Current Cancer Therapy Reviews最新文献

Revolutionizing Oral Cancer Treatment: Immunotherapeutic Approaches 革新口腔癌治疗：免疫治疗方法

Current Cancer Therapy Reviews Pub Date : 2024-04-18 DOI: 10.2174/0115733947290954240402060311

Md Moidul Islam, Sarjana Raikwar

{"title":"Revolutionizing Oral Cancer Treatment: Immunotherapeutic Approaches","authors":"Md Moidul Islam, Sarjana Raikwar","doi":"10.2174/0115733947290954240402060311","DOIUrl":"https://doi.org/10.2174/0115733947290954240402060311","url":null,"abstract":"\u0000\u0000Immunotherapy is a promising addition to the cancer treatment arsenal, with\u0000the potential to be an effective adjuvant therapy. In the ever-changing landscape of cancer care, it\u0000appears as a potential fourth pillar, supplementing surgery, chemotherapy, and radiation. The key to\u0000effective immunotherapy is cautious patient selection, which is based on a thorough study of the\u0000unique immune makeup of each patient.\u0000\u0000\u0000\u0000This review article aims to provide a comprehensive understanding of the fundamental principles\u0000of tumor immunity and immunotherapy, with a specific focus on oral squamous cell carcinoma.\u0000\u0000\u0000\u0000The review involved a thorough investigation of scientific databases and relevant publications,\u0000including studies conducted up to the present date obtained from PubMed, Science Direct, and\u0000Google Scholar Key. The selected studies underwent careful evaluation for methodological rigor and\u0000the significance of their findings.\u0000\u0000\u0000\u0000Checkpoint inhibitors, targeted monoclonal antibodies, adoptive cell transfer, cancer vaccines,\u0000biomarkers and prediction tools, and cytokine immunotherapy are all promising treatments for\u0000oral cancer.\u0000\u0000\u0000\u0000In recent decades, there has been a substantial increase in interest and study in cancer\u0000immunotherapy, indicating a turning point in our approach to cancer treatment. While significant\u0000progress has been made, major hurdles remain across a range of cancers.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":" 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Cancer Diagnosis Using Computational Model: Recent Advancement 利用计算模型诊断乳腺癌：最新进展

Current Cancer Therapy Reviews Pub Date : 2024-04-16 DOI: 10.2174/0115733947288059240405041146

Rishav Sharma, R. Malviya, Prerna Uniyal

{"title":"Breast Cancer Diagnosis Using Computational Model: Recent Advancement","authors":"Rishav Sharma, R. Malviya, Prerna Uniyal","doi":"10.2174/0115733947288059240405041146","DOIUrl":"https://doi.org/10.2174/0115733947288059240405041146","url":null,"abstract":"\u0000\u0000Since breast cancer affects one in every four women, it is of the utmost need to investigate\u0000novel diagnostic technologies and treatment techniques. This requires the development of diagnostic\u0000techniques to simplify the identification of cancer cells, which helps monitor the success of cancer\u0000therapy. One of the most significant obstacles that chemotherapy must overcome is the absence of\u0000technologies that can measure its effectiveness while it is being administered. Additionally, due to its\u0000steadily expanding prevalence and mortality rate, cancer has surpassed AIDS as the world's secondlargest\u0000killer. Breast cancer accounts for a disproportionately high number of cancer-related deaths\u0000among women worldwide, making precise, sensitive imaging a necessity for this disease. When\u0000breast cancer is diagnosed early it can be treated successfully. As an alternate strategy, the use of cutting-\u0000edge computational methodologies has been advocated for creating innovative breast cancer diagnostic\u0000imaging techniques. The following article provides an overview of the traditional diagnostic\u0000procedures that have historically been employed for the detection of breast carcinoma, as well as the\u0000current methods that are being utilized. Furthermore, the investigators provided a comprehensive\u0000overview of various mathematical frameworks, including Machine Learning, Deep Learning, Artificial\u0000Neural Networks, and Robotics, highlighting their progress and potential applications in the field\u0000of breast cancer diagnostic imaging.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"159 8‐10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Efficacy and Mechanism of Action of Recently FDA ApprovedAnticancer Drugs: An Updated Review 最近获得 FDA 批准的抗癌药物的临床疗效和作用机制：最新综述

Current Cancer Therapy Reviews Pub Date : 2024-04-09 DOI: 10.2174/0115733947301362240330090709

Shikha Sharma, Anurag Agrawal, Anuj Kumar Singh, B. Banik

{"title":"Clinical Efficacy and Mechanism of Action of Recently FDA Approved\u0000Anticancer Drugs: An Updated Review","authors":"Shikha Sharma, Anurag Agrawal, Anuj Kumar Singh, B. Banik","doi":"10.2174/0115733947301362240330090709","DOIUrl":"https://doi.org/10.2174/0115733947301362240330090709","url":null,"abstract":"\u0000\u0000Since the beginning of the 21st century, there have been significant advancements in the\u0000field of cancer treatment, resulting in markedly improved outcomes for patients. This review provides\u0000an updated view of some recently developed and FDA-approved small molecules that have been used\u0000to treat various types of cancer on different indications and targets. Some popular search engines,\u0000such as Pubmed, Google Scholar, etc., were considered for the literature review, and drugs approved\u0000by the FDA from 2019 to 2023 were considered for study in this review. This review focuses on the\u0000mechanism of actions and targets via which these FDA-approved small molecules could demonstrate\u0000their clinical efficacy. Moreover, this review would pave the way for the scientific community to look\u0000into the chemical structures of these small molecules to discover more small synthetic compounds\u0000after modification based on structural activity that might be useful in treating various types of cancer.\u0000However, much attention is being paid to how new therapies and tools will change how cancer is\u0000treated in the coming years. This review indicated the increased rate of approvals by the FDA for oncology\u0000treatment during 2019-2023. This surge is primarily driven by the approval of targeted therapies\u0000and the introduction of novel therapeutic approaches.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"58 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140727558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Cervical Cancer and Premalignant Cases Based on Pap Smear Screening in Iran in 2022 2022 年伊朗根据巴氏涂片筛查得出的宫颈癌和恶性前病变患病率

Current Cancer Therapy Reviews Pub Date : 2024-04-05 DOI: 10.2174/0115733947295059240326055329

Saeideh Salari, Rasoul Raesi, S. Daneshi, Shohreh Alian Samakkhah, Atefeh Eshaghi

{"title":"Prevalence of Cervical Cancer and Premalignant Cases Based on Pap Smear Screening in Iran in 2022","authors":"Saeideh Salari, Rasoul Raesi, S. Daneshi, Shohreh Alian Samakkhah, Atefeh Eshaghi","doi":"10.2174/0115733947295059240326055329","DOIUrl":"https://doi.org/10.2174/0115733947295059240326055329","url":null,"abstract":"\u0000\u0000Oral or cervical cancer is caused by the abnormal growth of cells, which in\u000090% of cases is caused by the human papillomavirus infection.\u0000\u0000\u0000\u0000The present study aimed to determine the prevalence of cervical cancer and premalignant\u0000cases based on the results of Pap smears performed in Jiroft health centers in 2022.\u0000\u0000\u0000\u0000This cross-sectional study was conducted on 440 women using a census method, and the\u0000demographic information of the people and the results of their Pap smears were recorded using a researcher-\u0000made questionnaire.\u0000\u0000\u0000\u0000The average age of the investigated women was 37.20 ± 9.09 years, with the highest frequency\u0000in the age group of 30 to 40 years (44.7%), and the average number of previous pregnancies\u0000was 3.06 ± 2.26 times, with the highest frequency observed in the group 1 to 2 times (50.6%). The\u0000average number of abortions was 0.45 ± 0.86, with the highest frequency (70.4%) related to the group\u0000that had no history of abortion. Out of 440 people examined, 6 (1.4%) with a 95% confidence interval\u0000equal to 0.50-2.94% had abnormal Pap smears.\u0000\u0000\u0000\u0000The number of pregnancies and the increase in the number of abortions can be factors\u0000influencing the incidence of cervical cancer. By performing a Pap smear screening test with early\u0000diagnosis of the disease in the early stages, it is possible to prevent the spread of this disease in the\u0000body and the transformation of these cells into cancer.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"41 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Genome Editing: The Synergy of CRISPR and Nanotechnologyin Cancer Treatment 精准基因组编辑：CRISPR 和纳米技术在癌症治疗中的协同作用

Current Cancer Therapy Reviews Pub Date : 2024-03-26 DOI: 10.2174/0115733947290474240315062214

Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Rajveer Singh, Ghanshyam Das Gupta, B. Kurmi

{"title":"Precision Genome Editing: The Synergy of CRISPR and Nanotechnology\u0000in Cancer Treatment","authors":"Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Rajveer Singh, Ghanshyam Das Gupta, B. Kurmi","doi":"10.2174/0115733947290474240315062214","DOIUrl":"https://doi.org/10.2174/0115733947290474240315062214","url":null,"abstract":"\u0000\u0000In recent years, the applications of Clustered Regularly Interspaced Short Palindromic Repeats\u0000(CRISPR) technology have revolutionized genetics and molecular biology. It has expanded beyond\u0000genetic editing to include innovative cancer treatment and nanotechnology approaches as a\u0000ground-breaking genome editing tool. It has emerged as a potent tool in the battle against cancer. By\u0000targeting and modifying specific genes associated with tumor development and growth, CRISPR offers\u0000a precise means of combating this devastating disease. Researchers are increasingly utilizing\u0000CRISPR to enhance cancer therapies, from boosting the efficacy of traditional treatments to developing\u0000novel immunotherapies. Simultaneously, nanotechnology, on the other hand, has opened up new\u0000avenues in diagnosing and treating cancer. Due to their unique physical properties, nanoparticles can\u0000be engineered for targeted drug delivery and imaging and even be used as vehicles for gene-editing\u0000tools like CRISPR. These nanoparticles can navigate the intricate biological environment, homing in\u0000on cancer cells while minimizing collateral damage to healthy tissue. This precision is essential in\u0000reducing side effects and enhancing the therapeutic potential of anticancer agents. In this review, we\u0000emphasize the synergistic potential of CRISPR and nanotechnology, particularly in cancer treatment,\u0000highlighting their valuable role in advancing immunotherapy approaches. This nanotechnological\u0000perspective contributes significantly to the evolving landscape of research in this field\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"110 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calixarene in Chemotherapy Drug Delivery: Its Role and Strategies 化疗药物输送中的卡利卡林：作用与策略

Current Cancer Therapy Reviews Pub Date : 2024-03-25 DOI: 10.2174/0115733947283247240314034927

Prasoon Pandey, Ritika Singh, Manoj Kumar Mishra, Rajat Srivastava

引用次数: 0

Exploring the Functional Roles of lncRNA-HOTAIR in Glioma: Unraveling its Impact on Tumor Progression 探索lncRNA-HOTAIR在胶质瘤中的功能作用：揭示其对肿瘤进展的影响

Current Cancer Therapy Reviews Pub Date : 2024-03-20 DOI: 10.2174/0115733947296461240312051407

Arya Moftakhar, S. Khoshnam, D. Dayer, Maryam Farzaneh

{"title":"Exploring the Functional Roles of lncRNA-HOTAIR in Glioma: Unraveling its Impact on Tumor Progression","authors":"Arya Moftakhar, S. Khoshnam, D. Dayer, Maryam Farzaneh","doi":"10.2174/0115733947296461240312051407","DOIUrl":"https://doi.org/10.2174/0115733947296461240312051407","url":null,"abstract":"\u0000\u0000Gliomas, a heterogeneous class of brain cancers, pose significant challenges as they are\u0000considered incurable. They represent the most recurrent primary intracranial cancer and exhibit distinct\u0000clinical and biological characteristics. Traditional treatment options for glioma include radiotherapy,\u0000chemotherapy, and surgery; however, the emergence of molecular-targeted therapy has provided\u0000a new avenue for improved therapeutic responses. One intriguing oncogene type of long noncoding\u0000RNAs (lncRNAs) in glioma is the HOX Transcript Antisense RNA, commonly referred to as\u0000HOTAIR. HOTAIR is characterized by its overexpression in various cancers and is situated in the\u0000intergenic region between HOXC12 and HOXC11 of the HOXC cluster on chromosome 12. Its upregulation\u0000in glioma has been found to be associated with tumor grade and plays a significant role in\u0000disease progression. HOTAIR exerts vital functions in glioma, including promoting angiogenesis,\u0000modulating glutamine catabolism, and influencing sensitivity to temozolomide (TMZ), a commonly\u0000used chemotherapy drug. Knockdown of HOTAIR has been shown to suppress cell invasion, migration,\u0000and proliferation, while inducing apoptosis, ultimately leading to tumor repression. HOTAIR\u0000achieves its biological effects, by targeting specific microRNAs (miRNAs). In this review study, we\u0000have summarized several signaling pathways that are intricately linked to HOTAIR in the context of\u0000glioma. Understanding the mechanisms and interactions involving HOTAIR and these signaling\u0000pathways may provide valuable insights for the development of targeted therapies and improved\u0000management strategies for glioma. This review provides a summary of the potential roles of HOTAIR\u0000in glioma, encompassing its effects in commercial cell lines, patient-derived cell lines, animal studies,\u0000and clinical trials.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing Cancer Treatment: Harnessing Cell-membrane Coated Nanoparticles for Precise Targeting and Therapy 革新癌症治疗：利用细胞膜涂层纳米粒子实现精确靶向和治疗

Current Cancer Therapy Reviews Pub Date : 2024-03-20 DOI: 10.2174/0115733947295006240313045718

Pranali Waghode, S. N. K. Rao G, Sanika Deshpande, Roja Rani Budha, R. R. Alavala, Surya Kovvasu

{"title":"Revolutionizing Cancer Treatment: Harnessing Cell-membrane Coated Nanoparticles for Precise Targeting and Therapy","authors":"Pranali Waghode, S. N. K. Rao G, Sanika Deshpande, Roja Rani Budha, R. R. Alavala, Surya Kovvasu","doi":"10.2174/0115733947295006240313045718","DOIUrl":"https://doi.org/10.2174/0115733947295006240313045718","url":null,"abstract":"\u0000\u0000Cancer is still a significant worldwide health issue that requires novel techniques for diagnosis\u0000and treatment. The complications associated with cancer are explored in this article, which also\u0000introduces the novel concept of biomimetic nanoparticles as potential breakthrough in the fight\u0000against the disease. The introduction gives a general review of cancer, explaining its complexity and\u0000the underlying mechanisms that give rise to it. Epidemiological findings highlight the impact of cancer\u0000on the entire world and the most extensively found cancer driving the demand for innovative therapeutic\u0000approaches. A comprehensive review of the various cancer types follows with emphasis on\u0000unique traits, diagnostic methods, and treatment modalities, highlighting the variety of difficulties.\u0000An achievable path forward for targeted cancer therapy is the emerging science of biomimetic nanoparticles.\u0000A thorough review of their many varieties and applications follows their introduction. These\u0000nanoparticles’ inventive nature, which was inspired by biological systems, is highlighted by the explanation\u0000of how they were synthesized. The focus is on biomimetic nanoparticles based on cancer cell\u0000membranes as a novel means of medication administration and targeted therapy. Their use in the treatment\u0000of cancer is being investigated, with an emphasis on their potential to improve therapeutic efficacy\u0000and lessen side effects. Particularly noteworthy are the in-depth discussions of the unique difficulties\u0000encountered in treating lung, breast, prostate, colon, colorectal, ovarian, leukemia, lymphoma, melanoma,\u0000pancreatic, bladder, oral, gastric, hepatic, perihilar cholangiocarcinoma, and cervical cancers. The\u0000article also mentions the various challenges which may occur during this entire process.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140389087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Breast Cancer Drug Delivery: The Transformative Potential ofBioinformatics and Artificial Intelligence 推进乳腺癌药物输送：生物信息学和人工智能的变革潜力

Current Cancer Therapy Reviews Pub Date : 2024-03-13 DOI: 10.2174/0115733947287709240229104857

Dilpreet Singh, Diksha Sachdeva, Lovedeep Singh

{"title":"Advancing Breast Cancer Drug Delivery: The Transformative Potential of\u0000Bioinformatics and Artificial Intelligence","authors":"Dilpreet Singh, Diksha Sachdeva, Lovedeep Singh","doi":"10.2174/0115733947287709240229104857","DOIUrl":"https://doi.org/10.2174/0115733947287709240229104857","url":null,"abstract":"\u0000\u0000Breast cancer remains a significant global health challenge, necessitating innovative approaches\u0000to improve treatment efficacy while minimizing side effects. This review explores the promising\u0000advancements in breast cancer drug delivery driven by the transformative potential of bioinformatics\u0000and Artificial Intelligence (AI). Bioinformatics plays a pivotal role in unraveling the intricate\u0000genomic landscape of breast cancer, enabling the identification of potential drug targets and biomarkers.\u0000The integration of multi-omics data facilitates a comprehensive understanding of the disease,\u0000guiding personalized treatment strategies. Moreover, bioinformatics-driven approaches aid in\u0000biomarker discovery and prediction, offering novel tools for prognosis and treatment response assessment.\u0000AI, particularly machine learning and deep learning, has revolutionized breast cancer research.\u0000Machine learning models empower accurate diagnosis through image analysis, improve survival\u0000prediction, and enhance risk assessment. Deep learning algorithms, such as convolutional neural\u0000networks, enable precise tumor detection and classification from medical imaging data, notably\u0000mammograms and MRI scans. Additionally, natural language processing techniques facilitate the\u0000mining of vast scientific literature, uncovering hidden insights and identifying potential drug targets.\u0000Network-based approaches integrated with AI algorithms facilitate the identification of central proteins\u0000as promising drug targets within complex biological networks. This review also examines AIoptimized\u0000nanoformulations designed to enhance targeted drug delivery. AI-guided design of drugloaded\u0000nanoparticles improves drug encapsulation efficiency, release kinetics, and site-specific delivery,\u0000offering promising solutions to overcome the challenges of conventional drug delivery.\u0000","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140245414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth Hormone-Releasing Hormone as Potential Diagnostic andTherapeutic Target in Colorectal Cancer 作为结直肠癌潜在诊断和治疗靶点的生长激素释放激素

Current Cancer Therapy Reviews Pub Date : 2024-03-12 DOI: 10.2174/0115733947278625240304050815

S. Mehrabadi, Azam Alinaghipour, Ghazaleh Khalili-tanha, Amir Avan

引用次数: 0