Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Rajveer Singh, Ghanshyam Das Gupta, B. Kurmi
{"title":"精准基因组编辑:CRISPR 和纳米技术在癌症治疗中的协同作用","authors":"Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Rajveer Singh, Ghanshyam Das Gupta, B. Kurmi","doi":"10.2174/0115733947290474240315062214","DOIUrl":null,"url":null,"abstract":"\n\nIn recent years, the applications of Clustered Regularly Interspaced Short Palindromic Repeats\n(CRISPR) technology have revolutionized genetics and molecular biology. It has expanded beyond\ngenetic editing to include innovative cancer treatment and nanotechnology approaches as a\nground-breaking genome editing tool. It has emerged as a potent tool in the battle against cancer. By\ntargeting and modifying specific genes associated with tumor development and growth, CRISPR offers\na precise means of combating this devastating disease. Researchers are increasingly utilizing\nCRISPR to enhance cancer therapies, from boosting the efficacy of traditional treatments to developing\nnovel immunotherapies. Simultaneously, nanotechnology, on the other hand, has opened up new\navenues in diagnosing and treating cancer. Due to their unique physical properties, nanoparticles can\nbe engineered for targeted drug delivery and imaging and even be used as vehicles for gene-editing\ntools like CRISPR. These nanoparticles can navigate the intricate biological environment, homing in\non cancer cells while minimizing collateral damage to healthy tissue. This precision is essential in\nreducing side effects and enhancing the therapeutic potential of anticancer agents. In this review, we\nemphasize the synergistic potential of CRISPR and nanotechnology, particularly in cancer treatment,\nhighlighting their valuable role in advancing immunotherapy approaches. This nanotechnological\nperspective contributes significantly to the evolving landscape of research in this field\n","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"110 11","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Precision Genome Editing: The Synergy of CRISPR and Nanotechnology\\nin Cancer Treatment\",\"authors\":\"Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Rajveer Singh, Ghanshyam Das Gupta, B. Kurmi\",\"doi\":\"10.2174/0115733947290474240315062214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nIn recent years, the applications of Clustered Regularly Interspaced Short Palindromic Repeats\\n(CRISPR) technology have revolutionized genetics and molecular biology. It has expanded beyond\\ngenetic editing to include innovative cancer treatment and nanotechnology approaches as a\\nground-breaking genome editing tool. It has emerged as a potent tool in the battle against cancer. By\\ntargeting and modifying specific genes associated with tumor development and growth, CRISPR offers\\na precise means of combating this devastating disease. Researchers are increasingly utilizing\\nCRISPR to enhance cancer therapies, from boosting the efficacy of traditional treatments to developing\\nnovel immunotherapies. Simultaneously, nanotechnology, on the other hand, has opened up new\\navenues in diagnosing and treating cancer. Due to their unique physical properties, nanoparticles can\\nbe engineered for targeted drug delivery and imaging and even be used as vehicles for gene-editing\\ntools like CRISPR. These nanoparticles can navigate the intricate biological environment, homing in\\non cancer cells while minimizing collateral damage to healthy tissue. This precision is essential in\\nreducing side effects and enhancing the therapeutic potential of anticancer agents. In this review, we\\nemphasize the synergistic potential of CRISPR and nanotechnology, particularly in cancer treatment,\\nhighlighting their valuable role in advancing immunotherapy approaches. 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Precision Genome Editing: The Synergy of CRISPR and Nanotechnology
in Cancer Treatment
In recent years, the applications of Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR) technology have revolutionized genetics and molecular biology. It has expanded beyond
genetic editing to include innovative cancer treatment and nanotechnology approaches as a
ground-breaking genome editing tool. It has emerged as a potent tool in the battle against cancer. By
targeting and modifying specific genes associated with tumor development and growth, CRISPR offers
a precise means of combating this devastating disease. Researchers are increasingly utilizing
CRISPR to enhance cancer therapies, from boosting the efficacy of traditional treatments to developing
novel immunotherapies. Simultaneously, nanotechnology, on the other hand, has opened up new
avenues in diagnosing and treating cancer. Due to their unique physical properties, nanoparticles can
be engineered for targeted drug delivery and imaging and even be used as vehicles for gene-editing
tools like CRISPR. These nanoparticles can navigate the intricate biological environment, homing in
on cancer cells while minimizing collateral damage to healthy tissue. This precision is essential in
reducing side effects and enhancing the therapeutic potential of anticancer agents. In this review, we
emphasize the synergistic potential of CRISPR and nanotechnology, particularly in cancer treatment,
highlighting their valuable role in advancing immunotherapy approaches. This nanotechnological
perspective contributes significantly to the evolving landscape of research in this field