrl":"10.1111/gbb.12835","url":null,"abstract":"Genetic studies on attention have mainly focused on children with attention-deficit/hyperactivity disorder (ADHD), so little systematic research has been conducted on genetic correlates of attention performance and their potential brain mechanisms among healthy individuals. The current study included a genome-wide association study (GWAS, N = 1145 healthy young adults) aimed to identify genes associated with sustained attention and an imaging genetics study (an independent sample of 483 healthy young adults) to examine any identified genes' influences on brain function. The GWAS found that TTLL11 showed genome-wide significant associations with sustained attention, with rs13298112 as the most significant SNP and the GG homozygotes showing more impulsive but also more focused responses than the A allele carriers. A retrospective examination of previously published ADHD GWAS results confirmed an un-reported, small but statistically significant effect of TTLL11 on ADHD. The imaging genetics study replicated this association and showed that the TTLL11 gene was associated with resting state activity and connectivity of the somatomoter network, and can be predicted by dorsal attention network connectivity. Specifically, the GG homozygotes showed lower brain activity, weaker brain network connectivity, and non-significant brain-attention association compared to the A allele carriers. Expression database showed that expression of this gene is enriched in the brain and that the G allele is associated with lower expression level than the A allele. These results suggest that TTLL11 may play a major role in healthy individuals' attention performance and may also contribute to the etiology of ADHD.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"22 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/2d/GBB-22-e12835.PMC9994169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9134739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A genome-wide association study identifies a new variant associated with word reading fluency in Chinese children 一项全基因组关联研究发现了一个与中国儿童单词阅读流利性相关的新变异

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-12-13 DOI: 10.1111/gbb.12833

Zhengjun Wang, Shunan Zhao, Liming Zhang, Qing Yang, Chen Cheng, Ning Ding, Zijian Zhu, Hua Shu, Chunyu Liu, Jingjing Zhao

{"title":"A genome-wide association study identifies a new variant associated with word reading fluency in Chinese children","authors":"Zhengjun Wang, Shunan Zhao, Liming Zhang, Qing Yang, Chen Cheng, Ning Ding, Zijian Zhu, Hua Shu, Chunyu Liu, Jingjing Zhao","doi":"10.1111/gbb.12833","DOIUrl":"10.1111/gbb.12833","url":null,"abstract":"Reading disability exhibited defects in different cognitive domains, including word reading fluency, word reading accuracy, phonological awareness, rapid automatized naming and morphological awareness. To identify the genetic basis of Chinese reading disability, we conducted a genome-wide association study (GWAS) of the cognitive traits related to Chinese reading disability in 2284 unrelated Chinese children. Among the traits analyzed in the present GWAS, we detected one genome-wide significant association (p < 5 × 10−8) on word reading fluency for one SNP on 4p16.2, within EVC genes (rs6446395, p = 7.33 × 10−10). Rs6446395 also showed significant association with Chinese character reading accuracy (p = 2.95 × 10−4), phonological awareness (p = 7.11 × 10−3) and rapid automatized naming (p = 4.71 × 10−3), implying multiple effects of this variant. The eQTL data showed that rs6446395 affected EVC expression in the cerebellum. Gene-based analyses identified a gene (PRDM10) to be associated with word reading fluency at the genome-wide level. Our study discovered a new candidate susceptibility variant for reading ability and provided new insights into the genetics of developmental dyslexia in Chinese children.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"22 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/78/GBB-22-e12833.PMC9994172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9082098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Genome-wide assessment reveals a significant association between ACSS3 and physical activity 全基因组评估揭示了ACSS3与身体活动之间的显著关联

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-12-12 DOI: 10.1111/gbb.12834

Jinyeon Jo, Youngkyu Song, Dankyu Yoon, Chung Gun Lee, Sungho Won

{"title":"Genome-wide assessment reveals a significant association between ACSS3 and physical activity","authors":"Jinyeon Jo, Youngkyu Song, Dankyu Yoon, Chung Gun Lee, Sungho Won","doi":"10.1111/gbb.12834","DOIUrl":"10.1111/gbb.12834","url":null,"abstract":"Recent genetic studies have identified physical activity (PA)-susceptible loci in European ancestry subjects; however, due to considerable genetic differences, these findings are not likely extendable to East Asian populations. Therefore, the present study aimed to identify significantly associated PA-susceptible loci using genome-wide association studies (GWASs) with East Asian (EAS) subjects and to generalize the findings to European (EUR) ancestries. The mRNA levels of genes located near the genome-wide significantly associated single-nucleotide polymorphisms (SNP) were compared under PA and control conditions. Rs74937256, located in ACSS3 (chromosome 12), which primarily functions in skeletal muscle tissues, was identified as a genome-wide significant variant (P = 6.06 × 10−9) in EAS. Additionally, the rs2525840, also in ACSS3 satisfied the Bonferroni corrected significance (P = 3.77 × 10−5) in EUR. We found that rs74937256 is an expressed trait locus of ACSS3 (P = 10−4), and ACSS3 mRNA expression significantly differs after PA, based on PrediXcan (P = 7 × 10−8) and the gene expression omnibus database (P = 0.043).","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"22 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/36/GBB-22-e12834.PMC9994161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9134738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropathic pain as a trigger for histone modifications in limbic circuitry 神经性疼痛是边缘回路中组蛋白修饰的触发因素

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-11-22 DOI: 10.1111/gbb.12830

Svetlana Bryant, Julie-Anne Balouek, Luke T. Geiger, David J. Barker, Catherine J. Peña

{"title":"Neuropathic pain as a trigger for histone modifications in limbic circuitry","authors":"Svetlana Bryant, Julie-Anne Balouek, Luke T. Geiger, David J. Barker, Catherine J. Peña","doi":"10.1111/gbb.12830","DOIUrl":"10.1111/gbb.12830","url":null,"abstract":"Chronic pain involves both central and peripheral neuronal plasticity that encompasses changes in the brain, spinal cord, and peripheral nociceptors. Within the forebrain, mesocorticolimbic regions associated with emotional regulation have recently been shown to exhibit lasting gene expression changes in models of chronic pain. To better understand how such enduring transcriptional changes might be regulated within brain structures associated with processing of pain or affect, we examined epigenetic modifications involved with active or permissive transcriptional states (histone H3 lysine 4 mono and trimethylation, and histone H3 lysine 27 acetylation) in periaqueductal gray (PAG), lateral hypothalamus (LH), nucleus accumbens (NAc), and ventral tegmental area (VTA) 5 weeks after sciatic nerve injury in mice to model chronic pain. For both male and female mice in chronic pain, we observed an overall trend for a reduction of these epigenetic markers in periaqueductal gray, LH, and NAc, but not VTA. Moreover, we discovered that some epigenetic modifications exhibited changes associated with pain history, while others were associated with individual differences in pain sensitivity. When taken together, these results suggest that nerve injury leads to chronic chromatin-mediated suppression of transcription in key limbic brain structures and circuits, which may underlie enduring changes in pain processing and sensitivity within these systems.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"22 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/a1/GBB-22-e12830.PMC9994138.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Allele-specific cis-regulatory methylation of the gene for vasoactive intestinal peptide in white-throated sparrows 白喉麻雀血管活性肠肽基因等位基因特异性顺式调控甲基化

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-10-11 DOI: 10.1111/gbb.12831

Mackenzie R. Prichard, Kathleen E. Grogan, Jennifer R. Merritt, Jessica Root, Donna L. Maney

{"title":"Allele-specific cis-regulatory methylation of the gene for vasoactive intestinal peptide in white-throated sparrows","authors":"Mackenzie R. Prichard, Kathleen E. Grogan, Jennifer R. Merritt, Jessica Root, Donna L. Maney","doi":"10.1111/gbb.12831","DOIUrl":"10.1111/gbb.12831","url":null,"abstract":"White-throated sparrows (Zonotrichia albicollis) offer a unique opportunity to connect genotype with behavioral phenotype. In this species, a rearrangement of the second chromosome is linked with territorial aggression; birds with a copy of this “supergene” rearrangement are more aggressive than those without it. The supergene has captured the gene VIP, which encodes vasoactive intestinal peptide, a neuromodulator that drives aggression in other songbirds. In white-throated sparrows, VIP expression is higher in the anterior hypothalamus of birds with the supergene than those without it, and expression of VIP in this region predicts the level of territorial aggression regardless of genotype. Here, we aimed to identify epigenetic mechanisms that could contribute to differential expression of VIP both in breeding adults, which exhibit morph differences in territorial aggression, and in nestlings, before territorial behavior develops. We extracted and bisulfite-converted DNA from samples of the hypothalamus in wild-caught adults and nestlings and used high-throughput sequencing to measure DNA methylation of a region upstream of the VIP start site. We found that the allele inside the supergene was less methylated than the alternative allele in both adults and nestlings. The differential methylation was attributed primarily to CpG sites that were shared between the alleles, not to polymorphic sites, which suggests that epigenetic regulation is occurring independently of the genetic differentiation within the supergene. This work represents an initial step toward understanding how epigenetic differentiation inside chromosomal inversions leads to the development of alternative behavioral phenotypes.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"21 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/2a/GBB-21-e12831.PMC9744568.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10678448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia 昼夜节律转录因子NPAS2在阿片类药物耐受、戒断和镇痛中的性别特异性作用

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-08-20 DOI: 10.1111/gbb.12829

Stephanie Puig, Micah A. Shelton, Kelly Barko, Marianne L. Seney, Ryan W. Logan

{"title":"Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia","authors":"Stephanie Puig, Micah A. Shelton, Kelly Barko, Marianne L. Seney, Ryan W. Logan","doi":"10.1111/gbb.12829","DOIUrl":"10.1111/gbb.12829","url":null,"abstract":"Opioids like fentanyl remain the mainstay treatment for chronic pain. Unfortunately, opioid's high dependence liability has led to the current opioid crisis, in part, because of side-effects that develop during long-term use, including analgesic tolerance and physical dependence. Both tolerance and dependence to opioids may lead to escalation of required doses to achieve previous therapeutic efficacy. Additionally, altered sleep and circadian rhythms are common in people on opioid therapy. Opioids impact sleep and circadian rhythms, while disruptions to sleep and circadian rhythms likely mediate the effects of opioids. However, the mechanisms underlying these bidirectional relationships between circadian rhythms and opioids remain largely unknown. The circadian protein, neuronal PAS domain protein 2 (NPAS2), regulates circadian-dependent gene transcription in structure of the central nervous system that modulate opioids and pain. Here, male and female wild-type and NPAS2-deficient (NPAS2−/−) mice were used to investigate the role of NPAS2 in fentanyl analgesia, tolerance, hyperalgesia and physical dependence. Overall, thermal pain thresholds, acute analgesia and tolerance to a fixed dose of fentanyl were largely similar between wild-type and NPAS2−/− mice. However, female NPAS2−/− exhibited augmented analgesic tolerance and significantly more behavioral symptoms of physical dependence to fentanyl. Only male NPAS2−/− mice had increased fentanyl-induced hypersensitivity, when compared with wild-type males. Together, our findings suggest sex-specific effects of NPAS2 signaling in the regulation of fentanyl-induced tolerance, hyperalgesia and dependence.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10677956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity 嗜Latrophilin-3杂合与纯合突变在Sprague Dawley大鼠中的作用:对自我中心和异中心记忆和运动活动的影响

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-08-19 DOI: 10.1111/gbb.12817

Samantha L. Regan, Chiho Sugimoto, Hannah E. Dawson, Michael T. Williams, Charles V. Vorhees

{"title":"Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity","authors":"Samantha L. Regan, Chiho Sugimoto, Hannah E. Dawson, Michael T. Williams, Charles V. Vorhees","doi":"10.1111/gbb.12817","DOIUrl":"10.1111/gbb.12817","url":null,"abstract":"Latrophilin-3 (LPHN3) is a brain specific G-protein coupled receptor associated with increased risk of attention deficit hyperactivity disorder (ADHD) and cognitive deficits. CRISPR/Cas9 was used to generate a constitutive knockout (KO) rat of Lphn3 by deleting exon 3, based on human data that LPHN3 variants are associated with some cases of ADHD. Lphn3 KO rats are hyperactive with an attenuated response to ADHD medication and have cognitive deficits. Here, we tested KO, heterozygous (HET), and wildtype (WT) rats to determine if there was a gene-dosage effect. We tested the rats in home-cage activity starting at postnatal day (P)35 and P50, followed by tests of egocentric learning (Cincinnati water maze [CWM]), spatial learning (Morris water maze [MWM]), working memory (radial water maze [RWM]), incidental learning (novel object recognition [NOR]), acoustic startle response (ASR) habituation, tactile startle response (TSR) habituation, prepulse modification of acoustic startle, shuttle-box passive avoidance, conditioned freezing, and a mirror image version of the CWM. KO and HET rats were hyperactive. KO and HET rats had egocentric (CWM) and spatial deficits (MWM), increased startle response, and KO rats showed less conditioned freezing on contextual and cued memory; there were no effects on working memory (RWM) or passive avoidance. The selective gene-dosage effect in Lphn3 HET rats indicates that Lphn3 exhibits dominate expression on functions where it is most abundantly expressed (striatum, hippocampus) but not on behaviors mediated by regions of low expression. The data add further evidence to the impact of this synaptic protein on brain function and behavior.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/3d/GBB-21-e12817.PMC9744505.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum Reelin缺乏通过增强背内侧纹状体的神经元活动加剧了可卡因诱导的过度运动

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-07-29 DOI: 10.1111/gbb.12828

Giordano de Guglielmo, Attilio Iemolo, Aisha Nur, Andrew Turner, Patricia Montilla-Perez, Angelica Martinez, Caitlin Crook, Amanda Roberts, Francesca Telese

{"title":"Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum","authors":"Giordano de Guglielmo, Attilio Iemolo, Aisha Nur, Andrew Turner, Patricia Montilla-Perez, Angelica Martinez, Caitlin Crook, Amanda Roberts, Francesca Telese","doi":"10.1111/gbb.12828","DOIUrl":"10.1111/gbb.12828","url":null,"abstract":"The Reln gene encodes for the extracellular glycoprotein Reelin, which regulates several brain functions from development to adulthood, including neuronal migration, dendritic growth and branching and synapse formation and plasticity. Human studies have implicated Reelin signaling in several neurodevelopmental and psychiatric disorders. Mouse studies using the heterozygous Reeler (HR) mice have shown that reduced levels of Reln expression are associated with deficits in learning and memory and increased disinhibition. Although these traits are relevant to substance use disorders, the role of Reelin in cellular and behavioral responses to addictive drugs remains largely unknown. Here, we compared HR mice to wild-type (WT) littermate controls to investigate whether Reelin signaling contributes to the hyperlocomotor and rewarding effects of cocaine. After a single or repeated cocaine injections, HR mice showed enhanced cocaine-induced locomotor activity compared with WT controls. This effect persisted after withdrawal. In contrast, Reelin deficiency did not induce cocaine sensitization, and did not affect the rewarding effects of cocaine measured in the conditioned place preference assay. The elevated cocaine-induced hyperlocomotion in HR mice was associated with increased protein Fos expression in the dorsal medial striatum (DMS) compared with WT. Lastly, we performed an RNA fluorescent in situ hybridization experiment and found that Reln was highly co-expressed with the Drd1 gene, which encodes for the dopamine receptor D1, in the DMS. These findings show that Reelin signaling contributes to the locomotor effects of cocaine and improve our understanding of the neurobiological mechanisms underlying the cellular and behavioral effects of cocaine.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/18/GBB-21-e12828.PMC9744517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10729263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment 缺乏proSAAS的小鼠在情绪、完成行为和昼夜节律方面表现出改变

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-07-25 DOI: 10.1111/gbb.12827

Dipendra K. Aryal, Ramona M. Rodriguiz, Ngoc Lien Nguyen, Matthew W. Pease, Daniel J. Morgan, John Pintar, Lloyd D. Fricker, William C. Wetsel

{"title":"Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment","authors":"Dipendra K. Aryal, Ramona M. Rodriguiz, Ngoc Lien Nguyen, Matthew W. Pease, Daniel J. Morgan, John Pintar, Lloyd D. Fricker, William C. Wetsel","doi":"10.1111/gbb.12827","DOIUrl":"10.1111/gbb.12827","url":null,"abstract":"ProSAAS is a neuroendocrine protein that is cleaved by neuropeptide-processing enzymes into more than a dozen products including the bigLEN and PEN peptides, which bind and activate the receptors GPR171 and GPR83, respectively. Previous studies have suggested that proSAAS-derived peptides are involved in physiological functions that include body weight regulation, circadian rhythms and anxiety-like behavior. In the present study, we find that proSAAS knockout mice display robust anxiety-like behaviors in the open field, light–dark emergence and elevated zero maze tests. These mutant mice also show a reduction in cued fear and an impairment in fear-potentiated startle, indicating an important role for proSAAS-derived peptides in emotional behaviors. ProSAAS knockout mice exhibit reduced water consumption and urine production relative to wild-type controls. No differences in food consumption and overall energy expenditure were observed between the genotypes. However, the respiratory exchange ratio was elevated in the mutants during the light portion of the light–dark cycle, indicating decreased fat metabolism during this period. While proSAAS knockout mice show normal circadian patterns of activity, even upon long-term exposure to constant darkness, they were unable to shift their circadian clock upon exposure to a light pulse. Taken together, these results show that proSAAS-derived peptides modulate a wide range of behaviors including emotion, metabolism and the regulation of the circadian clock.","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/fc/GBB-21-e12827.PMC9444949.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The complexity of ventral CA1 and its multiple functionalities 腹侧CA1的复杂性及其多种功能

IF 2.5 4区心理学

Genes Brain and Behavior Pub Date : 2022-07-11 DOI: 10.1111/gbb.12826

Ilgang Hong, Bong-Kiun Kaang

引用次数: 1