遗传和环境对小鼠单试验条件情境厌恶的影响

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Çınar Furkan İlhan, Gonzalo P. Urcelay, Sezen Kışlal
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引用次数: 0

摘要

预期性恶心(AN)是由环境线索和恶心体验(化疗或放疗的副作用)之间的关联引起的,主要发生在接受化疗的女性患者中。啮齿类动物的临床前研究表明,在存在新的情境线索的情况下,使用一种疾病诱导剂可以引起条件性情境厌恶(CCA),这已经被提出用于模拟an。文献还表明,在休克前短暂的预先暴露于一个新的环境对啮齿动物的情境恐惧条件反射的发展至关重要(一种被称为即时休克缺陷的现象),但这在CCA中尚未得到评估。本研究的目的是建立一种CCA范式来评估远交系(CD1)和近交系(C57BL/6J)小鼠的这种差异,并评估潜在的性别差异。结果表明,在一种特殊的环境中与licl诱导的疾病配对的单一条件作用试验足以在雌性和雄性CD1近交小鼠中引发条件反应,但在C57BL/6J近交小鼠中却没有。此外,当动物先前对环境有经验时,CCA也会得到促进。最后,近亲繁殖的雌性小鼠比雄性小鼠表现出更长、更强的CCA保留,这与临床研究结果相一致。这些结果表明,使用CD1近交小鼠作为an的动物模型以及在CCA范式中检查性别差异的重要性。在人类中类似的发现鼓励了这种新型CCA临床前小鼠模型的未来使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Genetic and environmental influences on one-trial conditioned context aversion in mice

Genetic and environmental influences on one-trial conditioned context aversion in mice

Anticipatory nausea (AN) is caused by an association between contextual cues and the experience of nausea (the side effects of chemotherapy or radiation treatment) and it develops predominantly in female patients undergoing chemotherapy. Preclinical studies in rodents show that the administration of an illness-inducing agent in the presence of novel contextual cues can cause conditioned context aversion (CCA) and this has been proposed to model AN. The literature also suggests that brief pre-exposure to a novel context prior to shock delivery is critical in the development of contextual fear conditioning in rodents (a phenomenon known as Immediate Shock Deficit), but this has not been assessed in CCA. The aim of present study was to develop a CCA paradigm to assess this in outbred (CD1) and inbred (C57BL/6J) mice and evaluate potential sex differences. The results revealed that a single conditioning trial in which a distinctive context was paired with LiCl-induced illness was sufficient to elicit a conditioned response in both female and male CD1 outbred mice, but not in C57BL/6J inbred mice. In addition, CCA was facilitated when animals had prior experience with the context. Finally, outbred female mice showed longer and more robust retention of CCA than male mice, which parallels clinical findings. The results indicate the importance of using CD1 outbred mice as an animal model of AN as well as examining sex differences in the CCA paradigm. Similar findings in humans encourage the future use of this novel CCA preclinical mouse model.

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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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